Amino acid dipepetide frequency for Influenza B virus (strain B/Singapore/222/1979)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.215AlaAla: 4.215 ± 0.821
1.984AlaCys: 1.984 ± 0.846
2.727AlaAsp: 2.727 ± 1.237
3.967AlaGlu: 3.967 ± 1.473
0.992AlaPhe: 0.992 ± 0.535
3.471AlaGly: 3.471 ± 0.996
1.24AlaHis: 1.24 ± 0.708
3.719AlaIle: 3.719 ± 0.994
5.455AlaLys: 5.455 ± 1.008
6.943AlaLeu: 6.943 ± 1.208
2.232AlaMet: 2.232 ± 0.945
2.727AlaAsn: 2.727 ± 0.837
1.488AlaPro: 1.488 ± 0.675
1.984AlaGln: 1.984 ± 0.513
2.232AlaArg: 2.232 ± 0.358
4.959AlaSer: 4.959 ± 0.866
3.967AlaThr: 3.967 ± 0.854
3.471AlaVal: 3.471 ± 0.884
1.24AlaTrp: 1.24 ± 0.527
1.488AlaTyr: 1.488 ± 0.412
0.0AlaXaa: 0.0 ± 0.0
Cys
0.992CysAla: 0.992 ± 0.522
0.248CysCys: 0.248 ± 0.227
0.496CysAsp: 0.496 ± 0.295
0.992CysGlu: 0.992 ± 0.456
1.488CysPhe: 1.488 ± 0.373
0.992CysGly: 0.992 ± 0.591
0.496CysHis: 0.496 ± 0.301
0.744CysIle: 0.744 ± 0.477
0.744CysLys: 0.744 ± 0.285
3.471CysLeu: 3.471 ± 0.74
0.992CysMet: 0.992 ± 0.351
1.24CysAsn: 1.24 ± 0.599
1.488CysPro: 1.488 ± 0.787
0.744CysGln: 0.744 ± 0.285
1.736CysArg: 1.736 ± 0.516
1.488CysSer: 1.488 ± 0.496
1.736CysThr: 1.736 ± 0.832
1.24CysVal: 1.24 ± 0.597
0.248CysTrp: 0.248 ± 0.288
0.992CysTyr: 0.992 ± 0.324
0.0CysXaa: 0.0 ± 0.0
Asp
1.24AspAla: 1.24 ± 0.664
1.24AspCys: 1.24 ± 0.475
2.975AspAsp: 2.975 ± 0.775
3.719AspGlu: 3.719 ± 1.013
1.736AspPhe: 1.736 ± 0.771
4.215AspGly: 4.215 ± 1.227
0.248AspHis: 0.248 ± 0.275
3.719AspIle: 3.719 ± 0.764
0.992AspLys: 0.992 ± 0.603
3.471AspLeu: 3.471 ± 0.625
2.232AspMet: 2.232 ± 0.673
2.727AspAsn: 2.727 ± 0.487
2.232AspPro: 2.232 ± 0.679
2.232AspGln: 2.232 ± 0.742
2.48AspArg: 2.48 ± 0.767
2.232AspSer: 2.232 ± 0.73
3.471AspThr: 3.471 ± 0.851
2.232AspVal: 2.232 ± 0.521
0.248AspTrp: 0.248 ± 0.227
2.48AspTyr: 2.48 ± 0.604
0.0AspXaa: 0.0 ± 0.0
Glu
4.463GluAla: 4.463 ± 0.672
1.984GluCys: 1.984 ± 0.629
3.967GluAsp: 3.967 ± 0.923
6.695GluGlu: 6.695 ± 1.625
1.736GluPhe: 1.736 ± 0.441
6.695GluGly: 6.695 ± 1.932
1.736GluHis: 1.736 ± 0.51
4.463GluIle: 4.463 ± 0.911
5.207GluLys: 5.207 ± 1.798
6.695GluLeu: 6.695 ± 1.873
2.232GluMet: 2.232 ± 0.622
2.48GluAsn: 2.48 ± 0.586
3.223GluPro: 3.223 ± 0.97
0.992GluGln: 0.992 ± 0.494
4.463GluArg: 4.463 ± 0.716
5.207GluSer: 5.207 ± 1.437
3.967GluThr: 3.967 ± 0.901
4.711GluVal: 4.711 ± 1.37
0.992GluTrp: 0.992 ± 0.516
1.24GluTyr: 1.24 ± 0.864
0.0GluXaa: 0.0 ± 0.0
Phe
1.736PheAla: 1.736 ± 0.631
0.992PheCys: 0.992 ± 0.513
1.736PheAsp: 1.736 ± 0.6
3.719PheGlu: 3.719 ± 0.594
1.24PhePhe: 1.24 ± 0.531
2.975PheGly: 2.975 ± 0.551
1.24PheHis: 1.24 ± 0.352
2.975PheIle: 2.975 ± 0.464
0.992PheLys: 0.992 ± 0.588
4.711PheLeu: 4.711 ± 1.092
0.992PheMet: 0.992 ± 0.415
2.232PheAsn: 2.232 ± 0.571
1.488PhePro: 1.488 ± 0.469
1.488PheGln: 1.488 ± 0.412
0.992PheArg: 0.992 ± 0.427
3.719PheSer: 3.719 ± 0.786
1.24PheThr: 1.24 ± 0.692
1.984PheVal: 1.984 ± 0.84
0.248PheTrp: 0.248 ± 0.237
0.496PheTyr: 0.496 ± 0.455
0.0PheXaa: 0.0 ± 0.0
Gly
2.48GlyAla: 2.48 ± 0.644
0.992GlyCys: 0.992 ± 0.568
3.471GlyAsp: 3.471 ± 0.615
5.455GlyGlu: 5.455 ± 1.48
4.959GlyPhe: 4.959 ± 0.759
4.959GlyGly: 4.959 ± 1.5
1.24GlyHis: 1.24 ± 0.704
5.703GlyIle: 5.703 ± 0.651
6.447GlyLys: 6.447 ± 1.183
4.463GlyLeu: 4.463 ± 1.102
3.223GlyMet: 3.223 ± 1.089
3.223GlyAsn: 3.223 ± 0.538
3.719GlyPro: 3.719 ± 0.614
2.48GlyGln: 2.48 ± 0.73
4.463GlyArg: 4.463 ± 0.819
3.223GlySer: 3.223 ± 1.279
4.711GlyThr: 4.711 ± 0.96
5.207GlyVal: 5.207 ± 1.33
0.992GlyTrp: 0.992 ± 0.431
2.232GlyTyr: 2.232 ± 0.495
0.0GlyXaa: 0.0 ± 0.0
His
0.248HisAla: 0.248 ± 0.209
0.496HisCys: 0.496 ± 0.35
0.744HisAsp: 0.744 ± 0.502
1.488HisGlu: 1.488 ± 0.663
0.744HisPhe: 0.744 ± 0.373
1.736HisGly: 1.736 ± 0.579
0.0HisHis: 0.0 ± 0.0
0.992HisIle: 0.992 ± 0.489
0.248HisLys: 0.248 ± 0.209
1.736HisLeu: 1.736 ± 0.505
0.496HisMet: 0.496 ± 0.334
0.496HisAsn: 0.496 ± 0.335
0.992HisPro: 0.992 ± 0.479
0.248HisGln: 0.248 ± 0.229
1.984HisArg: 1.984 ± 0.829
2.232HisSer: 2.232 ± 0.808
0.744HisThr: 0.744 ± 0.335
0.744HisVal: 0.744 ± 0.269
0.0HisTrp: 0.0 ± 0.0
0.744HisTyr: 0.744 ± 0.335
0.0HisXaa: 0.0 ± 0.0
Ile
3.967IleAla: 3.967 ± 1.013
2.232IleCys: 2.232 ± 0.647
2.48IleAsp: 2.48 ± 0.836
4.959IleGlu: 4.959 ± 1.401
1.736IlePhe: 1.736 ± 0.606
6.447IleGly: 6.447 ± 0.694
0.248IleHis: 0.248 ± 0.233
3.719IleIle: 3.719 ± 0.662
5.951IleLys: 5.951 ± 1.682
5.703IleLeu: 5.703 ± 1.411
1.984IleMet: 1.984 ± 0.694
3.223IleAsn: 3.223 ± 0.778
3.223IlePro: 3.223 ± 0.614
3.223IleGln: 3.223 ± 0.924
3.719IleArg: 3.719 ± 0.977
3.967IleSer: 3.967 ± 0.993
4.959IleThr: 4.959 ± 0.642
2.727IleVal: 2.727 ± 0.71
0.744IleTrp: 0.744 ± 0.275
0.992IleTyr: 0.992 ± 0.242
0.0IleXaa: 0.0 ± 0.0
Lys
4.711LysAla: 4.711 ± 0.87
2.48LysCys: 2.48 ± 0.69
2.975LysAsp: 2.975 ± 0.738
6.943LysGlu: 6.943 ± 1.414
1.24LysPhe: 1.24 ± 0.592
7.191LysGly: 7.191 ± 1.295
0.744LysHis: 0.744 ± 0.402
4.711LysIle: 4.711 ± 0.79
4.711LysLys: 4.711 ± 1.249
7.687LysLeu: 7.687 ± 0.565
2.48LysMet: 2.48 ± 0.847
4.463LysAsn: 4.463 ± 0.897
2.727LysPro: 2.727 ± 0.666
1.488LysGln: 1.488 ± 0.798
5.951LysArg: 5.951 ± 1.367
2.48LysSer: 2.48 ± 0.586
4.959LysThr: 4.959 ± 0.911
2.727LysVal: 2.727 ± 0.508
1.488LysTrp: 1.488 ± 0.829
3.223LysTyr: 3.223 ± 1.202
0.0LysXaa: 0.0 ± 0.0
Leu
5.703LeuAla: 5.703 ± 1.45
0.992LeuCys: 0.992 ± 0.582
4.215LeuAsp: 4.215 ± 0.806
6.695LeuGlu: 6.695 ± 0.956
4.463LeuPhe: 4.463 ± 1.044
4.463LeuGly: 4.463 ± 0.656
2.727LeuHis: 2.727 ± 0.819
4.215LeuIle: 4.215 ± 1.229
8.678LeuLys: 8.678 ± 2.448
8.43LeuLeu: 8.43 ± 1.321
3.967LeuMet: 3.967 ± 0.782
5.455LeuAsn: 5.455 ± 1.32
3.967LeuPro: 3.967 ± 0.983
2.232LeuGln: 2.232 ± 0.807
5.455LeuArg: 5.455 ± 0.95
8.43LeuSer: 8.43 ± 1.663
4.463LeuThr: 4.463 ± 0.757
3.223LeuVal: 3.223 ± 0.925
1.488LeuTrp: 1.488 ± 0.632
2.232LeuTyr: 2.232 ± 0.727
0.0LeuXaa: 0.0 ± 0.0
Met
2.975MetAla: 2.975 ± 0.654
0.992MetCys: 0.992 ± 0.469
1.736MetAsp: 1.736 ± 0.818
2.975MetGlu: 2.975 ± 0.744
1.24MetPhe: 1.24 ± 0.693
3.471MetGly: 3.471 ± 0.927
0.496MetHis: 0.496 ± 0.282
2.48MetIle: 2.48 ± 0.567
3.471MetLys: 3.471 ± 0.64
2.48MetLeu: 2.48 ± 0.421
1.24MetMet: 1.24 ± 0.371
2.232MetAsn: 2.232 ± 0.784
0.496MetPro: 0.496 ± 0.294
0.744MetGln: 0.744 ± 0.632
1.488MetArg: 1.488 ± 0.928
2.232MetSer: 2.232 ± 0.409
2.727MetThr: 2.727 ± 0.816
2.975MetVal: 2.975 ± 0.824
0.248MetTrp: 0.248 ± 0.233
0.744MetTyr: 0.744 ± 0.402
0.0MetXaa: 0.0 ± 0.0
Asn
3.967AsnAla: 3.967 ± 0.488
1.736AsnCys: 1.736 ± 0.793
1.736AsnAsp: 1.736 ± 0.833
4.959AsnGlu: 4.959 ± 1.496
2.48AsnPhe: 2.48 ± 0.909
4.215AsnGly: 4.215 ± 0.945
0.496AsnHis: 0.496 ± 0.282
3.471AsnIle: 3.471 ± 0.71
4.463AsnLys: 4.463 ± 0.772
4.463AsnLeu: 4.463 ± 1.13
2.232AsnMet: 2.232 ± 1.007
1.736AsnAsn: 1.736 ± 0.767
2.975AsnPro: 2.975 ± 0.775
1.24AsnGln: 1.24 ± 0.47
2.727AsnArg: 2.727 ± 0.766
3.223AsnSer: 3.223 ± 0.759
2.975AsnThr: 2.975 ± 0.855
3.471AsnVal: 3.471 ± 1.344
0.496AsnTrp: 0.496 ± 0.343
1.24AsnTyr: 1.24 ± 0.66
0.0AsnXaa: 0.0 ± 0.0
Pro
1.736ProAla: 1.736 ± 0.818
0.744ProCys: 0.744 ± 0.484
1.488ProAsp: 1.488 ± 0.48
2.975ProGlu: 2.975 ± 0.97
1.984ProPhe: 1.984 ± 0.763
3.471ProGly: 3.471 ± 0.962
0.744ProHis: 0.744 ± 0.335
2.727ProIle: 2.727 ± 0.513
3.719ProLys: 3.719 ± 1.551
3.719ProLeu: 3.719 ± 1.022
0.496ProMet: 0.496 ± 0.269
2.48ProAsn: 2.48 ± 1.015
1.488ProPro: 1.488 ± 0.528
1.736ProGln: 1.736 ± 0.512
1.736ProArg: 1.736 ± 0.519
2.232ProSer: 2.232 ± 0.699
2.232ProThr: 2.232 ± 1.108
2.232ProVal: 2.232 ± 0.78
0.744ProTrp: 0.744 ± 0.489
2.232ProTyr: 2.232 ± 0.701
0.0ProXaa: 0.0 ± 0.0
Gln
1.984GlnAla: 1.984 ± 0.484
0.248GlnCys: 0.248 ± 0.227
0.992GlnAsp: 0.992 ± 0.276
2.232GlnGlu: 2.232 ± 0.849
0.992GlnPhe: 0.992 ± 0.733
2.232GlnGly: 2.232 ± 0.707
0.248GlnHis: 0.248 ± 0.227
2.232GlnIle: 2.232 ± 0.821
3.719GlnLys: 3.719 ± 1.087
2.48GlnLeu: 2.48 ± 0.9
1.488GlnMet: 1.488 ± 0.575
0.992GlnAsn: 0.992 ± 0.363
0.744GlnPro: 0.744 ± 0.285
0.248GlnGln: 0.248 ± 0.237
2.48GlnArg: 2.48 ± 0.678
2.48GlnSer: 2.48 ± 0.655
2.727GlnThr: 2.727 ± 0.62
0.496GlnVal: 0.496 ± 0.381
0.744GlnTrp: 0.744 ± 0.699
0.992GlnTyr: 0.992 ± 0.404
0.0GlnXaa: 0.0 ± 0.0
Arg
3.223ArgAla: 3.223 ± 0.707
0.992ArgCys: 0.992 ± 0.634
3.471ArgAsp: 3.471 ± 0.631
2.727ArgGlu: 2.727 ± 0.968
1.736ArgPhe: 1.736 ± 0.582
3.719ArgGly: 3.719 ± 0.68
0.496ArgHis: 0.496 ± 0.337
4.215ArgIle: 4.215 ± 0.841
3.967ArgLys: 3.967 ± 1.063
5.703ArgLeu: 5.703 ± 1.682
3.223ArgMet: 3.223 ± 1.036
2.975ArgAsn: 2.975 ± 0.636
1.736ArgPro: 1.736 ± 0.613
1.736ArgGln: 1.736 ± 0.837
2.48ArgArg: 2.48 ± 1.092
2.975ArgSer: 2.975 ± 0.971
2.232ArgThr: 2.232 ± 0.861
2.975ArgVal: 2.975 ± 1.407
0.248ArgTrp: 0.248 ± 0.229
0.992ArgTyr: 0.992 ± 0.537
0.0ArgXaa: 0.0 ± 0.0
Ser
6.199SerAla: 6.199 ± 1.475
0.992SerCys: 0.992 ± 0.431
2.232SerAsp: 2.232 ± 0.536
2.232SerGlu: 2.232 ± 0.549
2.48SerPhe: 2.48 ± 0.756
5.455SerGly: 5.455 ± 0.944
1.736SerHis: 1.736 ± 0.737
4.215SerIle: 4.215 ± 0.653
3.967SerLys: 3.967 ± 0.843
6.695SerLeu: 6.695 ± 1.078
2.975SerMet: 2.975 ± 0.813
6.695SerAsn: 6.695 ± 0.607
3.223SerPro: 3.223 ± 0.588
2.232SerGln: 2.232 ± 0.803
2.232SerArg: 2.232 ± 0.654
3.223SerSer: 3.223 ± 1.136
3.719SerThr: 3.719 ± 0.628
1.984SerVal: 1.984 ± 0.937
0.496SerTrp: 0.496 ± 0.33
2.232SerTyr: 2.232 ± 0.636
0.0SerXaa: 0.0 ± 0.0
Thr
4.215ThrAla: 4.215 ± 1.383
0.992ThrCys: 0.992 ± 0.52
3.223ThrAsp: 3.223 ± 0.864
4.463ThrGlu: 4.463 ± 1.042
2.975ThrPhe: 2.975 ± 0.651
3.967ThrGly: 3.967 ± 1.423
1.24ThrHis: 1.24 ± 0.557
5.207ThrIle: 5.207 ± 0.627
6.199ThrLys: 6.199 ± 0.993
2.975ThrLeu: 2.975 ± 0.801
2.48ThrMet: 2.48 ± 0.445
2.727ThrAsn: 2.727 ± 1.076
2.48ThrPro: 2.48 ± 0.401
1.984ThrGln: 1.984 ± 0.761
1.984ThrArg: 1.984 ± 0.571
3.719ThrSer: 3.719 ± 1.021
2.975ThrThr: 2.975 ± 0.679
4.959ThrVal: 4.959 ± 0.732
0.992ThrTrp: 0.992 ± 0.695
2.232ThrTyr: 2.232 ± 0.923
0.0ThrXaa: 0.0 ± 0.0
Val
4.215ValAla: 4.215 ± 0.783
0.496ValCys: 0.496 ± 0.247
2.975ValAsp: 2.975 ± 0.631
3.471ValGlu: 3.471 ± 0.55
1.24ValPhe: 1.24 ± 0.749
1.736ValGly: 1.736 ± 0.698
0.744ValHis: 0.744 ± 0.477
4.215ValIle: 4.215 ± 1.29
4.463ValLys: 4.463 ± 0.848
7.191ValLeu: 7.191 ± 1.282
1.24ValMet: 1.24 ± 0.604
3.223ValAsn: 3.223 ± 1.056
2.232ValPro: 2.232 ± 0.661
1.488ValGln: 1.488 ± 0.486
1.24ValArg: 1.24 ± 0.946
4.215ValSer: 4.215 ± 0.667
3.967ValThr: 3.967 ± 0.947
2.232ValVal: 2.232 ± 0.594
0.496ValTrp: 0.496 ± 0.417
1.24ValTyr: 1.24 ± 0.417
0.0ValXaa: 0.0 ± 0.0
Trp
0.992TrpAla: 0.992 ± 0.417
0.248TrpCys: 0.248 ± 0.209
0.992TrpAsp: 0.992 ± 0.449
0.992TrpGlu: 0.992 ± 0.202
0.744TrpPhe: 0.744 ± 0.356
0.992TrpGly: 0.992 ± 0.417
0.496TrpHis: 0.496 ± 0.309
0.496TrpIle: 0.496 ± 0.35
0.496TrpLys: 0.496 ± 0.474
0.248TrpLeu: 0.248 ± 0.237
0.248TrpMet: 0.248 ± 0.237
0.496TrpAsn: 0.496 ± 0.269
0.248TrpPro: 0.248 ± 0.237
0.496TrpGln: 0.496 ± 0.309
0.744TrpArg: 0.744 ± 0.24
0.248TrpSer: 0.248 ± 0.229
1.488TrpThr: 1.488 ± 0.76
1.24TrpVal: 1.24 ± 0.658
0.248TrpTrp: 0.248 ± 0.233
0.496TrpTyr: 0.496 ± 0.458
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.24TyrAla: 1.24 ± 0.537
1.488TyrCys: 1.488 ± 0.461
1.488TyrAsp: 1.488 ± 0.391
1.488TyrGlu: 1.488 ± 0.343
0.992TyrPhe: 0.992 ± 0.394
1.24TyrGly: 1.24 ± 0.398
0.496TyrHis: 0.496 ± 0.295
1.984TyrIle: 1.984 ± 0.765
1.488TyrLys: 1.488 ± 0.397
2.232TyrLeu: 2.232 ± 0.993
0.744TyrMet: 0.744 ± 0.392
2.48TyrAsn: 2.48 ± 0.507
0.744TyrPro: 0.744 ± 0.574
1.736TyrGln: 1.736 ± 0.84
1.24TyrArg: 1.24 ± 0.928
2.975TyrSer: 2.975 ± 0.561
2.727TyrThr: 2.727 ± 0.619
1.488TyrVal: 1.488 ± 0.763
0.248TyrTrp: 0.248 ± 0.237
0.744TyrTyr: 0.744 ± 0.475
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (4034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski