Amino acid dipepetide frequency for Candidatus Methylospira mobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.744AlaAla: 11.744 ± 0.154	1.246AlaCys: 1.246 ± 0.033	5.455AlaAsp: 5.455 ± 0.064	6.716AlaGlu: 6.716 ± 0.088	3.675AlaPhe: 3.675 ± 0.062	8.419AlaGly: 8.419 ± 0.09	2.328AlaHis: 2.328 ± 0.044	5.659AlaIle: 5.659 ± 0.069	3.501AlaLys: 3.501 ± 0.06	12.166AlaLeu: 12.166 ± 0.165	2.703AlaMet: 2.703 ± 0.047	3.11AlaAsn: 3.11 ± 0.055	3.939AlaPro: 3.939 ± 0.058	4.282AlaGln: 4.282 ± 0.06	6.45AlaArg: 6.45 ± 0.094	5.778AlaSer: 5.778 ± 0.08	4.695AlaThr: 4.695 ± 0.066	7.341AlaVal: 7.341 ± 0.085	1.383AlaTrp: 1.383 ± 0.03	2.706AlaTyr: 2.706 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.126CysAla: 1.126 ± 0.031	0.185CysCys: 0.185 ± 0.013	0.572CysAsp: 0.572 ± 0.021	0.611CysGlu: 0.611 ± 0.025	0.459CysPhe: 0.459 ± 0.017	1.014CysGly: 1.014 ± 0.028	0.294CysHis: 0.294 ± 0.017	0.566CysIle: 0.566 ± 0.021	0.367CysLys: 0.367 ± 0.019	1.089CysLeu: 1.089 ± 0.028	0.225CysMet: 0.225 ± 0.013	0.372CysAsn: 0.372 ± 0.018	0.514CysPro: 0.514 ± 0.022	0.33CysGln: 0.33 ± 0.017	0.826CysArg: 0.826 ± 0.026	0.722CysSer: 0.722 ± 0.026	0.424CysThr: 0.424 ± 0.018	0.711CysVal: 0.711 ± 0.025	0.169CysTrp: 0.169 ± 0.012	0.313CysTyr: 0.313 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.716AspAla: 5.716 ± 0.076	0.585AspCys: 0.585 ± 0.022	2.823AspAsp: 2.823 ± 0.055	3.612AspGlu: 3.612 ± 0.055	2.367AspPhe: 2.367 ± 0.041	3.884AspGly: 3.884 ± 0.058	1.147AspHis: 1.147 ± 0.033	3.585AspIle: 3.585 ± 0.054	2.199AspLys: 2.199 ± 0.039	5.164AspLeu: 5.164 ± 0.069	1.262AspMet: 1.262 ± 0.031	1.838AspAsn: 1.838 ± 0.039	2.405AspPro: 2.405 ± 0.049	1.845AspGln: 1.845 ± 0.038	3.144AspArg: 3.144 ± 0.053	3.048AspSer: 3.048 ± 0.053	2.553AspThr: 2.553 ± 0.039	3.417AspVal: 3.417 ± 0.066	0.898AspTrp: 0.898 ± 0.032	1.829AspTyr: 1.829 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.099GluAla: 6.099 ± 0.082	0.538GluCys: 0.538 ± 0.022	2.504GluAsp: 2.504 ± 0.046	3.268GluGlu: 3.268 ± 0.07	2.081GluPhe: 2.081 ± 0.039	3.445GluGly: 3.445 ± 0.054	1.528GluHis: 1.528 ± 0.038	3.965GluIle: 3.965 ± 0.059	3.037GluLys: 3.037 ± 0.055	6.577GluLeu: 6.577 ± 0.08	1.49GluMet: 1.49 ± 0.035	2.379GluAsn: 2.379 ± 0.048	2.25GluPro: 2.25 ± 0.048	3.394GluGln: 3.394 ± 0.062	4.465GluArg: 4.465 ± 0.059	3.424GluSer: 3.424 ± 0.054	3.456GluThr: 3.456 ± 0.058	3.645GluVal: 3.645 ± 0.066	0.746GluTrp: 0.746 ± 0.021	1.604GluTyr: 1.604 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.618PheAla: 3.618 ± 0.052	0.495PheCys: 0.495 ± 0.02	2.601PheAsp: 2.601 ± 0.044	2.262PheGlu: 2.262 ± 0.044	1.76PhePhe: 1.76 ± 0.041	2.96PheGly: 2.96 ± 0.048	0.908PheHis: 0.908 ± 0.026	2.255PheIle: 2.255 ± 0.045	1.403PheLys: 1.403 ± 0.033	3.682PheLeu: 3.682 ± 0.059	0.898PheMet: 0.898 ± 0.025	1.563PheAsn: 1.563 ± 0.041	1.673PhePro: 1.673 ± 0.043	1.286PheGln: 1.286 ± 0.03	2.155PheArg: 2.155 ± 0.044	2.968PheSer: 2.968 ± 0.048	2.033PheThr: 2.033 ± 0.041	2.539PheVal: 2.539 ± 0.047	0.546PheTrp: 0.546 ± 0.021	1.244PheTyr: 1.244 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.75GlyAla: 6.75 ± 0.108	1.082GlyCys: 1.082 ± 0.031	3.775GlyAsp: 3.775 ± 0.06	4.266GlyGlu: 4.266 ± 0.064	3.408GlyPhe: 3.408 ± 0.049	5.702GlyGly: 5.702 ± 0.087	1.736GlyHis: 1.736 ± 0.039	4.638GlyIle: 4.638 ± 0.076	3.795GlyLys: 3.795 ± 0.058	7.956GlyLeu: 7.956 ± 0.085	2.089GlyMet: 2.089 ± 0.048	2.896GlyAsn: 2.896 ± 0.064	2.061GlyPro: 2.061 ± 0.051	2.72GlyGln: 2.72 ± 0.052	4.432GlyArg: 4.432 ± 0.064	4.671GlySer: 4.671 ± 0.079	3.35GlyThr: 3.35 ± 0.07	5.647GlyVal: 5.647 ± 0.072	1.201GlyTrp: 1.201 ± 0.033	2.646GlyTyr: 2.646 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.427HisAla: 2.427 ± 0.045	0.261HisCys: 0.261 ± 0.014	1.317HisAsp: 1.317 ± 0.034	1.419HisGlu: 1.419 ± 0.035	1.013HisPhe: 1.013 ± 0.029	1.92HisGly: 1.92 ± 0.036	0.725HisHis: 0.725 ± 0.026	1.341HisIle: 1.341 ± 0.03	0.748HisLys: 0.748 ± 0.026	2.386HisLeu: 2.386 ± 0.048	0.528HisMet: 0.528 ± 0.023	0.735HisAsn: 0.735 ± 0.026	1.472HisPro: 1.472 ± 0.037	0.906HisGln: 0.906 ± 0.029	1.459HisArg: 1.459 ± 0.038	1.236HisSer: 1.236 ± 0.031	1.064HisThr: 1.064 ± 0.034	1.396HisVal: 1.396 ± 0.031	0.358HisTrp: 0.358 ± 0.016	0.827HisTyr: 0.827 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.688IleAla: 6.688 ± 0.086	0.581IleCys: 0.581 ± 0.024	3.648IleAsp: 3.648 ± 0.057	3.876IleGlu: 3.876 ± 0.06	1.931IlePhe: 1.931 ± 0.039	4.527IleGly: 4.527 ± 0.068	1.279IleHis: 1.279 ± 0.032	2.889IleIle: 2.889 ± 0.052	2.5IleLys: 2.5 ± 0.051	5.055IleLeu: 5.055 ± 0.077	1.111IleMet: 1.111 ± 0.031	2.369IleAsn: 2.369 ± 0.045	2.784IlePro: 2.784 ± 0.048	1.85IleGln: 1.85 ± 0.035	3.564IleArg: 3.564 ± 0.051	3.638IleSer: 3.638 ± 0.066	3.132IleThr: 3.132 ± 0.054	3.869IleVal: 3.869 ± 0.061	0.663IleTrp: 0.663 ± 0.026	1.532IleTyr: 1.532 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.926LysAla: 3.926 ± 0.064	0.261LysCys: 0.261 ± 0.017	1.844LysAsp: 1.844 ± 0.043	2.211LysGlu: 2.211 ± 0.047	1.108LysPhe: 1.108 ± 0.028	2.507LysGly: 2.507 ± 0.048	0.936LysHis: 0.936 ± 0.027	2.422LysIle: 2.422 ± 0.048	2.033LysLys: 2.033 ± 0.049	4.297LysLeu: 4.297 ± 0.062	0.925LysMet: 0.925 ± 0.029	1.736LysAsn: 1.736 ± 0.037	2.203LysPro: 2.203 ± 0.05	1.961LysGln: 1.961 ± 0.037	2.58LysArg: 2.58 ± 0.061	2.514LysSer: 2.514 ± 0.046	2.724LysThr: 2.724 ± 0.052	2.391LysVal: 2.391 ± 0.049	0.398LysTrp: 0.398 ± 0.019	0.963LysTyr: 0.963 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.452LeuAla: 11.452 ± 0.126	1.185LeuCys: 1.185 ± 0.032	6.076LeuAsp: 6.076 ± 0.091	6.199LeuGlu: 6.199 ± 0.076	4.257LeuPhe: 4.257 ± 0.061	7.452LeuGly: 7.452 ± 0.086	2.542LeuHis: 2.542 ± 0.054	6.055LeuIle: 6.055 ± 0.085	4.517LeuLys: 4.517 ± 0.071	12.23LeuLeu: 12.23 ± 0.141	2.398LeuMet: 2.398 ± 0.044	3.995LeuAsn: 3.995 ± 0.055	5.679LeuPro: 5.679 ± 0.103	4.402LeuGln: 4.402 ± 0.068	6.693LeuArg: 6.693 ± 0.081	7.574LeuSer: 7.574 ± 0.093	5.653LeuThr: 5.653 ± 0.064	6.334LeuVal: 6.334 ± 0.071	1.216LeuTrp: 1.216 ± 0.036	2.636LeuTyr: 2.636 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.441MetAla: 2.441 ± 0.044	0.141MetCys: 0.141 ± 0.011	1.211MetAsp: 1.211 ± 0.031	1.338MetGlu: 1.338 ± 0.039	0.648MetPhe: 0.648 ± 0.025	1.62MetGly: 1.62 ± 0.041	0.567MetHis: 0.567 ± 0.022	1.206MetIle: 1.206 ± 0.031	1.14MetLys: 1.14 ± 0.03	2.653MetLeu: 2.653 ± 0.053	0.549MetMet: 0.549 ± 0.025	1.05MetAsn: 1.05 ± 0.026	1.313MetPro: 1.313 ± 0.036	1.018MetGln: 1.018 ± 0.029	1.538MetArg: 1.538 ± 0.033	1.625MetSer: 1.625 ± 0.04	1.461MetThr: 1.461 ± 0.034	1.458MetVal: 1.458 ± 0.031	0.173MetTrp: 0.173 ± 0.012	0.431MetTyr: 0.431 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.797AsnAla: 3.797 ± 0.063	0.372AsnCys: 0.372 ± 0.018	1.851AsnAsp: 1.851 ± 0.04	1.985AsnGlu: 1.985 ± 0.045	1.234AsnPhe: 1.234 ± 0.036	2.892AsnGly: 2.892 ± 0.054	0.756AsnHis: 0.756 ± 0.023	2.225AsnIle: 2.225 ± 0.045	1.35AsnLys: 1.35 ± 0.036	3.63AsnLeu: 3.63 ± 0.065	0.819AsnMet: 0.819 ± 0.024	1.462AsnAsn: 1.462 ± 0.045	2.165AsnPro: 2.165 ± 0.046	1.461AsnGln: 1.461 ± 0.029	2.303AsnArg: 2.303 ± 0.04	2.113AsnSer: 2.113 ± 0.05	1.952AsnThr: 1.952 ± 0.052	2.169AsnVal: 2.169 ± 0.053	0.517AsnTrp: 0.517 ± 0.021	1.086AsnTyr: 1.086 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.859ProAla: 4.859 ± 0.093	0.427ProCys: 0.427 ± 0.022	3.105ProAsp: 3.105 ± 0.059	3.618ProGlu: 3.618 ± 0.054	1.734ProPhe: 1.734 ± 0.043	3.828ProGly: 3.828 ± 0.063	0.989ProHis: 0.989 ± 0.023	2.074ProIle: 2.074 ± 0.039	1.417ProLys: 1.417 ± 0.034	4.86ProLeu: 4.86 ± 0.096	0.942ProMet: 0.942 ± 0.029	1.335ProAsn: 1.335 ± 0.036	2.173ProPro: 2.173 ± 0.056	1.677ProGln: 1.677 ± 0.035	2.146ProArg: 2.146 ± 0.044	2.549ProSer: 2.549 ± 0.037	1.808ProThr: 1.808 ± 0.038	3.895ProVal: 3.895 ± 0.066	0.659ProTrp: 0.659 ± 0.021	1.289ProTyr: 1.289 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.681GlnAla: 4.681 ± 0.067	0.377GlnCys: 0.377 ± 0.019	1.797GlnAsp: 1.797 ± 0.038	2.173GlnGlu: 2.173 ± 0.043	1.407GlnPhe: 1.407 ± 0.032	2.953GlnGly: 2.953 ± 0.05	1.054GlnHis: 1.054 ± 0.031	2.349GlnIle: 2.349 ± 0.049	1.59GlnLys: 1.59 ± 0.04	4.084GlnLeu: 4.084 ± 0.056	0.937GlnMet: 0.937 ± 0.03	1.406GlnAsn: 1.406 ± 0.037	1.905GlnPro: 1.905 ± 0.039	2.311GlnGln: 2.311 ± 0.051	2.864GlnArg: 2.864 ± 0.046	2.399GlnSer: 2.399 ± 0.045	2.281GlnThr: 2.281 ± 0.042	2.604GlnVal: 2.604 ± 0.047	0.547GlnTrp: 0.547 ± 0.022	1.1GlnTyr: 1.1 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.484ArgAla: 5.484 ± 0.071	0.69ArgCys: 0.69 ± 0.022	3.218ArgAsp: 3.218 ± 0.052	3.987ArgGlu: 3.987 ± 0.064	2.931ArgPhe: 2.931 ± 0.042	3.56ArgGly: 3.56 ± 0.056	1.814ArgHis: 1.814 ± 0.038	4.144ArgIle: 4.144 ± 0.06	2.748ArgLys: 2.748 ± 0.057	7.625ArgLeu: 7.625 ± 0.101	1.713ArgMet: 1.713 ± 0.039	2.286ArgAsn: 2.286 ± 0.046	2.487ArgPro: 2.487 ± 0.049	2.945ArgGln: 2.945 ± 0.05	4.173ArgArg: 4.173 ± 0.066	3.44ArgSer: 3.44 ± 0.046	2.578ArgThr: 2.578 ± 0.05	4.018ArgVal: 4.018 ± 0.058	0.954ArgTrp: 0.954 ± 0.026	2.164ArgTyr: 2.164 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.593SerAla: 6.593 ± 0.08	0.661SerCys: 0.661 ± 0.027	3.13SerAsp: 3.13 ± 0.05	3.465SerGlu: 3.465 ± 0.052	2.466SerPhe: 2.466 ± 0.051	6.104SerGly: 6.104 ± 0.077	1.334SerHis: 1.334 ± 0.033	3.494SerIle: 3.494 ± 0.057	2.061SerLys: 2.061 ± 0.043	6.543SerLeu: 6.543 ± 0.085	1.434SerMet: 1.434 ± 0.041	2.123SerAsn: 2.123 ± 0.053	2.658SerPro: 2.658 ± 0.048	2.011SerGln: 2.011 ± 0.047	3.608SerArg: 3.608 ± 0.058	4.048SerSer: 4.048 ± 0.081	2.992SerThr: 2.992 ± 0.059	4.326SerVal: 4.326 ± 0.059	0.853SerTrp: 0.853 ± 0.029	1.664SerTyr: 1.664 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.361ThrAla: 5.361 ± 0.069	0.473ThrCys: 0.473 ± 0.018	2.594ThrAsp: 2.594 ± 0.045	2.782ThrGlu: 2.782 ± 0.051	1.658ThrPhe: 1.658 ± 0.039	4.64ThrGly: 4.64 ± 0.073	1.255ThrHis: 1.255 ± 0.029	2.472ThrIle: 2.472 ± 0.053	1.303ThrLys: 1.303 ± 0.041	6.388ThrLeu: 6.388 ± 0.079	0.922ThrMet: 0.922 ± 0.029	1.38ThrAsn: 1.38 ± 0.042	2.96ThrPro: 2.96 ± 0.055	2.123ThrGln: 2.123 ± 0.037	3.162ThrArg: 3.162 ± 0.054	2.783ThrSer: 2.783 ± 0.053	2.533ThrThr: 2.533 ± 0.06	3.838ThrVal: 3.838 ± 0.059	0.553ThrTrp: 0.553 ± 0.024	1.105ThrTyr: 1.105 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.793ValAla: 6.793 ± 0.088	0.783ValCys: 0.783 ± 0.025	3.709ValAsp: 3.709 ± 0.059	4.048ValGlu: 4.048 ± 0.06	2.871ValPhe: 2.871 ± 0.055	4.386ValGly: 4.386 ± 0.057	1.313ValHis: 1.313 ± 0.036	4.128ValIle: 4.128 ± 0.056	2.687ValLys: 2.687 ± 0.052	7.089ValLeu: 7.089 ± 0.072	1.774ValMet: 1.774 ± 0.044	2.576ValAsn: 2.576 ± 0.046	2.795ValPro: 2.795 ± 0.044	2.286ValGln: 2.286 ± 0.053	4.016ValArg: 4.016 ± 0.056	4.48ValSer: 4.48 ± 0.066	3.638ValThr: 3.638 ± 0.053	4.9ValVal: 4.9 ± 0.076	0.872ValTrp: 0.872 ± 0.026	1.863ValTyr: 1.863 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.017TrpAla: 1.017 ± 0.029	0.153TrpCys: 0.153 ± 0.012	0.599TrpAsp: 0.599 ± 0.023	0.642TrpGlu: 0.642 ± 0.024	0.58TrpPhe: 0.58 ± 0.022	0.829TrpGly: 0.829 ± 0.027	0.346TrpHis: 0.346 ± 0.018	0.716TrpIle: 0.716 ± 0.025	0.594TrpLys: 0.594 ± 0.021	1.9TrpLeu: 1.9 ± 0.041	0.344TrpMet: 0.344 ± 0.015	0.551TrpAsn: 0.551 ± 0.023	0.56TrpPro: 0.56 ± 0.02	0.695TrpGln: 0.695 ± 0.021	1.02TrpArg: 1.02 ± 0.035	0.826TrpSer: 0.826 ± 0.027	0.552TrpThr: 0.552 ± 0.021	0.891TrpVal: 0.891 ± 0.027	0.212TrpTrp: 0.212 ± 0.013	0.359TrpTyr: 0.359 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.725TyrAla: 2.725 ± 0.046	0.392TyrCys: 0.392 ± 0.019	1.493TyrAsp: 1.493 ± 0.036	1.416TyrGlu: 1.416 ± 0.036	1.264TyrPhe: 1.264 ± 0.031	2.182TyrGly: 2.182 ± 0.047	0.686TyrHis: 0.686 ± 0.023	1.304TyrIle: 1.304 ± 0.03	0.947TyrLys: 0.947 ± 0.028	3.17TyrLeu: 3.17 ± 0.055	0.517TyrMet: 0.517 ± 0.02	0.977TyrAsn: 0.977 ± 0.034	1.388TyrPro: 1.388 ± 0.031	1.315TyrGln: 1.315 ± 0.032	2.359TyrArg: 2.359 ± 0.051	1.732TyrSer: 1.732 ± 0.04	1.408TyrThr: 1.408 ± 0.035	1.618TyrVal: 1.618 ± 0.039	0.47TyrTrp: 0.47 ± 0.019	0.929TyrTyr: 0.929 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3961 proteins (1288933 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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