Amino acid dipepetide frequency for Eggerthia catenaformis OT 569 = DSM 20559

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.835AlaAla: 3.835 ± 0.121
0.773AlaCys: 0.773 ± 0.039
3.322AlaAsp: 3.322 ± 0.078
2.861AlaGlu: 2.861 ± 0.076
2.629AlaPhe: 2.629 ± 0.068
4.029AlaGly: 4.029 ± 0.095
1.351AlaHis: 1.351 ± 0.051
5.221AlaIle: 5.221 ± 0.113
4.618AlaLys: 4.618 ± 0.113
6.284AlaLeu: 6.284 ± 0.135
1.795AlaMet: 1.795 ± 0.065
2.47AlaAsn: 2.47 ± 0.067
1.391AlaPro: 1.391 ± 0.047
1.655AlaGln: 1.655 ± 0.053
2.145AlaArg: 2.145 ± 0.068
3.982AlaSer: 3.982 ± 0.091
2.443AlaThr: 2.443 ± 0.068
4.063AlaVal: 4.063 ± 0.095
0.37AlaTrp: 0.37 ± 0.028
2.779AlaTyr: 2.779 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.622CysAla: 0.622 ± 0.034
0.189CysCys: 0.189 ± 0.017
0.681CysAsp: 0.681 ± 0.036
0.619CysGlu: 0.619 ± 0.038
0.612CysPhe: 0.612 ± 0.036
0.946CysGly: 0.946 ± 0.048
0.373CysHis: 0.373 ± 0.025
1.158CysIle: 1.158 ± 0.056
0.684CysLys: 0.684 ± 0.042
1.193CysLeu: 1.193 ± 0.054
0.281CysMet: 0.281 ± 0.021
0.467CysAsn: 0.467 ± 0.028
0.417CysPro: 0.417 ± 0.028
0.377CysGln: 0.377 ± 0.025
0.41CysArg: 0.41 ± 0.027
0.737CysSer: 0.737 ± 0.034
0.527CysThr: 0.527 ± 0.033
0.652CysVal: 0.652 ± 0.037
0.058CysTrp: 0.058 ± 0.011
0.49CysTyr: 0.49 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
3.112AspAla: 3.112 ± 0.083
0.659AspCys: 0.659 ± 0.036
3.287AspAsp: 3.287 ± 0.088
4.411AspGlu: 4.411 ± 0.092
3.002AspPhe: 3.002 ± 0.075
3.396AspGly: 3.396 ± 0.101
1.618AspHis: 1.618 ± 0.054
5.783AspIle: 5.783 ± 0.115
4.917AspLys: 4.917 ± 0.109
5.211AspLeu: 5.211 ± 0.1
1.692AspMet: 1.692 ± 0.055
2.93AspAsn: 2.93 ± 0.068
1.621AspPro: 1.621 ± 0.057
1.888AspGln: 1.888 ± 0.064
2.028AspArg: 2.028 ± 0.062
3.087AspSer: 3.087 ± 0.079
2.684AspThr: 2.684 ± 0.064
3.469AspVal: 3.469 ± 0.084
0.407AspTrp: 0.407 ± 0.026
3.867AspTyr: 3.867 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
4.128GluAla: 4.128 ± 0.088
0.661GluCys: 0.661 ± 0.034
3.964GluAsp: 3.964 ± 0.096
5.651GluGlu: 5.651 ± 0.143
2.528GluPhe: 2.528 ± 0.072
3.471GluGly: 3.471 ± 0.093
1.324GluHis: 1.324 ± 0.055
6.01GluIle: 6.01 ± 0.12
6.733GluLys: 6.733 ± 0.128
6.379GluLeu: 6.379 ± 0.111
2.131GluMet: 2.131 ± 0.065
4.388GluAsn: 4.388 ± 0.099
1.289GluPro: 1.289 ± 0.046
1.765GluGln: 1.765 ± 0.06
2.599GluArg: 2.599 ± 0.081
3.181GluSer: 3.181 ± 0.082
3.474GluThr: 3.474 ± 0.079
3.844GluVal: 3.844 ± 0.089
0.499GluTrp: 0.499 ± 0.031
3.211GluTyr: 3.211 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.29PheAla: 2.29 ± 0.078
0.479PheCys: 0.479 ± 0.03
2.855PheAsp: 2.855 ± 0.073
2.679PheGlu: 2.679 ± 0.071
2.063PhePhe: 2.063 ± 0.071
2.64PheGly: 2.64 ± 0.084
0.964PheHis: 0.964 ± 0.044
4.537PheIle: 4.537 ± 0.105
3.503PheLys: 3.503 ± 0.078
3.812PheLeu: 3.812 ± 0.097
1.25PheMet: 1.25 ± 0.05
2.691PheAsn: 2.691 ± 0.06
1.222PhePro: 1.222 ± 0.045
1.022PheGln: 1.022 ± 0.041
1.246PheArg: 1.246 ± 0.046
3.117PheSer: 3.117 ± 0.086
2.35PheThr: 2.35 ± 0.06
2.656PheVal: 2.656 ± 0.068
0.272PheTrp: 0.272 ± 0.027
2.162PheTyr: 2.162 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
3.642GlyAla: 3.642 ± 0.096
0.881GlyCys: 0.881 ± 0.038
3.034GlyAsp: 3.034 ± 0.075
3.568GlyGlu: 3.568 ± 0.103
2.983GlyPhe: 2.983 ± 0.074
3.884GlyGly: 3.884 ± 0.122
1.524GlyHis: 1.524 ± 0.051
6.031GlyIle: 6.031 ± 0.118
5.097GlyLys: 5.097 ± 0.114
5.409GlyLeu: 5.409 ± 0.116
1.86GlyMet: 1.86 ± 0.062
2.914GlyAsn: 2.914 ± 0.079
1.109GlyPro: 1.109 ± 0.05
1.747GlyGln: 1.747 ± 0.051
2.245GlyArg: 2.245 ± 0.068
3.465GlySer: 3.465 ± 0.094
3.418GlyThr: 3.418 ± 0.088
3.6GlyVal: 3.6 ± 0.095
0.523GlyTrp: 0.523 ± 0.032
3.407GlyTyr: 3.407 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
1.119HisAla: 1.119 ± 0.043
0.322HisCys: 0.322 ± 0.025
1.216HisAsp: 1.216 ± 0.044
1.135HisGlu: 1.135 ± 0.049
1.215HisPhe: 1.215 ± 0.046
1.202HisGly: 1.202 ± 0.049
0.829HisHis: 0.829 ± 0.048
2.272HisIle: 2.272 ± 0.078
1.54HisLys: 1.54 ± 0.047
2.32HisLeu: 2.32 ± 0.071
0.649HisMet: 0.649 ± 0.036
1.086HisAsn: 1.086 ± 0.044
0.99HisPro: 0.99 ± 0.037
1.027HisGln: 1.027 ± 0.044
0.808HisArg: 0.808 ± 0.042
1.321HisSer: 1.321 ± 0.051
1.3HisThr: 1.3 ± 0.05
1.188HisVal: 1.188 ± 0.052
0.15HisTrp: 0.15 ± 0.019
1.333HisTyr: 1.333 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
5.752IleAla: 5.752 ± 0.12
1.16IleCys: 1.16 ± 0.044
5.739IleAsp: 5.739 ± 0.101
6.231IleGlu: 6.231 ± 0.121
3.8IlePhe: 3.8 ± 0.101
5.642IleGly: 5.642 ± 0.138
2.09IleHis: 2.09 ± 0.071
8.476IleIle: 8.476 ± 0.186
7.744IleLys: 7.744 ± 0.133
8.298IleLeu: 8.298 ± 0.16
2.261IleMet: 2.261 ± 0.068
4.77IleAsn: 4.77 ± 0.086
3.276IlePro: 3.276 ± 0.083
2.544IleGln: 2.544 ± 0.074
3.414IleArg: 3.414 ± 0.082
6.224IleSer: 6.224 ± 0.121
4.86IleThr: 4.86 ± 0.087
5.469IleVal: 5.469 ± 0.111
0.516IleTrp: 0.516 ± 0.029
3.911IleTyr: 3.911 ± 0.09
0.0IleXaa: 0.0 ± 0.0
Lys
5.447LysAla: 5.447 ± 0.109
0.622LysCys: 0.622 ± 0.037
5.918LysAsp: 5.918 ± 0.116
8.867LysGlu: 8.867 ± 0.148
2.184LysPhe: 2.184 ± 0.066
4.899LysGly: 4.899 ± 0.083
1.545LysHis: 1.545 ± 0.047
6.973LysIle: 6.973 ± 0.113
8.95LysLys: 8.95 ± 0.142
6.077LysLeu: 6.077 ± 0.111
2.399LysMet: 2.399 ± 0.061
5.437LysAsn: 5.437 ± 0.105
2.125LysPro: 2.125 ± 0.066
2.979LysGln: 2.979 ± 0.077
3.312LysArg: 3.312 ± 0.076
4.42LysSer: 4.42 ± 0.112
4.905LysThr: 4.905 ± 0.098
4.657LysVal: 4.657 ± 0.1
0.638LysTrp: 0.638 ± 0.035
3.824LysTyr: 3.824 ± 0.092
0.0LysXaa: 0.0 ± 0.0
Leu
5.405LeuAla: 5.405 ± 0.111
1.16LeuCys: 1.16 ± 0.051
5.571LeuAsp: 5.571 ± 0.112
6.043LeuGlu: 6.043 ± 0.129
4.372LeuPhe: 4.372 ± 0.106
5.41LeuGly: 5.41 ± 0.115
1.701LeuHis: 1.701 ± 0.058
8.075LeuIle: 8.075 ± 0.158
8.724LeuLys: 8.724 ± 0.112
8.92LeuLeu: 8.92 ± 0.172
2.774LeuMet: 2.774 ± 0.074
5.223LeuAsn: 5.223 ± 0.105
3.066LeuPro: 3.066 ± 0.067
2.348LeuGln: 2.348 ± 0.074
3.329LeuArg: 3.329 ± 0.07
7.323LeuSer: 7.323 ± 0.132
4.837LeuThr: 4.837 ± 0.089
4.689LeuVal: 4.689 ± 0.091
0.598LeuTrp: 0.598 ± 0.033
3.943LeuTyr: 3.943 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.655MetAla: 1.655 ± 0.057
0.262MetCys: 0.262 ± 0.021
1.533MetAsp: 1.533 ± 0.048
1.607MetGlu: 1.607 ± 0.055
1.029MetPhe: 1.029 ± 0.044
1.62MetGly: 1.62 ± 0.052
0.52MetHis: 0.52 ± 0.031
3.151MetIle: 3.151 ± 0.091
2.774MetLys: 2.774 ± 0.063
2.378MetLeu: 2.378 ± 0.058
0.988MetMet: 0.988 ± 0.051
2.148MetAsn: 2.148 ± 0.067
0.967MetPro: 0.967 ± 0.043
0.81MetGln: 0.81 ± 0.039
0.93MetArg: 0.93 ± 0.041
1.881MetSer: 1.881 ± 0.058
1.614MetThr: 1.614 ± 0.053
1.317MetVal: 1.317 ± 0.05
0.124MetTrp: 0.124 ± 0.013
0.98MetTyr: 0.98 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.997AsnAla: 2.997 ± 0.089
0.499AsnCys: 0.499 ± 0.028
3.296AsnAsp: 3.296 ± 0.078
3.715AsnGlu: 3.715 ± 0.087
1.754AsnPhe: 1.754 ± 0.064
3.446AsnGly: 3.446 ± 0.092
1.482AsnHis: 1.482 ± 0.05
5.0AsnIle: 5.0 ± 0.097
5.212AsnLys: 5.212 ± 0.107
4.231AsnLeu: 4.231 ± 0.082
1.376AsnMet: 1.376 ± 0.049
3.154AsnAsn: 3.154 ± 0.087
1.954AsnPro: 1.954 ± 0.062
2.106AsnGln: 2.106 ± 0.07
2.003AsnArg: 2.003 ± 0.058
2.815AsnSer: 2.815 ± 0.08
2.836AsnThr: 2.836 ± 0.083
2.878AsnVal: 2.878 ± 0.07
0.438AsnTrp: 0.438 ± 0.032
2.666AsnTyr: 2.666 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.593ProAla: 1.593 ± 0.05
0.316ProCys: 0.316 ± 0.024
1.837ProAsp: 1.837 ± 0.058
2.109ProGlu: 2.109 ± 0.072
1.381ProPhe: 1.381 ± 0.053
1.593ProGly: 1.593 ± 0.055
0.714ProHis: 0.714 ± 0.036
2.484ProIle: 2.484 ± 0.062
1.933ProLys: 1.933 ± 0.067
2.864ProLeu: 2.864 ± 0.077
0.698ProMet: 0.698 ± 0.035
1.314ProAsn: 1.314 ± 0.047
0.47ProPro: 0.47 ± 0.024
0.888ProGln: 0.888 ± 0.041
0.886ProArg: 0.886 ± 0.042
1.869ProSer: 1.869 ± 0.053
1.294ProThr: 1.294 ± 0.05
2.074ProVal: 2.074 ± 0.057
0.228ProTrp: 0.228 ± 0.019
1.549ProTyr: 1.549 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
1.966GlnAla: 1.966 ± 0.056
0.308GlnCys: 0.308 ± 0.027
1.475GlnAsp: 1.475 ± 0.049
2.316GlnGlu: 2.316 ± 0.078
1.218GlnPhe: 1.218 ± 0.042
1.902GlnGly: 1.902 ± 0.055
0.414GlnHis: 0.414 ± 0.028
2.836GlnIle: 2.836 ± 0.075
2.638GlnLys: 2.638 ± 0.071
3.016GlnLeu: 3.016 ± 0.069
1.086GlnMet: 1.086 ± 0.041
1.519GlnAsn: 1.519 ± 0.058
0.686GlnPro: 0.686 ± 0.033
0.916GlnGln: 0.916 ± 0.042
1.391GlnArg: 1.391 ± 0.041
1.904GlnSer: 1.904 ± 0.069
1.643GlnThr: 1.643 ± 0.056
1.664GlnVal: 1.664 ± 0.049
0.301GlnTrp: 0.301 ± 0.023
1.535GlnTyr: 1.535 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
1.747ArgAla: 1.747 ± 0.06
0.438ArgCys: 0.438 ± 0.028
2.023ArgAsp: 2.023 ± 0.062
2.661ArgGlu: 2.661 ± 0.079
1.674ArgPhe: 1.674 ± 0.055
1.984ArgGly: 1.984 ± 0.061
0.905ArgHis: 0.905 ± 0.042
3.444ArgIle: 3.444 ± 0.088
3.442ArgLys: 3.442 ± 0.088
3.46ArgLeu: 3.46 ± 0.077
1.155ArgMet: 1.155 ± 0.044
2.017ArgAsn: 2.017 ± 0.064
0.932ArgPro: 0.932 ± 0.045
1.243ArgGln: 1.243 ± 0.051
1.473ArgArg: 1.473 ± 0.056
1.825ArgSer: 1.825 ± 0.057
1.711ArgThr: 1.711 ± 0.052
2.123ArgVal: 2.123 ± 0.062
0.269ArgTrp: 0.269 ± 0.022
1.991ArgTyr: 1.991 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
3.419SerAla: 3.419 ± 0.086
0.633SerCys: 0.633 ± 0.033
3.425SerAsp: 3.425 ± 0.083
3.349SerGlu: 3.349 ± 0.075
3.395SerPhe: 3.395 ± 0.079
4.111SerGly: 4.111 ± 0.101
1.65SerHis: 1.65 ± 0.06
5.767SerIle: 5.767 ± 0.108
4.8SerLys: 4.8 ± 0.105
6.894SerLeu: 6.894 ± 0.136
1.717SerMet: 1.717 ± 0.06
2.809SerAsn: 2.809 ± 0.071
1.519SerPro: 1.519 ± 0.05
2.215SerGln: 2.215 ± 0.068
2.306SerArg: 2.306 ± 0.069
4.302SerSer: 4.302 ± 0.117
2.527SerThr: 2.527 ± 0.074
3.824SerVal: 3.824 ± 0.09
0.435SerTrp: 0.435 ± 0.031
3.343SerTyr: 3.343 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
3.126ThrAla: 3.126 ± 0.085
0.507ThrCys: 0.507 ± 0.032
3.115ThrAsp: 3.115 ± 0.067
2.666ThrGlu: 2.666 ± 0.073
2.222ThrPhe: 2.222 ± 0.062
3.701ThrGly: 3.701 ± 0.092
1.163ThrHis: 1.163 ± 0.042
4.855ThrIle: 4.855 ± 0.093
3.777ThrLys: 3.777 ± 0.09
5.076ThrLeu: 5.076 ± 0.106
1.183ThrMet: 1.183 ± 0.047
2.5ThrAsn: 2.5 ± 0.08
1.74ThrPro: 1.74 ± 0.052
1.457ThrGln: 1.457 ± 0.051
1.742ThrArg: 1.742 ± 0.059
3.211ThrSer: 3.211 ± 0.086
2.268ThrThr: 2.268 ± 0.068
3.95ThrVal: 3.95 ± 0.09
0.38ThrTrp: 0.38 ± 0.032
2.231ThrTyr: 2.231 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
3.227ValAla: 3.227 ± 0.081
0.831ValCys: 0.831 ± 0.043
3.142ValAsp: 3.142 ± 0.08
3.559ValGlu: 3.559 ± 0.094
3.023ValPhe: 3.023 ± 0.086
3.165ValGly: 3.165 ± 0.081
1.124ValHis: 1.124 ± 0.051
5.529ValIle: 5.529 ± 0.114
4.898ValLys: 4.898 ± 0.098
5.996ValLeu: 5.996 ± 0.098
1.609ValMet: 1.609 ± 0.048
3.122ValAsn: 3.122 ± 0.084
1.694ValPro: 1.694 ± 0.056
1.278ValGln: 1.278 ± 0.045
2.095ValArg: 2.095 ± 0.057
4.372ValSer: 4.372 ± 0.096
3.273ValThr: 3.273 ± 0.084
3.434ValVal: 3.434 ± 0.093
0.375ValTrp: 0.375 ± 0.029
2.633ValTyr: 2.633 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.368TrpAla: 0.368 ± 0.027
0.106TrpCys: 0.106 ± 0.014
0.488TrpAsp: 0.488 ± 0.033
0.322TrpGlu: 0.322 ± 0.027
0.341TrpPhe: 0.341 ± 0.026
0.483TrpGly: 0.483 ± 0.036
0.17TrpHis: 0.17 ± 0.019
0.663TrpIle: 0.663 ± 0.034
0.591TrpLys: 0.591 ± 0.037
0.654TrpLeu: 0.654 ± 0.037
0.203TrpMet: 0.203 ± 0.024
0.465TrpAsn: 0.465 ± 0.031
0.136TrpPro: 0.136 ± 0.017
0.265TrpGln: 0.265 ± 0.022
0.24TrpArg: 0.24 ± 0.019
0.355TrpSer: 0.355 ± 0.025
0.341TrpThr: 0.341 ± 0.027
0.354TrpVal: 0.354 ± 0.026
0.083TrpTrp: 0.083 ± 0.013
0.401TrpTyr: 0.401 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.565TyrAla: 2.565 ± 0.062
0.688TyrCys: 0.688 ± 0.041
3.149TyrAsp: 3.149 ± 0.073
2.861TyrGlu: 2.861 ± 0.088
2.383TyrPhe: 2.383 ± 0.078
2.817TyrGly: 2.817 ± 0.078
1.561TyrHis: 1.561 ± 0.059
3.913TyrIle: 3.913 ± 0.087
3.605TyrLys: 3.605 ± 0.099
5.041TyrLeu: 5.041 ± 0.101
1.179TyrMet: 1.179 ± 0.045
2.433TyrAsn: 2.433 ± 0.066
1.49TyrPro: 1.49 ± 0.056
2.203TyrGln: 2.203 ± 0.078
1.915TyrArg: 1.915 ± 0.063
3.048TyrSer: 3.048 ± 0.07
2.565TyrThr: 2.565 ± 0.079
2.474TyrVal: 2.474 ± 0.062
0.366TyrTrp: 0.366 ± 0.027
2.686TyrTyr: 2.686 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1874 proteins (565588 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski