Amino acid dipepetide frequency for Rozella allomycis (strain CSF55)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.991AlaAla: 2.991 ± 0.045	0.805AlaCys: 0.805 ± 0.018	2.43AlaAsp: 2.43 ± 0.037	3.145AlaGlu: 3.145 ± 0.046	2.448AlaPhe: 2.448 ± 0.037	2.251AlaGly: 2.251 ± 0.034	0.94AlaHis: 0.94 ± 0.018	3.921AlaIle: 3.921 ± 0.046	4.088AlaLys: 4.088 ± 0.052	5.148AlaLeu: 5.148 ± 0.052	1.344AlaMet: 1.344 ± 0.026	2.687AlaAsn: 2.687 ± 0.038	1.723AlaPro: 1.723 ± 0.031	1.679AlaGln: 1.679 ± 0.028	2.159AlaArg: 2.159 ± 0.037	3.949AlaSer: 3.949 ± 0.043	2.668AlaThr: 2.668 ± 0.039	3.045AlaVal: 3.045 ± 0.041	0.424AlaTrp: 0.424 ± 0.015	1.543AlaTyr: 1.543 ± 0.029	0.01AlaXaa: 0.01 ± 0.002
Cys	0.71CysAla: 0.71 ± 0.019	0.303CysCys: 0.303 ± 0.013	0.833CysAsp: 0.833 ± 0.021	0.962CysGlu: 0.962 ± 0.019	0.871CysPhe: 0.871 ± 0.018	0.844CysGly: 0.844 ± 0.021	0.38CysHis: 0.38 ± 0.011	1.16CysIle: 1.16 ± 0.023	1.096CysLys: 1.096 ± 0.023	1.783CysLeu: 1.783 ± 0.032	0.339CysMet: 0.339 ± 0.012	0.746CysAsn: 0.746 ± 0.017	0.598CysPro: 0.598 ± 0.015	0.566CysGln: 0.566 ± 0.013	0.65CysArg: 0.65 ± 0.016	1.235CysSer: 1.235 ± 0.023	0.627CysThr: 0.627 ± 0.016	1.023CysVal: 1.023 ± 0.022	0.149CysTrp: 0.149 ± 0.008	0.552CysTyr: 0.552 ± 0.017	0.002CysXaa: 0.002 ± 0.001
Asp	2.795AspAla: 2.795 ± 0.035	0.928AspCys: 0.928 ± 0.02	3.632AspAsp: 3.632 ± 0.051	5.018AspGlu: 5.018 ± 0.058	3.059AspPhe: 3.059 ± 0.04	2.548AspGly: 2.548 ± 0.04	1.125AspHis: 1.125 ± 0.037	4.218AspIle: 4.218 ± 0.045	4.027AspLys: 4.027 ± 0.044	5.913AspLeu: 5.913 ± 0.054	1.217AspMet: 1.217 ± 0.021	2.908AspAsn: 2.908 ± 0.042	2.278AspPro: 2.278 ± 0.036	1.921AspGln: 1.921 ± 0.029	2.086AspArg: 2.086 ± 0.038	4.405AspSer: 4.405 ± 0.06	2.135AspThr: 2.135 ± 0.032	3.623AspVal: 3.623 ± 0.042	0.63AspTrp: 0.63 ± 0.019	2.248AspTyr: 2.248 ± 0.032	0.008AspXaa: 0.008 ± 0.002
Glu	3.62GluAla: 3.62 ± 0.047	1.054GluCys: 1.054 ± 0.022	4.126GluAsp: 4.126 ± 0.049	7.027GluGlu: 7.027 ± 0.097	3.544GluPhe: 3.544 ± 0.044	2.753GluGly: 2.753 ± 0.04	1.263GluHis: 1.263 ± 0.024	6.55GluIle: 6.55 ± 0.071	7.748GluLys: 7.748 ± 0.098	6.847GluLeu: 6.847 ± 0.078	2.257GluMet: 2.257 ± 0.033	5.859GluAsn: 5.859 ± 0.068	1.802GluPro: 1.802 ± 0.027	2.55GluGln: 2.55 ± 0.035	3.774GluArg: 3.774 ± 0.059	5.613GluSer: 5.613 ± 0.063	3.806GluThr: 3.806 ± 0.044	3.437GluVal: 3.437 ± 0.052	0.764GluTrp: 0.764 ± 0.02	2.754GluTyr: 2.754 ± 0.036	0.012GluXaa: 0.012 ± 0.002
Phe	2.34PheAla: 2.34 ± 0.034	0.814PheCys: 0.814 ± 0.019	3.244PheAsp: 3.244 ± 0.038	3.779PheGlu: 3.779 ± 0.042	2.12PhePhe: 2.12 ± 0.042	2.613PheGly: 2.613 ± 0.044	1.167PheHis: 1.167 ± 0.024	3.533PheIle: 3.533 ± 0.043	3.924PheLys: 3.924 ± 0.043	4.623PheLeu: 4.623 ± 0.049	1.085PheMet: 1.085 ± 0.022	3.075PheAsn: 3.075 ± 0.042	1.804PhePro: 1.804 ± 0.031	1.993PheGln: 1.993 ± 0.032	1.8PheArg: 1.8 ± 0.027	4.051PheSer: 4.051 ± 0.049	2.273PheThr: 2.273 ± 0.036	3.17PheVal: 3.17 ± 0.036	0.431PheTrp: 0.431 ± 0.013	1.885PheTyr: 1.885 ± 0.03	0.008PheXaa: 0.008 ± 0.002
Gly	2.132GlyAla: 2.132 ± 0.035	0.75GlyCys: 0.75 ± 0.019	2.457GlyAsp: 2.457 ± 0.032	2.712GlyGlu: 2.712 ± 0.039	2.392GlyPhe: 2.392 ± 0.032	2.455GlyGly: 2.455 ± 0.051	1.199GlyHis: 1.199 ± 0.032	3.481GlyIle: 3.481 ± 0.037	3.658GlyLys: 3.658 ± 0.049	4.209GlyLeu: 4.209 ± 0.049	1.118GlyMet: 1.118 ± 0.023	2.549GlyAsn: 2.549 ± 0.031	1.27GlyPro: 1.27 ± 0.023	1.533GlyGln: 1.533 ± 0.028	2.09GlyArg: 2.09 ± 0.032	3.397GlySer: 3.397 ± 0.042	2.277GlyThr: 2.277 ± 0.035	2.807GlyVal: 2.807 ± 0.042	0.482GlyTrp: 0.482 ± 0.015	1.748GlyTyr: 1.748 ± 0.034	0.008GlyXaa: 0.008 ± 0.002
His	1.032HisAla: 1.032 ± 0.023	0.357HisCys: 0.357 ± 0.011	1.085HisAsp: 1.085 ± 0.024	1.443HisGlu: 1.443 ± 0.023	1.123HisPhe: 1.123 ± 0.022	1.046HisGly: 1.046 ± 0.034	0.524HisHis: 0.524 ± 0.018	1.26HisIle: 1.26 ± 0.021	1.264HisLys: 1.264 ± 0.023	2.216HisLeu: 2.216 ± 0.032	0.403HisMet: 0.403 ± 0.013	0.946HisAsn: 0.946 ± 0.022	1.017HisPro: 1.017 ± 0.019	0.825HisGln: 0.825 ± 0.017	0.919HisArg: 0.919 ± 0.022	1.674HisSer: 1.674 ± 0.025	0.8HisThr: 0.8 ± 0.017	1.3HisVal: 1.3 ± 0.023	0.218HisTrp: 0.218 ± 0.009	0.725HisTyr: 0.725 ± 0.016	0.002HisXaa: 0.002 ± 0.001
Ile	3.617IleAla: 3.617 ± 0.044	1.185IleCys: 1.185 ± 0.025	4.668IleAsp: 4.668 ± 0.043	6.068IleGlu: 6.068 ± 0.067	3.364IlePhe: 3.364 ± 0.05	3.178IleGly: 3.178 ± 0.042	1.588IleHis: 1.588 ± 0.025	4.803IleIle: 4.803 ± 0.05	6.327IleLys: 6.327 ± 0.064	7.207IleLeu: 7.207 ± 0.063	1.484IleMet: 1.484 ± 0.024	4.463IleAsn: 4.463 ± 0.05	3.22IlePro: 3.22 ± 0.038	3.135IleGln: 3.135 ± 0.043	2.943IleArg: 2.943 ± 0.038	6.058IleSer: 6.058 ± 0.064	3.164IleThr: 3.164 ± 0.039	4.496IleVal: 4.496 ± 0.045	0.576IleTrp: 0.576 ± 0.015	2.355IleTyr: 2.355 ± 0.034	0.016IleXaa: 0.016 ± 0.003
Lys	4.062LysAla: 4.062 ± 0.046	1.203LysCys: 1.203 ± 0.022	4.785LysAsp: 4.785 ± 0.054	7.525LysGlu: 7.525 ± 0.092	3.482LysPhe: 3.482 ± 0.035	3.293LysGly: 3.293 ± 0.039	1.486LysHis: 1.486 ± 0.025	6.313LysIle: 6.313 ± 0.054	7.334LysLys: 7.334 ± 0.086	7.452LysLeu: 7.452 ± 0.083	2.417LysMet: 2.417 ± 0.036	5.159LysAsn: 5.159 ± 0.055	2.743LysPro: 2.743 ± 0.042	3.083LysGln: 3.083 ± 0.043	4.346LysArg: 4.346 ± 0.048	6.506LysSer: 6.506 ± 0.057	4.04LysThr: 4.04 ± 0.045	4.667LysVal: 4.667 ± 0.049	0.734LysTrp: 0.734 ± 0.019	2.899LysTyr: 2.899 ± 0.041	0.015LysXaa: 0.015 ± 0.003
Leu	5.078LeuAla: 5.078 ± 0.051	1.515LeuCys: 1.515 ± 0.025	5.358LeuAsp: 5.358 ± 0.048	7.45LeuGlu: 7.45 ± 0.076	4.758LeuPhe: 4.758 ± 0.06	4.043LeuGly: 4.043 ± 0.044	1.856LeuHis: 1.856 ± 0.026	6.838LeuIle: 6.838 ± 0.067	9.358LeuLys: 9.358 ± 0.09	9.323LeuLeu: 9.323 ± 0.067	2.375LeuMet: 2.375 ± 0.04	6.769LeuAsn: 6.769 ± 0.074	3.622LeuPro: 3.622 ± 0.042	3.749LeuGln: 3.749 ± 0.039	4.093LeuArg: 4.093 ± 0.04	7.843LeuSer: 7.843 ± 0.062	4.573LeuThr: 4.573 ± 0.049	5.288LeuVal: 5.288 ± 0.049	0.779LeuTrp: 0.779 ± 0.022	3.027LeuTyr: 3.027 ± 0.042	0.01LeuXaa: 0.01 ± 0.002
Met	1.4MetAla: 1.4 ± 0.026	0.281MetCys: 0.281 ± 0.012	1.469MetAsp: 1.469 ± 0.028	1.9MetGlu: 1.9 ± 0.027	1.073MetPhe: 1.073 ± 0.021	1.02MetGly: 1.02 ± 0.022	0.454MetHis: 0.454 ± 0.014	1.898MetIle: 1.898 ± 0.027	2.373MetLys: 2.373 ± 0.036	2.017MetLeu: 2.017 ± 0.028	0.646MetMet: 0.646 ± 0.018	1.736MetAsn: 1.736 ± 0.023	0.816MetPro: 0.816 ± 0.02	0.905MetGln: 0.905 ± 0.02	1.026MetArg: 1.026 ± 0.021	1.867MetSer: 1.867 ± 0.025	1.354MetThr: 1.354 ± 0.022	1.215MetVal: 1.215 ± 0.023	0.173MetTrp: 0.173 ± 0.009	0.677MetTyr: 0.677 ± 0.016	0.004MetXaa: 0.004 ± 0.001
Asn	3.081AsnAla: 3.081 ± 0.035	0.903AsnCys: 0.903 ± 0.02	3.821AsnAsp: 3.821 ± 0.047	5.556AsnGlu: 5.556 ± 0.077	2.905AsnPhe: 2.905 ± 0.033	2.921AsnGly: 2.921 ± 0.04	1.206AsnHis: 1.206 ± 0.024	4.391AsnIle: 4.391 ± 0.049	4.446AsnLys: 4.446 ± 0.054	5.964AsnLeu: 5.964 ± 0.057	1.307AsnMet: 1.307 ± 0.023	3.688AsnAsn: 3.688 ± 0.054	2.358AsnPro: 2.358 ± 0.033	2.433AsnGln: 2.433 ± 0.04	2.277AsnArg: 2.277 ± 0.032	4.825AsnSer: 4.825 ± 0.058	2.634AsnThr: 2.634 ± 0.034	4.071AsnVal: 4.071 ± 0.041	0.515AsnTrp: 0.515 ± 0.014	2.052AsnTyr: 2.052 ± 0.028	0.012AsnXaa: 0.012 ± 0.002
Pro	1.615ProAla: 1.615 ± 0.031	0.492ProCys: 0.492 ± 0.014	1.854ProAsp: 1.854 ± 0.028	2.661ProGlu: 2.661 ± 0.037	2.105ProPhe: 2.105 ± 0.034	1.607ProGly: 1.607 ± 0.029	0.687ProHis: 0.687 ± 0.015	2.677ProIle: 2.677 ± 0.035	2.85ProLys: 2.85 ± 0.042	3.547ProLeu: 3.547 ± 0.037	0.797ProMet: 0.797 ± 0.02	2.196ProAsn: 2.196 ± 0.033	1.67ProPro: 1.67 ± 0.046	1.246ProGln: 1.246 ± 0.026	1.459ProArg: 1.459 ± 0.026	3.258ProSer: 3.258 ± 0.046	2.006ProThr: 2.006 ± 0.036	2.326ProVal: 2.326 ± 0.032	0.327ProTrp: 0.327 ± 0.011	1.116ProTyr: 1.116 ± 0.028	0.004ProXaa: 0.004 ± 0.001
Gln	1.752GlnAla: 1.752 ± 0.031	0.493GlnCys: 0.493 ± 0.014	1.765GlnAsp: 1.765 ± 0.025	2.719GlnGlu: 2.719 ± 0.041	1.695GlnPhe: 1.695 ± 0.031	1.636GlnGly: 1.636 ± 0.028	0.649GlnHis: 0.649 ± 0.019	2.91GlnIle: 2.91 ± 0.034	3.138GlnLys: 3.138 ± 0.043	3.536GlnLeu: 3.536 ± 0.047	1.162GlnMet: 1.162 ± 0.025	2.445GlnAsn: 2.445 ± 0.034	1.175GlnPro: 1.175 ± 0.025	1.624GlnGln: 1.624 ± 0.038	1.878GlnArg: 1.878 ± 0.027	2.853GlnSer: 2.853 ± 0.038	1.88GlnThr: 1.88 ± 0.032	2.282GlnVal: 2.282 ± 0.033	0.34GlnTrp: 0.34 ± 0.013	1.122GlnTyr: 1.122 ± 0.025	0.005GlnXaa: 0.005 ± 0.001
Arg	1.961ArgAla: 1.961 ± 0.03	0.606ArgCys: 0.606 ± 0.015	2.397ArgAsp: 2.397 ± 0.041	3.184ArgGlu: 3.184 ± 0.044	2.099ArgPhe: 2.099 ± 0.028	1.868ArgGly: 1.868 ± 0.033	1.016ArgHis: 1.016 ± 0.025	3.391ArgIle: 3.391 ± 0.041	3.898ArgLys: 3.898 ± 0.043	4.313ArgLeu: 4.313 ± 0.049	1.204ArgMet: 1.204 ± 0.024	2.72ArgAsn: 2.72 ± 0.032	1.486ArgPro: 1.486 ± 0.028	1.684ArgGln: 1.684 ± 0.03	2.523ArgArg: 2.523 ± 0.043	2.875ArgSer: 2.875 ± 0.039	1.834ArgThr: 1.834 ± 0.029	2.638ArgVal: 2.638 ± 0.042	0.411ArgTrp: 0.411 ± 0.013	1.484ArgTyr: 1.484 ± 0.025	0.012ArgXaa: 0.012 ± 0.002
Ser	3.542SerAla: 3.542 ± 0.041	1.181SerCys: 1.181 ± 0.022	4.078SerAsp: 4.078 ± 0.048	5.144SerGlu: 5.144 ± 0.054	4.661SerPhe: 4.661 ± 0.057	3.529SerGly: 3.529 ± 0.041	1.617SerHis: 1.617 ± 0.027	6.281SerIle: 6.281 ± 0.055	6.332SerLys: 6.332 ± 0.059	8.389SerLeu: 8.389 ± 0.071	1.79SerMet: 1.79 ± 0.029	4.915SerAsn: 4.915 ± 0.059	2.892SerPro: 2.892 ± 0.046	2.849SerGln: 2.849 ± 0.035	3.34SerArg: 3.34 ± 0.042	7.001SerSer: 7.001 ± 0.103	4.046SerThr: 4.046 ± 0.054	4.714SerVal: 4.714 ± 0.051	0.698SerTrp: 0.698 ± 0.018	2.373SerTyr: 2.373 ± 0.036	0.009SerXaa: 0.009 ± 0.002
Thr	2.32ThrAla: 2.32 ± 0.036	0.796ThrCys: 0.796 ± 0.017	2.311ThrAsp: 2.311 ± 0.034	3.109ThrGlu: 3.109 ± 0.04	2.697ThrPhe: 2.697 ± 0.035	2.36ThrGly: 2.36 ± 0.038	0.856ThrHis: 0.856 ± 0.02	3.684ThrIle: 3.684 ± 0.044	3.644ThrLys: 3.644 ± 0.035	4.953ThrLeu: 4.953 ± 0.05	1.091ThrMet: 1.091 ± 0.022	2.687ThrAsn: 2.687 ± 0.032	2.139ThrPro: 2.139 ± 0.031	1.537ThrGln: 1.537 ± 0.031	2.065ThrArg: 2.065 ± 0.032	3.868ThrSer: 3.868 ± 0.052	2.631ThrThr: 2.631 ± 0.069	2.855ThrVal: 2.855 ± 0.034	0.418ThrTrp: 0.418 ± 0.012	1.279ThrTyr: 1.279 ± 0.02	0.009ThrXaa: 0.009 ± 0.002
Val	3.255ValAla: 3.255 ± 0.045	1.021ValCys: 1.021 ± 0.023	3.88ValAsp: 3.88 ± 0.053	4.765ValGlu: 4.765 ± 0.061	2.832ValPhe: 2.832 ± 0.042	2.794ValGly: 2.794 ± 0.037	1.197ValHis: 1.197 ± 0.021	3.793ValIle: 3.793 ± 0.042	4.796ValLys: 4.796 ± 0.05	5.648ValLeu: 5.648 ± 0.053	1.25ValMet: 1.25 ± 0.025	3.327ValAsn: 3.327 ± 0.041	2.363ValPro: 2.363 ± 0.033	2.111ValGln: 2.111 ± 0.033	2.26ValArg: 2.26 ± 0.034	4.572ValSer: 4.572 ± 0.047	2.748ValThr: 2.748 ± 0.037	3.844ValVal: 3.844 ± 0.071	0.544ValTrp: 0.544 ± 0.015	2.119ValTyr: 2.119 ± 0.033	0.009ValXaa: 0.009 ± 0.002
Trp	0.426TrpAla: 0.426 ± 0.013	0.14TrpCys: 0.14 ± 0.008	0.589TrpAsp: 0.589 ± 0.019	0.521TrpGlu: 0.521 ± 0.015	0.42TrpPhe: 0.42 ± 0.013	0.318TrpGly: 0.318 ± 0.013	0.195TrpHis: 0.195 ± 0.01	0.765TrpIle: 0.765 ± 0.02	0.855TrpLys: 0.855 ± 0.02	0.859TrpLeu: 0.859 ± 0.02	0.297TrpMet: 0.297 ± 0.013	0.683TrpAsn: 0.683 ± 0.021	0.246TrpPro: 0.246 ± 0.01	0.304TrpGln: 0.304 ± 0.012	0.424TrpArg: 0.424 ± 0.012	0.674TrpSer: 0.674 ± 0.019	0.487TrpThr: 0.487 ± 0.014	0.438TrpVal: 0.438 ± 0.013	0.105TrpTrp: 0.105 ± 0.009	0.307TrpTyr: 0.307 ± 0.012	0.002TrpXaa: 0.002 ± 0.001
Tyr	1.667TyrAla: 1.667 ± 0.03	0.602TyrCys: 0.602 ± 0.017	1.931TyrAsp: 1.931 ± 0.029	2.458TyrGlu: 2.458 ± 0.038	2.071TyrPhe: 2.071 ± 0.032	1.642TyrGly: 1.642 ± 0.027	0.773TyrHis: 0.773 ± 0.02	2.036TyrIle: 2.036 ± 0.029	2.382TyrLys: 2.382 ± 0.033	3.74TyrLeu: 3.74 ± 0.047	0.712TyrMet: 0.712 ± 0.018	1.795TyrAsn: 1.795 ± 0.03	1.273TyrPro: 1.273 ± 0.029	1.325TyrGln: 1.325 ± 0.027	1.48TyrArg: 1.48 ± 0.022	2.848TyrSer: 2.848 ± 0.04	1.315TyrThr: 1.315 ± 0.022	1.881TyrVal: 1.881 ± 0.03	0.336TyrTrp: 0.336 ± 0.013	1.296TyrTyr: 1.296 ± 0.028	0.003TyrXaa: 0.003 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.001	0.002XaaCys: 0.002 ± 0.001	0.008XaaAsp: 0.008 ± 0.002	0.012XaaGlu: 0.012 ± 0.002	0.009XaaPhe: 0.009 ± 0.002	0.006XaaGly: 0.006 ± 0.002	0.002XaaHis: 0.002 ± 0.001	0.013XaaIle: 0.013 ± 0.002	0.008XaaLys: 0.008 ± 0.002	0.019XaaLeu: 0.019 ± 0.002	0.008XaaMet: 0.008 ± 0.002	0.011XaaAsn: 0.011 ± 0.002	0.005XaaPro: 0.005 ± 0.001	0.008XaaGln: 0.008 ± 0.002	0.01XaaArg: 0.01 ± 0.002	0.01XaaSer: 0.01 ± 0.002	0.011XaaThr: 0.011 ± 0.002	0.007XaaVal: 0.007 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.005XaaTyr: 0.005 ± 0.001	0.057XaaXaa: 0.057 ± 0.026

Statistics based on 6337 proteins (2471604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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