Amino acid dipepetide frequency for Pseudozyma antarctica (Yeast) (Candida antarctica)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.007AlaAla: 17.007 ± 0.159	1.085AlaCys: 1.085 ± 0.021	6.272AlaAsp: 6.272 ± 0.058	6.141AlaGlu: 6.141 ± 0.06	3.378AlaPhe: 3.378 ± 0.037	7.786AlaGly: 7.786 ± 0.074	2.797AlaHis: 2.797 ± 0.035	4.006AlaIle: 4.006 ± 0.039	4.977AlaLys: 4.977 ± 0.067	9.425AlaLeu: 9.425 ± 0.075	2.203AlaMet: 2.203 ± 0.028	3.514AlaAsn: 3.514 ± 0.039	7.447AlaPro: 7.447 ± 0.085	5.038AlaGln: 5.038 ± 0.058	7.26AlaArg: 7.26 ± 0.064	13.082AlaSer: 13.082 ± 0.108	6.709AlaThr: 6.709 ± 0.066	6.237AlaVal: 6.237 ± 0.048	1.258AlaTrp: 1.258 ± 0.024	2.236AlaTyr: 2.236 ± 0.032	0.002AlaXaa: 0.002 ± 0.001
Cys	0.937CysAla: 0.937 ± 0.021	0.179CysCys: 0.179 ± 0.008	0.542CysAsp: 0.542 ± 0.013	0.408CysGlu: 0.408 ± 0.012	0.427CysPhe: 0.427 ± 0.012	0.692CysGly: 0.692 ± 0.014	0.266CysHis: 0.266 ± 0.01	0.546CysIle: 0.546 ± 0.014	0.386CysLys: 0.386 ± 0.012	1.009CysLeu: 1.009 ± 0.021	0.202CysMet: 0.202 ± 0.008	0.327CysAsn: 0.327 ± 0.01	0.533CysPro: 0.533 ± 0.015	0.335CysGln: 0.335 ± 0.012	0.643CysArg: 0.643 ± 0.016	0.815CysSer: 0.815 ± 0.018	0.616CysThr: 0.616 ± 0.015	0.629CysVal: 0.629 ± 0.016	0.148CysTrp: 0.148 ± 0.008	0.252CysTyr: 0.252 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.67AspAla: 7.67 ± 0.07	0.464AspCys: 0.464 ± 0.013	5.295AspAsp: 5.295 ± 0.088	4.649AspGlu: 4.649 ± 0.054	1.762AspPhe: 1.762 ± 0.027	4.009AspGly: 4.009 ± 0.039	1.311AspHis: 1.311 ± 0.023	2.005AspIle: 2.005 ± 0.029	2.243AspLys: 2.243 ± 0.036	4.712AspLeu: 4.712 ± 0.046	1.065AspMet: 1.065 ± 0.018	1.418AspAsn: 1.418 ± 0.022	3.376AspPro: 3.376 ± 0.034	1.963AspGln: 1.963 ± 0.025	3.275AspArg: 3.275 ± 0.039	4.279AspSer: 4.279 ± 0.052	2.872AspThr: 2.872 ± 0.033	3.72AspVal: 3.72 ± 0.039	0.744AspTrp: 0.744 ± 0.017	1.207AspTyr: 1.207 ± 0.02	0.001AspXaa: 0.001 ± 0.001
Glu	6.469GluAla: 6.469 ± 0.067	0.466GluCys: 0.466 ± 0.014	3.389GluAsp: 3.389 ± 0.049	4.069GluGlu: 4.069 ± 0.061	1.425GluPhe: 1.425 ± 0.025	3.085GluGly: 3.085 ± 0.04	1.43GluHis: 1.43 ± 0.025	1.995GluIle: 1.995 ± 0.029	2.4GluLys: 2.4 ± 0.039	5.238GluLeu: 5.238 ± 0.063	1.226GluMet: 1.226 ± 0.019	1.241GluAsn: 1.241 ± 0.021	2.686GluPro: 2.686 ± 0.033	2.612GluGln: 2.612 ± 0.035	4.089GluArg: 4.089 ± 0.049	3.935GluSer: 3.935 ± 0.042	2.678GluThr: 2.678 ± 0.034	3.085GluVal: 3.085 ± 0.042	0.707GluTrp: 0.707 ± 0.016	1.166GluTyr: 1.166 ± 0.022	0.001GluXaa: 0.001 ± 0.001
Phe	3.401PheAla: 3.401 ± 0.039	0.421PheCys: 0.421 ± 0.012	2.08PheAsp: 2.08 ± 0.032	1.787PheGlu: 1.787 ± 0.026	1.282PhePhe: 1.282 ± 0.028	2.856PheGly: 2.856 ± 0.05	0.783PheHis: 0.783 ± 0.016	1.156PheIle: 1.156 ± 0.023	1.117PheLys: 1.117 ± 0.023	2.766PheLeu: 2.766 ± 0.039	0.568PheMet: 0.568 ± 0.015	1.059PheAsn: 1.059 ± 0.02	1.523PhePro: 1.523 ± 0.027	1.06PheGln: 1.06 ± 0.021	1.844PheArg: 1.844 ± 0.028	2.627PheSer: 2.627 ± 0.037	1.612PheThr: 1.612 ± 0.027	2.258PheVal: 2.258 ± 0.035	0.479PheTrp: 0.479 ± 0.014	0.842PheTyr: 0.842 ± 0.021	0.001PheXaa: 0.001 ± 0.001
Gly	7.609GlyAla: 7.609 ± 0.073	0.679GlyCys: 0.679 ± 0.017	3.382GlyAsp: 3.382 ± 0.042	3.314GlyGlu: 3.314 ± 0.035	2.42GlyPhe: 2.42 ± 0.037	6.198GlyGly: 6.198 ± 0.089	1.65GlyHis: 1.65 ± 0.031	2.7GlyIle: 2.7 ± 0.038	3.126GlyLys: 3.126 ± 0.038	5.71GlyLeu: 5.71 ± 0.047	1.513GlyMet: 1.513 ± 0.03	1.997GlyAsn: 1.997 ± 0.05	3.325GlyPro: 3.325 ± 0.045	2.491GlyGln: 2.491 ± 0.039	4.238GlyArg: 4.238 ± 0.042	6.836GlySer: 6.836 ± 0.069	3.738GlyThr: 3.738 ± 0.044	4.126GlyVal: 4.126 ± 0.046	1.038GlyTrp: 1.038 ± 0.022	1.674GlyTyr: 1.674 ± 0.031	0.002GlyXaa: 0.002 ± 0.001
His	3.07HisAla: 3.07 ± 0.037	0.275HisCys: 0.275 ± 0.009	1.583HisAsp: 1.583 ± 0.027	1.282HisGlu: 1.282 ± 0.023	0.883HisPhe: 0.883 ± 0.019	1.681HisGly: 1.681 ± 0.028	1.146HisHis: 1.146 ± 0.031	1.028HisIle: 1.028 ± 0.022	0.853HisLys: 0.853 ± 0.018	2.446HisLeu: 2.446 ± 0.035	0.462HisMet: 0.462 ± 0.013	0.726HisAsn: 0.726 ± 0.016	2.047HisPro: 2.047 ± 0.03	1.112HisGln: 1.112 ± 0.025	1.861HisArg: 1.861 ± 0.027	2.171HisSer: 2.171 ± 0.029	1.458HisThr: 1.458 ± 0.021	1.486HisVal: 1.486 ± 0.024	0.292HisTrp: 0.292 ± 0.012	0.571HisTyr: 0.571 ± 0.015	0.001HisXaa: 0.001 ± 0.001
Ile	4.029IleAla: 4.029 ± 0.039	0.505IleCys: 0.505 ± 0.016	2.589IleAsp: 2.589 ± 0.032	2.217IleGlu: 2.217 ± 0.029	1.385IlePhe: 1.385 ± 0.029	2.536IleGly: 2.536 ± 0.036	1.005IleHis: 1.005 ± 0.018	1.506IleIle: 1.506 ± 0.029	1.654IleLys: 1.654 ± 0.029	3.265IleLeu: 3.265 ± 0.044	0.692IleMet: 0.692 ± 0.014	1.301IleAsn: 1.301 ± 0.026	2.203IlePro: 2.203 ± 0.029	1.468IleGln: 1.468 ± 0.023	2.402IleArg: 2.402 ± 0.026	3.021IleSer: 3.021 ± 0.039	2.025IleThr: 2.025 ± 0.028	2.617IleVal: 2.617 ± 0.037	0.487IleTrp: 0.487 ± 0.016	0.897IleTyr: 0.897 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.528LysAla: 4.528 ± 0.053	0.336LysCys: 0.336 ± 0.011	2.294LysAsp: 2.294 ± 0.033	2.277LysGlu: 2.277 ± 0.032	0.995LysPhe: 0.995 ± 0.022	2.498LysGly: 2.498 ± 0.039	1.071LysHis: 1.071 ± 0.02	1.6LysIle: 1.6 ± 0.024	2.586LysLys: 2.586 ± 0.048	3.783LysLeu: 3.783 ± 0.045	0.879LysMet: 0.879 ± 0.016	1.166LysAsn: 1.166 ± 0.023	2.649LysPro: 2.649 ± 0.038	1.947LysGln: 1.947 ± 0.033	3.293LysArg: 3.293 ± 0.04	3.048LysSer: 3.048 ± 0.039	2.271LysThr: 2.271 ± 0.03	2.449LysVal: 2.449 ± 0.03	0.48LysTrp: 0.48 ± 0.011	0.892LysTyr: 0.892 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	10.1LeuAla: 10.1 ± 0.074	1.04LeuCys: 1.04 ± 0.02	5.572LeuAsp: 5.572 ± 0.054	4.972LeuGlu: 4.972 ± 0.056	2.885LeuPhe: 2.885 ± 0.039	6.044LeuGly: 6.044 ± 0.054	2.417LeuHis: 2.417 ± 0.033	3.174LeuIle: 3.174 ± 0.039	3.325LeuLys: 3.325 ± 0.042	8.408LeuLeu: 8.408 ± 0.08	1.546LeuMet: 1.546 ± 0.027	2.65LeuAsn: 2.65 ± 0.029	5.894LeuPro: 5.894 ± 0.047	3.649LeuGln: 3.649 ± 0.042	6.154LeuArg: 6.154 ± 0.064	7.493LeuSer: 7.493 ± 0.06	4.517LeuThr: 4.517 ± 0.039	5.701LeuVal: 5.701 ± 0.057	0.927LeuTrp: 0.927 ± 0.02	1.869LeuTyr: 1.869 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.196MetAla: 2.196 ± 0.031	0.182MetCys: 0.182 ± 0.009	1.115MetAsp: 1.115 ± 0.019	0.864MetGlu: 0.864 ± 0.02	0.519MetPhe: 0.519 ± 0.015	1.29MetGly: 1.29 ± 0.025	0.59MetHis: 0.59 ± 0.015	0.707MetIle: 0.707 ± 0.015	0.622MetLys: 0.622 ± 0.016	1.946MetLeu: 1.946 ± 0.028	0.473MetMet: 0.473 ± 0.013	0.534MetAsn: 0.534 ± 0.014	1.356MetPro: 1.356 ± 0.025	0.976MetGln: 0.976 ± 0.022	1.339MetArg: 1.339 ± 0.024	1.788MetSer: 1.788 ± 0.024	1.02MetThr: 1.02 ± 0.02	1.157MetVal: 1.157 ± 0.021	0.216MetTrp: 0.216 ± 0.01	0.419MetTyr: 0.419 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.762AsnAla: 3.762 ± 0.038	0.274AsnCys: 0.274 ± 0.011	1.699AsnAsp: 1.699 ± 0.024	1.457AsnGlu: 1.457 ± 0.022	0.989AsnPhe: 0.989 ± 0.019	2.53AsnGly: 2.53 ± 0.052	0.72AsnHis: 0.72 ± 0.017	1.184AsnIle: 1.184 ± 0.023	1.213AsnLys: 1.213 ± 0.022	2.648AsnLeu: 2.648 ± 0.032	0.644AsnMet: 0.644 ± 0.017	1.049AsnAsn: 1.049 ± 0.029	2.001AsnPro: 2.001 ± 0.031	1.031AsnGln: 1.031 ± 0.023	1.717AsnArg: 1.717 ± 0.025	2.206AsnSer: 2.206 ± 0.034	1.763AsnThr: 1.763 ± 0.028	1.995AsnVal: 1.995 ± 0.031	0.358AsnTrp: 0.358 ± 0.011	0.677AsnTyr: 0.677 ± 0.016	0.001AsnXaa: 0.001 ± 0.0
Pro	7.935ProAla: 7.935 ± 0.086	0.465ProCys: 0.465 ± 0.015	3.085ProAsp: 3.085 ± 0.038	3.043ProGlu: 3.043 ± 0.034	1.935ProPhe: 1.935 ± 0.028	3.969ProGly: 3.969 ± 0.052	1.739ProHis: 1.739 ± 0.026	2.18ProIle: 2.18 ± 0.029	2.347ProLys: 2.347 ± 0.038	5.113ProLeu: 5.113 ± 0.049	1.049ProMet: 1.049 ± 0.022	1.989ProAsn: 1.989 ± 0.035	5.815ProPro: 5.815 ± 0.085	2.533ProGln: 2.533 ± 0.036	3.968ProArg: 3.968 ± 0.049	7.747ProSer: 7.747 ± 0.083	4.416ProThr: 4.416 ± 0.041	3.494ProVal: 3.494 ± 0.043	0.6ProTrp: 0.6 ± 0.013	1.254ProTyr: 1.254 ± 0.021	0.001ProXaa: 0.001 ± 0.001
Gln	4.687GlnAla: 4.687 ± 0.054	0.361GlnCys: 0.361 ± 0.012	2.178GlnAsp: 2.178 ± 0.032	1.958GlnGlu: 1.958 ± 0.031	0.992GlnPhe: 0.992 ± 0.018	2.427GlnGly: 2.427 ± 0.036	1.506GlnHis: 1.506 ± 0.029	1.568GlnIle: 1.568 ± 0.026	1.535GlnLys: 1.535 ± 0.025	4.043GlnLeu: 4.043 ± 0.046	0.875GlnMet: 0.875 ± 0.02	1.161GlnAsn: 1.161 ± 0.022	3.273GlnPro: 3.273 ± 0.046	3.376GlnGln: 3.376 ± 0.114	3.153GlnArg: 3.153 ± 0.033	3.32GlnSer: 3.32 ± 0.038	2.155GlnThr: 2.155 ± 0.028	2.104GlnVal: 2.104 ± 0.03	0.428GlnTrp: 0.428 ± 0.013	0.878GlnTyr: 0.878 ± 0.019	0.001GlnXaa: 0.001 ± 0.0
Arg	6.858ArgAla: 6.858 ± 0.066	0.702ArgCys: 0.702 ± 0.018	3.496ArgAsp: 3.496 ± 0.039	3.414ArgGlu: 3.414 ± 0.046	2.236ArgPhe: 2.236 ± 0.031	3.874ArgGly: 3.874 ± 0.045	1.758ArgHis: 1.758 ± 0.03	2.886ArgIle: 2.886 ± 0.03	3.311ArgLys: 3.311 ± 0.035	5.966ArgLeu: 5.966 ± 0.054	1.334ArgMet: 1.334 ± 0.022	2.115ArgAsn: 2.115 ± 0.028	4.157ArgPro: 4.157 ± 0.051	2.846ArgGln: 2.846 ± 0.036	5.988ArgArg: 5.988 ± 0.071	6.586ArgSer: 6.586 ± 0.08	3.928ArgThr: 3.928 ± 0.039	3.363ArgVal: 3.363 ± 0.034	0.843ArgTrp: 0.843 ± 0.021	1.413ArgTyr: 1.413 ± 0.022	0.001ArgXaa: 0.001 ± 0.001
Ser	11.267SerAla: 11.267 ± 0.102	0.757SerCys: 0.757 ± 0.019	4.82SerAsp: 4.82 ± 0.057	3.916SerGlu: 3.916 ± 0.045	2.871SerPhe: 2.871 ± 0.033	6.178SerGly: 6.178 ± 0.052	2.427SerHis: 2.427 ± 0.033	3.609SerIle: 3.609 ± 0.037	3.488SerLys: 3.488 ± 0.041	7.787SerLeu: 7.787 ± 0.048	1.778SerMet: 1.778 ± 0.03	2.995SerAsn: 2.995 ± 0.036	6.335SerPro: 6.335 ± 0.075	3.562SerGln: 3.562 ± 0.048	6.114SerArg: 6.114 ± 0.076	12.879SerSer: 12.879 ± 0.143	6.783SerThr: 6.783 ± 0.06	4.985SerVal: 4.985 ± 0.04	0.953SerTrp: 0.953 ± 0.019	1.813SerTyr: 1.813 ± 0.03	0.003SerXaa: 0.003 ± 0.001
Thr	6.542ThrAla: 6.542 ± 0.059	0.564ThrCys: 0.564 ± 0.014	2.818ThrAsp: 2.818 ± 0.032	2.444ThrGlu: 2.444 ± 0.033	1.933ThrPhe: 1.933 ± 0.027	3.739ThrGly: 3.739 ± 0.04	1.426ThrHis: 1.426 ± 0.024	2.29ThrIle: 2.29 ± 0.031	2.142ThrLys: 2.142 ± 0.032	5.25ThrLeu: 5.25 ± 0.047	1.057ThrMet: 1.057 ± 0.017	1.754ThrAsn: 1.754 ± 0.025	4.734ThrPro: 4.734 ± 0.06	2.135ThrGln: 2.135 ± 0.027	3.478ThrArg: 3.478 ± 0.04	6.176ThrSer: 6.176 ± 0.058	3.873ThrThr: 3.873 ± 0.047	3.172ThrVal: 3.172 ± 0.039	0.644ThrTrp: 0.644 ± 0.016	1.195ThrTyr: 1.195 ± 0.02	0.002ThrXaa: 0.002 ± 0.001
Val	6.495ValAla: 6.495 ± 0.049	0.702ValCys: 0.702 ± 0.017	3.689ValAsp: 3.689 ± 0.041	3.54ValGlu: 3.54 ± 0.038	1.96ValPhe: 1.96 ± 0.034	4.038ValGly: 4.038 ± 0.047	1.543ValHis: 1.543 ± 0.027	2.143ValIle: 2.143 ± 0.029	2.374ValLys: 2.374 ± 0.033	5.556ValLeu: 5.556 ± 0.061	1.039ValMet: 1.039 ± 0.021	1.648ValAsn: 1.648 ± 0.028	3.575ValPro: 3.575 ± 0.038	2.52ValGln: 2.52 ± 0.031	3.998ValArg: 3.998 ± 0.043	4.644ValSer: 4.644 ± 0.04	2.86ValThr: 2.86 ± 0.033	4.244ValVal: 4.244 ± 0.046	0.814ValTrp: 0.814 ± 0.019	1.385ValTyr: 1.385 ± 0.024	0.001ValXaa: 0.001 ± 0.0
Trp	1.019TrpAla: 1.019 ± 0.021	0.158TrpCys: 0.158 ± 0.008	0.706TrpAsp: 0.706 ± 0.016	0.546TrpGlu: 0.546 ± 0.013	0.409TrpPhe: 0.409 ± 0.013	0.677TrpGly: 0.677 ± 0.017	0.319TrpHis: 0.319 ± 0.011	0.625TrpIle: 0.625 ± 0.017	0.576TrpLys: 0.576 ± 0.014	1.178TrpLeu: 1.178 ± 0.023	0.297TrpMet: 0.297 ± 0.011	0.489TrpAsn: 0.489 ± 0.012	0.567TrpPro: 0.567 ± 0.015	0.544TrpGln: 0.544 ± 0.014	0.829TrpArg: 0.829 ± 0.017	1.061TrpSer: 1.061 ± 0.023	0.815TrpThr: 0.815 ± 0.016	0.589TrpVal: 0.589 ± 0.019	0.221TrpTrp: 0.221 ± 0.009	0.299TrpTyr: 0.299 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.031	0.279TyrCys: 0.279 ± 0.011	1.433TyrAsp: 1.433 ± 0.027	1.097TyrGlu: 1.097 ± 0.025	0.835TyrPhe: 0.835 ± 0.021	1.656TyrGly: 1.656 ± 0.033	0.528TyrHis: 0.528 ± 0.016	0.898TyrIle: 0.898 ± 0.017	0.766TyrLys: 0.766 ± 0.017	2.084TyrLeu: 2.084 ± 0.033	0.409TyrMet: 0.409 ± 0.011	0.785TyrAsn: 0.785 ± 0.018	1.179TyrPro: 1.179 ± 0.024	0.78TyrGln: 0.78 ± 0.019	1.432TyrArg: 1.432 ± 0.027	1.604TyrSer: 1.604 ± 0.026	1.259TyrThr: 1.259 ± 0.022	1.356TyrVal: 1.356 ± 0.022	0.285TyrTrp: 0.285 ± 0.011	0.589TyrTyr: 0.589 ± 0.017	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.022XaaXaa: 0.022 ± 0.009

Statistics based on 4672 proteins (2859900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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