Amino acid dipepetide frequency for Sanxia tombus-like virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.549AlaAla: 2.549 ± 1.04
0.85AlaCys: 0.85 ± 1.468
3.398AlaAsp: 3.398 ± 2.377
0.85AlaGlu: 0.85 ± 0.594
4.248AlaPhe: 4.248 ± 1.158
3.398AlaGly: 3.398 ± 0.859
1.699AlaHis: 1.699 ± 1.12
5.947AlaIle: 5.947 ± 1.638
1.699AlaLys: 1.699 ± 0.429
5.947AlaLeu: 5.947 ± 2.447
0.85AlaMet: 0.85 ± 0.526
3.398AlaAsn: 3.398 ± 0.859
3.398AlaPro: 3.398 ± 1.43
1.699AlaGln: 1.699 ± 1.188
3.398AlaArg: 3.398 ± 2.716
3.398AlaSer: 3.398 ± 0.859
7.647AlaThr: 7.647 ± 4.408
4.248AlaVal: 4.248 ± 2.353
0.0AlaTrp: 0.0 ± 0.0
1.699AlaTyr: 1.699 ± 1.188
0.0AlaXaa: 0.0 ± 0.0
Cys
0.85CysAla: 0.85 ± 0.594
0.0CysCys: 0.0 ± 0.0
0.85CysAsp: 0.85 ± 0.56
0.0CysGlu: 0.0 ± 0.0
1.699CysPhe: 1.699 ± 0.429
1.699CysGly: 1.699 ± 0.429
1.699CysHis: 1.699 ± 1.12
1.699CysIle: 1.699 ± 1.358
0.85CysLys: 0.85 ± 1.468
1.699CysLeu: 1.699 ± 0.429
1.699CysMet: 1.699 ± 1.027
0.85CysAsn: 0.85 ± 0.594
0.0CysPro: 0.0 ± 0.0
1.699CysGln: 1.699 ± 1.12
1.699CysArg: 1.699 ± 1.358
2.549CysSer: 2.549 ± 0.872
0.85CysThr: 0.85 ± 1.468
2.549CysVal: 2.549 ± 1.491
0.0CysTrp: 0.0 ± 0.0
0.85CysTyr: 0.85 ± 0.594
0.0CysXaa: 0.0 ± 0.0
Asp
2.549AspAla: 2.549 ± 0.872
0.85AspCys: 0.85 ± 0.56
0.85AspAsp: 0.85 ± 0.56
0.85AspGlu: 0.85 ± 0.56
0.85AspPhe: 0.85 ± 0.56
4.248AspGly: 4.248 ± 1.158
0.0AspHis: 0.0 ± 0.0
1.699AspIle: 1.699 ± 1.12
1.699AspLys: 1.699 ± 1.12
5.947AspLeu: 5.947 ± 2.104
1.699AspMet: 1.699 ± 0.429
0.0AspAsn: 0.0 ± 0.0
0.85AspPro: 0.85 ± 0.594
0.85AspGln: 0.85 ± 0.56
1.699AspArg: 1.699 ± 1.12
4.248AspSer: 4.248 ± 5.673
0.0AspThr: 0.0 ± 0.0
4.248AspVal: 4.248 ± 1.24
0.0AspTrp: 0.0 ± 0.0
1.699AspTyr: 1.699 ± 1.188
0.0AspXaa: 0.0 ± 0.0
Glu
3.398GluAla: 3.398 ± 1.43
0.0GluCys: 0.0 ± 0.0
1.699GluAsp: 1.699 ± 1.12
0.85GluGlu: 0.85 ± 0.56
0.85GluPhe: 0.85 ± 0.56
1.699GluGly: 1.699 ± 1.12
1.699GluHis: 1.699 ± 0.429
0.85GluIle: 0.85 ± 0.594
5.098GluLys: 5.098 ± 1.603
5.098GluLeu: 5.098 ± 2.594
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
0.85GluPro: 0.85 ± 0.56
3.398GluGln: 3.398 ± 1.315
0.85GluArg: 0.85 ± 0.56
2.549GluSer: 2.549 ± 0.802
2.549GluThr: 2.549 ± 1.68
1.699GluVal: 1.699 ± 0.429
0.85GluTrp: 0.85 ± 0.56
1.699GluTyr: 1.699 ± 0.429
0.0GluXaa: 0.0 ± 0.0
Phe
0.85PheAla: 0.85 ± 1.468
0.85PheCys: 0.85 ± 0.56
3.398PheAsp: 3.398 ± 0.859
2.549PheGlu: 2.549 ± 1.68
0.85PhePhe: 0.85 ± 0.594
4.248PheGly: 4.248 ± 1.855
1.699PheHis: 1.699 ± 1.37
0.85PheIle: 0.85 ± 0.594
2.549PheLys: 2.549 ± 0.872
5.947PheLeu: 5.947 ± 1.164
0.85PheMet: 0.85 ± 0.594
1.699PheAsn: 1.699 ± 1.188
2.549PhePro: 2.549 ± 0.802
0.85PheGln: 0.85 ± 0.594
4.248PheArg: 4.248 ± 2.808
2.549PheSer: 2.549 ± 0.872
2.549PheThr: 2.549 ± 0.802
5.098PheVal: 5.098 ± 1.745
0.85PheTrp: 0.85 ± 0.56
1.699PheTyr: 1.699 ± 0.429
0.0PheXaa: 0.0 ± 0.0
Gly
4.248GlyAla: 4.248 ± 1.27
1.699GlyCys: 1.699 ± 1.12
2.549GlyAsp: 2.549 ± 1.68
0.0GlyGlu: 0.0 ± 0.0
4.248GlyPhe: 4.248 ± 1.158
1.699GlyGly: 1.699 ± 1.12
0.85GlyHis: 0.85 ± 0.594
4.248GlyIle: 4.248 ± 1.27
1.699GlyLys: 1.699 ± 1.188
5.947GlyLeu: 5.947 ± 1.638
1.699GlyMet: 1.699 ± 1.12
3.398GlyAsn: 3.398 ± 1.315
1.699GlyPro: 1.699 ± 1.188
7.647GlyGln: 7.647 ± 1.96
2.549GlyArg: 2.549 ± 1.496
5.098GlySer: 5.098 ± 0.716
3.398GlyThr: 3.398 ± 0.973
2.549GlyVal: 2.549 ± 1.04
3.398GlyTrp: 3.398 ± 2.508
5.098GlyTyr: 5.098 ± 1.603
0.0GlyXaa: 0.0 ± 0.0
His
2.549HisAla: 2.549 ± 1.496
0.85HisCys: 0.85 ± 0.56
0.0HisAsp: 0.0 ± 0.0
0.85HisGlu: 0.85 ± 0.56
0.85HisPhe: 0.85 ± 0.56
0.85HisGly: 0.85 ± 1.468
0.85HisHis: 0.85 ± 0.56
0.85HisIle: 0.85 ± 0.56
0.85HisLys: 0.85 ± 0.594
2.549HisLeu: 2.549 ± 1.68
0.0HisMet: 0.0 ± 0.0
0.85HisAsn: 0.85 ± 0.56
0.0HisPro: 0.0 ± 0.0
0.85HisGln: 0.85 ± 0.56
0.85HisArg: 0.85 ± 0.56
1.699HisSer: 1.699 ± 1.37
0.85HisThr: 0.85 ± 0.594
1.699HisVal: 1.699 ± 1.12
0.85HisTrp: 0.85 ± 0.56
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.398IleAla: 3.398 ± 0.997
3.398IleCys: 3.398 ± 1.827
1.699IleAsp: 1.699 ± 1.12
3.398IleGlu: 3.398 ± 1.43
1.699IlePhe: 1.699 ± 1.37
1.699IleGly: 1.699 ± 0.429
0.0IleHis: 0.0 ± 0.0
2.549IleIle: 2.549 ± 1.496
2.549IleLys: 2.549 ± 0.872
5.947IleLeu: 5.947 ± 0.2
0.0IleMet: 0.0 ± 0.0
4.248IleAsn: 4.248 ± 0.614
1.699IlePro: 1.699 ± 1.12
0.0IleGln: 0.0 ± 0.0
3.398IleArg: 3.398 ± 0.997
5.098IleSer: 5.098 ± 1.745
1.699IleThr: 1.699 ± 1.37
5.098IleVal: 5.098 ± 1.745
0.85IleTrp: 0.85 ± 0.594
0.85IleTyr: 0.85 ± 0.56
0.0IleXaa: 0.0 ± 0.0
Lys
1.699LysAla: 1.699 ± 1.12
0.0LysCys: 0.0 ± 0.0
1.699LysAsp: 1.699 ± 1.37
0.85LysGlu: 0.85 ± 0.594
2.549LysPhe: 2.549 ± 1.496
4.248LysGly: 4.248 ± 1.855
1.699LysHis: 1.699 ± 0.429
1.699LysIle: 1.699 ± 1.12
1.699LysLys: 1.699 ± 1.37
5.947LysLeu: 5.947 ± 1.551
5.098LysMet: 5.098 ± 0.716
1.699LysAsn: 1.699 ± 1.188
1.699LysPro: 1.699 ± 0.429
3.398LysGln: 3.398 ± 1.788
2.549LysArg: 2.549 ± 1.491
1.699LysSer: 1.699 ± 2.937
2.549LysThr: 2.549 ± 1.783
7.647LysVal: 7.647 ± 2.049
4.248LysTrp: 4.248 ± 0.614
3.398LysTyr: 3.398 ± 2.377
0.0LysXaa: 0.0 ± 0.0
Leu
9.346LeuAla: 9.346 ± 2.881
1.699LeuCys: 1.699 ± 1.188
3.398LeuAsp: 3.398 ± 0.973
6.797LeuGlu: 6.797 ± 1.945
5.098LeuPhe: 5.098 ± 0.622
11.045LeuGly: 11.045 ± 2.876
2.549LeuHis: 2.549 ± 0.802
3.398LeuIle: 3.398 ± 0.997
5.098LeuLys: 5.098 ± 1.603
11.895LeuLeu: 11.895 ± 3.87
0.0LeuMet: 0.0 ± 0.0
3.398LeuAsn: 3.398 ± 1.43
4.248LeuPro: 4.248 ± 2.008
5.947LeuGln: 5.947 ± 1.012
9.346LeuArg: 9.346 ± 5.132
11.895LeuSer: 11.895 ± 1.92
4.248LeuThr: 4.248 ± 2.353
5.947LeuVal: 5.947 ± 1.164
1.699LeuTrp: 1.699 ± 1.37
3.398LeuTyr: 3.398 ± 0.859
0.0LeuXaa: 0.0 ± 0.0
Met
2.549MetAla: 2.549 ± 0.872
0.85MetCys: 0.85 ± 1.468
0.85MetAsp: 0.85 ± 0.594
2.549MetGlu: 2.549 ± 0.872
0.0MetPhe: 0.0 ± 0.0
1.699MetGly: 1.699 ± 0.429
0.0MetHis: 0.0 ± 0.0
0.85MetIle: 0.85 ± 0.56
2.549MetLys: 2.549 ± 0.802
0.85MetLeu: 0.85 ± 0.56
0.0MetMet: 0.0 ± 0.0
2.549MetAsn: 2.549 ± 1.491
0.0MetPro: 0.0 ± 0.0
3.398MetGln: 3.398 ± 0.859
1.699MetArg: 1.699 ± 1.37
0.0MetSer: 0.0 ± 0.0
0.85MetThr: 0.85 ± 0.594
3.398MetVal: 3.398 ± 2.24
0.85MetTrp: 0.85 ± 0.594
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.699AsnAla: 1.699 ± 1.188
1.699AsnCys: 1.699 ± 1.12
0.85AsnAsp: 0.85 ± 0.56
0.0AsnGlu: 0.0 ± 0.0
0.85AsnPhe: 0.85 ± 0.56
3.398AsnGly: 3.398 ± 0.973
0.0AsnHis: 0.0 ± 0.0
4.248AsnIle: 4.248 ± 0.614
2.549AsnLys: 2.549 ± 1.04
5.947AsnLeu: 5.947 ± 1.638
2.549AsnMet: 2.549 ± 0.802
3.398AsnAsn: 3.398 ± 0.859
4.248AsnPro: 4.248 ± 2.971
0.85AsnGln: 0.85 ± 1.468
0.85AsnArg: 0.85 ± 0.594
3.398AsnSer: 3.398 ± 0.859
2.549AsnThr: 2.549 ± 0.872
1.699AsnVal: 1.699 ± 1.188
1.699AsnTrp: 1.699 ± 1.358
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.549ProAla: 2.549 ± 1.783
0.0ProCys: 0.0 ± 0.0
1.699ProAsp: 1.699 ± 1.12
2.549ProGlu: 2.549 ± 0.872
1.699ProPhe: 1.699 ± 1.188
1.699ProGly: 1.699 ± 1.188
0.0ProHis: 0.0 ± 0.0
0.85ProIle: 0.85 ± 0.56
5.098ProLys: 5.098 ± 1.745
2.549ProLeu: 2.549 ± 0.872
1.699ProMet: 1.699 ± 0.429
2.549ProAsn: 2.549 ± 1.496
1.699ProPro: 1.699 ± 1.12
4.248ProGln: 4.248 ± 1.24
2.549ProArg: 2.549 ± 1.68
5.098ProSer: 5.098 ± 0.622
1.699ProThr: 1.699 ± 1.188
5.947ProVal: 5.947 ± 1.551
0.85ProTrp: 0.85 ± 0.594
1.699ProTyr: 1.699 ± 1.358
0.0ProXaa: 0.0 ± 0.0
Gln
2.549GlnAla: 2.549 ± 0.802
1.699GlnCys: 1.699 ± 1.188
0.0GlnAsp: 0.0 ± 0.0
1.699GlnGlu: 1.699 ± 1.12
1.699GlnPhe: 1.699 ± 0.429
1.699GlnGly: 1.699 ± 0.429
3.398GlnHis: 3.398 ± 2.24
5.947GlnIle: 5.947 ± 0.2
1.699GlnLys: 1.699 ± 1.358
8.496GlnLeu: 8.496 ± 2.399
1.699GlnMet: 1.699 ± 0.429
1.699GlnAsn: 1.699 ± 1.188
5.947GlnPro: 5.947 ± 2.104
2.549GlnGln: 2.549 ± 1.491
3.398GlnArg: 3.398 ± 2.24
4.248GlnSer: 4.248 ± 1.24
5.098GlnThr: 5.098 ± 1.745
5.098GlnVal: 5.098 ± 0.622
1.699GlnTrp: 1.699 ± 1.12
0.85GlnTyr: 0.85 ± 0.56
0.0GlnXaa: 0.0 ± 0.0
Arg
1.699ArgAla: 1.699 ± 1.12
2.549ArgCys: 2.549 ± 1.04
2.549ArgAsp: 2.549 ± 1.491
1.699ArgGlu: 1.699 ± 1.12
5.098ArgPhe: 5.098 ± 1.288
1.699ArgGly: 1.699 ± 1.12
0.0ArgHis: 0.0 ± 0.0
4.248ArgIle: 4.248 ± 2.008
4.248ArgLys: 4.248 ± 0.614
11.895ArgLeu: 11.895 ± 7.185
0.85ArgMet: 0.85 ± 0.56
3.398ArgAsn: 3.398 ± 1.315
1.699ArgPro: 1.699 ± 1.358
6.797ArgGln: 6.797 ± 2.584
2.549ArgArg: 2.549 ± 0.872
4.248ArgSer: 4.248 ± 4.135
0.85ArgThr: 0.85 ± 0.56
5.098ArgVal: 5.098 ± 2.337
0.0ArgTrp: 0.0 ± 0.0
3.398ArgTyr: 3.398 ± 1.315
0.0ArgXaa: 0.0 ± 0.0
Ser
4.248SerAla: 4.248 ± 2.008
2.549SerCys: 2.549 ± 1.491
0.85SerAsp: 0.85 ± 0.56
0.85SerGlu: 0.85 ± 0.56
2.549SerPhe: 2.549 ± 0.802
5.947SerGly: 5.947 ± 0.2
0.85SerHis: 0.85 ± 1.468
5.098SerIle: 5.098 ± 1.288
5.098SerLys: 5.098 ± 3.794
3.398SerLeu: 3.398 ± 0.859
0.85SerMet: 0.85 ± 1.468
5.098SerAsn: 5.098 ± 0.716
4.248SerPro: 4.248 ± 0.614
4.248SerGln: 4.248 ± 0.614
11.045SerArg: 11.045 ± 3.061
9.346SerSer: 9.346 ± 1.101
4.248SerThr: 4.248 ± 1.24
1.699SerVal: 1.699 ± 1.188
0.85SerTrp: 0.85 ± 1.468
2.549SerTyr: 2.549 ± 0.802
0.0SerXaa: 0.0 ± 0.0
Thr
5.947ThrAla: 5.947 ± 3.183
1.699ThrCys: 1.699 ± 1.358
0.85ThrAsp: 0.85 ± 0.594
0.0ThrGlu: 0.0 ± 0.0
1.699ThrPhe: 1.699 ± 1.358
2.549ThrGly: 2.549 ± 2.784
0.0ThrHis: 0.0 ± 0.0
0.0ThrIle: 0.0 ± 0.0
4.248ThrLys: 4.248 ± 1.24
5.098ThrLeu: 5.098 ± 4.074
2.549ThrMet: 2.549 ± 1.68
1.699ThrAsn: 1.699 ± 1.188
5.098ThrPro: 5.098 ± 1.603
3.398ThrGln: 3.398 ± 1.43
5.098ThrArg: 5.098 ± 1.603
0.85ThrSer: 0.85 ± 0.56
3.398ThrThr: 3.398 ± 0.997
5.947ThrVal: 5.947 ± 3.183
0.85ThrTrp: 0.85 ± 0.594
2.549ThrTyr: 2.549 ± 0.872
0.0ThrXaa: 0.0 ± 0.0
Val
5.098ValAla: 5.098 ± 1.288
0.85ValCys: 0.85 ± 0.56
4.248ValAsp: 4.248 ± 1.24
6.797ValGlu: 6.797 ± 2.629
5.098ValPhe: 5.098 ± 1.603
8.496ValGly: 8.496 ± 1.799
1.699ValHis: 1.699 ± 1.37
2.549ValIle: 2.549 ± 1.496
2.549ValLys: 2.549 ± 0.802
8.496ValLeu: 8.496 ± 1.228
0.85ValMet: 0.85 ± 0.514
1.699ValAsn: 1.699 ± 1.358
5.098ValPro: 5.098 ± 2.594
4.248ValGln: 4.248 ± 1.24
2.549ValArg: 2.549 ± 0.802
4.248ValSer: 4.248 ± 0.614
5.098ValThr: 5.098 ± 1.714
5.098ValVal: 5.098 ± 5.445
0.0ValTrp: 0.0 ± 0.0
1.699ValTyr: 1.699 ± 1.12
0.0ValXaa: 0.0 ± 0.0
Trp
0.85TrpAla: 0.85 ± 0.56
0.85TrpCys: 0.85 ± 0.56
1.699TrpAsp: 1.699 ± 1.37
0.0TrpGlu: 0.0 ± 0.0
3.398TrpPhe: 3.398 ± 0.997
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.699TrpIle: 1.699 ± 1.358
1.699TrpLys: 1.699 ± 1.37
5.098TrpLeu: 5.098 ± 0.622
0.85TrpMet: 0.85 ± 0.594
0.0TrpAsn: 0.0 ± 0.0
0.85TrpPro: 0.85 ± 1.468
0.85TrpGln: 0.85 ± 0.594
1.699TrpArg: 1.699 ± 0.429
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.85TrpTyr: 0.85 ± 0.594
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.549TyrAla: 2.549 ± 1.496
0.85TyrCys: 0.85 ± 0.594
1.699TyrAsp: 1.699 ± 1.188
2.549TyrGlu: 2.549 ± 0.872
1.699TyrPhe: 1.699 ± 1.188
1.699TyrGly: 1.699 ± 1.188
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
2.549TyrLys: 2.549 ± 0.802
1.699TyrLeu: 1.699 ± 1.188
0.85TyrMet: 0.85 ± 0.56
0.85TyrAsn: 0.85 ± 0.56
0.85TyrPro: 0.85 ± 0.594
4.248TyrGln: 4.248 ± 2.8
2.549TyrArg: 2.549 ± 0.872
3.398TyrSer: 3.398 ± 0.859
3.398TyrThr: 3.398 ± 1.315
1.699TyrVal: 1.699 ± 1.12
0.85TyrTrp: 0.85 ± 0.594
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski