Amino acid dipepetide frequency for Niabella drilacis (strain DSM 25811 / CCM 8410 / LMG 26954 / E90)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.967AlaAla: 8.967 ± 0.106
0.822AlaCys: 0.822 ± 0.024
4.507AlaAsp: 4.507 ± 0.051
4.111AlaGlu: 4.111 ± 0.053
3.83AlaPhe: 3.83 ± 0.055
7.302AlaGly: 7.302 ± 0.077
1.411AlaHis: 1.411 ± 0.027
5.131AlaIle: 5.131 ± 0.062
3.967AlaLys: 3.967 ± 0.058
7.972AlaLeu: 7.972 ± 0.089
1.743AlaMet: 1.743 ± 0.033
3.397AlaAsn: 3.397 ± 0.052
3.322AlaPro: 3.322 ± 0.053
3.15AlaGln: 3.15 ± 0.043
3.594AlaArg: 3.594 ± 0.045
4.63AlaSer: 4.63 ± 0.055
4.562AlaThr: 4.562 ± 0.054
5.707AlaVal: 5.707 ± 0.067
0.939AlaTrp: 0.939 ± 0.021
3.106AlaTyr: 3.106 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.58CysAla: 0.58 ± 0.02
0.187CysCys: 0.187 ± 0.011
0.356CysAsp: 0.356 ± 0.016
0.346CysGlu: 0.346 ± 0.018
0.529CysPhe: 0.529 ± 0.018
0.665CysGly: 0.665 ± 0.022
0.203CysHis: 0.203 ± 0.014
0.664CysIle: 0.664 ± 0.019
0.454CysLys: 0.454 ± 0.015
0.796CysLeu: 0.796 ± 0.023
0.21CysMet: 0.21 ± 0.012
0.417CysAsn: 0.417 ± 0.016
0.356CysPro: 0.356 ± 0.015
0.216CysGln: 0.216 ± 0.011
0.469CysArg: 0.469 ± 0.016
0.609CysSer: 0.609 ± 0.019
0.493CysThr: 0.493 ± 0.017
0.45CysVal: 0.45 ± 0.016
0.123CysTrp: 0.123 ± 0.008
0.399CysTyr: 0.399 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.44AspAla: 4.44 ± 0.054
0.373AspCys: 0.373 ± 0.016
2.217AspAsp: 2.217 ± 0.04
2.851AspGlu: 2.851 ± 0.044
2.748AspPhe: 2.748 ± 0.04
3.89AspGly: 3.89 ± 0.055
1.151AspHis: 1.151 ± 0.026
3.393AspIle: 3.393 ± 0.045
3.065AspLys: 3.065 ± 0.052
4.732AspLeu: 4.732 ± 0.058
1.066AspMet: 1.066 ± 0.021
2.319AspAsn: 2.319 ± 0.038
2.642AspPro: 2.642 ± 0.042
1.832AspGln: 1.832 ± 0.036
2.569AspArg: 2.569 ± 0.038
2.833AspSer: 2.833 ± 0.048
2.722AspThr: 2.722 ± 0.044
3.092AspVal: 3.092 ± 0.044
0.856AspTrp: 0.856 ± 0.025
2.405AspTyr: 2.405 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
4.824GluAla: 4.824 ± 0.057
0.328GluCys: 0.328 ± 0.014
2.488GluAsp: 2.488 ± 0.042
3.285GluGlu: 3.285 ± 0.06
1.887GluPhe: 1.887 ± 0.036
3.591GluGly: 3.591 ± 0.044
1.082GluHis: 1.082 ± 0.028
3.494GluIle: 3.494 ± 0.045
4.511GluLys: 4.511 ± 0.064
5.358GluLeu: 5.358 ± 0.066
1.422GluMet: 1.422 ± 0.027
2.857GluAsn: 2.857 ± 0.037
1.794GluPro: 1.794 ± 0.03
2.701GluGln: 2.701 ± 0.043
2.74GluArg: 2.74 ± 0.044
2.369GluSer: 2.369 ± 0.035
2.974GluThr: 2.974 ± 0.04
3.384GluVal: 3.384 ± 0.048
0.737GluTrp: 0.737 ± 0.021
1.958GluTyr: 1.958 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.303PheAla: 3.303 ± 0.047
0.518PheCys: 0.518 ± 0.018
2.752PheAsp: 2.752 ± 0.038
2.664PheGlu: 2.664 ± 0.041
2.605PhePhe: 2.605 ± 0.045
3.231PheGly: 3.231 ± 0.05
0.861PheHis: 0.861 ± 0.023
3.317PheIle: 3.317 ± 0.047
2.736PheLys: 2.736 ± 0.042
4.547PheLeu: 4.547 ± 0.062
1.131PheMet: 1.131 ± 0.025
2.649PheAsn: 2.649 ± 0.04
1.829PhePro: 1.829 ± 0.03
1.385PheGln: 1.385 ± 0.029
2.311PheArg: 2.311 ± 0.039
3.583PheSer: 3.583 ± 0.048
2.958PheThr: 2.958 ± 0.044
2.76PheVal: 2.76 ± 0.041
0.632PheTrp: 0.632 ± 0.021
2.169PheTyr: 2.169 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.802GlyAla: 5.802 ± 0.068
0.692GlyCys: 0.692 ± 0.021
3.545GlyAsp: 3.545 ± 0.047
3.242GlyGlu: 3.242 ± 0.042
3.766GlyPhe: 3.766 ± 0.047
5.547GlyGly: 5.547 ± 0.083
1.317GlyHis: 1.317 ± 0.03
5.366GlyIle: 5.366 ± 0.066
5.124GlyLys: 5.124 ± 0.054
6.567GlyLeu: 6.567 ± 0.068
1.903GlyMet: 1.903 ± 0.033
4.06GlyAsn: 4.06 ± 0.062
1.924GlyPro: 1.924 ± 0.033
2.481GlyGln: 2.481 ± 0.036
3.576GlyArg: 3.576 ± 0.049
4.836GlySer: 4.836 ± 0.06
4.669GlyThr: 4.669 ± 0.066
4.609GlyVal: 4.609 ± 0.054
1.221GlyTrp: 1.221 ± 0.028
3.563GlyTyr: 3.563 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.214HisAla: 1.214 ± 0.023
0.224HisCys: 0.224 ± 0.012
0.723HisAsp: 0.723 ± 0.023
0.875HisGlu: 0.875 ± 0.022
1.242HisPhe: 1.242 ± 0.026
1.118HisGly: 1.118 ± 0.025
0.55HisHis: 0.55 ± 0.019
1.374HisIle: 1.374 ± 0.028
1.011HisLys: 1.011 ± 0.024
1.887HisLeu: 1.887 ± 0.038
0.381HisMet: 0.381 ± 0.017
0.869HisAsn: 0.869 ± 0.023
1.13HisPro: 1.13 ± 0.03
0.755HisGln: 0.755 ± 0.02
0.987HisArg: 0.987 ± 0.022
1.111HisSer: 1.111 ± 0.024
1.161HisThr: 1.161 ± 0.028
0.897HisVal: 0.897 ± 0.022
0.333HisTrp: 0.333 ± 0.013
0.998HisTyr: 0.998 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
5.661IleAla: 5.661 ± 0.063
0.653IleCys: 0.653 ± 0.021
3.655IleAsp: 3.655 ± 0.047
3.472IleGlu: 3.472 ± 0.049
2.636IlePhe: 2.636 ± 0.041
4.528IleGly: 4.528 ± 0.054
1.259IleHis: 1.259 ± 0.028
4.105IleIle: 4.105 ± 0.054
3.942IleLys: 3.942 ± 0.052
5.547IleLeu: 5.547 ± 0.07
1.244IleMet: 1.244 ± 0.027
3.345IleAsn: 3.345 ± 0.049
3.049IlePro: 3.049 ± 0.038
2.118IleGln: 2.118 ± 0.035
3.83IleArg: 3.83 ± 0.046
4.301IleSer: 4.301 ± 0.053
4.337IleThr: 4.337 ± 0.05
3.818IleVal: 3.818 ± 0.048
0.74IleTrp: 0.74 ± 0.021
2.37IleTyr: 2.37 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
5.073LysAla: 5.073 ± 0.056
0.295LysCys: 0.295 ± 0.013
3.883LysAsp: 3.883 ± 0.049
4.703LysGlu: 4.703 ± 0.059
1.982LysPhe: 1.982 ± 0.038
4.405LysGly: 4.405 ± 0.048
0.997LysHis: 0.997 ± 0.023
4.234LysIle: 4.234 ± 0.058
5.61LysLys: 5.61 ± 0.07
4.919LysLeu: 4.919 ± 0.058
1.81LysMet: 1.81 ± 0.035
3.779LysAsn: 3.779 ± 0.047
2.544LysPro: 2.544 ± 0.042
2.692LysGln: 2.692 ± 0.043
2.986LysArg: 2.986 ± 0.039
3.109LysSer: 3.109 ± 0.046
4.087LysThr: 4.087 ± 0.044
3.546LysVal: 3.546 ± 0.043
0.859LysTrp: 0.859 ± 0.021
2.389LysTyr: 2.389 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
6.866LeuAla: 6.866 ± 0.07
0.882LeuCys: 0.882 ± 0.021
4.337LeuAsp: 4.337 ± 0.056
4.887LeuGlu: 4.887 ± 0.054
5.036LeuPhe: 5.036 ± 0.06
5.856LeuGly: 5.856 ± 0.065
1.807LeuHis: 1.807 ± 0.037
5.449LeuIle: 5.449 ± 0.069
6.78LeuLys: 6.78 ± 0.058
10.776LeuLeu: 10.776 ± 0.115
2.204LeuMet: 2.204 ± 0.036
4.889LeuAsn: 4.889 ± 0.062
4.595LeuPro: 4.595 ± 0.052
4.364LeuGln: 4.364 ± 0.065
4.275LeuArg: 4.275 ± 0.056
6.372LeuSer: 6.372 ± 0.066
5.082LeuThr: 5.082 ± 0.049
5.798LeuVal: 5.798 ± 0.069
1.103LeuTrp: 1.103 ± 0.029
3.628LeuTyr: 3.628 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
1.946MetAla: 1.946 ± 0.038
0.135MetCys: 0.135 ± 0.009
1.244MetAsp: 1.244 ± 0.027
1.405MetGlu: 1.405 ± 0.03
0.71MetPhe: 0.71 ± 0.021
1.602MetGly: 1.602 ± 0.032
0.468MetHis: 0.468 ± 0.015
1.5MetIle: 1.5 ± 0.029
1.926MetLys: 1.926 ± 0.033
2.039MetLeu: 2.039 ± 0.037
0.613MetMet: 0.613 ± 0.019
1.317MetAsn: 1.317 ± 0.027
1.085MetPro: 1.085 ± 0.026
1.118MetGln: 1.118 ± 0.027
1.12MetArg: 1.12 ± 0.024
1.227MetSer: 1.227 ± 0.026
1.149MetThr: 1.149 ± 0.023
1.372MetVal: 1.372 ± 0.025
0.223MetTrp: 0.223 ± 0.011
0.713MetTyr: 0.713 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
4.1AsnAla: 4.1 ± 0.056
0.4AsnCys: 0.4 ± 0.015
2.571AsnAsp: 2.571 ± 0.04
2.681AsnGlu: 2.681 ± 0.039
2.287AsnPhe: 2.287 ± 0.039
4.439AsnGly: 4.439 ± 0.062
0.883AsnHis: 0.883 ± 0.025
3.622AsnIle: 3.622 ± 0.046
3.104AsnLys: 3.104 ± 0.046
4.117AsnLeu: 4.117 ± 0.056
1.103AsnMet: 1.103 ± 0.025
3.021AsnAsn: 3.021 ± 0.051
2.567AsnPro: 2.567 ± 0.047
1.666AsnGln: 1.666 ± 0.035
2.787AsnArg: 2.787 ± 0.039
2.826AsnSer: 2.826 ± 0.045
3.238AsnThr: 3.238 ± 0.048
2.732AsnVal: 2.732 ± 0.039
0.803AsnTrp: 0.803 ± 0.021
2.301AsnTyr: 2.301 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
4.361ProAla: 4.361 ± 0.061
0.276ProCys: 0.276 ± 0.013
2.851ProAsp: 2.851 ± 0.04
3.071ProGlu: 3.071 ± 0.042
2.098ProPhe: 2.098 ± 0.038
4.098ProGly: 4.098 ± 0.062
0.766ProHis: 0.766 ± 0.02
1.809ProIle: 1.809 ± 0.035
1.723ProLys: 1.723 ± 0.035
3.783ProLeu: 3.783 ± 0.047
0.796ProMet: 0.796 ± 0.021
1.584ProAsn: 1.584 ± 0.033
1.501ProPro: 1.501 ± 0.04
1.629ProGln: 1.629 ± 0.036
1.636ProArg: 1.636 ± 0.033
2.287ProSer: 2.287 ± 0.034
1.638ProThr: 1.638 ± 0.029
4.354ProVal: 4.354 ± 0.055
0.531ProTrp: 0.531 ± 0.02
1.678ProTyr: 1.678 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
2.802GlnAla: 2.802 ± 0.042
0.248GlnCys: 0.248 ± 0.012
1.619GlnAsp: 1.619 ± 0.031
2.156GlnGlu: 2.156 ± 0.037
1.709GlnPhe: 1.709 ± 0.03
2.206GlnGly: 2.206 ± 0.033
0.89GlnHis: 0.89 ± 0.022
2.032GlnIle: 2.032 ± 0.03
2.872GlnLys: 2.872 ± 0.049
4.368GlnLeu: 4.368 ± 0.061
0.963GlnMet: 0.963 ± 0.023
1.814GlnAsn: 1.814 ± 0.033
1.79GlnPro: 1.79 ± 0.031
2.53GlnGln: 2.53 ± 0.044
1.867GlnArg: 1.867 ± 0.036
2.019GlnSer: 2.019 ± 0.031
2.216GlnThr: 2.216 ± 0.038
2.546GlnVal: 2.546 ± 0.039
0.636GlnTrp: 0.636 ± 0.018
1.742GlnTyr: 1.742 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.086ArgAla: 3.086 ± 0.039
0.326ArgCys: 0.326 ± 0.014
2.266ArgAsp: 2.266 ± 0.035
2.712ArgGlu: 2.712 ± 0.047
2.87ArgPhe: 2.87 ± 0.041
2.731ArgGly: 2.731 ± 0.044
0.932ArgHis: 0.932 ± 0.024
3.565ArgIle: 3.565 ± 0.044
3.23ArgLys: 3.23 ± 0.039
4.792ArgLeu: 4.792 ± 0.058
1.299ArgMet: 1.299 ± 0.027
2.808ArgAsn: 2.808 ± 0.041
1.84ArgPro: 1.84 ± 0.032
2.095ArgGln: 2.095 ± 0.037
2.179ArgArg: 2.179 ± 0.032
3.059ArgSer: 3.059 ± 0.043
2.446ArgThr: 2.446 ± 0.039
2.892ArgVal: 2.892 ± 0.042
0.722ArgTrp: 0.722 ± 0.023
2.539ArgTyr: 2.539 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.6SerAla: 4.6 ± 0.057
0.643SerCys: 0.643 ± 0.02
2.898SerAsp: 2.898 ± 0.039
2.619SerGlu: 2.619 ± 0.036
3.5SerPhe: 3.5 ± 0.044
5.506SerGly: 5.506 ± 0.064
0.937SerHis: 0.937 ± 0.023
3.981SerIle: 3.981 ± 0.053
3.324SerLys: 3.324 ± 0.047
5.703SerLeu: 5.703 ± 0.063
1.301SerMet: 1.301 ± 0.025
2.884SerAsn: 2.884 ± 0.048
2.307SerPro: 2.307 ± 0.038
1.74SerGln: 1.74 ± 0.033
3.114SerArg: 3.114 ± 0.043
3.744SerSer: 3.744 ± 0.056
3.01SerThr: 3.01 ± 0.046
4.093SerVal: 4.093 ± 0.048
0.951SerTrp: 0.951 ± 0.027
2.602SerTyr: 2.602 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.435ThrAla: 5.435 ± 0.055
0.403ThrCys: 0.403 ± 0.017
3.295ThrAsp: 3.295 ± 0.048
2.898ThrGlu: 2.898 ± 0.04
2.393ThrPhe: 2.393 ± 0.038
5.626ThrGly: 5.626 ± 0.066
0.997ThrHis: 0.997 ± 0.026
3.999ThrIle: 3.999 ± 0.043
2.73ThrLys: 2.73 ± 0.038
5.344ThrLeu: 5.344 ± 0.055
1.031ThrMet: 1.031 ± 0.024
2.584ThrAsn: 2.584 ± 0.039
2.904ThrPro: 2.904 ± 0.046
1.854ThrGln: 1.854 ± 0.032
2.599ThrArg: 2.599 ± 0.037
3.028ThrSer: 3.028 ± 0.041
3.404ThrThr: 3.404 ± 0.051
4.153ThrVal: 4.153 ± 0.05
0.757ThrTrp: 0.757 ± 0.024
2.205ThrTyr: 2.205 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
5.108ValAla: 5.108 ± 0.059
0.602ValCys: 0.602 ± 0.018
2.98ValAsp: 2.98 ± 0.044
3.005ValGlu: 3.005 ± 0.046
3.198ValPhe: 3.198 ± 0.043
3.43ValGly: 3.43 ± 0.048
1.183ValHis: 1.183 ± 0.029
4.308ValIle: 4.308 ± 0.059
4.154ValLys: 4.154 ± 0.053
6.548ValLeu: 6.548 ± 0.076
1.418ValMet: 1.418 ± 0.031
3.346ValAsn: 3.346 ± 0.046
2.941ValPro: 2.941 ± 0.042
2.385ValGln: 2.385 ± 0.038
2.736ValArg: 2.736 ± 0.043
4.162ValSer: 4.162 ± 0.055
4.082ValThr: 4.082 ± 0.051
4.218ValVal: 4.218 ± 0.056
0.787ValTrp: 0.787 ± 0.021
2.619ValTyr: 2.619 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.904TrpAla: 0.904 ± 0.022
0.14TrpCys: 0.14 ± 0.009
0.727TrpAsp: 0.727 ± 0.023
0.731TrpGlu: 0.731 ± 0.022
0.616TrpPhe: 0.616 ± 0.018
1.034TrpGly: 1.034 ± 0.028
0.286TrpHis: 0.286 ± 0.014
0.823TrpIle: 0.823 ± 0.023
1.05TrpLys: 1.05 ± 0.027
1.35TrpLeu: 1.35 ± 0.031
0.441TrpMet: 0.441 ± 0.015
0.883TrpAsn: 0.883 ± 0.024
0.446TrpPro: 0.446 ± 0.017
0.633TrpGln: 0.633 ± 0.02
0.624TrpArg: 0.624 ± 0.022
0.8TrpSer: 0.8 ± 0.021
0.724TrpThr: 0.724 ± 0.023
0.823TrpVal: 0.823 ± 0.021
0.271TrpTrp: 0.271 ± 0.013
0.556TrpTyr: 0.556 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.098TyrAla: 3.098 ± 0.044
0.375TyrCys: 0.375 ± 0.012
2.281TyrAsp: 2.281 ± 0.041
2.073TyrGlu: 2.073 ± 0.039
2.297TyrPhe: 2.297 ± 0.033
3.004TyrGly: 3.004 ± 0.047
0.861TyrHis: 0.861 ± 0.021
2.447TyrIle: 2.447 ± 0.038
2.585TyrLys: 2.585 ± 0.039
3.844TyrLeu: 3.844 ± 0.054
0.833TyrMet: 0.833 ± 0.022
2.425TyrAsn: 2.425 ± 0.044
1.907TyrPro: 1.907 ± 0.033
1.682TyrGln: 1.682 ± 0.032
2.39TyrArg: 2.39 ± 0.036
2.552TyrSer: 2.552 ± 0.04
2.685TyrThr: 2.685 ± 0.039
1.965TyrVal: 1.965 ± 0.033
0.638TyrTrp: 0.638 ± 0.019
2.084TyrTyr: 2.084 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5113 proteins (1773835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski