Amino acid dipepetide frequency for Mycoplasma mustelae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.42AlaAla: 3.42 ± 0.183
0.283AlaCys: 0.283 ± 0.039
2.564AlaAsp: 2.564 ± 0.124
2.898AlaGlu: 2.898 ± 0.123
2.691AlaPhe: 2.691 ± 0.11
2.624AlaGly: 2.624 ± 0.114
0.804AlaHis: 0.804 ± 0.074
5.43AlaIle: 5.43 ± 0.175
5.339AlaLys: 5.339 ± 0.185
5.422AlaLeu: 5.422 ± 0.168
1.039AlaMet: 1.039 ± 0.072
3.766AlaAsn: 3.766 ± 0.148
1.222AlaPro: 1.222 ± 0.067
2.054AlaGln: 2.054 ± 0.117
1.931AlaArg: 1.931 ± 0.091
3.348AlaSer: 3.348 ± 0.124
3.225AlaThr: 3.225 ± 0.129
2.823AlaVal: 2.823 ± 0.128
0.398AlaTrp: 0.398 ± 0.04
2.066AlaTyr: 2.066 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.287CysAla: 0.287 ± 0.036
0.052CysCys: 0.052 ± 0.013
0.311CysAsp: 0.311 ± 0.041
0.283CysGlu: 0.283 ± 0.037
0.287CysPhe: 0.287 ± 0.035
0.382CysGly: 0.382 ± 0.041
0.104CysHis: 0.104 ± 0.018
0.426CysIle: 0.426 ± 0.047
0.334CysLys: 0.334 ± 0.037
0.418CysLeu: 0.418 ± 0.041
0.04CysMet: 0.04 ± 0.013
0.247CysAsn: 0.247 ± 0.034
0.151CysPro: 0.151 ± 0.024
0.227CysGln: 0.227 ± 0.029
0.131CysArg: 0.131 ± 0.024
0.291CysSer: 0.291 ± 0.035
0.171CysThr: 0.171 ± 0.024
0.287CysVal: 0.287 ± 0.036
0.032CysTrp: 0.032 ± 0.01
0.147CysTyr: 0.147 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.464AspAla: 3.464 ± 0.148
0.203AspCys: 0.203 ± 0.028
2.755AspAsp: 2.755 ± 0.105
3.949AspGlu: 3.949 ± 0.141
3.854AspPhe: 3.854 ± 0.138
2.56AspGly: 2.56 ± 0.108
0.633AspHis: 0.633 ± 0.054
4.817AspIle: 4.817 ± 0.125
5.052AspLys: 5.052 ± 0.15
5.805AspLeu: 5.805 ± 0.172
0.673AspMet: 0.673 ± 0.047
3.599AspAsn: 3.599 ± 0.115
1.37AspPro: 1.37 ± 0.09
1.636AspGln: 1.636 ± 0.088
1.465AspArg: 1.465 ± 0.076
3.424AspSer: 3.424 ± 0.14
2.52AspThr: 2.52 ± 0.113
3.452AspVal: 3.452 ± 0.136
0.565AspTrp: 0.565 ± 0.04
2.536AspTyr: 2.536 ± 0.1
0.0AspXaa: 0.0 ± 0.0
Glu
3.062GluAla: 3.062 ± 0.141
0.219GluCys: 0.219 ± 0.033
2.333GluAsp: 2.333 ± 0.099
3.157GluGlu: 3.157 ± 0.133
3.75GluPhe: 3.75 ± 0.118
1.979GluGly: 1.979 ± 0.091
0.872GluHis: 0.872 ± 0.066
6.915GluIle: 6.915 ± 0.226
6.075GluLys: 6.075 ± 0.195
6.171GluLeu: 6.171 ± 0.18
1.318GluMet: 1.318 ± 0.076
5.363GluAsn: 5.363 ± 0.163
1.091GluPro: 1.091 ± 0.072
2.21GluGln: 2.21 ± 0.112
1.887GluArg: 1.887 ± 0.099
3.221GluSer: 3.221 ± 0.123
3.269GluThr: 3.269 ± 0.116
3.535GluVal: 3.535 ± 0.128
0.442GluTrp: 0.442 ± 0.044
2.651GluTyr: 2.651 ± 0.109
0.0GluXaa: 0.0 ± 0.0
Phe
2.926PheAla: 2.926 ± 0.12
0.358PheCys: 0.358 ± 0.038
3.854PheAsp: 3.854 ± 0.126
3.169PheGlu: 3.169 ± 0.121
2.866PhePhe: 2.866 ± 0.139
2.827PheGly: 2.827 ± 0.14
0.565PheHis: 0.565 ± 0.048
5.693PheIle: 5.693 ± 0.202
5.625PheLys: 5.625 ± 0.169
5.426PheLeu: 5.426 ± 0.185
0.896PheMet: 0.896 ± 0.056
4.252PheAsn: 4.252 ± 0.146
1.166PhePro: 1.166 ± 0.069
1.632PheGln: 1.632 ± 0.079
1.461PheArg: 1.461 ± 0.078
4.152PheSer: 4.152 ± 0.137
2.536PheThr: 2.536 ± 0.115
3.511PheVal: 3.511 ± 0.136
0.713PheTrp: 0.713 ± 0.05
2.608PheTyr: 2.608 ± 0.127
0.0PheXaa: 0.0 ± 0.0
Gly
2.564GlyAla: 2.564 ± 0.128
0.243GlyCys: 0.243 ± 0.028
2.46GlyAsp: 2.46 ± 0.111
2.365GlyGlu: 2.365 ± 0.108
3.034GlyPhe: 3.034 ± 0.128
2.974GlyGly: 2.974 ± 0.161
0.88GlyHis: 0.88 ± 0.06
4.761GlyIle: 4.761 ± 0.158
3.699GlyLys: 3.699 ± 0.142
4.423GlyLeu: 4.423 ± 0.153
0.836GlyMet: 0.836 ± 0.065
2.616GlyAsn: 2.616 ± 0.111
0.912GlyPro: 0.912 ± 0.069
1.521GlyGln: 1.521 ± 0.089
1.489GlyArg: 1.489 ± 0.07
3.201GlySer: 3.201 ± 0.139
2.452GlyThr: 2.452 ± 0.124
3.093GlyVal: 3.093 ± 0.114
0.458GlyTrp: 0.458 ± 0.042
2.273GlyTyr: 2.273 ± 0.118
0.0GlyXaa: 0.0 ± 0.0
His
0.697HisAla: 0.697 ± 0.061
0.107HisCys: 0.107 ± 0.021
0.593HisAsp: 0.593 ± 0.05
0.717HisGlu: 0.717 ± 0.061
0.892HisPhe: 0.892 ± 0.056
0.673HisGly: 0.673 ± 0.053
0.354HisHis: 0.354 ± 0.037
1.453HisIle: 1.453 ± 0.078
1.457HisLys: 1.457 ± 0.076
1.577HisLeu: 1.577 ± 0.082
0.195HisMet: 0.195 ± 0.025
1.079HisAsn: 1.079 ± 0.068
0.665HisPro: 0.665 ± 0.056
0.76HisGln: 0.76 ± 0.061
0.482HisArg: 0.482 ± 0.038
1.027HisSer: 1.027 ± 0.068
0.816HisThr: 0.816 ± 0.057
0.605HisVal: 0.605 ± 0.05
0.155HisTrp: 0.155 ± 0.025
0.569HisTyr: 0.569 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.478IleAla: 5.478 ± 0.172
0.577IleCys: 0.577 ± 0.055
5.462IleAsp: 5.462 ± 0.139
5.295IleGlu: 5.295 ± 0.166
5.183IlePhe: 5.183 ± 0.192
4.228IleGly: 4.228 ± 0.157
1.374IleHis: 1.374 ± 0.08
8.862IleIle: 8.862 ± 0.294
9.332IleLys: 9.332 ± 0.21
9.232IleLeu: 9.232 ± 0.279
1.326IleMet: 1.326 ± 0.067
8.169IleAsn: 8.169 ± 0.218
2.862IlePro: 2.862 ± 0.121
3.32IleGln: 3.32 ± 0.122
2.393IleArg: 2.393 ± 0.104
6.712IleSer: 6.712 ± 0.175
5.438IleThr: 5.438 ± 0.154
4.933IleVal: 4.933 ± 0.139
0.848IleTrp: 0.848 ± 0.061
3.87IleTyr: 3.87 ± 0.141
0.0IleXaa: 0.0 ± 0.0
Lys
4.399LysAla: 4.399 ± 0.168
0.346LysCys: 0.346 ± 0.035
5.51LysAsp: 5.51 ± 0.169
6.864LysGlu: 6.864 ± 0.198
4.722LysPhe: 4.722 ± 0.146
3.499LysGly: 3.499 ± 0.149
1.537LysHis: 1.537 ± 0.085
9.885LysIle: 9.885 ± 0.249
9.372LysLys: 9.372 ± 0.222
9.4LysLeu: 9.4 ± 0.212
2.341LysMet: 2.341 ± 0.105
8.56LysAsn: 8.56 ± 0.212
2.572LysPro: 2.572 ± 0.108
4.718LysGln: 4.718 ± 0.139
3.073LysArg: 3.073 ± 0.118
5.084LysSer: 5.084 ± 0.137
5.996LysThr: 5.996 ± 0.16
5.064LysVal: 5.064 ± 0.161
0.952LysTrp: 0.952 ± 0.065
4.925LysTyr: 4.925 ± 0.17
0.0LysXaa: 0.0 ± 0.0
Leu
5.263LeuAla: 5.263 ± 0.138
0.426LeuCys: 0.426 ± 0.042
5.438LeuAsp: 5.438 ± 0.175
5.721LeuGlu: 5.721 ± 0.193
5.438LeuPhe: 5.438 ± 0.224
4.718LeuGly: 4.718 ± 0.15
1.318LeuHis: 1.318 ± 0.076
9.153LeuIle: 9.153 ± 0.258
10.331LeuLys: 10.331 ± 0.251
9.376LeuLeu: 9.376 ± 0.286
1.565LeuMet: 1.565 ± 0.087
8.189LeuAsn: 8.189 ± 0.225
2.807LeuPro: 2.807 ± 0.118
3.75LeuGln: 3.75 ± 0.121
2.779LeuArg: 2.779 ± 0.101
7.445LeuSer: 7.445 ± 0.18
5.279LeuThr: 5.279 ± 0.161
5.307LeuVal: 5.307 ± 0.178
0.92LeuTrp: 0.92 ± 0.048
3.631LeuTyr: 3.631 ± 0.132
0.0LeuXaa: 0.0 ± 0.0
Met
0.776MetAla: 0.776 ± 0.064
0.111MetCys: 0.111 ± 0.023
0.8MetAsp: 0.8 ± 0.063
0.685MetGlu: 0.685 ± 0.053
0.979MetPhe: 0.979 ± 0.059
0.657MetGly: 0.657 ± 0.054
0.35MetHis: 0.35 ± 0.036
1.465MetIle: 1.465 ± 0.072
1.664MetLys: 1.664 ± 0.072
1.792MetLeu: 1.792 ± 0.089
0.338MetMet: 0.338 ± 0.04
1.163MetAsn: 1.163 ± 0.067
0.506MetPro: 0.506 ± 0.048
1.095MetGln: 1.095 ± 0.058
0.533MetArg: 0.533 ± 0.054
1.075MetSer: 1.075 ± 0.067
0.864MetThr: 0.864 ± 0.064
0.979MetVal: 0.979 ± 0.066
0.139MetTrp: 0.139 ± 0.025
0.577MetTyr: 0.577 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
3.559AsnAla: 3.559 ± 0.158
0.287AsnCys: 0.287 ± 0.033
4.415AsnAsp: 4.415 ± 0.148
5.18AsnGlu: 5.18 ± 0.161
4.196AsnPhe: 4.196 ± 0.183
3.117AsnGly: 3.117 ± 0.115
1.039AsnHis: 1.039 ± 0.063
7.098AsnIle: 7.098 ± 0.224
8.444AsnLys: 8.444 ± 0.211
7.954AsnLeu: 7.954 ± 0.227
0.912AsnMet: 0.912 ± 0.062
6.398AsnAsn: 6.398 ± 0.249
2.64AsnPro: 2.64 ± 0.111
3.679AsnGln: 3.679 ± 0.146
1.855AsnArg: 1.855 ± 0.089
5.51AsnSer: 5.51 ± 0.18
3.953AsnThr: 3.953 ± 0.158
3.579AsnVal: 3.579 ± 0.122
0.784AsnTrp: 0.784 ± 0.06
3.484AsnTyr: 3.484 ± 0.135
0.0AsnXaa: 0.0 ± 0.0
Pro
1.298ProAla: 1.298 ± 0.083
0.1ProCys: 0.1 ± 0.023
1.529ProAsp: 1.529 ± 0.078
1.947ProGlu: 1.947 ± 0.108
1.385ProPhe: 1.385 ± 0.087
1.437ProGly: 1.437 ± 0.088
0.565ProHis: 0.565 ± 0.046
2.321ProIle: 2.321 ± 0.116
2.588ProLys: 2.588 ± 0.107
2.257ProLeu: 2.257 ± 0.11
0.418ProMet: 0.418 ± 0.044
2.218ProAsn: 2.218 ± 0.105
0.434ProPro: 0.434 ± 0.046
1.099ProGln: 1.099 ± 0.059
0.637ProArg: 0.637 ± 0.052
1.553ProSer: 1.553 ± 0.083
1.732ProThr: 1.732 ± 0.091
1.421ProVal: 1.421 ± 0.083
0.291ProTrp: 0.291 ± 0.032
1.127ProTyr: 1.127 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
2.221GlnAla: 2.221 ± 0.108
0.107GlnCys: 0.107 ± 0.023
1.656GlnAsp: 1.656 ± 0.087
2.5GlnGlu: 2.5 ± 0.105
1.676GlnPhe: 1.676 ± 0.086
1.581GlnGly: 1.581 ± 0.077
0.577GlnHis: 0.577 ± 0.056
3.933GlnIle: 3.933 ± 0.14
4.905GlnLys: 4.905 ± 0.15
3.83GlnLeu: 3.83 ± 0.134
0.593GlnMet: 0.593 ± 0.048
3.611GlnAsn: 3.611 ± 0.142
1.258GlnPro: 1.258 ± 0.087
2.269GlnGln: 2.269 ± 0.126
1.489GlnArg: 1.489 ± 0.076
2.182GlnSer: 2.182 ± 0.106
2.536GlnThr: 2.536 ± 0.14
1.855GlnVal: 1.855 ± 0.087
0.45GlnTrp: 0.45 ± 0.048
1.401GlnTyr: 1.401 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
1.596ArgAla: 1.596 ± 0.091
0.1ArgCys: 0.1 ± 0.02
1.78ArgAsp: 1.78 ± 0.091
1.991ArgGlu: 1.991 ± 0.093
1.537ArgPhe: 1.537 ± 0.085
1.481ArgGly: 1.481 ± 0.082
0.406ArgHis: 0.406 ± 0.045
2.616ArgIle: 2.616 ± 0.103
2.851ArgLys: 2.851 ± 0.107
2.508ArgLeu: 2.508 ± 0.102
0.705ArgMet: 0.705 ± 0.049
2.206ArgAsn: 2.206 ± 0.11
0.772ArgPro: 0.772 ± 0.059
1.139ArgGln: 1.139 ± 0.072
1.17ArgArg: 1.17 ± 0.077
1.855ArgSer: 1.855 ± 0.091
1.513ArgThr: 1.513 ± 0.081
1.748ArgVal: 1.748 ± 0.089
0.307ArgTrp: 0.307 ± 0.037
1.366ArgTyr: 1.366 ± 0.086
0.004ArgXaa: 0.004 ± 0.004
Ser
3.145SerAla: 3.145 ± 0.114
0.394SerCys: 0.394 ± 0.04
3.83SerAsp: 3.83 ± 0.144
3.874SerGlu: 3.874 ± 0.123
3.902SerPhe: 3.902 ± 0.13
3.726SerGly: 3.726 ± 0.14
0.995SerHis: 0.995 ± 0.066
5.828SerIle: 5.828 ± 0.156
6.613SerLys: 6.613 ± 0.165
6.776SerLeu: 6.776 ± 0.191
0.991SerMet: 0.991 ± 0.065
4.813SerAsn: 4.813 ± 0.162
1.318SerPro: 1.318 ± 0.076
2.703SerGln: 2.703 ± 0.115
1.863SerArg: 1.863 ± 0.089
4.033SerSer: 4.033 ± 0.146
3.404SerThr: 3.404 ± 0.171
3.706SerVal: 3.706 ± 0.117
0.689SerTrp: 0.689 ± 0.062
2.759SerTyr: 2.759 ± 0.116
0.0SerXaa: 0.0 ± 0.0
Thr
2.771ThrAla: 2.771 ± 0.136
0.131ThrCys: 0.131 ± 0.021
2.779ThrAsp: 2.779 ± 0.117
3.073ThrGlu: 3.073 ± 0.121
3.249ThrPhe: 3.249 ± 0.12
2.488ThrGly: 2.488 ± 0.115
0.828ThrHis: 0.828 ± 0.062
4.511ThrIle: 4.511 ± 0.145
5.494ThrLys: 5.494 ± 0.164
5.315ThrLeu: 5.315 ± 0.171
0.661ThrMet: 0.661 ± 0.053
4.22ThrAsn: 4.22 ± 0.154
1.895ThrPro: 1.895 ± 0.098
2.289ThrGln: 2.289 ± 0.112
1.549ThrArg: 1.549 ± 0.063
3.906ThrSer: 3.906 ± 0.12
3.91ThrThr: 3.91 ± 0.195
2.568ThrVal: 2.568 ± 0.103
0.518ThrTrp: 0.518 ± 0.048
2.186ThrTyr: 2.186 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
3.73ValAla: 3.73 ± 0.132
0.334ValCys: 0.334 ± 0.036
3.233ValAsp: 3.233 ± 0.124
3.089ValGlu: 3.089 ± 0.133
3.424ValPhe: 3.424 ± 0.11
3.03ValGly: 3.03 ± 0.118
0.784ValHis: 0.784 ± 0.053
5.012ValIle: 5.012 ± 0.157
4.355ValLys: 4.355 ± 0.155
5.546ValLeu: 5.546 ± 0.162
0.979ValMet: 0.979 ± 0.057
3.635ValAsn: 3.635 ± 0.118
1.493ValPro: 1.493 ± 0.084
1.592ValGln: 1.592 ± 0.077
1.624ValArg: 1.624 ± 0.085
4.176ValSer: 4.176 ± 0.142
2.448ValThr: 2.448 ± 0.118
3.778ValVal: 3.778 ± 0.119
0.506ValTrp: 0.506 ± 0.043
2.122ValTyr: 2.122 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.482TrpAla: 0.482 ± 0.041
0.068TrpCys: 0.068 ± 0.019
0.557TrpAsp: 0.557 ± 0.048
0.569TrpGlu: 0.569 ± 0.045
0.649TrpPhe: 0.649 ± 0.055
0.426TrpGly: 0.426 ± 0.037
0.135TrpHis: 0.135 ± 0.023
1.027TrpIle: 1.027 ± 0.067
1.031TrpLys: 1.031 ± 0.072
0.983TrpLeu: 0.983 ± 0.053
0.163TrpMet: 0.163 ± 0.025
0.752TrpAsn: 0.752 ± 0.056
0.183TrpPro: 0.183 ± 0.026
0.267TrpGln: 0.267 ± 0.03
0.322TrpArg: 0.322 ± 0.033
0.593TrpSer: 0.593 ± 0.048
0.498TrpThr: 0.498 ± 0.045
0.466TrpVal: 0.466 ± 0.044
0.163TrpTrp: 0.163 ± 0.025
0.498TrpTyr: 0.498 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.21TyrAla: 2.21 ± 0.089
0.159TyrCys: 0.159 ± 0.031
2.472TyrAsp: 2.472 ± 0.121
2.194TyrGlu: 2.194 ± 0.098
2.524TyrPhe: 2.524 ± 0.123
1.847TyrGly: 1.847 ± 0.089
0.752TyrHis: 0.752 ± 0.057
3.687TyrIle: 3.687 ± 0.144
4.252TyrLys: 4.252 ± 0.149
4.642TyrLeu: 4.642 ± 0.149
0.557TyrMet: 0.557 ± 0.057
3.229TyrAsn: 3.229 ± 0.127
1.039TyrPro: 1.039 ± 0.07
2.671TyrGln: 2.671 ± 0.093
1.513TyrArg: 1.513 ± 0.091
2.58TyrSer: 2.58 ± 0.109
1.78TyrThr: 1.78 ± 0.092
2.182TyrVal: 2.182 ± 0.081
0.506TyrTrp: 0.506 ± 0.049
1.76TyrTyr: 1.76 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.004XaaLys: 0.004 ± 0.004
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.012XaaXaa: 0.012 ± 0.012
Statistics based on 686 proteins (251183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski