Amino acid dipepetide frequency for Beak and feather disease virus (BFDV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.738AlaAla: 3.738 ± 0.205
1.869AlaCys: 1.869 ± 1.409
5.607AlaAsp: 5.607 ± 1.615
0.0AlaGlu: 0.0 ± 0.0
5.607AlaPhe: 5.607 ± 0.999
1.869AlaGly: 1.869 ± 1.409
3.738AlaHis: 3.738 ± 2.409
1.869AlaIle: 1.869 ± 1.204
5.607AlaLys: 5.607 ± 1.615
5.607AlaLeu: 5.607 ± 1.615
0.0AlaMet: 0.0 ± 0.0
3.738AlaAsn: 3.738 ± 0.205
3.738AlaPro: 3.738 ± 2.819
0.0AlaGln: 0.0 ± 0.0
7.477AlaArg: 7.477 ± 0.41
0.0AlaSer: 0.0 ± 0.0
1.869AlaThr: 1.869 ± 1.409
7.477AlaVal: 7.477 ± 0.41
0.0AlaTrp: 0.0 ± 0.0
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
3.738CysAla: 3.738 ± 2.819
0.0CysCys: 0.0 ± 0.0
3.738CysAsp: 3.738 ± 2.409
1.869CysGlu: 1.869 ± 1.204
1.869CysPhe: 1.869 ± 1.204
1.869CysGly: 1.869 ± 1.204
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.869CysArg: 1.869 ± 1.204
1.869CysSer: 1.869 ± 1.204
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.869AspAla: 1.869 ± 1.204
1.869AspCys: 1.869 ± 1.204
3.738AspAsp: 3.738 ± 0.205
1.869AspGlu: 1.869 ± 1.204
7.477AspPhe: 7.477 ± 2.203
13.084AspGly: 13.084 ± 3.202
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
1.869AspLys: 1.869 ± 1.204
1.869AspLeu: 1.869 ± 1.409
0.0AspMet: 0.0 ± 0.0
1.869AspAsn: 1.869 ± 1.204
3.738AspPro: 3.738 ± 0.205
1.869AspGln: 1.869 ± 1.409
1.869AspArg: 1.869 ± 1.204
1.869AspSer: 1.869 ± 1.409
0.0AspThr: 0.0 ± 0.0
5.607AspVal: 5.607 ± 3.613
0.0AspTrp: 0.0 ± 0.0
3.738AspTyr: 3.738 ± 2.819
0.0AspXaa: 0.0 ± 0.0
Glu
0.0GluAla: 0.0 ± 0.0
0.0GluCys: 0.0 ± 0.0
7.477GluAsp: 7.477 ± 0.41
0.0GluGlu: 0.0 ± 0.0
7.477GluPhe: 7.477 ± 4.817
3.738GluGly: 3.738 ± 2.409
0.0GluHis: 0.0 ± 0.0
1.869GluIle: 1.869 ± 1.204
1.869GluLys: 1.869 ± 1.204
0.0GluLeu: 0.0 ± 0.0
3.738GluMet: 3.738 ± 0.205
0.0GluAsn: 0.0 ± 0.0
0.0GluPro: 0.0 ± 0.0
9.346GluGln: 9.346 ± 3.408
1.869GluArg: 1.869 ± 1.204
0.0GluSer: 0.0 ± 0.0
1.869GluThr: 1.869 ± 1.204
5.607GluVal: 5.607 ± 3.613
1.869GluTrp: 1.869 ± 1.204
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
3.738PheAla: 3.738 ± 2.819
0.0PheCys: 0.0 ± 0.0
3.738PheAsp: 3.738 ± 0.205
3.738PheGlu: 3.738 ± 0.205
0.0PhePhe: 0.0 ± 0.0
1.869PheGly: 1.869 ± 1.409
1.869PheHis: 1.869 ± 1.204
0.0PheIle: 0.0 ± 0.0
9.346PheLys: 9.346 ± 1.82
3.738PheLeu: 3.738 ± 0.205
0.0PheMet: 0.0 ± 0.0
1.869PheAsn: 1.869 ± 1.409
3.738PhePro: 3.738 ± 0.205
3.738PheGln: 3.738 ± 2.819
5.607PheArg: 5.607 ± 1.615
3.738PheSer: 3.738 ± 2.819
5.607PheThr: 5.607 ± 3.613
5.607PheVal: 5.607 ± 0.999
0.0PheTrp: 0.0 ± 0.0
3.738PheTyr: 3.738 ± 2.409
0.0PheXaa: 0.0 ± 0.0
Gly
5.607GlyAla: 5.607 ± 0.999
3.738GlyCys: 3.738 ± 2.409
1.869GlyAsp: 1.869 ± 1.204
7.477GlyGlu: 7.477 ± 4.817
3.738GlyPhe: 3.738 ± 2.819
3.738GlyGly: 3.738 ± 2.819
5.607GlyHis: 5.607 ± 1.615
3.738GlyIle: 3.738 ± 0.205
1.869GlyLys: 1.869 ± 1.204
1.869GlyLeu: 1.869 ± 1.204
0.0GlyMet: 0.0 ± 0.0
1.869GlyAsn: 1.869 ± 1.409
5.607GlyPro: 5.607 ± 0.999
0.0GlyGln: 0.0 ± 0.0
5.607GlyArg: 5.607 ± 3.613
5.607GlySer: 5.607 ± 3.613
7.477GlyThr: 7.477 ± 0.41
0.0GlyVal: 0.0 ± 0.0
3.738GlyTrp: 3.738 ± 0.205
3.738GlyTyr: 3.738 ± 2.409
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
5.607HisPhe: 5.607 ± 0.999
1.869HisGly: 1.869 ± 1.204
0.0HisHis: 0.0 ± 0.0
1.869HisIle: 1.869 ± 1.409
1.869HisLys: 1.869 ± 1.204
1.869HisLeu: 1.869 ± 1.204
0.0HisMet: 0.0 ± 0.0
1.869HisAsn: 1.869 ± 1.204
1.869HisPro: 1.869 ± 1.204
0.0HisGln: 0.0 ± 0.0
1.869HisArg: 1.869 ± 1.204
0.0HisSer: 0.0 ± 0.0
3.738HisThr: 3.738 ± 2.819
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
3.738HisTyr: 3.738 ± 2.819
0.0HisXaa: 0.0 ± 0.0
Ile
1.869IleAla: 1.869 ± 1.409
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
3.738IleGlu: 3.738 ± 0.205
1.869IlePhe: 1.869 ± 1.409
0.0IleGly: 0.0 ± 0.0
0.0IleHis: 0.0 ± 0.0
3.738IleIle: 3.738 ± 2.409
1.869IleLys: 1.869 ± 1.409
3.738IleLeu: 3.738 ± 2.409
0.0IleMet: 0.0 ± 0.0
3.738IleAsn: 3.738 ± 0.205
1.869IlePro: 1.869 ± 1.409
1.869IleGln: 1.869 ± 1.409
3.738IleArg: 3.738 ± 2.819
0.0IleSer: 0.0 ± 0.0
9.346IleThr: 9.346 ± 4.434
3.738IleVal: 3.738 ± 2.409
0.0IleTrp: 0.0 ± 0.0
3.738IleTyr: 3.738 ± 0.205
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
7.477LysGlu: 7.477 ± 4.817
0.0LysPhe: 0.0 ± 0.0
5.607LysGly: 5.607 ± 3.613
0.0LysHis: 0.0 ± 0.0
1.869LysIle: 1.869 ± 1.409
5.607LysLys: 5.607 ± 0.999
7.477LysLeu: 7.477 ± 0.41
5.607LysMet: 5.607 ± 0.999
1.869LysAsn: 1.869 ± 1.204
3.738LysPro: 3.738 ± 0.205
1.869LysGln: 1.869 ± 1.409
5.607LysArg: 5.607 ± 0.999
1.869LysSer: 1.869 ± 1.204
3.738LysThr: 3.738 ± 0.205
3.738LysVal: 3.738 ± 0.205
1.869LysTrp: 1.869 ± 1.409
1.869LysTyr: 1.869 ± 1.204
0.0LysXaa: 0.0 ± 0.0
Leu
5.607LeuAla: 5.607 ± 1.615
1.869LeuCys: 1.869 ± 1.204
3.738LeuAsp: 3.738 ± 0.205
1.869LeuGlu: 1.869 ± 1.204
1.869LeuPhe: 1.869 ± 1.204
3.738LeuGly: 3.738 ± 2.409
1.869LeuHis: 1.869 ± 1.204
1.869LeuIle: 1.869 ± 1.409
1.869LeuLys: 1.869 ± 1.204
5.607LeuLeu: 5.607 ± 0.999
0.0LeuMet: 0.0 ± 0.0
5.607LeuAsn: 5.607 ± 1.615
3.738LeuPro: 3.738 ± 2.409
5.607LeuGln: 5.607 ± 1.615
5.607LeuArg: 5.607 ± 1.615
3.738LeuSer: 3.738 ± 2.409
7.477LeuThr: 7.477 ± 3.024
1.869LeuVal: 1.869 ± 1.204
1.869LeuTrp: 1.869 ± 1.409
1.869LeuTyr: 1.869 ± 1.409
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
1.869MetGlu: 1.869 ± 1.409
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.869MetLys: 1.869 ± 1.204
1.869MetLeu: 1.869 ± 1.204
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.869MetPro: 1.869 ± 1.204
0.0MetGln: 0.0 ± 0.0
3.738MetArg: 3.738 ± 0.205
1.869MetSer: 1.869 ± 1.204
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
1.869MetTrp: 1.869 ± 1.409
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.869AsnAla: 1.869 ± 1.409
1.869AsnCys: 1.869 ± 1.409
0.0AsnAsp: 0.0 ± 0.0
3.738AsnGlu: 3.738 ± 2.409
1.869AsnPhe: 1.869 ± 1.409
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
5.607AsnLys: 5.607 ± 0.999
3.738AsnLeu: 3.738 ± 0.205
0.0AsnMet: 0.0 ± 0.0
3.738AsnAsn: 3.738 ± 0.205
5.607AsnPro: 5.607 ± 1.615
1.869AsnGln: 1.869 ± 1.409
1.869AsnArg: 1.869 ± 1.409
3.738AsnSer: 3.738 ± 2.819
0.0AsnThr: 0.0 ± 0.0
1.869AsnVal: 1.869 ± 1.204
0.0AsnTrp: 0.0 ± 0.0
1.869AsnTyr: 1.869 ± 1.204
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
3.738ProAsp: 3.738 ± 2.409
5.607ProGlu: 5.607 ± 0.999
1.869ProPhe: 1.869 ± 1.409
3.738ProGly: 3.738 ± 2.409
5.607ProHis: 5.607 ± 0.999
1.869ProIle: 1.869 ± 1.204
1.869ProLys: 1.869 ± 1.409
5.607ProLeu: 5.607 ± 1.615
0.0ProMet: 0.0 ± 0.0
5.607ProAsn: 5.607 ± 4.228
3.738ProPro: 3.738 ± 2.409
3.738ProGln: 3.738 ± 2.819
5.607ProArg: 5.607 ± 3.613
3.738ProSer: 3.738 ± 0.205
3.738ProThr: 3.738 ± 0.205
1.869ProVal: 1.869 ± 1.204
0.0ProTrp: 0.0 ± 0.0
3.738ProTyr: 3.738 ± 0.205
0.0ProXaa: 0.0 ± 0.0
Gln
1.869GlnAla: 1.869 ± 1.409
0.0GlnCys: 0.0 ± 0.0
3.738GlnAsp: 3.738 ± 2.819
0.0GlnGlu: 0.0 ± 0.0
7.477GlnPhe: 7.477 ± 5.638
5.607GlnGly: 5.607 ± 0.999
0.0GlnHis: 0.0 ± 0.0
3.738GlnIle: 3.738 ± 2.819
0.0GlnLys: 0.0 ± 0.0
0.0GlnLeu: 0.0 ± 0.0
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
3.738GlnPro: 3.738 ± 0.205
0.0GlnGln: 0.0 ± 0.0
0.0GlnArg: 0.0 ± 0.0
3.738GlnSer: 3.738 ± 2.819
5.607GlnThr: 5.607 ± 4.228
1.869GlnVal: 1.869 ± 1.204
0.0GlnTrp: 0.0 ± 0.0
1.869GlnTyr: 1.869 ± 1.204
0.0GlnXaa: 0.0 ± 0.0
Arg
5.607ArgAla: 5.607 ± 3.613
0.0ArgCys: 0.0 ± 0.0
3.738ArgAsp: 3.738 ± 2.409
3.738ArgGlu: 3.738 ± 2.409
5.607ArgPhe: 5.607 ± 1.615
5.607ArgGly: 5.607 ± 0.999
7.477ArgHis: 7.477 ± 3.024
7.477ArgIle: 7.477 ± 3.024
1.869ArgLys: 1.869 ± 1.204
7.477ArgLeu: 7.477 ± 0.41
0.0ArgMet: 0.0 ± 0.0
0.0ArgAsn: 0.0 ± 0.0
11.215ArgPro: 11.215 ± 0.616
3.738ArgGln: 3.738 ± 2.819
26.168ArgArg: 26.168 ± 14.505
1.869ArgSer: 1.869 ± 1.204
1.869ArgThr: 1.869 ± 1.409
1.869ArgVal: 1.869 ± 1.204
3.738ArgTrp: 3.738 ± 2.409
5.607ArgTyr: 5.607 ± 1.615
0.0ArgXaa: 0.0 ± 0.0
Ser
7.477SerAla: 7.477 ± 3.024
0.0SerCys: 0.0 ± 0.0
3.738SerAsp: 3.738 ± 0.205
0.0SerGlu: 0.0 ± 0.0
1.869SerPhe: 1.869 ± 1.409
3.738SerGly: 3.738 ± 2.409
0.0SerHis: 0.0 ± 0.0
0.0SerIle: 0.0 ± 0.0
5.607SerLys: 5.607 ± 3.613
3.738SerLeu: 3.738 ± 2.409
0.0SerMet: 0.0 ± 0.0
3.738SerAsn: 3.738 ± 0.205
0.0SerPro: 0.0 ± 0.0
0.0SerGln: 0.0 ± 0.0
7.477SerArg: 7.477 ± 0.41
0.0SerSer: 0.0 ± 0.0
3.738SerThr: 3.738 ± 2.819
1.869SerVal: 1.869 ± 1.409
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
5.607ThrAla: 5.607 ± 4.228
0.0ThrCys: 0.0 ± 0.0
1.869ThrAsp: 1.869 ± 1.204
1.869ThrGlu: 1.869 ± 1.204
3.738ThrPhe: 3.738 ± 2.819
3.738ThrGly: 3.738 ± 2.819
0.0ThrHis: 0.0 ± 0.0
3.738ThrIle: 3.738 ± 2.819
5.607ThrLys: 5.607 ± 1.615
9.346ThrLeu: 9.346 ± 1.82
1.869ThrMet: 1.869 ± 0.978
1.869ThrAsn: 1.869 ± 1.409
1.869ThrPro: 1.869 ± 1.204
1.869ThrGln: 1.869 ± 1.409
5.607ThrArg: 5.607 ± 1.615
7.477ThrSer: 7.477 ± 0.41
5.607ThrThr: 5.607 ± 4.228
1.869ThrVal: 1.869 ± 1.409
1.869ThrTrp: 1.869 ± 1.204
1.869ThrTyr: 1.869 ± 1.409
0.0ThrXaa: 0.0 ± 0.0
Val
5.607ValAla: 5.607 ± 3.613
0.0ValCys: 0.0 ± 0.0
3.738ValAsp: 3.738 ± 2.409
1.869ValGlu: 1.869 ± 1.204
0.0ValPhe: 0.0 ± 0.0
5.607ValGly: 5.607 ± 0.999
0.0ValHis: 0.0 ± 0.0
7.477ValIle: 7.477 ± 2.203
1.869ValLys: 1.869 ± 1.204
0.0ValLeu: 0.0 ± 0.0
1.869ValMet: 1.869 ± 1.204
0.0ValAsn: 0.0 ± 0.0
3.738ValPro: 3.738 ± 0.205
3.738ValGln: 3.738 ± 2.819
7.477ValArg: 7.477 ± 2.203
1.869ValSer: 1.869 ± 1.409
1.869ValThr: 1.869 ± 1.409
1.869ValVal: 1.869 ± 1.204
1.869ValTrp: 1.869 ± 1.204
1.869ValTyr: 1.869 ± 1.204
0.0ValXaa: 0.0 ± 0.0
Trp
1.869TrpAla: 1.869 ± 1.204
1.869TrpCys: 1.869 ± 1.204
1.869TrpAsp: 1.869 ± 1.204
0.0TrpGlu: 0.0 ± 0.0
1.869TrpPhe: 1.869 ± 1.409
1.869TrpGly: 1.869 ± 1.409
0.0TrpHis: 0.0 ± 0.0
1.869TrpIle: 1.869 ± 1.409
0.0TrpLys: 0.0 ± 0.0
3.738TrpLeu: 3.738 ± 0.205
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
3.738TrpTrp: 3.738 ± 2.409
3.738TrpTyr: 3.738 ± 2.409
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.738TyrAla: 3.738 ± 0.205
3.738TyrCys: 3.738 ± 2.409
1.869TyrAsp: 1.869 ± 1.204
0.0TyrGlu: 0.0 ± 0.0
1.869TyrPhe: 1.869 ± 1.204
5.607TyrGly: 5.607 ± 0.999
0.0TyrHis: 0.0 ± 0.0
1.869TyrIle: 1.869 ± 1.409
3.738TyrLys: 3.738 ± 2.409
0.0TyrLeu: 0.0 ± 0.0
0.0TyrMet: 0.0 ± 0.906
1.869TyrAsn: 1.869 ± 1.204
1.869TyrPro: 1.869 ± 1.204
0.0TyrGln: 0.0 ± 0.0
5.607TyrArg: 5.607 ± 4.228
0.0TyrSer: 0.0 ± 0.0
3.738TyrThr: 3.738 ± 2.819
5.607TyrVal: 5.607 ± 1.615
0.0TyrTrp: 0.0 ± 0.0
3.738TyrTyr: 3.738 ± 2.409
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (536 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski