Amino acid dipepetide frequency for Aeromonas virus 44RR2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.256AlaAla: 5.256 ± 0.366
0.617AlaCys: 0.617 ± 0.114
4.583AlaAsp: 4.583 ± 0.309
5.537AlaGlu: 5.537 ± 0.346
2.768AlaPhe: 2.768 ± 0.282
4.77AlaGly: 4.77 ± 0.33
1.291AlaHis: 1.291 ± 0.163
5.593AlaIle: 5.593 ± 0.377
5.163AlaLys: 5.163 ± 0.363
5.256AlaLeu: 5.256 ± 0.352
2.507AlaMet: 2.507 ± 0.219
3.853AlaAsn: 3.853 ± 0.322
2.357AlaPro: 2.357 ± 0.198
2.731AlaGln: 2.731 ± 0.287
3.479AlaArg: 3.479 ± 0.247
4.377AlaSer: 4.377 ± 0.299
3.984AlaThr: 3.984 ± 0.466
4.527AlaVal: 4.527 ± 0.274
1.253AlaTrp: 1.253 ± 0.162
2.507AlaTyr: 2.507 ± 0.231
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.112
0.243CysCys: 0.243 ± 0.073
0.786CysAsp: 0.786 ± 0.121
0.86CysGlu: 0.86 ± 0.138
0.561CysPhe: 0.561 ± 0.092
0.748CysGly: 0.748 ± 0.111
0.281CysHis: 0.281 ± 0.066
0.617CysIle: 0.617 ± 0.11
0.804CysLys: 0.804 ± 0.12
0.599CysLeu: 0.599 ± 0.098
0.206CysMet: 0.206 ± 0.054
0.599CysAsn: 0.599 ± 0.105
0.505CysPro: 0.505 ± 0.095
0.393CysGln: 0.393 ± 0.087
0.823CysArg: 0.823 ± 0.136
0.711CysSer: 0.711 ± 0.106
0.449CysThr: 0.449 ± 0.071
0.767CysVal: 0.767 ± 0.107
0.206CysTrp: 0.206 ± 0.075
0.412CysTyr: 0.412 ± 0.092
0.0CysXaa: 0.0 ± 0.0
Asp
4.377AspAla: 4.377 ± 0.224
0.73AspCys: 0.73 ± 0.125
4.62AspAsp: 4.62 ± 0.356
4.732AspGlu: 4.732 ± 0.338
3.273AspPhe: 3.273 ± 0.276
4.882AspGly: 4.882 ± 0.325
1.216AspHis: 1.216 ± 0.16
4.957AspIle: 4.957 ± 0.312
3.479AspLys: 3.479 ± 0.287
4.302AspLeu: 4.302 ± 0.317
2.058AspMet: 2.058 ± 0.196
2.525AspAsn: 2.525 ± 0.223
2.17AspPro: 2.17 ± 0.2
1.964AspGln: 1.964 ± 0.177
3.124AspArg: 3.124 ± 0.206
3.61AspSer: 3.61 ± 0.242
3.03AspThr: 3.03 ± 0.234
5.088AspVal: 5.088 ± 0.312
1.216AspTrp: 1.216 ± 0.16
2.75AspTyr: 2.75 ± 0.285
0.0AspXaa: 0.0 ± 0.0
Glu
5.107GluAla: 5.107 ± 0.368
1.029GluCys: 1.029 ± 0.147
3.404GluAsp: 3.404 ± 0.251
4.489GluGlu: 4.489 ± 0.361
3.311GluPhe: 3.311 ± 0.272
3.928GluGly: 3.928 ± 0.305
1.59GluHis: 1.59 ± 0.175
5.574GluIle: 5.574 ± 0.399
4.377GluLys: 4.377 ± 0.321
6.715GluLeu: 6.715 ± 0.366
2.469GluMet: 2.469 ± 0.193
3.46GluAsn: 3.46 ± 0.307
1.59GluPro: 1.59 ± 0.196
2.432GluGln: 2.432 ± 0.245
3.03GluArg: 3.03 ± 0.234
3.535GluSer: 3.535 ± 0.238
3.591GluThr: 3.591 ± 0.279
4.583GluVal: 4.583 ± 0.331
1.141GluTrp: 1.141 ± 0.155
2.824GluTyr: 2.824 ± 0.223
0.0GluXaa: 0.0 ± 0.0
Phe
3.367PheAla: 3.367 ± 0.286
0.486PheCys: 0.486 ± 0.09
3.928PheAsp: 3.928 ± 0.231
3.648PheGlu: 3.648 ± 0.259
1.702PhePhe: 1.702 ± 0.177
3.255PheGly: 3.255 ± 0.272
0.767PheHis: 0.767 ± 0.118
2.881PheIle: 2.881 ± 0.213
3.535PheLys: 3.535 ± 0.274
2.469PheLeu: 2.469 ± 0.258
1.422PheMet: 1.422 ± 0.151
2.694PheAsn: 2.694 ± 0.202
1.309PhePro: 1.309 ± 0.122
1.197PheGln: 1.197 ± 0.137
1.721PheArg: 1.721 ± 0.197
2.824PheSer: 2.824 ± 0.22
2.787PheThr: 2.787 ± 0.245
3.049PheVal: 3.049 ± 0.271
0.58PheTrp: 0.58 ± 0.113
1.609PheTyr: 1.609 ± 0.157
0.0PheXaa: 0.0 ± 0.0
Gly
4.62GlyAla: 4.62 ± 0.401
0.973GlyCys: 0.973 ± 0.154
4.283GlyAsp: 4.283 ± 0.282
4.134GlyGlu: 4.134 ± 0.279
2.881GlyPhe: 2.881 ± 0.218
4.227GlyGly: 4.227 ± 0.363
1.347GlyHis: 1.347 ± 0.137
4.452GlyIle: 4.452 ± 0.288
4.601GlyLys: 4.601 ± 0.266
4.396GlyLeu: 4.396 ± 0.312
1.908GlyMet: 1.908 ± 0.222
3.423GlyAsn: 3.423 ± 0.342
1.758GlyPro: 1.758 ± 0.172
2.563GlyGln: 2.563 ± 0.242
3.255GlyArg: 3.255 ± 0.24
4.714GlySer: 4.714 ± 0.379
4.153GlyThr: 4.153 ± 0.435
4.414GlyVal: 4.414 ± 0.295
1.047GlyTrp: 1.047 ± 0.147
3.105GlyTyr: 3.105 ± 0.237
0.0GlyXaa: 0.0 ± 0.0
His
1.291HisAla: 1.291 ± 0.137
0.243HisCys: 0.243 ± 0.072
1.646HisAsp: 1.646 ± 0.17
1.44HisGlu: 1.44 ± 0.165
1.328HisPhe: 1.328 ± 0.183
1.365HisGly: 1.365 ± 0.144
0.542HisHis: 0.542 ± 0.115
1.796HisIle: 1.796 ± 0.186
1.403HisLys: 1.403 ± 0.164
1.796HisLeu: 1.796 ± 0.178
0.599HisMet: 0.599 ± 0.117
0.86HisAsn: 0.86 ± 0.152
0.973HisPro: 0.973 ± 0.141
0.542HisGln: 0.542 ± 0.109
0.655HisArg: 0.655 ± 0.113
0.935HisSer: 0.935 ± 0.119
0.879HisThr: 0.879 ± 0.153
1.478HisVal: 1.478 ± 0.17
0.318HisTrp: 0.318 ± 0.065
0.655HisTyr: 0.655 ± 0.114
0.0HisXaa: 0.0 ± 0.0
Ile
5.967IleAla: 5.967 ± 0.35
0.823IleCys: 0.823 ± 0.141
5.612IleAsp: 5.612 ± 0.371
5.144IleGlu: 5.144 ± 0.358
2.45IlePhe: 2.45 ± 0.216
4.396IleGly: 4.396 ± 0.337
1.365IleHis: 1.365 ± 0.178
4.433IleIle: 4.433 ± 0.292
4.807IleLys: 4.807 ± 0.272
4.153IleLeu: 4.153 ± 0.304
1.683IleMet: 1.683 ± 0.184
4.396IleAsn: 4.396 ± 0.288
2.881IlePro: 2.881 ± 0.274
2.02IleGln: 2.02 ± 0.172
3.573IleArg: 3.573 ± 0.294
4.508IleSer: 4.508 ± 0.319
4.695IleThr: 4.695 ± 0.256
4.789IleVal: 4.789 ± 0.337
0.524IleTrp: 0.524 ± 0.09
2.357IleTyr: 2.357 ± 0.21
0.0IleXaa: 0.0 ± 0.0
Lys
5.574LysAla: 5.574 ± 0.355
0.786LysCys: 0.786 ± 0.123
3.18LysAsp: 3.18 ± 0.247
4.078LysGlu: 4.078 ± 0.278
3.367LysPhe: 3.367 ± 0.266
3.648LysGly: 3.648 ± 0.281
1.758LysHis: 1.758 ± 0.174
4.433LysIle: 4.433 ± 0.269
3.853LysLys: 3.853 ± 0.348
5.499LysLeu: 5.499 ± 0.367
2.637LysMet: 2.637 ± 0.266
3.778LysAsn: 3.778 ± 0.296
2.619LysPro: 2.619 ± 0.231
2.376LysGln: 2.376 ± 0.21
3.068LysArg: 3.068 ± 0.282
4.171LysSer: 4.171 ± 0.284
3.778LysThr: 3.778 ± 0.296
3.909LysVal: 3.909 ± 0.263
0.917LysTrp: 0.917 ± 0.148
2.432LysTyr: 2.432 ± 0.243
0.0LysXaa: 0.0 ± 0.0
Leu
5.686LeuAla: 5.686 ± 0.395
0.935LeuCys: 0.935 ± 0.159
4.377LeuAsp: 4.377 ± 0.303
4.789LeuGlu: 4.789 ± 0.287
3.049LeuPhe: 3.049 ± 0.279
4.471LeuGly: 4.471 ± 0.223
1.422LeuHis: 1.422 ± 0.161
4.19LeuIle: 4.19 ± 0.245
4.901LeuLys: 4.901 ± 0.265
4.396LeuLeu: 4.396 ± 0.261
2.357LeuMet: 2.357 ± 0.217
4.34LeuAsn: 4.34 ± 0.278
3.124LeuPro: 3.124 ± 0.238
2.17LeuGln: 2.17 ± 0.195
4.04LeuArg: 4.04 ± 0.274
4.901LeuSer: 4.901 ± 0.278
4.022LeuThr: 4.022 ± 0.339
5.05LeuVal: 5.05 ± 0.374
0.599LeuTrp: 0.599 ± 0.106
2.806LeuTyr: 2.806 ± 0.259
0.0LeuXaa: 0.0 ± 0.0
Met
2.544MetAla: 2.544 ± 0.199
0.318MetCys: 0.318 ± 0.076
1.515MetAsp: 1.515 ± 0.168
1.777MetGlu: 1.777 ± 0.202
1.571MetPhe: 1.571 ± 0.165
1.44MetGly: 1.44 ± 0.186
0.767MetHis: 0.767 ± 0.116
2.207MetIle: 2.207 ± 0.196
2.581MetLys: 2.581 ± 0.236
2.282MetLeu: 2.282 ± 0.197
1.029MetMet: 1.029 ± 0.134
1.665MetAsn: 1.665 ± 0.175
1.422MetPro: 1.422 ± 0.163
1.291MetGln: 1.291 ± 0.161
1.459MetArg: 1.459 ± 0.139
2.301MetSer: 2.301 ± 0.221
1.852MetThr: 1.852 ± 0.194
1.852MetVal: 1.852 ± 0.164
0.281MetTrp: 0.281 ± 0.073
0.991MetTyr: 0.991 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
3.797AsnAla: 3.797 ± 0.259
0.449AsnCys: 0.449 ± 0.097
2.843AsnAsp: 2.843 ± 0.235
3.142AsnGlu: 3.142 ± 0.242
2.226AsnPhe: 2.226 ± 0.215
4.583AsnGly: 4.583 ± 0.386
1.235AsnHis: 1.235 ± 0.153
4.003AsnIle: 4.003 ± 0.288
3.273AsnLys: 3.273 ± 0.23
3.666AsnLeu: 3.666 ± 0.208
1.553AsnMet: 1.553 ± 0.187
2.768AsnAsn: 2.768 ± 0.216
2.787AsnPro: 2.787 ± 0.203
2.076AsnGln: 2.076 ± 0.2
2.45AsnArg: 2.45 ± 0.216
3.18AsnSer: 3.18 ± 0.22
3.105AsnThr: 3.105 ± 0.248
3.517AsnVal: 3.517 ± 0.227
0.767AsnTrp: 0.767 ± 0.105
1.758AsnTyr: 1.758 ± 0.144
0.0AsnXaa: 0.0 ± 0.0
Pro
2.993ProAla: 2.993 ± 0.23
0.281ProCys: 0.281 ± 0.075
2.394ProAsp: 2.394 ± 0.208
3.03ProGlu: 3.03 ± 0.263
1.646ProPhe: 1.646 ± 0.155
2.862ProGly: 2.862 ± 0.24
0.673ProHis: 0.673 ± 0.107
2.058ProIle: 2.058 ± 0.221
2.544ProLys: 2.544 ± 0.209
2.189ProLeu: 2.189 ± 0.211
1.029ProMet: 1.029 ± 0.128
2.114ProAsn: 2.114 ± 0.217
0.898ProPro: 0.898 ± 0.155
0.917ProGln: 0.917 ± 0.124
1.59ProArg: 1.59 ± 0.174
2.151ProSer: 2.151 ± 0.206
2.301ProThr: 2.301 ± 0.206
2.787ProVal: 2.787 ± 0.222
0.58ProTrp: 0.58 ± 0.121
1.422ProTyr: 1.422 ± 0.169
0.0ProXaa: 0.0 ± 0.0
Gln
2.488GlnAla: 2.488 ± 0.259
0.337GlnCys: 0.337 ± 0.092
1.478GlnAsp: 1.478 ± 0.181
1.908GlnGlu: 1.908 ± 0.193
1.721GlnPhe: 1.721 ± 0.167
2.058GlnGly: 2.058 ± 0.178
0.767GlnHis: 0.767 ± 0.115
2.637GlnIle: 2.637 ± 0.247
2.226GlnLys: 2.226 ± 0.184
3.479GlnLeu: 3.479 ± 0.277
1.178GlnMet: 1.178 ± 0.161
1.44GlnAsn: 1.44 ± 0.175
0.917GlnPro: 0.917 ± 0.133
1.235GlnGln: 1.235 ± 0.149
1.403GlnArg: 1.403 ± 0.155
2.245GlnSer: 2.245 ± 0.209
2.151GlnThr: 2.151 ± 0.246
2.563GlnVal: 2.563 ± 0.245
0.486GlnTrp: 0.486 ± 0.085
1.496GlnTyr: 1.496 ± 0.171
0.0GlnXaa: 0.0 ± 0.0
Arg
2.955ArgAla: 2.955 ± 0.251
0.636ArgCys: 0.636 ± 0.109
3.105ArgAsp: 3.105 ± 0.271
3.442ArgGlu: 3.442 ± 0.241
2.413ArgPhe: 2.413 ± 0.199
2.937ArgGly: 2.937 ± 0.259
1.029ArgHis: 1.029 ± 0.154
3.76ArgIle: 3.76 ± 0.248
2.862ArgLys: 2.862 ± 0.255
3.984ArgLeu: 3.984 ± 0.284
1.291ArgMet: 1.291 ± 0.155
2.394ArgAsn: 2.394 ± 0.213
1.496ArgPro: 1.496 ± 0.164
2.039ArgGln: 2.039 ± 0.22
2.563ArgArg: 2.563 ± 0.281
2.824ArgSer: 2.824 ± 0.225
2.525ArgThr: 2.525 ± 0.23
2.899ArgVal: 2.899 ± 0.255
0.935ArgTrp: 0.935 ± 0.119
1.983ArgTyr: 1.983 ± 0.229
0.0ArgXaa: 0.0 ± 0.0
Ser
3.872SerAla: 3.872 ± 0.333
0.673SerCys: 0.673 ± 0.104
4.134SerAsp: 4.134 ± 0.276
3.872SerGlu: 3.872 ± 0.242
2.787SerPhe: 2.787 ± 0.244
4.714SerGly: 4.714 ± 0.421
1.178SerHis: 1.178 ± 0.15
4.845SerIle: 4.845 ± 0.289
3.666SerLys: 3.666 ± 0.259
4.134SerLeu: 4.134 ± 0.239
1.702SerMet: 1.702 ± 0.199
3.348SerAsn: 3.348 ± 0.233
2.207SerPro: 2.207 ± 0.198
2.338SerGln: 2.338 ± 0.207
3.33SerArg: 3.33 ± 0.275
4.377SerSer: 4.377 ± 0.362
3.76SerThr: 3.76 ± 0.342
4.171SerVal: 4.171 ± 0.332
0.954SerTrp: 0.954 ± 0.141
2.656SerTyr: 2.656 ± 0.227
0.0SerXaa: 0.0 ± 0.0
Thr
3.797ThrAla: 3.797 ± 0.348
0.412ThrCys: 0.412 ± 0.084
3.517ThrAsp: 3.517 ± 0.269
3.217ThrGlu: 3.217 ± 0.244
2.675ThrPhe: 2.675 ± 0.211
4.62ThrGly: 4.62 ± 0.302
1.16ThrHis: 1.16 ± 0.146
4.283ThrIle: 4.283 ± 0.304
3.33ThrLys: 3.33 ± 0.26
4.265ThrLeu: 4.265 ± 0.318
1.646ThrMet: 1.646 ± 0.161
2.881ThrAsn: 2.881 ± 0.277
3.124ThrPro: 3.124 ± 0.282
1.983ThrGln: 1.983 ± 0.243
2.881ThrArg: 2.881 ± 0.232
3.591ThrSer: 3.591 ± 0.289
3.142ThrThr: 3.142 ± 0.287
3.722ThrVal: 3.722 ± 0.265
0.842ThrTrp: 0.842 ± 0.118
2.001ThrTyr: 2.001 ± 0.216
0.0ThrXaa: 0.0 ± 0.0
Val
4.321ValAla: 4.321 ± 0.286
0.748ValCys: 0.748 ± 0.114
4.658ValAsp: 4.658 ± 0.33
5.499ValGlu: 5.499 ± 0.379
2.955ValPhe: 2.955 ± 0.265
4.433ValGly: 4.433 ± 0.354
1.122ValHis: 1.122 ± 0.154
4.414ValIle: 4.414 ± 0.28
5.088ValLys: 5.088 ± 0.285
4.377ValLeu: 4.377 ± 0.269
2.058ValMet: 2.058 ± 0.212
3.722ValAsn: 3.722 ± 0.284
2.263ValPro: 2.263 ± 0.193
2.039ValGln: 2.039 ± 0.212
3.068ValArg: 3.068 ± 0.28
4.321ValSer: 4.321 ± 0.281
3.778ValThr: 3.778 ± 0.349
4.994ValVal: 4.994 ± 0.381
0.842ValTrp: 0.842 ± 0.131
3.086ValTyr: 3.086 ± 0.29
0.0ValXaa: 0.0 ± 0.0
Trp
0.991TrpAla: 0.991 ± 0.127
0.318TrpCys: 0.318 ± 0.08
1.029TrpAsp: 1.029 ± 0.144
1.01TrpGlu: 1.01 ± 0.129
0.767TrpPhe: 0.767 ± 0.103
0.505TrpGly: 0.505 ± 0.106
0.262TrpHis: 0.262 ± 0.069
0.804TrpIle: 0.804 ± 0.118
1.066TrpLys: 1.066 ± 0.164
1.216TrpLeu: 1.216 ± 0.176
0.636TrpMet: 0.636 ± 0.102
0.561TrpAsn: 0.561 ± 0.108
0.468TrpPro: 0.468 ± 0.104
0.617TrpGln: 0.617 ± 0.117
0.636TrpArg: 0.636 ± 0.122
0.898TrpSer: 0.898 ± 0.146
0.804TrpThr: 0.804 ± 0.112
0.86TrpVal: 0.86 ± 0.12
0.187TrpTrp: 0.187 ± 0.052
0.655TrpTyr: 0.655 ± 0.105
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.544TyrAla: 2.544 ± 0.164
0.393TyrCys: 0.393 ± 0.08
3.012TyrAsp: 3.012 ± 0.24
2.432TyrGlu: 2.432 ± 0.216
1.777TyrPhe: 1.777 ± 0.21
2.413TyrGly: 2.413 ± 0.204
0.991TyrHis: 0.991 ± 0.145
2.637TyrIle: 2.637 ± 0.209
2.301TyrLys: 2.301 ± 0.199
2.45TyrLeu: 2.45 ± 0.229
1.16TyrMet: 1.16 ± 0.155
2.357TyrAsn: 2.357 ± 0.212
1.59TyrPro: 1.59 ± 0.175
1.291TyrGln: 1.291 ± 0.137
1.927TyrArg: 1.927 ± 0.193
2.544TyrSer: 2.544 ± 0.228
2.301TyrThr: 2.301 ± 0.187
2.768TyrVal: 2.768 ± 0.235
0.617TyrTrp: 0.617 ± 0.107
1.141TyrTyr: 1.141 ± 0.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 252 proteins (53462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski