Amino acid dipepetide frequency for Spirosoma taeanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.425AlaAla: 7.425 ± 0.083
0.72AlaCys: 0.72 ± 0.022
5.455AlaAsp: 5.455 ± 0.062
4.94AlaGlu: 4.94 ± 0.06
3.709AlaPhe: 3.709 ± 0.052
7.067AlaGly: 7.067 ± 0.086
1.442AlaHis: 1.442 ± 0.03
4.924AlaIle: 4.924 ± 0.059
3.684AlaLys: 3.684 ± 0.049
8.573AlaLeu: 8.573 ± 0.094
1.92AlaMet: 1.92 ± 0.038
3.831AlaAsn: 3.831 ± 0.057
3.403AlaPro: 3.403 ± 0.05
3.977AlaGln: 3.977 ± 0.055
4.593AlaArg: 4.593 ± 0.05
5.113AlaSer: 5.113 ± 0.064
5.154AlaThr: 5.154 ± 0.07
5.955AlaVal: 5.955 ± 0.073
0.949AlaTrp: 0.949 ± 0.025
3.143AlaTyr: 3.143 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.522CysAla: 0.522 ± 0.021
0.108CysCys: 0.108 ± 0.008
0.373CysAsp: 0.373 ± 0.015
0.376CysGlu: 0.376 ± 0.022
0.348CysPhe: 0.348 ± 0.014
0.589CysGly: 0.589 ± 0.024
0.205CysHis: 0.205 ± 0.013
0.406CysIle: 0.406 ± 0.014
0.256CysLys: 0.256 ± 0.014
0.81CysLeu: 0.81 ± 0.024
0.14CysMet: 0.14 ± 0.008
0.263CysAsn: 0.263 ± 0.013
0.348CysPro: 0.348 ± 0.016
0.359CysGln: 0.359 ± 0.021
0.441CysArg: 0.441 ± 0.016
0.478CysSer: 0.478 ± 0.021
0.411CysThr: 0.411 ± 0.02
0.493CysVal: 0.493 ± 0.019
0.107CysTrp: 0.107 ± 0.01
0.273CysTyr: 0.273 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.571AspAla: 4.571 ± 0.058
0.353AspCys: 0.353 ± 0.018
2.663AspAsp: 2.663 ± 0.041
3.44AspGlu: 3.44 ± 0.054
2.607AspPhe: 2.607 ± 0.041
4.014AspGly: 4.014 ± 0.068
0.905AspHis: 0.905 ± 0.025
2.97AspIle: 2.97 ± 0.042
2.646AspLys: 2.646 ± 0.045
5.21AspLeu: 5.21 ± 0.065
1.067AspMet: 1.067 ± 0.025
2.277AspAsn: 2.277 ± 0.042
2.642AspPro: 2.642 ± 0.039
2.261AspGln: 2.261 ± 0.035
3.229AspArg: 3.229 ± 0.049
2.879AspSer: 2.879 ± 0.046
2.678AspThr: 2.678 ± 0.045
3.801AspVal: 3.801 ± 0.056
0.921AspTrp: 0.921 ± 0.026
2.362AspTyr: 2.362 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
4.86GluAla: 4.86 ± 0.066
0.289GluCys: 0.289 ± 0.015
2.249GluAsp: 2.249 ± 0.044
2.961GluGlu: 2.961 ± 0.054
2.09GluPhe: 2.09 ± 0.039
3.367GluGly: 3.367 ± 0.054
1.014GluHis: 1.014 ± 0.029
2.984GluIle: 2.984 ± 0.042
3.012GluLys: 3.012 ± 0.052
5.462GluLeu: 5.462 ± 0.066
1.245GluMet: 1.245 ± 0.028
2.289GluAsn: 2.289 ± 0.038
2.236GluPro: 2.236 ± 0.044
2.879GluGln: 2.879 ± 0.051
3.421GluArg: 3.421 ± 0.048
2.708GluSer: 2.708 ± 0.044
3.237GluThr: 3.237 ± 0.042
3.661GluVal: 3.661 ± 0.052
0.682GluTrp: 0.682 ± 0.023
1.747GluTyr: 1.747 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.557PheAla: 3.557 ± 0.048
0.385PheCys: 0.385 ± 0.013
2.766PheAsp: 2.766 ± 0.042
2.207PheGlu: 2.207 ± 0.034
2.085PhePhe: 2.085 ± 0.045
3.585PheGly: 3.585 ± 0.054
0.718PheHis: 0.718 ± 0.02
2.485PheIle: 2.485 ± 0.043
1.733PheLys: 1.733 ± 0.037
4.206PheLeu: 4.206 ± 0.066
0.977PheMet: 0.977 ± 0.025
2.068PheAsn: 2.068 ± 0.04
1.827PhePro: 1.827 ± 0.036
1.648PheGln: 1.648 ± 0.032
2.721PheArg: 2.721 ± 0.038
3.059PheSer: 3.059 ± 0.048
2.832PheThr: 2.832 ± 0.044
3.098PheVal: 3.098 ± 0.052
0.658PheTrp: 0.658 ± 0.023
1.717PheTyr: 1.717 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
5.403GlyAla: 5.403 ± 0.065
0.724GlyCys: 0.724 ± 0.028
3.508GlyAsp: 3.508 ± 0.049
3.415GlyGlu: 3.415 ± 0.05
3.528GlyPhe: 3.528 ± 0.049
5.506GlyGly: 5.506 ± 0.07
1.371GlyHis: 1.371 ± 0.031
4.565GlyIle: 4.565 ± 0.053
4.008GlyLys: 4.008 ± 0.062
7.498GlyLeu: 7.498 ± 0.084
1.69GlyMet: 1.69 ± 0.03
3.284GlyAsn: 3.284 ± 0.065
2.4GlyPro: 2.4 ± 0.045
3.626GlyGln: 3.626 ± 0.052
4.192GlyArg: 4.192 ± 0.056
4.673GlySer: 4.673 ± 0.068
4.556GlyThr: 4.556 ± 0.074
5.18GlyVal: 5.18 ± 0.067
1.189GlyTrp: 1.189 ± 0.034
3.155GlyTyr: 3.155 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.219HisAla: 1.219 ± 0.027
0.182HisCys: 0.182 ± 0.01
0.939HisAsp: 0.939 ± 0.027
1.016HisGlu: 1.016 ± 0.03
0.973HisPhe: 0.973 ± 0.023
1.184HisGly: 1.184 ± 0.031
0.486HisHis: 0.486 ± 0.017
1.077HisIle: 1.077 ± 0.027
0.735HisLys: 0.735 ± 0.021
1.882HisLeu: 1.882 ± 0.038
0.295HisMet: 0.295 ± 0.015
0.741HisAsn: 0.741 ± 0.023
1.184HisPro: 1.184 ± 0.025
0.84HisGln: 0.84 ± 0.023
1.085HisArg: 1.085 ± 0.021
0.997HisSer: 0.997 ± 0.026
1.107HisThr: 1.107 ± 0.023
1.082HisVal: 1.082 ± 0.029
0.333HisTrp: 0.333 ± 0.013
0.82HisTyr: 0.82 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.974IleAla: 4.974 ± 0.058
0.507IleCys: 0.507 ± 0.018
3.403IleAsp: 3.403 ± 0.05
3.177IleGlu: 3.177 ± 0.05
2.02IlePhe: 2.02 ± 0.036
4.601IleGly: 4.601 ± 0.059
1.029IleHis: 1.029 ± 0.028
2.987IleIle: 2.987 ± 0.052
2.401IleLys: 2.401 ± 0.042
4.827IleLeu: 4.827 ± 0.071
1.024IleMet: 1.024 ± 0.027
2.837IleAsn: 2.837 ± 0.048
2.751IlePro: 2.751 ± 0.042
2.3IleGln: 2.3 ± 0.039
3.794IleArg: 3.794 ± 0.045
3.467IleSer: 3.467 ± 0.047
3.637IleThr: 3.637 ± 0.05
3.762IleVal: 3.762 ± 0.056
0.695IleTrp: 0.695 ± 0.025
1.831IleTyr: 1.831 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.483LysAla: 4.483 ± 0.056
0.189LysCys: 0.189 ± 0.011
2.42LysAsp: 2.42 ± 0.04
2.585LysGlu: 2.585 ± 0.046
1.524LysPhe: 1.524 ± 0.031
3.32LysGly: 3.32 ± 0.053
0.806LysHis: 0.806 ± 0.022
2.486LysIle: 2.486 ± 0.038
2.605LysLys: 2.605 ± 0.057
4.534LysLeu: 4.534 ± 0.056
1.076LysMet: 1.076 ± 0.027
2.196LysAsn: 2.196 ± 0.042
2.848LysPro: 2.848 ± 0.048
2.227LysGln: 2.227 ± 0.04
2.602LysArg: 2.602 ± 0.042
2.426LysSer: 2.426 ± 0.038
3.126LysThr: 3.126 ± 0.047
3.023LysVal: 3.023 ± 0.051
0.501LysTrp: 0.501 ± 0.018
1.553LysTyr: 1.553 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
8.977LeuAla: 8.977 ± 0.091
0.736LeuCys: 0.736 ± 0.021
5.065LeuAsp: 5.065 ± 0.059
4.532LeuGlu: 4.532 ± 0.055
4.631LeuPhe: 4.631 ± 0.069
6.567LeuGly: 6.567 ± 0.069
1.855LeuHis: 1.855 ± 0.035
5.801LeuIle: 5.801 ± 0.08
4.928LeuLys: 4.928 ± 0.063
10.856LeuLeu: 10.856 ± 0.116
2.22LeuMet: 2.22 ± 0.04
4.889LeuAsn: 4.889 ± 0.054
5.229LeuPro: 5.229 ± 0.069
3.77LeuGln: 3.77 ± 0.052
5.653LeuArg: 5.653 ± 0.068
6.676LeuSer: 6.676 ± 0.064
7.522LeuThr: 7.522 ± 0.073
6.605LeuVal: 6.605 ± 0.074
1.091LeuTrp: 1.091 ± 0.028
3.403LeuTyr: 3.403 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.121MetAla: 2.121 ± 0.037
0.11MetCys: 0.11 ± 0.007
1.064MetAsp: 1.064 ± 0.023
1.036MetGlu: 1.036 ± 0.028
0.642MetPhe: 0.642 ± 0.019
1.553MetGly: 1.553 ± 0.035
0.444MetHis: 0.444 ± 0.018
1.11MetIle: 1.11 ± 0.027
1.409MetLys: 1.409 ± 0.032
2.153MetLeu: 2.153 ± 0.034
0.494MetMet: 0.494 ± 0.015
1.167MetAsn: 1.167 ± 0.029
1.215MetPro: 1.215 ± 0.027
1.006MetGln: 1.006 ± 0.023
1.169MetArg: 1.169 ± 0.028
1.191MetSer: 1.191 ± 0.026
1.382MetThr: 1.382 ± 0.032
1.272MetVal: 1.272 ± 0.026
0.173MetTrp: 0.173 ± 0.011
0.526MetTyr: 0.526 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.823AsnAla: 3.823 ± 0.06
0.327AsnCys: 0.327 ± 0.019
2.382AsnAsp: 2.382 ± 0.043
2.382AsnGlu: 2.382 ± 0.045
1.945AsnPhe: 1.945 ± 0.036
3.756AsnGly: 3.756 ± 0.06
0.812AsnHis: 0.812 ± 0.024
2.302AsnIle: 2.302 ± 0.038
1.823AsnLys: 1.823 ± 0.035
4.491AsnLeu: 4.491 ± 0.052
0.831AsnMet: 0.831 ± 0.026
2.232AsnAsn: 2.232 ± 0.052
2.834AsnPro: 2.834 ± 0.048
2.271AsnGln: 2.271 ± 0.035
3.026AsnArg: 3.026 ± 0.045
2.555AsnSer: 2.555 ± 0.042
2.821AsnThr: 2.821 ± 0.059
3.164AsnVal: 3.164 ± 0.049
0.692AsnTrp: 0.692 ± 0.022
1.889AsnTyr: 1.889 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.925ProAla: 4.925 ± 0.058
0.214ProCys: 0.214 ± 0.013
3.529ProAsp: 3.529 ± 0.046
3.018ProGlu: 3.018 ± 0.043
2.066ProPhe: 2.066 ± 0.043
3.585ProGly: 3.585 ± 0.052
0.822ProHis: 0.822 ± 0.024
2.538ProIle: 2.538 ± 0.034
2.119ProLys: 2.119 ± 0.042
4.085ProLeu: 4.085 ± 0.05
0.956ProMet: 0.956 ± 0.022
2.399ProAsn: 2.399 ± 0.046
1.606ProPro: 1.606 ± 0.038
1.736ProGln: 1.736 ± 0.035
1.881ProArg: 1.881 ± 0.038
2.622ProSer: 2.622 ± 0.045
3.17ProThr: 3.17 ± 0.05
3.976ProVal: 3.976 ± 0.054
0.523ProTrp: 0.523 ± 0.02
1.726ProTyr: 1.726 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.011GlnAla: 4.011 ± 0.057
0.235GlnCys: 0.235 ± 0.013
1.691GlnAsp: 1.691 ± 0.031
2.082GlnGlu: 2.082 ± 0.042
1.984GlnPhe: 1.984 ± 0.034
2.526GlnGly: 2.526 ± 0.039
0.875GlnHis: 0.875 ± 0.025
2.541GlnIle: 2.541 ± 0.038
2.313GlnLys: 2.313 ± 0.039
4.877GlnLeu: 4.877 ± 0.059
1.001GlnMet: 1.001 ± 0.025
2.076GlnAsn: 2.076 ± 0.038
2.611GlnPro: 2.611 ± 0.044
2.657GlnGln: 2.657 ± 0.053
2.677GlnArg: 2.677 ± 0.047
2.571GlnSer: 2.571 ± 0.037
3.239GlnThr: 3.239 ± 0.046
2.837GlnVal: 2.837 ± 0.047
0.544GlnTrp: 0.544 ± 0.019
1.725GlnTyr: 1.725 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
4.277ArgAla: 4.277 ± 0.057
0.335ArgCys: 0.335 ± 0.015
2.699ArgAsp: 2.699 ± 0.042
3.064ArgGlu: 3.064 ± 0.049
2.861ArgPhe: 2.861 ± 0.044
3.128ArgGly: 3.128 ± 0.043
1.077ArgHis: 1.077 ± 0.027
3.625ArgIle: 3.625 ± 0.049
2.754ArgLys: 2.754 ± 0.042
6.302ArgLeu: 6.302 ± 0.07
1.431ArgMet: 1.431 ± 0.031
2.75ArgAsn: 2.75 ± 0.046
2.766ArgPro: 2.766 ± 0.044
3.42ArgGln: 3.42 ± 0.06
3.344ArgArg: 3.344 ± 0.053
3.223ArgSer: 3.223 ± 0.042
3.416ArgThr: 3.416 ± 0.05
3.838ArgVal: 3.838 ± 0.052
0.89ArgTrp: 0.89 ± 0.025
2.428ArgTyr: 2.428 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.306SerAla: 5.306 ± 0.063
0.481SerCys: 0.481 ± 0.015
3.067SerAsp: 3.067 ± 0.05
2.86SerGlu: 2.86 ± 0.044
2.937SerPhe: 2.937 ± 0.043
4.91SerGly: 4.91 ± 0.07
1.025SerHis: 1.025 ± 0.026
3.294SerIle: 3.294 ± 0.039
2.327SerLys: 2.327 ± 0.039
6.465SerLeu: 6.465 ± 0.069
1.212SerMet: 1.212 ± 0.025
2.467SerAsn: 2.467 ± 0.05
2.843SerPro: 2.843 ± 0.045
2.365SerGln: 2.365 ± 0.039
3.361SerArg: 3.361 ± 0.047
3.763SerSer: 3.763 ± 0.06
3.563SerThr: 3.563 ± 0.053
4.478SerVal: 4.478 ± 0.055
0.759SerTrp: 0.759 ± 0.025
2.229SerTyr: 2.229 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.55ThrAla: 5.55 ± 0.074
0.364ThrCys: 0.364 ± 0.016
3.818ThrAsp: 3.818 ± 0.049
3.069ThrGlu: 3.069 ± 0.043
2.91ThrPhe: 2.91 ± 0.037
5.423ThrGly: 5.423 ± 0.081
1.103ThrHis: 1.103 ± 0.026
3.695ThrIle: 3.695 ± 0.06
2.458ThrLys: 2.458 ± 0.04
6.562ThrLeu: 6.562 ± 0.068
1.087ThrMet: 1.087 ± 0.028
2.905ThrAsn: 2.905 ± 0.048
3.44ThrPro: 3.44 ± 0.054
2.315ThrGln: 2.315 ± 0.038
2.992ThrArg: 2.992 ± 0.041
3.659ThrSer: 3.659 ± 0.052
4.117ThrThr: 4.117 ± 0.068
4.763ThrVal: 4.763 ± 0.078
0.714ThrTrp: 0.714 ± 0.022
2.512ThrTyr: 2.512 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.031ValAla: 6.031 ± 0.071
0.629ValCys: 0.629 ± 0.023
3.598ValAsp: 3.598 ± 0.046
3.696ValGlu: 3.696 ± 0.057
3.035ValPhe: 3.035 ± 0.048
5.084ValGly: 5.084 ± 0.064
1.164ValHis: 1.164 ± 0.025
3.86ValIle: 3.86 ± 0.058
3.116ValLys: 3.116 ± 0.051
6.922ValLeu: 6.922 ± 0.076
1.537ValMet: 1.537 ± 0.034
3.249ValAsn: 3.249 ± 0.047
3.129ValPro: 3.129 ± 0.048
2.742ValGln: 2.742 ± 0.041
4.161ValArg: 4.161 ± 0.058
4.706ValSer: 4.706 ± 0.054
4.525ValThr: 4.525 ± 0.068
5.289ValVal: 5.289 ± 0.068
0.882ValTrp: 0.882 ± 0.024
2.411ValTyr: 2.411 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.995TrpAla: 0.995 ± 0.028
0.097TrpCys: 0.097 ± 0.008
0.612TrpAsp: 0.612 ± 0.02
0.595TrpGlu: 0.595 ± 0.02
0.618TrpPhe: 0.618 ± 0.02
0.899TrpGly: 0.899 ± 0.029
0.318TrpHis: 0.318 ± 0.015
0.639TrpIle: 0.639 ± 0.024
0.603TrpLys: 0.603 ± 0.019
1.62TrpLeu: 1.62 ± 0.037
0.366TrpMet: 0.366 ± 0.017
0.598TrpAsn: 0.598 ± 0.021
0.48TrpPro: 0.48 ± 0.017
0.783TrpGln: 0.783 ± 0.027
0.804TrpArg: 0.804 ± 0.025
0.723TrpSer: 0.723 ± 0.025
0.753TrpThr: 0.753 ± 0.025
0.868TrpVal: 0.868 ± 0.027
0.231TrpTrp: 0.231 ± 0.014
0.468TrpTyr: 0.468 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.948TyrAla: 2.948 ± 0.04
0.324TyrCys: 0.324 ± 0.013
2.197TyrAsp: 2.197 ± 0.036
1.944TyrGlu: 1.944 ± 0.04
1.82TyrPhe: 1.82 ± 0.034
2.808TyrGly: 2.808 ± 0.049
0.705TyrHis: 0.705 ± 0.021
1.733TyrIle: 1.733 ± 0.033
1.601TyrLys: 1.601 ± 0.032
3.671TyrLeu: 3.671 ± 0.057
0.669TyrMet: 0.669 ± 0.021
1.841TyrAsn: 1.841 ± 0.04
1.702TyrPro: 1.702 ± 0.032
1.89TyrGln: 1.89 ± 0.035
2.484TyrArg: 2.484 ± 0.045
2.222TyrSer: 2.222 ± 0.041
2.212TyrThr: 2.212 ± 0.035
2.618TyrVal: 2.618 ± 0.041
0.53TyrTrp: 0.53 ± 0.018
1.579TyrTyr: 1.579 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4629 proteins (1666099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski