Amino acid dipepetide frequency for Reinekea forsetii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.216AlaAla: 10.216 ± 0.135
0.972AlaCys: 0.972 ± 0.03
6.174AlaAsp: 6.174 ± 0.076
6.308AlaGlu: 6.308 ± 0.179
3.538AlaPhe: 3.538 ± 0.064
7.335AlaGly: 7.335 ± 0.109
2.125AlaHis: 2.125 ± 0.053
6.182AlaIle: 6.182 ± 0.081
4.12AlaLys: 4.12 ± 0.095
12.208AlaLeu: 12.208 ± 0.164
2.702AlaMet: 2.702 ± 0.055
3.668AlaAsn: 3.668 ± 0.066
3.571AlaPro: 3.571 ± 0.071
5.581AlaGln: 5.581 ± 0.183
5.053AlaArg: 5.053 ± 0.071
5.737AlaSer: 5.737 ± 0.079
4.961AlaThr: 4.961 ± 0.077
6.718AlaVal: 6.718 ± 0.084
1.279AlaTrp: 1.279 ± 0.036
2.552AlaTyr: 2.552 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.917CysAla: 0.917 ± 0.03
0.132CysCys: 0.132 ± 0.012
0.555CysAsp: 0.555 ± 0.022
0.434CysGlu: 0.434 ± 0.023
0.432CysPhe: 0.432 ± 0.02
0.784CysGly: 0.784 ± 0.03
0.322CysHis: 0.322 ± 0.022
0.475CysIle: 0.475 ± 0.02
0.288CysLys: 0.288 ± 0.017
1.003CysLeu: 1.003 ± 0.033
0.18CysMet: 0.18 ± 0.013
0.301CysAsn: 0.301 ± 0.018
0.459CysPro: 0.459 ± 0.024
0.485CysGln: 0.485 ± 0.023
0.521CysArg: 0.521 ± 0.025
0.652CysSer: 0.652 ± 0.024
0.454CysThr: 0.454 ± 0.021
0.629CysVal: 0.629 ± 0.025
0.116CysTrp: 0.116 ± 0.011
0.303CysTyr: 0.303 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.492AspAla: 5.492 ± 0.079
0.556AspCys: 0.556 ± 0.026
3.152AspAsp: 3.152 ± 0.067
3.277AspGlu: 3.277 ± 0.064
2.482AspPhe: 2.482 ± 0.055
4.143AspGly: 4.143 ± 0.077
1.216AspHis: 1.216 ± 0.036
3.768AspIle: 3.768 ± 0.057
2.017AspLys: 2.017 ± 0.048
6.434AspLeu: 6.434 ± 0.091
1.36AspMet: 1.36 ± 0.038
1.906AspAsn: 1.906 ± 0.047
2.595AspPro: 2.595 ± 0.058
2.835AspGln: 2.835 ± 0.056
3.399AspArg: 3.399 ± 0.056
3.387AspSer: 3.387 ± 0.067
2.687AspThr: 2.687 ± 0.062
3.623AspVal: 3.623 ± 0.067
1.029AspTrp: 1.029 ± 0.032
1.979AspTyr: 1.979 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.362GluAla: 5.362 ± 0.096
0.409GluCys: 0.409 ± 0.017
2.333GluAsp: 2.333 ± 0.046
2.308GluGlu: 2.308 ± 0.054
2.192GluPhe: 2.192 ± 0.045
3.047GluGly: 3.047 ± 0.056
1.475GluHis: 1.475 ± 0.04
3.268GluIle: 3.268 ± 0.065
2.21GluLys: 2.21 ± 0.058
6.755GluLeu: 6.755 ± 0.079
1.347GluMet: 1.347 ± 0.04
1.89GluAsn: 1.89 ± 0.04
2.345GluPro: 2.345 ± 0.068
3.651GluGln: 3.651 ± 0.07
3.774GluArg: 3.774 ± 0.071
2.99GluSer: 2.99 ± 0.052
2.83GluThr: 2.83 ± 0.053
3.733GluVal: 3.733 ± 0.068
0.659GluTrp: 0.659 ± 0.022
1.368GluTyr: 1.368 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.861PheAla: 3.861 ± 0.068
0.47PheCys: 0.47 ± 0.022
2.763PheAsp: 2.763 ± 0.056
2.261PheGlu: 2.261 ± 0.044
1.685PhePhe: 1.685 ± 0.047
3.256PheGly: 3.256 ± 0.058
0.795PheHis: 0.795 ± 0.027
2.365PheIle: 2.365 ± 0.046
1.562PheLys: 1.562 ± 0.041
3.436PheLeu: 3.436 ± 0.068
0.981PheMet: 0.981 ± 0.033
1.872PheAsn: 1.872 ± 0.041
1.42PhePro: 1.42 ± 0.033
1.406PheGln: 1.406 ± 0.042
1.87PheArg: 1.87 ± 0.042
3.035PheSer: 3.035 ± 0.059
2.096PheThr: 2.096 ± 0.046
2.769PheVal: 2.769 ± 0.057
0.593PheTrp: 0.593 ± 0.022
1.244PheTyr: 1.244 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
6.346GlyAla: 6.346 ± 0.082
0.848GlyCys: 0.848 ± 0.029
3.958GlyAsp: 3.958 ± 0.076
3.81GlyGlu: 3.81 ± 0.062
3.387GlyPhe: 3.387 ± 0.058
5.106GlyGly: 5.106 ± 0.099
1.744GlyHis: 1.744 ± 0.048
4.442GlyIle: 4.442 ± 0.061
3.074GlyLys: 3.074 ± 0.062
8.431GlyLeu: 8.431 ± 0.099
1.999GlyMet: 1.999 ± 0.048
2.359GlyAsn: 2.359 ± 0.058
2.276GlyPro: 2.276 ± 0.047
3.586GlyGln: 3.586 ± 0.067
3.794GlyArg: 3.794 ± 0.065
4.391GlySer: 4.391 ± 0.086
3.804GlyThr: 3.804 ± 0.071
5.244GlyVal: 5.244 ± 0.078
1.077GlyTrp: 1.077 ± 0.032
2.436GlyTyr: 2.436 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.798HisAla: 1.798 ± 0.046
0.339HisCys: 0.339 ± 0.02
1.116HisAsp: 1.116 ± 0.034
1.09HisGlu: 1.09 ± 0.034
1.064HisPhe: 1.064 ± 0.033
1.556HisGly: 1.556 ± 0.042
0.678HisHis: 0.678 ± 0.027
1.216HisIle: 1.216 ± 0.036
0.817HisLys: 0.817 ± 0.032
2.524HisLeu: 2.524 ± 0.055
0.46HisMet: 0.46 ± 0.019
0.805HisAsn: 0.805 ± 0.027
1.245HisPro: 1.245 ± 0.033
1.308HisGln: 1.308 ± 0.036
1.402HisArg: 1.402 ± 0.04
1.411HisSer: 1.411 ± 0.041
0.982HisThr: 0.982 ± 0.03
1.092HisVal: 1.092 ± 0.027
0.46HisTrp: 0.46 ± 0.025
0.829HisTyr: 0.829 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.318IleAla: 6.318 ± 0.092
0.603IleCys: 0.603 ± 0.027
4.409IleAsp: 4.409 ± 0.064
4.158IleGlu: 4.158 ± 0.075
2.025IlePhe: 2.025 ± 0.051
4.921IleGly: 4.921 ± 0.071
1.237IleHis: 1.237 ± 0.037
3.116IleIle: 3.116 ± 0.057
2.348IleLys: 2.348 ± 0.056
5.471IleLeu: 5.471 ± 0.093
1.121IleMet: 1.121 ± 0.036
2.516IleAsn: 2.516 ± 0.055
2.511IlePro: 2.511 ± 0.051
2.186IleGln: 2.186 ± 0.048
3.338IleArg: 3.338 ± 0.054
3.959IleSer: 3.959 ± 0.062
2.957IleThr: 2.957 ± 0.055
3.963IleVal: 3.963 ± 0.066
0.626IleTrp: 0.626 ± 0.025
1.51IleTyr: 1.51 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.084LysAla: 4.084 ± 0.084
0.2LysCys: 0.2 ± 0.015
2.0LysAsp: 2.0 ± 0.053
1.865LysGlu: 1.865 ± 0.051
1.115LysPhe: 1.115 ± 0.034
2.474LysGly: 2.474 ± 0.05
0.831LysHis: 0.831 ± 0.03
2.429LysIle: 2.429 ± 0.049
1.946LysLys: 1.946 ± 0.069
3.969LysLeu: 3.969 ± 0.071
1.051LysMet: 1.051 ± 0.033
1.541LysAsn: 1.541 ± 0.043
1.881LysPro: 1.881 ± 0.045
1.778LysGln: 1.778 ± 0.044
2.216LysArg: 2.216 ± 0.053
2.35LysSer: 2.35 ± 0.057
2.411LysThr: 2.411 ± 0.06
2.803LysVal: 2.803 ± 0.061
0.396LysTrp: 0.396 ± 0.018
0.907LysTyr: 0.907 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
13.01LeuAla: 13.01 ± 0.198
1.004LeuCys: 1.004 ± 0.033
6.399LeuAsp: 6.399 ± 0.087
5.572LeuGlu: 5.572 ± 0.076
4.301LeuPhe: 4.301 ± 0.078
7.822LeuGly: 7.822 ± 0.077
2.107LeuHis: 2.107 ± 0.048
6.765LeuIle: 6.765 ± 0.095
4.428LeuLys: 4.428 ± 0.078
11.941LeuLeu: 11.941 ± 0.175
2.954LeuMet: 2.954 ± 0.054
4.532LeuAsn: 4.532 ± 0.072
5.009LeuPro: 5.009 ± 0.073
4.224LeuGln: 4.224 ± 0.067
5.379LeuArg: 5.379 ± 0.082
7.88LeuSer: 7.88 ± 0.097
6.783LeuThr: 6.783 ± 0.093
8.192LeuVal: 8.192 ± 0.103
1.287LeuTrp: 1.287 ± 0.035
2.715LeuTyr: 2.715 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
3.086MetAla: 3.086 ± 0.063
0.155MetCys: 0.155 ± 0.013
1.254MetAsp: 1.254 ± 0.04
1.055MetGlu: 1.055 ± 0.033
0.757MetPhe: 0.757 ± 0.028
1.731MetGly: 1.731 ± 0.045
0.525MetHis: 0.525 ± 0.023
1.42MetIle: 1.42 ± 0.04
1.033MetLys: 1.033 ± 0.035
2.508MetLeu: 2.508 ± 0.052
0.658MetMet: 0.658 ± 0.026
1.008MetAsn: 1.008 ± 0.025
1.267MetPro: 1.267 ± 0.04
0.993MetGln: 0.993 ± 0.031
1.233MetArg: 1.233 ± 0.035
1.782MetSer: 1.782 ± 0.038
1.773MetThr: 1.773 ± 0.039
1.795MetVal: 1.795 ± 0.044
0.183MetTrp: 0.183 ± 0.014
0.421MetTyr: 0.421 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.263AsnAla: 3.263 ± 0.052
0.35AsnCys: 0.35 ± 0.018
2.14AsnAsp: 2.14 ± 0.053
1.925AsnGlu: 1.925 ± 0.044
1.406AsnPhe: 1.406 ± 0.035
2.779AsnGly: 2.779 ± 0.068
0.798AsnHis: 0.798 ± 0.027
2.216AsnIle: 2.216 ± 0.047
1.465AsnLys: 1.465 ± 0.044
3.901AsnLeu: 3.901 ± 0.062
0.882AsnMet: 0.882 ± 0.029
1.38AsnAsn: 1.38 ± 0.042
2.076AsnPro: 2.076 ± 0.047
1.771AsnGln: 1.771 ± 0.051
2.312AsnArg: 2.312 ± 0.052
2.384AsnSer: 2.384 ± 0.06
1.783AsnThr: 1.783 ± 0.041
2.069AsnVal: 2.069 ± 0.045
0.575AsnTrp: 0.575 ± 0.025
1.103AsnTyr: 1.103 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
4.329ProAla: 4.329 ± 0.076
0.301ProCys: 0.301 ± 0.017
2.849ProAsp: 2.849 ± 0.051
3.099ProGlu: 3.099 ± 0.061
1.738ProPhe: 1.738 ± 0.037
3.089ProGly: 3.089 ± 0.053
0.839ProHis: 0.839 ± 0.033
2.635ProIle: 2.635 ± 0.049
1.613ProLys: 1.613 ± 0.042
4.569ProLeu: 4.569 ± 0.074
1.161ProMet: 1.161 ± 0.032
1.629ProAsn: 1.629 ± 0.039
1.328ProPro: 1.328 ± 0.04
1.514ProGln: 1.514 ± 0.044
1.57ProArg: 1.57 ± 0.039
2.791ProSer: 2.791 ± 0.049
2.449ProThr: 2.449 ± 0.055
3.318ProVal: 3.318 ± 0.058
0.63ProTrp: 0.63 ± 0.03
1.171ProTyr: 1.171 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.476GlnAla: 5.476 ± 0.2
0.417GlnCys: 0.417 ± 0.021
2.152GlnAsp: 2.152 ± 0.051
2.103GlnGlu: 2.103 ± 0.043
1.703GlnPhe: 1.703 ± 0.045
3.343GlnGly: 3.343 ± 0.059
1.115GlnHis: 1.115 ± 0.037
2.671GlnIle: 2.671 ± 0.045
1.515GlnLys: 1.515 ± 0.04
5.722GlnLeu: 5.722 ± 0.095
1.199GlnMet: 1.199 ± 0.03
1.432GlnAsn: 1.432 ± 0.043
2.061GlnPro: 2.061 ± 0.048
2.996GlnGln: 2.996 ± 0.058
2.936GlnArg: 2.936 ± 0.061
2.939GlnSer: 2.939 ± 0.057
2.547GlnThr: 2.547 ± 0.053
3.487GlnVal: 3.487 ± 0.054
0.889GlnTrp: 0.889 ± 0.029
1.292GlnTyr: 1.292 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.049ArgAla: 5.049 ± 0.072
0.525ArgCys: 0.525 ± 0.023
2.758ArgAsp: 2.758 ± 0.055
2.681ArgGlu: 2.681 ± 0.057
2.596ArgPhe: 2.596 ± 0.06
3.055ArgGly: 3.055 ± 0.061
1.337ArgHis: 1.337 ± 0.039
3.43ArgIle: 3.43 ± 0.063
2.04ArgLys: 2.04 ± 0.054
6.763ArgLeu: 6.763 ± 0.103
1.434ArgMet: 1.434 ± 0.04
1.884ArgAsn: 1.884 ± 0.043
2.336ArgPro: 2.336 ± 0.05
2.765ArgGln: 2.765 ± 0.053
2.894ArgArg: 2.894 ± 0.066
3.347ArgSer: 3.347 ± 0.06
2.566ArgThr: 2.566 ± 0.051
3.946ArgVal: 3.946 ± 0.063
0.857ArgTrp: 0.857 ± 0.03
1.877ArgTyr: 1.877 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.804SerAla: 6.804 ± 0.098
0.525SerCys: 0.525 ± 0.023
3.629SerAsp: 3.629 ± 0.059
3.486SerGlu: 3.486 ± 0.062
2.602SerPhe: 2.602 ± 0.052
5.234SerGly: 5.234 ± 0.083
1.401SerHis: 1.401 ± 0.031
3.658SerIle: 3.658 ± 0.072
2.189SerLys: 2.189 ± 0.047
7.077SerLeu: 7.077 ± 0.087
1.594SerMet: 1.594 ± 0.038
2.109SerAsn: 2.109 ± 0.054
2.575SerPro: 2.575 ± 0.045
2.813SerGln: 2.813 ± 0.058
3.214SerArg: 3.214 ± 0.055
3.884SerSer: 3.884 ± 0.073
3.405SerThr: 3.405 ± 0.065
4.686SerVal: 4.686 ± 0.065
0.918SerTrp: 0.918 ± 0.033
1.742SerTyr: 1.742 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.099ThrAla: 5.099 ± 0.079
0.414ThrCys: 0.414 ± 0.02
3.264ThrAsp: 3.264 ± 0.058
2.923ThrGlu: 2.923 ± 0.054
1.974ThrPhe: 1.974 ± 0.046
4.538ThrGly: 4.538 ± 0.072
1.143ThrHis: 1.143 ± 0.036
2.932ThrIle: 2.932 ± 0.062
1.654ThrLys: 1.654 ± 0.038
6.948ThrLeu: 6.948 ± 0.098
1.009ThrMet: 1.009 ± 0.034
1.813ThrAsn: 1.813 ± 0.047
2.721ThrPro: 2.721 ± 0.052
2.316ThrGln: 2.316 ± 0.061
2.698ThrArg: 2.698 ± 0.047
3.098ThrSer: 3.098 ± 0.067
2.936ThrThr: 2.936 ± 0.078
3.96ThrVal: 3.96 ± 0.066
0.665ThrTrp: 0.665 ± 0.025
1.313ThrTyr: 1.313 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
7.139ValAla: 7.139 ± 0.097
0.718ValCys: 0.718 ± 0.025
4.304ValAsp: 4.304 ± 0.064
3.911ValGlu: 3.911 ± 0.066
2.896ValPhe: 2.896 ± 0.056
4.992ValGly: 4.992 ± 0.071
1.415ValHis: 1.415 ± 0.033
4.282ValIle: 4.282 ± 0.061
2.712ValLys: 2.712 ± 0.054
7.25ValLeu: 7.25 ± 0.094
1.711ValMet: 1.711 ± 0.042
2.511ValAsn: 2.511 ± 0.051
2.934ValPro: 2.934 ± 0.047
2.786ValGln: 2.786 ± 0.049
3.659ValArg: 3.659 ± 0.06
4.708ValSer: 4.708 ± 0.069
4.117ValThr: 4.117 ± 0.079
5.271ValVal: 5.271 ± 0.078
0.797ValTrp: 0.797 ± 0.029
1.787ValTyr: 1.787 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.068TrpAla: 1.068 ± 0.031
0.125TrpCys: 0.125 ± 0.011
0.608TrpAsp: 0.608 ± 0.026
0.417TrpGlu: 0.417 ± 0.02
0.569TrpPhe: 0.569 ± 0.024
0.765TrpGly: 0.765 ± 0.031
0.432TrpHis: 0.432 ± 0.02
0.676TrpIle: 0.676 ± 0.026
0.303TrpLys: 0.303 ± 0.015
2.143TrpLeu: 2.143 ± 0.053
0.313TrpMet: 0.313 ± 0.019
0.431TrpAsn: 0.431 ± 0.021
0.689TrpPro: 0.689 ± 0.028
1.163TrpGln: 1.163 ± 0.042
0.84TrpArg: 0.84 ± 0.031
0.857TrpSer: 0.857 ± 0.032
0.656TrpThr: 0.656 ± 0.028
1.053TrpVal: 1.053 ± 0.032
0.204TrpTrp: 0.204 ± 0.015
0.395TrpTyr: 0.395 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.281TyrAla: 2.281 ± 0.041
0.379TyrCys: 0.379 ± 0.018
1.52TyrAsp: 1.52 ± 0.043
1.264TyrGlu: 1.264 ± 0.035
1.279TyrPhe: 1.279 ± 0.038
2.144TyrGly: 2.144 ± 0.048
0.657TyrHis: 0.657 ± 0.027
1.345TyrIle: 1.345 ± 0.034
0.912TyrLys: 0.912 ± 0.031
3.251TyrLeu: 3.251 ± 0.06
0.521TyrMet: 0.521 ± 0.022
0.994TyrAsn: 0.994 ± 0.034
1.324TyrPro: 1.324 ± 0.036
1.837TyrGln: 1.837 ± 0.052
2.039TyrArg: 2.039 ± 0.051
1.96TyrSer: 1.96 ± 0.05
1.222TyrThr: 1.222 ± 0.039
1.548TyrVal: 1.548 ± 0.036
0.466TyrTrp: 0.466 ± 0.022
0.894TyrTyr: 0.894 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3259 proteins (1072189 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski