Amino acid dipepetide frequency for [Clostridium] asparagiforme DSM 15981

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.582AlaAla: 10.582 ± 0.111
1.416AlaCys: 1.416 ± 0.03
4.924AlaAsp: 4.924 ± 0.055
5.674AlaGlu: 5.674 ± 0.068
3.46AlaPhe: 3.46 ± 0.045
8.637AlaGly: 8.637 ± 0.085
1.235AlaHis: 1.235 ± 0.025
4.674AlaIle: 4.674 ± 0.056
3.931AlaLys: 3.931 ± 0.047
8.404AlaLeu: 8.404 ± 0.08
2.832AlaMet: 2.832 ± 0.039
2.379AlaAsn: 2.379 ± 0.034
2.762AlaPro: 2.762 ± 0.045
2.752AlaGln: 2.752 ± 0.043
4.438AlaArg: 4.438 ± 0.051
4.172AlaSer: 4.172 ± 0.054
3.18AlaThr: 3.18 ± 0.046
7.78AlaVal: 7.78 ± 0.085
0.82AlaTrp: 0.82 ± 0.02
2.82AlaTyr: 2.82 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.328CysAla: 1.328 ± 0.025
0.338CysCys: 0.338 ± 0.016
0.786CysAsp: 0.786 ± 0.023
0.879CysGlu: 0.879 ± 0.022
0.694CysPhe: 0.694 ± 0.019
1.818CysGly: 1.818 ± 0.031
0.309CysHis: 0.309 ± 0.014
0.917CysIle: 0.917 ± 0.023
0.616CysLys: 0.616 ± 0.018
1.501CysLeu: 1.501 ± 0.028
0.49CysMet: 0.49 ± 0.015
0.527CysAsn: 0.527 ± 0.016
0.777CysPro: 0.777 ± 0.023
0.442CysGln: 0.442 ± 0.016
1.142CysArg: 1.142 ± 0.027
0.961CysSer: 0.961 ± 0.02
0.767CysThr: 0.767 ± 0.019
1.046CysVal: 1.046 ± 0.024
0.156CysTrp: 0.156 ± 0.009
0.576CysTyr: 0.576 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.733AspAla: 3.733 ± 0.05
0.849AspCys: 0.849 ± 0.025
2.483AspAsp: 2.483 ± 0.053
4.032AspGlu: 4.032 ± 0.052
2.394AspPhe: 2.394 ± 0.032
5.278AspGly: 5.278 ± 0.079
0.926AspHis: 0.926 ± 0.024
3.563AspIle: 3.563 ± 0.048
2.45AspLys: 2.45 ± 0.042
4.683AspLeu: 4.683 ± 0.049
1.792AspMet: 1.792 ± 0.036
1.769AspAsn: 1.769 ± 0.037
2.159AspPro: 2.159 ± 0.037
1.87AspGln: 1.87 ± 0.038
3.258AspArg: 3.258 ± 0.05
2.898AspSer: 2.898 ± 0.046
2.66AspThr: 2.66 ± 0.038
3.639AspVal: 3.639 ± 0.054
0.656AspTrp: 0.656 ± 0.019
2.482AspTyr: 2.482 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.573GluAla: 6.573 ± 0.068
0.801GluCys: 0.801 ± 0.021
3.806GluAsp: 3.806 ± 0.053
6.233GluGlu: 6.233 ± 0.072
2.426GluPhe: 2.426 ± 0.037
4.603GluGly: 4.603 ± 0.058
1.215GluHis: 1.215 ± 0.023
4.664GluIle: 4.664 ± 0.055
4.492GluLys: 4.492 ± 0.055
6.738GluLeu: 6.738 ± 0.073
2.306GluMet: 2.306 ± 0.035
3.403GluAsn: 3.403 ± 0.042
2.319GluPro: 2.319 ± 0.041
3.012GluGln: 3.012 ± 0.045
4.302GluArg: 4.302 ± 0.053
3.27GluSer: 3.27 ± 0.049
3.764GluThr: 3.764 ± 0.053
3.966GluVal: 3.966 ± 0.054
0.625GluTrp: 0.625 ± 0.02
2.676GluTyr: 2.676 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.292PheAla: 3.292 ± 0.052
0.818PheCys: 0.818 ± 0.021
2.358PheAsp: 2.358 ± 0.036
2.46PheGlu: 2.46 ± 0.037
1.802PhePhe: 1.802 ± 0.037
3.271PheGly: 3.271 ± 0.051
0.79PheHis: 0.79 ± 0.019
2.453PheIle: 2.453 ± 0.042
1.812PheLys: 1.812 ± 0.03
4.073PheLeu: 4.073 ± 0.05
1.286PheMet: 1.286 ± 0.026
1.459PheAsn: 1.459 ± 0.03
1.57PhePro: 1.57 ± 0.033
1.238PheGln: 1.238 ± 0.026
1.937PheArg: 1.937 ± 0.036
2.82PheSer: 2.82 ± 0.044
2.302PheThr: 2.302 ± 0.036
2.838PheVal: 2.838 ± 0.045
0.475PheTrp: 0.475 ± 0.015
1.695PheTyr: 1.695 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
6.794GlyAla: 6.794 ± 0.069
1.531GlyCys: 1.531 ± 0.031
4.106GlyAsp: 4.106 ± 0.049
5.568GlyGlu: 5.568 ± 0.063
3.377GlyPhe: 3.377 ± 0.044
6.851GlyGly: 6.851 ± 0.089
1.34GlyHis: 1.34 ± 0.029
5.972GlyIle: 5.972 ± 0.058
4.704GlyLys: 4.704 ± 0.06
7.365GlyLeu: 7.365 ± 0.075
2.784GlyMet: 2.784 ± 0.042
3.117GlyAsn: 3.117 ± 0.045
2.13GlyPro: 2.13 ± 0.045
2.72GlyGln: 2.72 ± 0.046
4.765GlyArg: 4.765 ± 0.063
4.72GlySer: 4.72 ± 0.069
4.592GlyThr: 4.592 ± 0.06
5.685GlyVal: 5.685 ± 0.051
0.983GlyTrp: 0.983 ± 0.025
3.324GlyTyr: 3.324 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.041HisAla: 1.041 ± 0.023
0.355HisCys: 0.355 ± 0.013
0.786HisAsp: 0.786 ± 0.022
0.922HisGlu: 0.922 ± 0.022
0.86HisPhe: 0.86 ± 0.022
1.385HisGly: 1.385 ± 0.033
0.389HisHis: 0.389 ± 0.015
1.209HisIle: 1.209 ± 0.026
0.725HisLys: 0.725 ± 0.018
1.468HisLeu: 1.468 ± 0.028
0.605HisMet: 0.605 ± 0.018
0.649HisAsn: 0.649 ± 0.019
0.935HisPro: 0.935 ± 0.024
0.519HisGln: 0.519 ± 0.016
0.973HisArg: 0.973 ± 0.024
0.943HisSer: 0.943 ± 0.024
0.895HisThr: 0.895 ± 0.023
1.098HisVal: 1.098 ± 0.025
0.173HisTrp: 0.173 ± 0.01
0.747HisTyr: 0.747 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.452IleAla: 5.452 ± 0.052
1.281IleCys: 1.281 ± 0.027
3.165IleAsp: 3.165 ± 0.048
3.577IleGlu: 3.577 ± 0.047
2.562IlePhe: 2.562 ± 0.043
4.851IleGly: 4.851 ± 0.055
1.22IleHis: 1.22 ± 0.025
3.742IleIle: 3.742 ± 0.062
2.755IleLys: 2.755 ± 0.043
6.42IleLeu: 6.42 ± 0.071
1.758IleMet: 1.758 ± 0.03
2.35IleAsn: 2.35 ± 0.038
3.229IlePro: 3.229 ± 0.043
1.977IleGln: 1.977 ± 0.034
4.073IleArg: 4.073 ± 0.047
4.117IleSer: 4.117 ± 0.05
3.604IleThr: 3.604 ± 0.048
4.297IleVal: 4.297 ± 0.049
0.622IleTrp: 0.622 ± 0.02
2.268IleTyr: 2.268 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.458LysAla: 4.458 ± 0.063
0.587LysCys: 0.587 ± 0.019
2.78LysAsp: 2.78 ± 0.042
4.216LysGlu: 4.216 ± 0.049
1.476LysPhe: 1.476 ± 0.033
3.659LysGly: 3.659 ± 0.047
0.762LysHis: 0.762 ± 0.021
3.262LysIle: 3.262 ± 0.048
3.682LysLys: 3.682 ± 0.05
4.337LysLeu: 4.337 ± 0.052
1.743LysMet: 1.743 ± 0.031
2.328LysAsn: 2.328 ± 0.034
1.892LysPro: 1.892 ± 0.03
1.872LysGln: 1.872 ± 0.035
3.106LysArg: 3.106 ± 0.039
2.652LysSer: 2.652 ± 0.034
2.893LysThr: 2.893 ± 0.039
3.193LysVal: 3.193 ± 0.047
0.54LysTrp: 0.54 ± 0.017
1.903LysTyr: 1.903 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
8.316LeuAla: 8.316 ± 0.089
1.669LeuCys: 1.669 ± 0.033
5.173LeuAsp: 5.173 ± 0.064
6.781LeuGlu: 6.781 ± 0.077
4.022LeuPhe: 4.022 ± 0.059
6.795LeuGly: 6.795 ± 0.068
1.476LeuHis: 1.476 ± 0.029
5.57LeuIle: 5.57 ± 0.064
5.284LeuLys: 5.284 ± 0.051
8.995LeuLeu: 8.995 ± 0.091
2.758LeuMet: 2.758 ± 0.038
3.575LeuAsn: 3.575 ± 0.047
4.159LeuPro: 4.159 ± 0.055
2.623LeuGln: 2.623 ± 0.036
4.767LeuArg: 4.767 ± 0.054
6.077LeuSer: 6.077 ± 0.07
5.227LeuThr: 5.227 ± 0.052
6.019LeuVal: 6.019 ± 0.068
0.932LeuTrp: 0.932 ± 0.026
3.346LeuTyr: 3.346 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.002MetAla: 3.002 ± 0.045
0.39MetCys: 0.39 ± 0.015
1.968MetAsp: 1.968 ± 0.03
2.79MetGlu: 2.79 ± 0.041
1.093MetPhe: 1.093 ± 0.03
2.534MetGly: 2.534 ± 0.04
0.389MetHis: 0.389 ± 0.014
2.188MetIle: 2.188 ± 0.038
2.115MetLys: 2.115 ± 0.036
2.629MetLeu: 2.629 ± 0.04
1.009MetMet: 1.009 ± 0.025
1.383MetAsn: 1.383 ± 0.03
1.208MetPro: 1.208 ± 0.024
0.912MetGln: 0.912 ± 0.024
1.527MetArg: 1.527 ± 0.028
1.746MetSer: 1.746 ± 0.027
1.765MetThr: 1.765 ± 0.032
2.274MetVal: 2.274 ± 0.034
0.267MetTrp: 0.267 ± 0.012
0.877MetTyr: 0.877 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.937AsnAla: 2.937 ± 0.044
0.586AsnCys: 0.586 ± 0.018
1.669AsnAsp: 1.669 ± 0.035
2.115AsnGlu: 2.115 ± 0.039
1.462AsnPhe: 1.462 ± 0.03
3.312AsnGly: 3.312 ± 0.051
0.716AsnHis: 0.716 ± 0.019
2.479AsnIle: 2.479 ± 0.038
1.537AsnLys: 1.537 ± 0.032
3.515AsnLeu: 3.515 ± 0.043
1.27AsnMet: 1.27 ± 0.024
1.318AsnAsn: 1.318 ± 0.033
2.033AsnPro: 2.033 ± 0.034
1.362AsnGln: 1.362 ± 0.033
2.34AsnArg: 2.34 ± 0.034
2.009AsnSer: 2.009 ± 0.036
1.933AsnThr: 1.933 ± 0.032
2.541AsnVal: 2.541 ± 0.035
0.403AsnTrp: 0.403 ± 0.016
1.542AsnTyr: 1.542 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
3.574ProAla: 3.574 ± 0.05
0.544ProCys: 0.544 ± 0.018
2.668ProAsp: 2.668 ± 0.047
3.799ProGlu: 3.799 ± 0.045
1.682ProPhe: 1.682 ± 0.03
3.627ProGly: 3.627 ± 0.052
0.669ProHis: 0.669 ± 0.018
1.996ProIle: 1.996 ± 0.035
1.531ProLys: 1.531 ± 0.033
3.321ProLeu: 3.321 ± 0.038
1.149ProMet: 1.149 ± 0.029
1.136ProAsn: 1.136 ± 0.027
1.238ProPro: 1.238 ± 0.031
1.386ProGln: 1.386 ± 0.026
1.542ProArg: 1.542 ± 0.028
1.951ProSer: 1.951 ± 0.036
1.64ProThr: 1.64 ± 0.037
3.592ProVal: 3.592 ± 0.047
0.425ProTrp: 0.425 ± 0.015
1.555ProTyr: 1.555 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.01GlnAla: 3.01 ± 0.04
0.381GlnCys: 0.381 ± 0.014
1.601GlnAsp: 1.601 ± 0.031
2.569GlnGlu: 2.569 ± 0.036
1.221GlnPhe: 1.221 ± 0.029
2.338GlnGly: 2.338 ± 0.04
0.41GlnHis: 0.41 ± 0.016
2.344GlnIle: 2.344 ± 0.038
2.005GlnLys: 2.005 ± 0.036
2.856GlnLeu: 2.856 ± 0.043
1.257GlnMet: 1.257 ± 0.023
1.457GlnAsn: 1.457 ± 0.029
1.228GlnPro: 1.228 ± 0.03
1.114GlnGln: 1.114 ± 0.028
1.628GlnArg: 1.628 ± 0.03
1.693GlnSer: 1.693 ± 0.031
1.716GlnThr: 1.716 ± 0.034
2.527GlnVal: 2.527 ± 0.039
0.373GlnTrp: 0.373 ± 0.014
1.319GlnTyr: 1.319 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
4.085ArgAla: 4.085 ± 0.051
0.839ArgCys: 0.839 ± 0.023
2.984ArgAsp: 2.984 ± 0.043
5.128ArgGlu: 5.128 ± 0.067
2.369ArgPhe: 2.369 ± 0.035
3.595ArgGly: 3.595 ± 0.049
0.991ArgHis: 0.991 ± 0.023
3.76ArgIle: 3.76 ± 0.044
3.09ArgLys: 3.09 ± 0.04
5.584ArgLeu: 5.584 ± 0.063
1.931ArgMet: 1.931 ± 0.032
1.974ArgAsn: 1.974 ± 0.031
2.074ArgPro: 2.074 ± 0.037
2.23ArgGln: 2.23 ± 0.042
3.894ArgArg: 3.894 ± 0.051
2.736ArgSer: 2.736 ± 0.038
2.754ArgThr: 2.754 ± 0.042
3.414ArgVal: 3.414 ± 0.043
0.596ArgTrp: 0.596 ± 0.02
2.29ArgTyr: 2.29 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.721SerAla: 4.721 ± 0.05
0.885SerCys: 0.885 ± 0.024
2.767SerAsp: 2.767 ± 0.042
3.099SerGlu: 3.099 ± 0.048
2.498SerPhe: 2.498 ± 0.038
5.878SerGly: 5.878 ± 0.072
1.01SerHis: 1.01 ± 0.023
3.439SerIle: 3.439 ± 0.051
2.29SerLys: 2.29 ± 0.035
5.3SerLeu: 5.3 ± 0.065
1.861SerMet: 1.861 ± 0.035
1.766SerAsn: 1.766 ± 0.034
2.161SerPro: 2.161 ± 0.036
1.861SerGln: 1.861 ± 0.036
3.402SerArg: 3.402 ± 0.041
3.231SerSer: 3.231 ± 0.049
2.582SerThr: 2.582 ± 0.041
4.132SerVal: 4.132 ± 0.051
0.632SerTrp: 0.632 ± 0.017
2.184SerTyr: 2.184 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.191ThrAla: 5.191 ± 0.055
0.67ThrCys: 0.67 ± 0.018
2.844ThrAsp: 2.844 ± 0.043
3.235ThrGlu: 3.235 ± 0.047
2.032ThrPhe: 2.032 ± 0.031
5.277ThrGly: 5.277 ± 0.066
0.788ThrHis: 0.788 ± 0.022
3.27ThrIle: 3.27 ± 0.043
2.094ThrLys: 2.094 ± 0.033
4.662ThrLeu: 4.662 ± 0.061
1.512ThrMet: 1.512 ± 0.028
1.612ThrAsn: 1.612 ± 0.032
2.399ThrPro: 2.399 ± 0.04
1.394ThrGln: 1.394 ± 0.028
2.278ThrArg: 2.278 ± 0.032
2.652ThrSer: 2.652 ± 0.035
2.563ThrThr: 2.563 ± 0.044
4.671ThrVal: 4.671 ± 0.053
0.519ThrTrp: 0.519 ± 0.018
1.817ThrTyr: 1.817 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
5.314ValAla: 5.314 ± 0.07
1.329ValCys: 1.329 ± 0.026
3.892ValAsp: 3.892 ± 0.053
4.798ValGlu: 4.798 ± 0.055
3.128ValPhe: 3.128 ± 0.048
4.815ValGly: 4.815 ± 0.061
1.086ValHis: 1.086 ± 0.021
4.873ValIle: 4.873 ± 0.058
3.89ValLys: 3.89 ± 0.047
6.949ValLeu: 6.949 ± 0.072
2.249ValMet: 2.249 ± 0.034
2.83ValAsn: 2.83 ± 0.046
2.915ValPro: 2.915 ± 0.04
1.931ValGln: 1.931 ± 0.033
3.89ValArg: 3.89 ± 0.054
4.398ValSer: 4.398 ± 0.046
4.117ValThr: 4.117 ± 0.056
5.016ValVal: 5.016 ± 0.052
0.731ValTrp: 0.731 ± 0.02
2.625ValTyr: 2.625 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.677TrpAla: 0.677 ± 0.019
0.163TrpCys: 0.163 ± 0.01
0.661TrpAsp: 0.661 ± 0.02
0.753TrpGlu: 0.753 ± 0.02
0.442TrpPhe: 0.442 ± 0.016
0.76TrpGly: 0.76 ± 0.02
0.18TrpHis: 0.18 ± 0.011
0.649TrpIle: 0.649 ± 0.02
0.69TrpLys: 0.69 ± 0.017
1.064TrpLeu: 1.064 ± 0.026
0.352TrpMet: 0.352 ± 0.015
0.539TrpAsn: 0.539 ± 0.018
0.315TrpPro: 0.315 ± 0.012
0.404TrpGln: 0.404 ± 0.014
0.54TrpArg: 0.54 ± 0.019
0.54TrpSer: 0.54 ± 0.019
0.497TrpThr: 0.497 ± 0.018
0.618TrpVal: 0.618 ± 0.019
0.136TrpTrp: 0.136 ± 0.009
0.462TrpTyr: 0.462 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.789TyrAla: 2.789 ± 0.044
0.636TyrCys: 0.636 ± 0.018
2.153TyrAsp: 2.153 ± 0.037
2.565TyrGlu: 2.565 ± 0.043
1.75TyrPhe: 1.75 ± 0.031
3.142TyrGly: 3.142 ± 0.04
0.774TyrHis: 0.774 ± 0.02
2.298TyrIle: 2.298 ± 0.037
1.65TyrLys: 1.65 ± 0.034
3.702TyrLeu: 3.702 ± 0.053
1.122TyrMet: 1.122 ± 0.024
1.51TyrAsn: 1.51 ± 0.029
1.522TyrPro: 1.522 ± 0.029
1.428TyrGln: 1.428 ± 0.026
2.515TyrArg: 2.515 ± 0.04
2.113TyrSer: 2.113 ± 0.037
2.03TyrThr: 2.03 ± 0.036
2.429TyrVal: 2.429 ± 0.037
0.38TyrTrp: 0.38 ± 0.015
1.771TyrTyr: 1.771 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6817 proteins (1900233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski