Amino acid dipepetide frequency for Methylocapsa palsarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.493AlaAla: 19.493 ± 0.184	1.232AlaCys: 1.232 ± 0.036	6.744AlaAsp: 6.744 ± 0.094	7.358AlaGlu: 7.358 ± 0.1	4.896AlaPhe: 4.896 ± 0.065	10.965AlaGly: 10.965 ± 0.108	2.375AlaHis: 2.375 ± 0.051	6.907AlaIle: 6.907 ± 0.084	4.783AlaLys: 4.783 ± 0.087	14.165AlaLeu: 14.165 ± 0.129	3.013AlaMet: 3.013 ± 0.054	3.269AlaAsn: 3.269 ± 0.057	7.18AlaPro: 7.18 ± 0.106	4.278AlaGln: 4.278 ± 0.077	9.636AlaArg: 9.636 ± 0.107	7.496AlaSer: 7.496 ± 0.098	5.485AlaThr: 5.485 ± 0.074	7.976AlaVal: 7.976 ± 0.092	1.434AlaTrp: 1.434 ± 0.041	2.586AlaTyr: 2.586 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.274CysAla: 1.274 ± 0.034	0.12CysCys: 0.12 ± 0.012	0.605CysAsp: 0.605 ± 0.026	0.533CysGlu: 0.533 ± 0.024	0.371CysPhe: 0.371 ± 0.019	1.035CysGly: 1.035 ± 0.03	0.234CysHis: 0.234 ± 0.016	0.381CysIle: 0.381 ± 0.019	0.241CysLys: 0.241 ± 0.016	0.91CysLeu: 0.91 ± 0.028	0.164CysMet: 0.164 ± 0.014	0.224CysAsn: 0.224 ± 0.013	0.489CysPro: 0.489 ± 0.026	0.234CysGln: 0.234 ± 0.015	0.651CysArg: 0.651 ± 0.028	0.494CysSer: 0.494 ± 0.025	0.339CysThr: 0.339 ± 0.018	0.76CysVal: 0.76 ± 0.026	0.117CysTrp: 0.117 ± 0.011	0.193CysTyr: 0.193 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.202AspAla: 7.202 ± 0.097	0.536AspCys: 0.536 ± 0.023	2.906AspAsp: 2.906 ± 0.057	3.501AspGlu: 3.501 ± 0.063	2.301AspPhe: 2.301 ± 0.05	4.587AspGly: 4.587 ± 0.071	1.261AspHis: 1.261 ± 0.039	2.786AspIle: 2.786 ± 0.052	1.83AspLys: 1.83 ± 0.046	6.234AspLeu: 6.234 ± 0.083	1.091AspMet: 1.091 ± 0.03	1.182AspAsn: 1.182 ± 0.031	3.727AspPro: 3.727 ± 0.053	1.733AspGln: 1.733 ± 0.04	4.067AspArg: 4.067 ± 0.074	2.447AspSer: 2.447 ± 0.043	1.814AspThr: 1.814 ± 0.046	3.859AspVal: 3.859 ± 0.064	0.84AspTrp: 0.84 ± 0.03	1.435AspTyr: 1.435 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.934GluAla: 7.934 ± 0.106	0.402GluCys: 0.402 ± 0.018	2.778GluAsp: 2.778 ± 0.056	2.808GluGlu: 2.808 ± 0.059	1.914GluPhe: 1.914 ± 0.039	4.135GluGly: 4.135 ± 0.064	1.188GluHis: 1.188 ± 0.034	3.771GluIle: 3.771 ± 0.055	2.486GluLys: 2.486 ± 0.06	5.111GluLeu: 5.111 ± 0.072	1.272GluMet: 1.272 ± 0.036	1.595GluAsn: 1.595 ± 0.036	2.803GluPro: 2.803 ± 0.055	1.836GluGln: 1.836 ± 0.041	4.932GluArg: 4.932 ± 0.088	2.871GluSer: 2.871 ± 0.05	3.649GluThr: 3.649 ± 0.057	3.21GluVal: 3.21 ± 0.06	0.677GluTrp: 0.677 ± 0.024	0.915GluTyr: 0.915 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	5.079PheAla: 5.079 ± 0.068	0.484PheCys: 0.484 ± 0.019	2.772PheAsp: 2.772 ± 0.049	2.426PheGlu: 2.426 ± 0.051	1.616PhePhe: 1.616 ± 0.044	3.8PheGly: 3.8 ± 0.067	0.807PheHis: 0.807 ± 0.027	1.762PheIle: 1.762 ± 0.042	1.194PheLys: 1.194 ± 0.033	3.63PheLeu: 3.63 ± 0.061	0.766PheMet: 0.766 ± 0.029	1.144PheAsn: 1.144 ± 0.031	1.764PhePro: 1.764 ± 0.043	1.028PheGln: 1.028 ± 0.033	2.361PheArg: 2.361 ± 0.043	2.606PheSer: 2.606 ± 0.053	1.898PheThr: 1.898 ± 0.043	3.011PheVal: 3.011 ± 0.055	0.543PheTrp: 0.543 ± 0.024	0.911PheTyr: 0.911 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.244GlyAla: 11.244 ± 0.125	0.844GlyCys: 0.844 ± 0.032	4.424GlyAsp: 4.424 ± 0.068	4.78GlyGlu: 4.78 ± 0.069	3.78GlyPhe: 3.78 ± 0.067	7.716GlyGly: 7.716 ± 0.259	1.706GlyHis: 1.706 ± 0.041	3.422GlyIle: 3.422 ± 0.054	3.333GlyLys: 3.333 ± 0.072	9.004GlyLeu: 9.004 ± 0.109	1.795GlyMet: 1.795 ± 0.041	1.915GlyAsn: 1.915 ± 0.055	3.799GlyPro: 3.799 ± 0.061	2.592GlyGln: 2.592 ± 0.053	6.065GlyArg: 6.065 ± 0.083	4.745GlySer: 4.745 ± 0.082	3.265GlyThr: 3.265 ± 0.064	6.494GlyVal: 6.494 ± 0.073	1.285GlyTrp: 1.285 ± 0.038	2.052GlyTyr: 2.052 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.287HisAla: 2.287 ± 0.057	0.249HisCys: 0.249 ± 0.016	1.127HisAsp: 1.127 ± 0.028	1.043HisGlu: 1.043 ± 0.033	0.89HisPhe: 0.89 ± 0.029	1.88HisGly: 1.88 ± 0.044	0.567HisHis: 0.567 ± 0.03	0.928HisIle: 0.928 ± 0.029	0.537HisLys: 0.537 ± 0.025	1.986HisLeu: 1.986 ± 0.044	0.423HisMet: 0.423 ± 0.02	0.442HisAsn: 0.442 ± 0.018	1.329HisPro: 1.329 ± 0.035	0.546HisGln: 0.546 ± 0.022	1.383HisArg: 1.383 ± 0.04	1.071HisSer: 1.071 ± 0.029	0.722HisThr: 0.722 ± 0.026	1.447HisVal: 1.447 ± 0.041	0.31HisTrp: 0.31 ± 0.016	0.538HisTyr: 0.538 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.446IleAla: 7.446 ± 0.084	0.557IleCys: 0.557 ± 0.021	3.595IleAsp: 3.595 ± 0.056	3.908IleGlu: 3.908 ± 0.061	1.943IlePhe: 1.943 ± 0.044	5.008IleGly: 5.008 ± 0.078	0.949IleHis: 0.949 ± 0.029	2.34IleIle: 2.34 ± 0.053	1.638IleLys: 1.638 ± 0.04	4.776IleLeu: 4.776 ± 0.064	0.892IleMet: 0.892 ± 0.032	1.38IleAsn: 1.38 ± 0.038	2.299IlePro: 2.299 ± 0.049	1.152IleGln: 1.152 ± 0.032	3.038IleArg: 3.038 ± 0.049	2.941IleSer: 2.941 ± 0.052	2.235IleThr: 2.235 ± 0.043	4.411IleVal: 4.411 ± 0.063	0.603IleTrp: 0.603 ± 0.025	1.139IleTyr: 1.139 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.697LysAla: 4.697 ± 0.072	0.212LysCys: 0.212 ± 0.014	1.856LysAsp: 1.856 ± 0.053	1.696LysGlu: 1.696 ± 0.049	1.108LysPhe: 1.108 ± 0.039	2.823LysGly: 2.823 ± 0.055	0.615LysHis: 0.615 ± 0.026	2.21LysIle: 2.21 ± 0.047	1.415LysLys: 1.415 ± 0.05	3.476LysLeu: 3.476 ± 0.064	0.805LysMet: 0.805 ± 0.029	1.043LysAsn: 1.043 ± 0.031	2.314LysPro: 2.314 ± 0.046	1.068LysGln: 1.068 ± 0.029	2.459LysArg: 2.459 ± 0.051	2.237LysSer: 2.237 ± 0.047	2.283LysThr: 2.283 ± 0.05	2.312LysVal: 2.312 ± 0.06	0.391LysTrp: 0.391 ± 0.021	0.642LysTyr: 0.642 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	14.136LeuAla: 14.136 ± 0.124	0.979LeuCys: 0.979 ± 0.028	6.169LeuAsp: 6.169 ± 0.094	5.476LeuGlu: 5.476 ± 0.089	3.816LeuPhe: 3.816 ± 0.065	8.108LeuGly: 8.108 ± 0.087	1.79LeuHis: 1.79 ± 0.04	5.309LeuIle: 5.309 ± 0.07	3.717LeuLys: 3.717 ± 0.06	9.115LeuLeu: 9.115 ± 0.113	1.982LeuMet: 1.982 ± 0.04	2.708LeuAsn: 2.708 ± 0.049	5.483LeuPro: 5.483 ± 0.075	2.754LeuGln: 2.754 ± 0.051	7.457LeuArg: 7.457 ± 0.089	6.638LeuSer: 6.638 ± 0.091	5.595LeuThr: 5.595 ± 0.074	7.029LeuVal: 7.029 ± 0.088	1.133LeuTrp: 1.133 ± 0.034	2.087LeuTyr: 2.087 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.585MetAla: 2.585 ± 0.05	0.139MetCys: 0.139 ± 0.011	0.875MetAsp: 0.875 ± 0.028	0.939MetGlu: 0.939 ± 0.034	0.696MetPhe: 0.696 ± 0.023	1.439MetGly: 1.439 ± 0.036	0.358MetHis: 0.358 ± 0.019	1.283MetIle: 1.283 ± 0.033	0.969MetLys: 0.969 ± 0.027	2.101MetLeu: 2.101 ± 0.045	0.501MetMet: 0.501 ± 0.024	0.783MetAsn: 0.783 ± 0.027	1.171MetPro: 1.171 ± 0.031	0.687MetGln: 0.687 ± 0.024	1.737MetArg: 1.737 ± 0.038	1.538MetSer: 1.538 ± 0.041	1.612MetThr: 1.612 ± 0.035	1.23MetVal: 1.23 ± 0.03	0.174MetTrp: 0.174 ± 0.011	0.258MetTyr: 0.258 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.312AsnAla: 3.312 ± 0.059	0.278AsnCys: 0.278 ± 0.016	1.348AsnAsp: 1.348 ± 0.034	1.413AsnGlu: 1.413 ± 0.037	1.106AsnPhe: 1.106 ± 0.036	2.339AsnGly: 2.339 ± 0.052	0.531AsnHis: 0.531 ± 0.021	1.408AsnIle: 1.408 ± 0.038	0.804AsnLys: 0.804 ± 0.026	2.658AsnLeu: 2.658 ± 0.054	0.5AsnMet: 0.5 ± 0.021	0.668AsnAsn: 0.668 ± 0.03	1.849AsnPro: 1.849 ± 0.032	0.763AsnGln: 0.763 ± 0.028	1.746AsnArg: 1.746 ± 0.043	1.58AsnSer: 1.58 ± 0.042	1.155AsnThr: 1.155 ± 0.038	1.977AsnVal: 1.977 ± 0.048	0.422AsnTrp: 0.422 ± 0.02	0.732AsnTyr: 0.732 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.103ProAla: 7.103 ± 0.087	0.41ProCys: 0.41 ± 0.02	3.697ProAsp: 3.697 ± 0.063	3.439ProGlu: 3.439 ± 0.06	2.164ProPhe: 2.164 ± 0.047	4.957ProGly: 4.957 ± 0.073	1.114ProHis: 1.114 ± 0.033	2.477ProIle: 2.477 ± 0.052	1.931ProLys: 1.931 ± 0.044	4.983ProLeu: 4.983 ± 0.068	1.09ProMet: 1.09 ± 0.029	1.447ProAsn: 1.447 ± 0.044	3.404ProPro: 3.404 ± 0.105	1.893ProGln: 1.893 ± 0.045	3.411ProArg: 3.411 ± 0.051	3.291ProSer: 3.291 ± 0.053	2.323ProThr: 2.323 ± 0.043	3.877ProVal: 3.877 ± 0.056	0.726ProTrp: 0.726 ± 0.027	1.18ProTyr: 1.18 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.841GlnAla: 3.841 ± 0.067	0.207GlnCys: 0.207 ± 0.014	1.529GlnAsp: 1.529 ± 0.039	1.426GlnGlu: 1.426 ± 0.037	1.113GlnPhe: 1.113 ± 0.031	2.327GlnGly: 2.327 ± 0.052	0.54GlnHis: 0.54 ± 0.023	1.97GlnIle: 1.97 ± 0.038	1.216GlnLys: 1.216 ± 0.035	2.587GlnLeu: 2.587 ± 0.053	0.758GlnMet: 0.758 ± 0.029	0.956GlnAsn: 0.956 ± 0.031	1.665GlnPro: 1.665 ± 0.04	1.011GlnGln: 1.011 ± 0.038	2.176GlnArg: 2.176 ± 0.042	1.937GlnSer: 1.937 ± 0.044	1.885GlnThr: 1.885 ± 0.042	1.828GlnVal: 1.828 ± 0.043	0.401GlnTrp: 0.401 ± 0.02	0.6GlnTyr: 0.6 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.77ArgAla: 8.77 ± 0.091	0.549ArgCys: 0.549 ± 0.022	3.945ArgAsp: 3.945 ± 0.075	4.235ArgGlu: 4.235 ± 0.072	3.024ArgPhe: 3.024 ± 0.044	4.923ArgGly: 4.923 ± 0.069	1.58ArgHis: 1.58 ± 0.043	4.077ArgIle: 4.077 ± 0.053	2.508ArgLys: 2.508 ± 0.055	8.456ArgLeu: 8.456 ± 0.105	1.612ArgMet: 1.612 ± 0.035	1.889ArgAsn: 1.889 ± 0.046	3.888ArgPro: 3.888 ± 0.065	2.394ArgGln: 2.394 ± 0.052	6.483ArgArg: 6.483 ± 0.096	4.066ArgSer: 4.066 ± 0.071	3.25ArgThr: 3.25 ± 0.057	4.412ArgVal: 4.412 ± 0.069	0.974ArgTrp: 0.974 ± 0.028	1.608ArgTyr: 1.608 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.157SerAla: 7.157 ± 0.077	0.605SerCys: 0.605 ± 0.027	3.034SerAsp: 3.034 ± 0.051	3.105SerGlu: 3.105 ± 0.052	2.594SerPhe: 2.594 ± 0.051	5.894SerGly: 5.894 ± 0.104	1.123SerHis: 1.123 ± 0.031	3.083SerIle: 3.083 ± 0.063	1.87SerLys: 1.87 ± 0.045	6.099SerLeu: 6.099 ± 0.086	1.243SerMet: 1.243 ± 0.033	1.576SerAsn: 1.576 ± 0.045	3.493SerPro: 3.493 ± 0.059	1.68SerGln: 1.68 ± 0.035	4.057SerArg: 4.057 ± 0.06	3.563SerSer: 3.563 ± 0.061	2.574SerThr: 2.574 ± 0.051	4.028SerVal: 4.028 ± 0.072	0.754SerTrp: 0.754 ± 0.024	1.347SerTyr: 1.347 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.423ThrAla: 5.423 ± 0.074	0.421ThrCys: 0.421 ± 0.02	2.252ThrAsp: 2.252 ± 0.044	2.264ThrGlu: 2.264 ± 0.051	1.993ThrPhe: 1.993 ± 0.044	4.644ThrGly: 4.644 ± 0.083	0.952ThrHis: 0.952 ± 0.03	2.87ThrIle: 2.87 ± 0.05	1.513ThrLys: 1.513 ± 0.034	5.509ThrLeu: 5.509 ± 0.075	1.002ThrMet: 1.002 ± 0.029	1.302ThrAsn: 1.302 ± 0.035	3.336ThrPro: 3.336 ± 0.056	1.405ThrGln: 1.405 ± 0.037	3.094ThrArg: 3.094 ± 0.051	2.852ThrSer: 2.852 ± 0.06	2.388ThrThr: 2.388 ± 0.047	3.194ThrVal: 3.194 ± 0.065	0.526ThrTrp: 0.526 ± 0.021	1.067ThrTyr: 1.067 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.611ValAla: 8.611 ± 0.094	0.756ValCys: 0.756 ± 0.024	3.785ValAsp: 3.785 ± 0.055	4.355ValGlu: 4.355 ± 0.067	2.749ValPhe: 2.749 ± 0.054	4.927ValGly: 4.927 ± 0.088	1.282ValHis: 1.282 ± 0.035	3.655ValIle: 3.655 ± 0.059	2.57ValLys: 2.57 ± 0.057	6.975ValLeu: 6.975 ± 0.091	1.478ValMet: 1.478 ± 0.04	2.018ValAsn: 2.018 ± 0.044	3.041ValPro: 3.041 ± 0.058	1.862ValGln: 1.862 ± 0.037	4.763ValArg: 4.763 ± 0.074	4.331ValSer: 4.331 ± 0.071	3.737ValThr: 3.737 ± 0.071	5.126ValVal: 5.126 ± 0.081	0.847ValTrp: 0.847 ± 0.03	1.515ValTyr: 1.515 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.121TrpAla: 1.121 ± 0.036	0.131TrpCys: 0.131 ± 0.01	0.568TrpAsp: 0.568 ± 0.024	0.455TrpGlu: 0.455 ± 0.022	0.542TrpPhe: 0.542 ± 0.021	0.813TrpGly: 0.813 ± 0.031	0.257TrpHis: 0.257 ± 0.015	0.735TrpIle: 0.735 ± 0.028	0.439TrpLys: 0.439 ± 0.022	1.534TrpLeu: 1.534 ± 0.04	0.299TrpMet: 0.299 ± 0.017	0.414TrpAsn: 0.414 ± 0.024	0.755TrpPro: 0.755 ± 0.028	0.373TrpGln: 0.373 ± 0.021	1.446TrpArg: 1.446 ± 0.041	0.886TrpSer: 0.886 ± 0.028	0.828TrpThr: 0.828 ± 0.028	0.651TrpVal: 0.651 ± 0.026	0.191TrpTrp: 0.191 ± 0.013	0.239TrpTyr: 0.239 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.554TyrAla: 2.554 ± 0.049	0.255TyrCys: 0.255 ± 0.014	1.332TyrAsp: 1.332 ± 0.042	1.127TyrGlu: 1.127 ± 0.033	0.988TyrPhe: 0.988 ± 0.031	1.941TyrGly: 1.941 ± 0.046	0.477TyrHis: 0.477 ± 0.02	0.875TyrIle: 0.875 ± 0.028	0.666TyrLys: 0.666 ± 0.027	2.175TyrLeu: 2.175 ± 0.049	0.387TyrMet: 0.387 ± 0.02	0.631TyrAsn: 0.631 ± 0.023	1.126TyrPro: 1.126 ± 0.032	0.685TyrGln: 0.685 ± 0.025	1.681TyrArg: 1.681 ± 0.041	1.287TyrSer: 1.287 ± 0.037	0.973TyrThr: 0.973 ± 0.033	1.551TyrVal: 1.551 ± 0.04	0.33TyrTrp: 0.33 ± 0.018	0.595TyrTyr: 0.595 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3816 proteins (1162880 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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