Amino acid dipepetide frequency for Haloplanus vescus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.705AlaAla: 13.705 ± 0.195
0.728AlaCys: 0.728 ± 0.03
10.502AlaAsp: 10.502 ± 0.153
8.193AlaGlu: 8.193 ± 0.131
3.853AlaPhe: 3.853 ± 0.082
9.32AlaGly: 9.32 ± 0.126
1.891AlaHis: 1.891 ± 0.058
4.656AlaIle: 4.656 ± 0.083
1.677AlaLys: 1.677 ± 0.043
10.869AlaLeu: 10.869 ± 0.157
2.199AlaMet: 2.199 ± 0.053
2.321AlaAsn: 2.321 ± 0.059
4.175AlaPro: 4.175 ± 0.087
2.203AlaGln: 2.203 ± 0.059
6.565AlaArg: 6.565 ± 0.094
5.584AlaSer: 5.584 ± 0.093
7.907AlaThr: 7.907 ± 0.143
10.856AlaVal: 10.856 ± 0.161
1.148AlaTrp: 1.148 ± 0.042
2.857AlaTyr: 2.857 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.59CysAla: 0.59 ± 0.026
0.073CysCys: 0.073 ± 0.009
0.563CysAsp: 0.563 ± 0.028
0.542CysGlu: 0.542 ± 0.026
0.212CysPhe: 0.212 ± 0.015
0.819CysGly: 0.819 ± 0.038
0.193CysHis: 0.193 ± 0.016
0.26CysIle: 0.26 ± 0.018
0.121CysLys: 0.121 ± 0.013
0.59CysLeu: 0.59 ± 0.027
0.095CysMet: 0.095 ± 0.01
0.172CysAsn: 0.172 ± 0.014
0.545CysPro: 0.545 ± 0.03
0.159CysGln: 0.159 ± 0.013
0.506CysArg: 0.506 ± 0.022
0.463CysSer: 0.463 ± 0.024
0.396CysThr: 0.396 ± 0.024
0.477CysVal: 0.477 ± 0.024
0.086CysTrp: 0.086 ± 0.01
0.191CysTyr: 0.191 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
11.801AspAla: 11.801 ± 0.175
0.707AspCys: 0.707 ± 0.035
9.151AspAsp: 9.151 ± 0.153
7.979AspGlu: 7.979 ± 0.127
2.254AspPhe: 2.254 ± 0.06
7.531AspGly: 7.531 ± 0.12
2.101AspHis: 2.101 ± 0.062
3.513AspIle: 3.513 ± 0.082
0.889AspLys: 0.889 ± 0.035
7.593AspLeu: 7.593 ± 0.109
1.356AspMet: 1.356 ± 0.041
1.311AspAsn: 1.311 ± 0.047
5.028AspPro: 5.028 ± 0.092
1.737AspGln: 1.737 ± 0.052
6.793AspArg: 6.793 ± 0.107
3.803AspSer: 3.803 ± 0.08
4.518AspThr: 4.518 ± 0.09
7.659AspVal: 7.659 ± 0.125
1.085AspTrp: 1.085 ± 0.037
2.033AspTyr: 2.033 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
8.436GluAla: 8.436 ± 0.12
0.461GluCys: 0.461 ± 0.025
5.393GluAsp: 5.393 ± 0.104
6.196GluGlu: 6.196 ± 0.129
2.814GluPhe: 2.814 ± 0.067
5.315GluGly: 5.315 ± 0.091
1.834GluHis: 1.834 ± 0.047
3.246GluIle: 3.246 ± 0.069
1.671GluLys: 1.671 ± 0.062
6.745GluLeu: 6.745 ± 0.101
1.843GluMet: 1.843 ± 0.05
2.092GluAsn: 2.092 ± 0.06
3.206GluPro: 3.206 ± 0.067
2.498GluGln: 2.498 ± 0.064
7.937GluArg: 7.937 ± 0.117
5.211GluSer: 5.211 ± 0.093
6.551GluThr: 6.551 ± 0.101
5.567GluVal: 5.567 ± 0.098
1.048GluTrp: 1.048 ± 0.043
2.407GluTyr: 2.407 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.622PheAla: 3.622 ± 0.085
0.276PheCys: 0.276 ± 0.019
3.432PheAsp: 3.432 ± 0.078
3.245PheGlu: 3.245 ± 0.073
0.982PhePhe: 0.982 ± 0.04
3.135PheGly: 3.135 ± 0.072
0.657PheHis: 0.657 ± 0.031
0.996PheIle: 0.996 ± 0.039
0.478PheLys: 0.478 ± 0.027
2.747PheLeu: 2.747 ± 0.072
0.457PheMet: 0.457 ± 0.026
0.606PheAsn: 0.606 ± 0.028
1.269PhePro: 1.269 ± 0.038
0.784PheGln: 0.784 ± 0.03
1.796PheArg: 1.796 ± 0.05
1.616PheSer: 1.616 ± 0.045
1.792PheThr: 1.792 ± 0.047
3.322PheVal: 3.322 ± 0.072
0.375PheTrp: 0.375 ± 0.023
0.862PheTyr: 0.862 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
8.055GlyAla: 8.055 ± 0.137
0.667GlyCys: 0.667 ± 0.033
6.798GlyAsp: 6.798 ± 0.102
6.598GlyGlu: 6.598 ± 0.108
2.979GlyPhe: 2.979 ± 0.053
7.246GlyGly: 7.246 ± 0.118
1.637GlyHis: 1.637 ± 0.05
3.734GlyIle: 3.734 ± 0.082
1.715GlyLys: 1.715 ± 0.051
7.298GlyLeu: 7.298 ± 0.113
1.695GlyMet: 1.695 ± 0.052
1.867GlyAsn: 1.867 ± 0.059
3.275GlyPro: 3.275 ± 0.073
1.964GlyGln: 1.964 ± 0.045
4.916GlyArg: 4.916 ± 0.077
4.809GlySer: 4.809 ± 0.092
5.52GlyThr: 5.52 ± 0.085
8.127GlyVal: 8.127 ± 0.116
1.078GlyTrp: 1.078 ± 0.039
2.651GlyTyr: 2.651 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.103HisAla: 2.103 ± 0.055
0.191HisCys: 0.191 ± 0.018
1.969HisAsp: 1.969 ± 0.059
1.649HisGlu: 1.649 ± 0.048
0.55HisPhe: 0.55 ± 0.028
1.879HisGly: 1.879 ± 0.047
0.552HisHis: 0.552 ± 0.024
0.695HisIle: 0.695 ± 0.032
0.255HisLys: 0.255 ± 0.02
1.882HisLeu: 1.882 ± 0.054
0.324HisMet: 0.324 ± 0.022
0.43HisAsn: 0.43 ± 0.023
1.285HisPro: 1.285 ± 0.04
0.483HisGln: 0.483 ± 0.029
1.322HisArg: 1.322 ± 0.04
0.798HisSer: 0.798 ± 0.033
1.076HisThr: 1.076 ± 0.034
1.928HisVal: 1.928 ± 0.05
0.24HisTrp: 0.24 ± 0.016
0.599HisTyr: 0.599 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
4.345IleAla: 4.345 ± 0.093
0.224IleCys: 0.224 ± 0.017
3.934IleAsp: 3.934 ± 0.081
3.983IleGlu: 3.983 ± 0.072
0.907IlePhe: 0.907 ± 0.035
3.427IleGly: 3.427 ± 0.077
0.847IleHis: 0.847 ± 0.03
1.25IleIle: 1.25 ± 0.043
0.667IleLys: 0.667 ± 0.028
3.013IleLeu: 3.013 ± 0.062
0.457IleMet: 0.457 ± 0.027
0.934IleAsn: 0.934 ± 0.033
2.087IlePro: 2.087 ± 0.053
1.133IleGln: 1.133 ± 0.036
2.52IleArg: 2.52 ± 0.065
1.955IleSer: 1.955 ± 0.058
2.233IleThr: 2.233 ± 0.056
3.63IleVal: 3.63 ± 0.079
0.274IleTrp: 0.274 ± 0.02
0.816IleTyr: 0.816 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
1.563LysAla: 1.563 ± 0.054
0.13LysCys: 0.13 ± 0.014
0.968LysAsp: 0.968 ± 0.039
1.246LysGlu: 1.246 ± 0.046
0.535LysPhe: 0.535 ± 0.025
1.305LysGly: 1.305 ± 0.042
0.406LysHis: 0.406 ± 0.023
0.746LysIle: 0.746 ± 0.034
0.461LysLys: 0.461 ± 0.029
1.555LysLeu: 1.555 ± 0.045
0.326LysMet: 0.326 ± 0.021
0.479LysAsn: 0.479 ± 0.025
0.847LysPro: 0.847 ± 0.036
0.755LysGln: 0.755 ± 0.032
1.537LysArg: 1.537 ± 0.046
1.119LysSer: 1.119 ± 0.041
1.259LysThr: 1.259 ± 0.044
1.088LysVal: 1.088 ± 0.044
0.212LysTrp: 0.212 ± 0.017
0.527LysTyr: 0.527 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
11.095LeuAla: 11.095 ± 0.159
0.616LeuCys: 0.616 ± 0.027
8.837LeuAsp: 8.837 ± 0.11
6.271LeuGlu: 6.271 ± 0.095
3.02LeuPhe: 3.02 ± 0.074
7.644LeuGly: 7.644 ± 0.111
1.593LeuHis: 1.593 ± 0.047
2.838LeuIle: 2.838 ± 0.068
1.507LeuLys: 1.507 ± 0.047
8.719LeuLeu: 8.719 ± 0.16
1.355LeuMet: 1.355 ± 0.039
1.885LeuAsn: 1.885 ± 0.05
4.327LeuPro: 4.327 ± 0.077
2.122LeuGln: 2.122 ± 0.055
5.769LeuArg: 5.769 ± 0.099
5.621LeuSer: 5.621 ± 0.09
5.386LeuThr: 5.386 ± 0.089
8.998LeuVal: 8.998 ± 0.146
0.935LeuTrp: 0.935 ± 0.038
2.121LeuTyr: 2.121 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.873MetAla: 1.873 ± 0.06
0.117MetCys: 0.117 ± 0.015
1.274MetAsp: 1.274 ± 0.039
1.073MetGlu: 1.073 ± 0.04
0.499MetPhe: 0.499 ± 0.023
1.458MetGly: 1.458 ± 0.048
0.37MetHis: 0.37 ± 0.022
0.586MetIle: 0.586 ± 0.028
0.413MetLys: 0.413 ± 0.02
1.477MetLeu: 1.477 ± 0.048
0.289MetMet: 0.289 ± 0.02
0.55MetAsn: 0.55 ± 0.025
0.865MetPro: 0.865 ± 0.032
0.508MetGln: 0.508 ± 0.032
1.166MetArg: 1.166 ± 0.04
1.584MetSer: 1.584 ± 0.046
1.505MetThr: 1.505 ± 0.041
1.288MetVal: 1.288 ± 0.045
0.171MetTrp: 0.171 ± 0.014
0.386MetTyr: 0.386 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.446AsnAla: 2.446 ± 0.06
0.188AsnCys: 0.188 ± 0.018
1.684AsnAsp: 1.684 ± 0.05
1.654AsnGlu: 1.654 ± 0.051
0.643AsnPhe: 0.643 ± 0.027
1.817AsnGly: 1.817 ± 0.059
0.458AsnHis: 0.458 ± 0.027
0.905AsnIle: 0.905 ± 0.038
0.422AsnLys: 0.422 ± 0.026
1.989AsnLeu: 1.989 ± 0.053
0.382AsnMet: 0.382 ± 0.024
0.478AsnAsn: 0.478 ± 0.026
1.565AsnPro: 1.565 ± 0.049
0.629AsnGln: 0.629 ± 0.027
1.619AsnArg: 1.619 ± 0.048
0.979AsnSer: 0.979 ± 0.04
1.219AsnThr: 1.219 ± 0.043
2.319AsnVal: 2.319 ± 0.058
0.286AsnTrp: 0.286 ± 0.021
0.667AsnTyr: 0.667 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
4.618ProAla: 4.618 ± 0.085
0.244ProCys: 0.244 ± 0.019
5.149ProAsp: 5.149 ± 0.101
4.342ProGlu: 4.342 ± 0.076
1.623ProPhe: 1.623 ± 0.05
3.722ProGly: 3.722 ± 0.072
0.88ProHis: 0.88 ± 0.036
1.83ProIle: 1.83 ± 0.049
0.76ProLys: 0.76 ± 0.03
3.828ProLeu: 3.828 ± 0.088
0.784ProMet: 0.784 ± 0.029
1.129ProAsn: 1.129 ± 0.038
2.209ProPro: 2.209 ± 0.062
1.004ProGln: 1.004 ± 0.037
2.327ProArg: 2.327 ± 0.062
2.782ProSer: 2.782 ± 0.056
3.505ProThr: 3.505 ± 0.075
4.348ProVal: 4.348 ± 0.082
0.517ProTrp: 0.517 ± 0.024
1.085ProTyr: 1.085 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.503GlnAla: 2.503 ± 0.059
0.166GlnCys: 0.166 ± 0.017
1.351GlnAsp: 1.351 ± 0.047
1.63GlnGlu: 1.63 ± 0.053
1.088GlnPhe: 1.088 ± 0.037
1.586GlnGly: 1.586 ± 0.05
0.532GlnHis: 0.532 ± 0.027
1.096GlnIle: 1.096 ± 0.036
0.583GlnLys: 0.583 ± 0.033
2.287GlnLeu: 2.287 ± 0.059
0.552GlnMet: 0.552 ± 0.025
0.702GlnAsn: 0.702 ± 0.03
1.139GlnPro: 1.139 ± 0.042
1.032GlnGln: 1.032 ± 0.039
1.994GlnArg: 1.994 ± 0.052
1.82GlnSer: 1.82 ± 0.056
1.839GlnThr: 1.839 ± 0.051
1.853GlnVal: 1.853 ± 0.049
0.326GlnTrp: 0.326 ± 0.021
0.834GlnTyr: 0.834 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
6.998ArgAla: 6.998 ± 0.123
0.459ArgCys: 0.459 ± 0.022
5.585ArgAsp: 5.585 ± 0.093
6.37ArgGlu: 6.37 ± 0.099
2.277ArgPhe: 2.277 ± 0.047
4.611ArgGly: 4.611 ± 0.079
1.378ArgHis: 1.378 ± 0.047
3.045ArgIle: 3.045 ± 0.068
1.273ArgLys: 1.273 ± 0.045
6.754ArgLeu: 6.754 ± 0.099
1.309ArgMet: 1.309 ± 0.038
1.606ArgAsn: 1.606 ± 0.05
2.673ArgPro: 2.673 ± 0.068
1.906ArgGln: 1.906 ± 0.054
5.262ArgArg: 5.262 ± 0.107
3.487ArgSer: 3.487 ± 0.068
4.247ArgThr: 4.247 ± 0.073
5.825ArgVal: 5.825 ± 0.085
0.807ArgTrp: 0.807 ± 0.04
2.011ArgTyr: 2.011 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.315SerAla: 5.315 ± 0.093
0.326SerCys: 0.326 ± 0.022
4.579SerAsp: 4.579 ± 0.084
4.218SerGlu: 4.218 ± 0.085
1.812SerPhe: 1.812 ± 0.05
5.184SerGly: 5.184 ± 0.101
1.042SerHis: 1.042 ± 0.046
2.358SerIle: 2.358 ± 0.062
1.136SerLys: 1.136 ± 0.036
5.184SerLeu: 5.184 ± 0.089
1.082SerMet: 1.082 ± 0.039
1.33SerAsn: 1.33 ± 0.048
2.65SerPro: 2.65 ± 0.064
1.448SerGln: 1.448 ± 0.046
3.23SerArg: 3.23 ± 0.067
3.006SerSer: 3.006 ± 0.077
3.702SerThr: 3.702 ± 0.07
5.099SerVal: 5.099 ± 0.087
0.601SerTrp: 0.601 ± 0.025
1.332SerTyr: 1.332 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
7.245ThrAla: 7.245 ± 0.113
0.44ThrCys: 0.44 ± 0.023
5.75ThrAsp: 5.75 ± 0.085
4.581ThrGlu: 4.581 ± 0.092
2.139ThrPhe: 2.139 ± 0.054
5.735ThrGly: 5.735 ± 0.096
1.289ThrHis: 1.289 ± 0.045
2.683ThrIle: 2.683 ± 0.056
1.034ThrLys: 1.034 ± 0.035
6.514ThrLeu: 6.514 ± 0.115
1.011ThrMet: 1.011 ± 0.036
1.532ThrAsn: 1.532 ± 0.047
3.611ThrPro: 3.611 ± 0.078
1.459ThrGln: 1.459 ± 0.042
3.642ThrArg: 3.642 ± 0.065
2.86ThrSer: 2.86 ± 0.07
4.478ThrThr: 4.478 ± 0.096
7.591ThrVal: 7.591 ± 0.124
0.644ThrTrp: 0.644 ± 0.028
1.867ThrTyr: 1.867 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
11.214ValAla: 11.214 ± 0.163
0.741ValCys: 0.741 ± 0.03
8.581ValAsp: 8.581 ± 0.116
7.658ValGlu: 7.658 ± 0.109
3.045ValPhe: 3.045 ± 0.071
7.806ValGly: 7.806 ± 0.115
1.687ValHis: 1.687 ± 0.049
2.986ValIle: 2.986 ± 0.067
1.351ValLys: 1.351 ± 0.038
7.759ValLeu: 7.759 ± 0.131
1.347ValMet: 1.347 ± 0.043
1.979ValAsn: 1.979 ± 0.053
4.163ValPro: 4.163 ± 0.073
1.951ValGln: 1.951 ± 0.051
5.992ValArg: 5.992 ± 0.096
5.374ValSer: 5.374 ± 0.095
6.653ValThr: 6.653 ± 0.095
9.86ValVal: 9.86 ± 0.141
0.808ValTrp: 0.808 ± 0.032
2.099ValTyr: 2.099 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.037
0.086TrpCys: 0.086 ± 0.012
0.701TrpAsp: 0.701 ± 0.029
0.832TrpGlu: 0.832 ± 0.031
0.438TrpPhe: 0.438 ± 0.022
0.821TrpGly: 0.821 ± 0.033
0.22TrpHis: 0.22 ± 0.016
0.471TrpIle: 0.471 ± 0.025
0.244TrpLys: 0.244 ± 0.019
1.19TrpLeu: 1.19 ± 0.039
0.227TrpMet: 0.227 ± 0.016
0.36TrpAsn: 0.36 ± 0.023
0.45TrpPro: 0.45 ± 0.025
0.382TrpGln: 0.382 ± 0.023
0.928TrpArg: 0.928 ± 0.039
0.611TrpSer: 0.611 ± 0.03
0.794TrpThr: 0.794 ± 0.032
0.884TrpVal: 0.884 ± 0.037
0.194TrpTrp: 0.194 ± 0.017
0.369TrpTyr: 0.369 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.743TyrAla: 2.743 ± 0.062
0.212TyrCys: 0.212 ± 0.015
2.644TyrAsp: 2.644 ± 0.063
2.211TyrGlu: 2.211 ± 0.054
0.782TyrPhe: 0.782 ± 0.032
2.268TyrGly: 2.268 ± 0.047
0.64TyrHis: 0.64 ± 0.03
0.74TyrIle: 0.74 ± 0.03
0.407TyrLys: 0.407 ± 0.028
2.663TyrLeu: 2.663 ± 0.059
0.362TyrMet: 0.362 ± 0.02
0.584TyrAsn: 0.584 ± 0.028
1.316TyrPro: 1.316 ± 0.037
0.756TyrGln: 0.756 ± 0.028
2.067TyrArg: 2.067 ± 0.05
1.151TyrSer: 1.151 ± 0.036
1.524TyrThr: 1.524 ± 0.05
2.336TyrVal: 2.336 ± 0.057
0.306TyrTrp: 0.306 ± 0.021
0.845TyrTyr: 0.845 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2791 proteins (803080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski