Amino acid dipepetide frequency for Sinorhizobium phage phiM6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.302AlaAla: 6.302 ± 0.788
0.658AlaCys: 0.658 ± 0.177
3.857AlaAsp: 3.857 ± 0.485
4.421AlaGlu: 4.421 ± 0.456
2.775AlaPhe: 2.775 ± 0.356
4.844AlaGly: 4.844 ± 0.469
1.552AlaHis: 1.552 ± 0.291
4.609AlaIle: 4.609 ± 0.421
5.174AlaLys: 5.174 ± 0.555
5.926AlaLeu: 5.926 ± 0.43
2.069AlaMet: 2.069 ± 0.22
2.822AlaAsn: 2.822 ± 0.468
2.775AlaPro: 2.775 ± 0.48
2.869AlaGln: 2.869 ± 0.451
4.28AlaArg: 4.28 ± 0.469
3.669AlaSer: 3.669 ± 0.455
4.045AlaThr: 4.045 ± 0.556
4.374AlaVal: 4.374 ± 0.574
1.129AlaTrp: 1.129 ± 0.243
2.352AlaTyr: 2.352 ± 0.298
0.0AlaXaa: 0.0 ± 0.0
Cys
0.329CysAla: 0.329 ± 0.124
0.047CysCys: 0.047 ± 0.047
0.611CysAsp: 0.611 ± 0.151
0.753CysGlu: 0.753 ± 0.193
0.376CysPhe: 0.376 ± 0.124
0.611CysGly: 0.611 ± 0.223
0.376CysHis: 0.376 ± 0.14
1.082CysIle: 1.082 ± 0.22
0.611CysLys: 0.611 ± 0.178
1.27CysLeu: 1.27 ± 0.242
0.188CysMet: 0.188 ± 0.096
0.376CysAsn: 0.376 ± 0.106
0.47CysPro: 0.47 ± 0.156
0.235CysGln: 0.235 ± 0.111
0.47CysArg: 0.47 ± 0.157
0.705CysSer: 0.705 ± 0.17
0.753CysThr: 0.753 ± 0.218
0.564CysVal: 0.564 ± 0.162
0.047CysTrp: 0.047 ± 0.047
0.235CysTyr: 0.235 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
5.127AspAla: 5.127 ± 0.624
1.035AspCys: 1.035 ± 0.193
3.857AspAsp: 3.857 ± 0.447
4.891AspGlu: 4.891 ± 0.537
2.963AspPhe: 2.963 ± 0.474
4.609AspGly: 4.609 ± 0.474
1.552AspHis: 1.552 ± 0.267
4.468AspIle: 4.468 ± 0.441
4.844AspLys: 4.844 ± 0.603
4.938AspLeu: 4.938 ± 0.476
1.928AspMet: 1.928 ± 0.276
2.963AspAsn: 2.963 ± 0.314
4.139AspPro: 4.139 ± 0.535
2.869AspGln: 2.869 ± 0.426
3.245AspArg: 3.245 ± 0.396
3.433AspSer: 3.433 ± 0.435
3.339AspThr: 3.339 ± 0.436
3.151AspVal: 3.151 ± 0.389
1.27AspTrp: 1.27 ± 0.23
3.057AspTyr: 3.057 ± 0.344
0.0AspXaa: 0.0 ± 0.0
Glu
5.174GluAla: 5.174 ± 0.538
0.847GluCys: 0.847 ± 0.168
4.75GluAsp: 4.75 ± 0.449
7.196GluGlu: 7.196 ± 0.789
2.775GluPhe: 2.775 ± 0.352
5.738GluGly: 5.738 ± 0.552
1.646GluHis: 1.646 ± 0.28
4.656GluIle: 4.656 ± 0.534
5.079GluLys: 5.079 ± 0.48
5.221GluLeu: 5.221 ± 0.607
1.693GluMet: 1.693 ± 0.284
3.198GluAsn: 3.198 ± 0.36
2.305GluPro: 2.305 ± 0.355
2.352GluGln: 2.352 ± 0.398
3.716GluArg: 3.716 ± 0.476
2.258GluSer: 2.258 ± 0.359
3.386GluThr: 3.386 ± 0.431
6.867GluVal: 6.867 ± 0.546
0.941GluTrp: 0.941 ± 0.199
2.963GluTyr: 2.963 ± 0.359
0.0GluXaa: 0.0 ± 0.0
Phe
1.975PheAla: 1.975 ± 0.315
0.611PheCys: 0.611 ± 0.181
2.869PheAsp: 2.869 ± 0.397
2.587PheGlu: 2.587 ± 0.397
1.552PhePhe: 1.552 ± 0.265
3.48PheGly: 3.48 ± 0.45
0.988PheHis: 0.988 ± 0.227
2.963PheIle: 2.963 ± 0.466
3.386PheLys: 3.386 ± 0.434
3.245PheLeu: 3.245 ± 0.399
1.082PheMet: 1.082 ± 0.257
1.74PheAsn: 1.74 ± 0.294
1.599PhePro: 1.599 ± 0.245
1.74PheGln: 1.74 ± 0.294
1.928PheArg: 1.928 ± 0.352
2.54PheSer: 2.54 ± 0.413
2.352PheThr: 2.352 ± 0.361
2.399PheVal: 2.399 ± 0.335
0.423PheTrp: 0.423 ± 0.158
0.894PheTyr: 0.894 ± 0.21
0.0PheXaa: 0.0 ± 0.0
Gly
4.797GlyAla: 4.797 ± 0.588
0.517GlyCys: 0.517 ± 0.134
5.174GlyAsp: 5.174 ± 0.49
4.421GlyGlu: 4.421 ± 0.351
3.151GlyPhe: 3.151 ± 0.453
4.374GlyGly: 4.374 ± 0.576
1.552GlyHis: 1.552 ± 0.248
3.81GlyIle: 3.81 ± 0.377
4.938GlyLys: 4.938 ± 0.523
5.174GlyLeu: 5.174 ± 0.531
2.258GlyMet: 2.258 ± 0.372
3.245GlyAsn: 3.245 ± 0.452
2.446GlyPro: 2.446 ± 0.464
2.446GlyGln: 2.446 ± 0.328
3.245GlyArg: 3.245 ± 0.415
4.938GlySer: 4.938 ± 0.597
5.503GlyThr: 5.503 ± 0.753
5.597GlyVal: 5.597 ± 0.411
1.27GlyTrp: 1.27 ± 0.187
3.151GlyTyr: 3.151 ± 0.401
0.0GlyXaa: 0.0 ± 0.0
His
1.27HisAla: 1.27 ± 0.216
0.282HisCys: 0.282 ± 0.114
1.035HisAsp: 1.035 ± 0.236
1.458HisGlu: 1.458 ± 0.301
0.894HisPhe: 0.894 ± 0.205
1.082HisGly: 1.082 ± 0.27
0.376HisHis: 0.376 ± 0.138
1.27HisIle: 1.27 ± 0.259
1.317HisLys: 1.317 ± 0.221
1.74HisLeu: 1.74 ± 0.294
0.894HisMet: 0.894 ± 0.201
1.129HisAsn: 1.129 ± 0.251
1.364HisPro: 1.364 ± 0.281
0.47HisGln: 0.47 ± 0.148
1.411HisArg: 1.411 ± 0.248
1.599HisSer: 1.599 ± 0.357
1.599HisThr: 1.599 ± 0.558
1.552HisVal: 1.552 ± 0.275
0.376HisTrp: 0.376 ± 0.128
0.611HisTyr: 0.611 ± 0.132
0.0HisXaa: 0.0 ± 0.0
Ile
4.374IleAla: 4.374 ± 0.424
0.611IleCys: 0.611 ± 0.192
4.421IleAsp: 4.421 ± 0.46
4.703IleGlu: 4.703 ± 0.398
1.693IlePhe: 1.693 ± 0.276
4.186IleGly: 4.186 ± 0.429
1.317IleHis: 1.317 ± 0.252
3.386IleIle: 3.386 ± 0.361
3.857IleLys: 3.857 ± 0.456
4.327IleLeu: 4.327 ± 0.437
1.505IleMet: 1.505 ± 0.229
3.433IleAsn: 3.433 ± 0.385
2.446IlePro: 2.446 ± 0.386
2.352IleGln: 2.352 ± 0.298
2.728IleArg: 2.728 ± 0.341
4.656IleSer: 4.656 ± 0.63
3.433IleThr: 3.433 ± 0.466
3.339IleVal: 3.339 ± 0.406
0.988IleTrp: 0.988 ± 0.247
1.787IleTyr: 1.787 ± 0.308
0.0IleXaa: 0.0 ± 0.0
Lys
5.55LysAla: 5.55 ± 0.662
0.423LysCys: 0.423 ± 0.163
5.832LysAsp: 5.832 ± 0.495
6.302LysGlu: 6.302 ± 0.618
3.245LysPhe: 3.245 ± 0.443
5.315LysGly: 5.315 ± 0.56
1.223LysHis: 1.223 ± 0.24
4.797LysIle: 4.797 ± 0.387
6.208LysLys: 6.208 ± 0.648
4.374LysLeu: 4.374 ± 0.499
1.928LysMet: 1.928 ± 0.285
2.775LysAsn: 2.775 ± 0.41
2.493LysPro: 2.493 ± 0.315
2.352LysGln: 2.352 ± 0.341
4.186LysArg: 4.186 ± 0.454
3.951LysSer: 3.951 ± 0.404
3.669LysThr: 3.669 ± 0.331
4.703LysVal: 4.703 ± 0.531
0.847LysTrp: 0.847 ± 0.184
2.54LysTyr: 2.54 ± 0.429
0.0LysXaa: 0.0 ± 0.0
Leu
5.362LeuAla: 5.362 ± 0.583
0.941LeuCys: 0.941 ± 0.196
5.597LeuAsp: 5.597 ± 0.515
5.879LeuGlu: 5.879 ± 0.641
3.104LeuPhe: 3.104 ± 0.407
4.609LeuGly: 4.609 ± 0.516
1.599LeuHis: 1.599 ± 0.276
3.763LeuIle: 3.763 ± 0.497
6.208LeuLys: 6.208 ± 0.603
5.597LeuLeu: 5.597 ± 0.492
2.54LeuMet: 2.54 ± 0.339
3.574LeuAsn: 3.574 ± 0.421
2.869LeuPro: 2.869 ± 0.316
2.163LeuGln: 2.163 ± 0.288
4.985LeuArg: 4.985 ± 0.513
4.233LeuSer: 4.233 ± 0.445
3.81LeuThr: 3.81 ± 0.396
3.904LeuVal: 3.904 ± 0.491
0.941LeuTrp: 0.941 ± 0.201
2.399LeuTyr: 2.399 ± 0.421
0.0LeuXaa: 0.0 ± 0.0
Met
2.493MetAla: 2.493 ± 0.331
0.235MetCys: 0.235 ± 0.095
1.928MetAsp: 1.928 ± 0.243
1.881MetGlu: 1.881 ± 0.284
0.847MetPhe: 0.847 ± 0.199
1.458MetGly: 1.458 ± 0.283
0.611MetHis: 0.611 ± 0.189
1.74MetIle: 1.74 ± 0.249
1.834MetLys: 1.834 ± 0.293
1.505MetLeu: 1.505 ± 0.257
0.235MetMet: 0.235 ± 0.103
1.411MetAsn: 1.411 ± 0.251
1.082MetPro: 1.082 ± 0.214
0.705MetGln: 0.705 ± 0.173
1.458MetArg: 1.458 ± 0.233
1.787MetSer: 1.787 ± 0.255
1.505MetThr: 1.505 ± 0.262
1.599MetVal: 1.599 ± 0.279
0.47MetTrp: 0.47 ± 0.144
1.317MetTyr: 1.317 ± 0.25
0.0MetXaa: 0.0 ± 0.0
Asn
3.151AsnAla: 3.151 ± 0.498
0.329AsnCys: 0.329 ± 0.123
2.493AsnAsp: 2.493 ± 0.288
3.151AsnGlu: 3.151 ± 0.326
2.305AsnPhe: 2.305 ± 0.345
3.527AsnGly: 3.527 ± 0.584
1.27AsnHis: 1.27 ± 0.292
3.151AsnIle: 3.151 ± 0.406
3.386AsnLys: 3.386 ± 0.404
3.904AsnLeu: 3.904 ± 0.365
1.129AsnMet: 1.129 ± 0.242
2.211AsnAsn: 2.211 ± 0.333
3.151AsnPro: 3.151 ± 0.399
1.129AsnGln: 1.129 ± 0.331
2.163AsnArg: 2.163 ± 0.302
2.681AsnSer: 2.681 ± 0.319
2.352AsnThr: 2.352 ± 0.296
3.198AsnVal: 3.198 ± 0.401
0.517AsnTrp: 0.517 ± 0.164
2.116AsnTyr: 2.116 ± 0.303
0.0AsnXaa: 0.0 ± 0.0
Pro
2.211ProAla: 2.211 ± 0.318
0.235ProCys: 0.235 ± 0.127
3.198ProAsp: 3.198 ± 0.379
3.904ProGlu: 3.904 ± 0.451
1.975ProPhe: 1.975 ± 0.262
2.822ProGly: 2.822 ± 0.395
0.847ProHis: 0.847 ± 0.186
2.305ProIle: 2.305 ± 0.268
3.433ProLys: 3.433 ± 0.491
2.775ProLeu: 2.775 ± 0.333
1.035ProMet: 1.035 ± 0.229
1.928ProAsn: 1.928 ± 0.271
1.834ProPro: 1.834 ± 0.348
1.223ProGln: 1.223 ± 0.274
1.928ProArg: 1.928 ± 0.314
2.681ProSer: 2.681 ± 0.326
3.057ProThr: 3.057 ± 0.401
2.775ProVal: 2.775 ± 0.365
0.47ProTrp: 0.47 ± 0.154
1.458ProTyr: 1.458 ± 0.269
0.0ProXaa: 0.0 ± 0.0
Gln
2.681GlnAla: 2.681 ± 0.332
0.235GlnCys: 0.235 ± 0.118
2.116GlnAsp: 2.116 ± 0.364
3.48GlnGlu: 3.48 ± 0.392
1.411GlnPhe: 1.411 ± 0.237
2.587GlnGly: 2.587 ± 0.367
0.517GlnHis: 0.517 ± 0.15
2.258GlnIle: 2.258 ± 0.306
1.881GlnLys: 1.881 ± 0.287
2.822GlnLeu: 2.822 ± 0.401
1.082GlnMet: 1.082 ± 0.21
1.928GlnAsn: 1.928 ± 0.353
1.411GlnPro: 1.411 ± 0.268
1.317GlnGln: 1.317 ± 0.353
1.834GlnArg: 1.834 ± 0.273
1.646GlnSer: 1.646 ± 0.317
2.069GlnThr: 2.069 ± 0.295
2.493GlnVal: 2.493 ± 0.258
0.517GlnTrp: 0.517 ± 0.129
1.317GlnTyr: 1.317 ± 0.223
0.0GlnXaa: 0.0 ± 0.0
Arg
3.198ArgAla: 3.198 ± 0.398
0.423ArgCys: 0.423 ± 0.151
3.574ArgAsp: 3.574 ± 0.464
3.81ArgGlu: 3.81 ± 0.434
1.834ArgPhe: 1.834 ± 0.254
4.28ArgGly: 4.28 ± 0.442
1.176ArgHis: 1.176 ± 0.222
3.104ArgIle: 3.104 ± 0.37
3.998ArgLys: 3.998 ± 0.454
4.139ArgLeu: 4.139 ± 0.439
1.599ArgMet: 1.599 ± 0.219
2.728ArgAsn: 2.728 ± 0.307
2.163ArgPro: 2.163 ± 0.31
2.305ArgGln: 2.305 ± 0.384
3.339ArgArg: 3.339 ± 0.4
2.869ArgSer: 2.869 ± 0.399
2.634ArgThr: 2.634 ± 0.396
2.869ArgVal: 2.869 ± 0.391
1.129ArgTrp: 1.129 ± 0.232
2.305ArgTyr: 2.305 ± 0.329
0.0ArgXaa: 0.0 ± 0.0
Ser
4.515SerAla: 4.515 ± 0.457
0.423SerCys: 0.423 ± 0.166
3.951SerAsp: 3.951 ± 0.396
3.104SerGlu: 3.104 ± 0.345
2.493SerPhe: 2.493 ± 0.295
5.691SerGly: 5.691 ± 0.796
1.27SerHis: 1.27 ± 0.255
3.386SerIle: 3.386 ± 0.459
3.574SerLys: 3.574 ± 0.402
4.139SerLeu: 4.139 ± 0.421
1.599SerMet: 1.599 ± 0.184
2.587SerAsn: 2.587 ± 0.362
2.352SerPro: 2.352 ± 0.337
2.446SerGln: 2.446 ± 0.461
2.963SerArg: 2.963 ± 0.349
4.891SerSer: 4.891 ± 0.69
3.386SerThr: 3.386 ± 0.508
3.716SerVal: 3.716 ± 0.48
0.988SerTrp: 0.988 ± 0.196
2.258SerTyr: 2.258 ± 0.373
0.0SerXaa: 0.0 ± 0.0
Thr
4.28ThrAla: 4.28 ± 0.636
0.564ThrCys: 0.564 ± 0.138
3.151ThrAsp: 3.151 ± 0.353
2.775ThrGlu: 2.775 ± 0.305
2.305ThrPhe: 2.305 ± 0.378
4.28ThrGly: 4.28 ± 0.69
1.693ThrHis: 1.693 ± 0.403
3.151ThrIle: 3.151 ± 0.363
4.045ThrLys: 4.045 ± 0.424
4.844ThrLeu: 4.844 ± 0.396
0.988ThrMet: 0.988 ± 0.255
3.01ThrAsn: 3.01 ± 0.418
2.493ThrPro: 2.493 ± 0.391
1.787ThrGln: 1.787 ± 0.357
2.963ThrArg: 2.963 ± 0.467
4.374ThrSer: 4.374 ± 0.656
3.621ThrThr: 3.621 ± 0.66
3.574ThrVal: 3.574 ± 0.501
1.129ThrTrp: 1.129 ± 0.275
2.399ThrTyr: 2.399 ± 0.318
0.0ThrXaa: 0.0 ± 0.0
Val
4.092ValAla: 4.092 ± 0.429
0.753ValCys: 0.753 ± 0.189
5.174ValAsp: 5.174 ± 0.455
3.763ValGlu: 3.763 ± 0.456
2.681ValPhe: 2.681 ± 0.4
4.985ValGly: 4.985 ± 0.475
1.317ValHis: 1.317 ± 0.23
3.292ValIle: 3.292 ± 0.474
4.515ValLys: 4.515 ± 0.453
4.186ValLeu: 4.186 ± 0.417
1.082ValMet: 1.082 ± 0.186
3.339ValAsn: 3.339 ± 0.413
2.869ValPro: 2.869 ± 0.352
2.916ValGln: 2.916 ± 0.391
3.763ValArg: 3.763 ± 0.411
4.139ValSer: 4.139 ± 0.466
3.904ValThr: 3.904 ± 0.472
4.374ValVal: 4.374 ± 0.474
0.8ValTrp: 0.8 ± 0.176
2.54ValTyr: 2.54 ± 0.367
0.0ValXaa: 0.0 ± 0.0
Trp
1.129TrpAla: 1.129 ± 0.194
0.329TrpCys: 0.329 ± 0.131
1.458TrpAsp: 1.458 ± 0.265
1.552TrpGlu: 1.552 ± 0.256
0.47TrpPhe: 0.47 ± 0.147
0.847TrpGly: 0.847 ± 0.158
0.235TrpHis: 0.235 ± 0.102
0.8TrpIle: 0.8 ± 0.203
1.317TrpLys: 1.317 ± 0.274
0.847TrpLeu: 0.847 ± 0.222
0.376TrpMet: 0.376 ± 0.126
0.753TrpAsn: 0.753 ± 0.165
0.376TrpPro: 0.376 ± 0.128
0.376TrpGln: 0.376 ± 0.103
0.894TrpArg: 0.894 ± 0.209
0.658TrpSer: 0.658 ± 0.167
0.847TrpThr: 0.847 ± 0.24
1.223TrpVal: 1.223 ± 0.263
0.188TrpTrp: 0.188 ± 0.085
0.517TrpTyr: 0.517 ± 0.201
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.493TyrAla: 2.493 ± 0.262
0.611TyrCys: 0.611 ± 0.156
2.634TyrAsp: 2.634 ± 0.311
2.775TyrGlu: 2.775 ± 0.366
1.505TyrPhe: 1.505 ± 0.28
2.681TyrGly: 2.681 ± 0.369
0.611TyrHis: 0.611 ± 0.188
1.552TyrIle: 1.552 ± 0.224
3.104TyrLys: 3.104 ± 0.311
3.104TyrLeu: 3.104 ± 0.372
0.847TyrMet: 0.847 ± 0.168
2.163TyrAsn: 2.163 ± 0.295
1.458TyrPro: 1.458 ± 0.26
1.552TyrGln: 1.552 ± 0.277
1.975TyrArg: 1.975 ± 0.305
2.022TyrSer: 2.022 ± 0.335
2.163TyrThr: 2.163 ± 0.288
2.211TyrVal: 2.211 ± 0.309
0.753TyrTrp: 0.753 ± 0.229
0.894TyrTyr: 0.894 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 121 proteins (21263 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski