Amino acid dipepetide frequency for Chitinophaga sp. YR573

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.317AlaAla: 7.317 ± 0.088
0.694AlaCys: 0.694 ± 0.018
4.437AlaAsp: 4.437 ± 0.047
3.904AlaGlu: 3.904 ± 0.048
3.439AlaPhe: 3.439 ± 0.041
6.228AlaGly: 6.228 ± 0.075
1.273AlaHis: 1.273 ± 0.026
5.26AlaIle: 5.26 ± 0.051
4.013AlaLys: 4.013 ± 0.048
6.892AlaLeu: 6.892 ± 0.065
1.736AlaMet: 1.736 ± 0.033
3.719AlaAsn: 3.719 ± 0.055
2.68AlaPro: 2.68 ± 0.048
2.903AlaGln: 2.903 ± 0.037
2.732AlaArg: 2.732 ± 0.037
4.704AlaSer: 4.704 ± 0.056
5.059AlaThr: 5.059 ± 0.103
5.139AlaVal: 5.139 ± 0.05
0.928AlaTrp: 0.928 ± 0.021
3.068AlaTyr: 3.068 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.534CysAla: 0.534 ± 0.021
0.149CysCys: 0.149 ± 0.008
0.362CysAsp: 0.362 ± 0.016
0.382CysGlu: 0.382 ± 0.013
0.401CysPhe: 0.401 ± 0.014
0.632CysGly: 0.632 ± 0.024
0.18CysHis: 0.18 ± 0.011
0.644CysIle: 0.644 ± 0.015
0.468CysLys: 0.468 ± 0.015
0.816CysLeu: 0.816 ± 0.019
0.218CysMet: 0.218 ± 0.01
0.434CysAsn: 0.434 ± 0.015
0.32CysPro: 0.32 ± 0.014
0.242CysGln: 0.242 ± 0.011
0.366CysArg: 0.366 ± 0.014
0.606CysSer: 0.606 ± 0.027
0.563CysThr: 0.563 ± 0.024
0.455CysVal: 0.455 ± 0.016
0.115CysTrp: 0.115 ± 0.007
0.377CysTyr: 0.377 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.214AspAla: 4.214 ± 0.046
0.418AspCys: 0.418 ± 0.017
2.529AspAsp: 2.529 ± 0.045
2.935AspGlu: 2.935 ± 0.043
2.687AspPhe: 2.687 ± 0.036
3.965AspGly: 3.965 ± 0.048
0.999AspHis: 0.999 ± 0.02
4.101AspIle: 4.101 ± 0.043
3.687AspLys: 3.687 ± 0.044
4.654AspLeu: 4.654 ± 0.048
1.211AspMet: 1.211 ± 0.023
3.049AspAsn: 3.049 ± 0.036
2.189AspPro: 2.189 ± 0.029
1.76AspGln: 1.76 ± 0.028
1.9AspArg: 1.9 ± 0.033
3.187AspSer: 3.187 ± 0.054
3.057AspThr: 3.057 ± 0.039
3.451AspVal: 3.451 ± 0.041
0.754AspTrp: 0.754 ± 0.019
2.59AspTyr: 2.59 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
3.926GluAla: 3.926 ± 0.052
0.33GluCys: 0.33 ± 0.014
2.651GluAsp: 2.651 ± 0.038
3.539GluGlu: 3.539 ± 0.054
2.04GluPhe: 2.04 ± 0.034
3.31GluGly: 3.31 ± 0.041
1.127GluHis: 1.127 ± 0.024
3.952GluIle: 3.952 ± 0.054
4.449GluLys: 4.449 ± 0.054
5.239GluLeu: 5.239 ± 0.069
1.486GluMet: 1.486 ± 0.026
2.987GluAsn: 2.987 ± 0.04
1.529GluPro: 1.529 ± 0.027
2.474GluGln: 2.474 ± 0.037
2.392GluArg: 2.392 ± 0.043
2.601GluSer: 2.601 ± 0.036
2.772GluThr: 2.772 ± 0.034
3.402GluVal: 3.402 ± 0.041
0.73GluTrp: 0.73 ± 0.017
2.085GluTyr: 2.085 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
2.999PheAla: 2.999 ± 0.038
0.447PheCys: 0.447 ± 0.013
2.621PheAsp: 2.621 ± 0.037
2.362PheGlu: 2.362 ± 0.031
2.242PhePhe: 2.242 ± 0.04
3.026PheGly: 3.026 ± 0.035
0.884PheHis: 0.884 ± 0.019
3.3PheIle: 3.3 ± 0.045
2.668PheLys: 2.668 ± 0.036
4.035PheLeu: 4.035 ± 0.059
1.131PheMet: 1.131 ± 0.023
2.835PheAsn: 2.835 ± 0.038
1.795PhePro: 1.795 ± 0.024
1.366PheGln: 1.366 ± 0.025
1.984PheArg: 1.984 ± 0.032
3.65PheSer: 3.65 ± 0.039
3.321PheThr: 3.321 ± 0.044
2.59PheVal: 2.59 ± 0.037
0.545PheTrp: 0.545 ± 0.016
1.972PheTyr: 1.972 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
4.844GlyAla: 4.844 ± 0.066
0.696GlyCys: 0.696 ± 0.035
3.443GlyAsp: 3.443 ± 0.042
3.264GlyGlu: 3.264 ± 0.04
3.361GlyPhe: 3.361 ± 0.039
5.087GlyGly: 5.087 ± 0.067
1.261GlyHis: 1.261 ± 0.023
5.426GlyIle: 5.426 ± 0.05
5.017GlyLys: 5.017 ± 0.053
5.943GlyLeu: 5.943 ± 0.056
1.748GlyMet: 1.748 ± 0.031
4.053GlyAsn: 4.053 ± 0.06
1.68GlyPro: 1.68 ± 0.031
2.355GlyGln: 2.355 ± 0.036
2.641GlyArg: 2.641 ± 0.036
4.541GlySer: 4.541 ± 0.057
4.945GlyThr: 4.945 ± 0.084
4.642GlyVal: 4.642 ± 0.052
1.058GlyTrp: 1.058 ± 0.021
3.354GlyTyr: 3.354 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.262HisAla: 1.262 ± 0.028
0.219HisCys: 0.219 ± 0.016
0.887HisAsp: 0.887 ± 0.02
0.95HisGlu: 0.95 ± 0.017
1.195HisPhe: 1.195 ± 0.023
1.096HisGly: 1.096 ± 0.027
0.553HisHis: 0.553 ± 0.018
1.455HisIle: 1.455 ± 0.025
1.006HisLys: 1.006 ± 0.021
1.976HisLeu: 1.976 ± 0.034
0.432HisMet: 0.432 ± 0.013
0.961HisAsn: 0.961 ± 0.019
1.065HisPro: 1.065 ± 0.022
0.762HisGln: 0.762 ± 0.019
0.754HisArg: 0.754 ± 0.018
1.11HisSer: 1.11 ± 0.02
1.197HisThr: 1.197 ± 0.025
1.073HisVal: 1.073 ± 0.022
0.273HisTrp: 0.273 ± 0.01
0.97HisTyr: 0.97 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.585IleAla: 5.585 ± 0.054
0.694IleCys: 0.694 ± 0.022
3.864IleAsp: 3.864 ± 0.041
3.642IleGlu: 3.642 ± 0.049
2.871IlePhe: 2.871 ± 0.038
4.424IleGly: 4.424 ± 0.049
1.396IleHis: 1.396 ± 0.022
4.87IleIle: 4.87 ± 0.06
4.324IleLys: 4.324 ± 0.046
6.075IleLeu: 6.075 ± 0.066
1.422IleMet: 1.422 ± 0.026
3.933IleAsn: 3.933 ± 0.042
3.347IlePro: 3.347 ± 0.041
2.402IleGln: 2.402 ± 0.032
3.195IleArg: 3.195 ± 0.037
5.197IleSer: 5.197 ± 0.05
5.283IleThr: 5.283 ± 0.067
4.118IleVal: 4.118 ± 0.047
0.769IleTrp: 0.769 ± 0.02
2.749IleTyr: 2.749 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.667LysAla: 4.667 ± 0.051
0.285LysCys: 0.285 ± 0.01
4.097LysAsp: 4.097 ± 0.048
4.516LysGlu: 4.516 ± 0.059
2.099LysPhe: 2.099 ± 0.03
4.373LysGly: 4.373 ± 0.044
1.186LysHis: 1.186 ± 0.024
4.357LysIle: 4.357 ± 0.04
4.702LysLys: 4.702 ± 0.057
5.46LysLeu: 5.46 ± 0.054
1.815LysMet: 1.815 ± 0.03
3.395LysAsn: 3.395 ± 0.038
2.454LysPro: 2.454 ± 0.039
2.755LysGln: 2.755 ± 0.037
2.56LysArg: 2.56 ± 0.036
3.367LysSer: 3.367 ± 0.044
3.748LysThr: 3.748 ± 0.041
4.181LysVal: 4.181 ± 0.046
0.843LysTrp: 0.843 ± 0.02
2.662LysTyr: 2.662 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
6.495LeuAla: 6.495 ± 0.064
0.85LeuCys: 0.85 ± 0.02
4.651LeuAsp: 4.651 ± 0.049
4.752LeuGlu: 4.752 ± 0.059
4.452LeuPhe: 4.452 ± 0.058
5.556LeuGly: 5.556 ± 0.051
1.951LeuHis: 1.951 ± 0.034
6.011LeuIle: 6.011 ± 0.065
6.342LeuLys: 6.342 ± 0.061
10.134LeuLeu: 10.134 ± 0.105
2.109LeuMet: 2.109 ± 0.028
5.048LeuAsn: 5.048 ± 0.054
4.406LeuPro: 4.406 ± 0.052
4.532LeuGln: 4.532 ± 0.053
3.931LeuArg: 3.931 ± 0.038
7.096LeuSer: 7.096 ± 0.056
5.698LeuThr: 5.698 ± 0.063
5.282LeuVal: 5.282 ± 0.048
0.997LeuTrp: 0.997 ± 0.023
3.6LeuTyr: 3.6 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.786MetAla: 1.786 ± 0.033
0.137MetCys: 0.137 ± 0.007
1.27MetAsp: 1.27 ± 0.024
1.435MetGlu: 1.435 ± 0.026
0.815MetPhe: 0.815 ± 0.019
1.532MetGly: 1.532 ± 0.029
0.484MetHis: 0.484 ± 0.013
1.519MetIle: 1.519 ± 0.028
1.935MetLys: 1.935 ± 0.03
2.248MetLeu: 2.248 ± 0.033
0.63MetMet: 0.63 ± 0.018
1.334MetAsn: 1.334 ± 0.025
1.135MetPro: 1.135 ± 0.023
1.125MetGln: 1.125 ± 0.023
1.067MetArg: 1.067 ± 0.02
1.377MetSer: 1.377 ± 0.022
1.177MetThr: 1.177 ± 0.024
1.385MetVal: 1.385 ± 0.025
0.205MetTrp: 0.205 ± 0.01
0.77MetTyr: 0.77 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.05AsnAla: 4.05 ± 0.049
0.417AsnCys: 0.417 ± 0.018
2.785AsnAsp: 2.785 ± 0.036
2.667AsnGlu: 2.667 ± 0.036
2.31AsnPhe: 2.31 ± 0.033
4.341AsnGly: 4.341 ± 0.053
0.882AsnHis: 0.882 ± 0.023
4.264AsnIle: 4.264 ± 0.047
3.386AsnLys: 3.386 ± 0.045
4.53AsnLeu: 4.53 ± 0.055
1.29AsnMet: 1.29 ± 0.024
3.549AsnAsn: 3.549 ± 0.052
2.624AsnPro: 2.624 ± 0.04
1.697AsnGln: 1.697 ± 0.028
2.314AsnArg: 2.314 ± 0.031
3.253AsnSer: 3.253 ± 0.042
3.808AsnThr: 3.808 ± 0.053
3.406AsnVal: 3.406 ± 0.045
0.797AsnTrp: 0.797 ± 0.019
2.619AsnTyr: 2.619 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
3.979ProAla: 3.979 ± 0.07
0.248ProCys: 0.248 ± 0.01
2.763ProAsp: 2.763 ± 0.041
2.718ProGlu: 2.718 ± 0.037
1.993ProPhe: 1.993 ± 0.031
3.216ProGly: 3.216 ± 0.04
0.7ProHis: 0.7 ± 0.02
2.081ProIle: 2.081 ± 0.027
1.795ProLys: 1.795 ± 0.031
3.704ProLeu: 3.704 ± 0.042
0.737ProMet: 0.737 ± 0.019
1.758ProAsn: 1.758 ± 0.031
1.3ProPro: 1.3 ± 0.03
1.387ProGln: 1.387 ± 0.023
1.195ProArg: 1.195 ± 0.024
2.458ProSer: 2.458 ± 0.032
2.088ProThr: 2.088 ± 0.044
3.914ProVal: 3.914 ± 0.049
0.465ProTrp: 0.465 ± 0.016
1.729ProTyr: 1.729 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
2.672GlnAla: 2.672 ± 0.037
0.237GlnCys: 0.237 ± 0.012
1.773GlnAsp: 1.773 ± 0.032
2.193GlnGlu: 2.193 ± 0.03
1.683GlnPhe: 1.683 ± 0.027
2.145GlnGly: 2.145 ± 0.033
0.974GlnHis: 0.974 ± 0.021
2.364GlnIle: 2.364 ± 0.032
2.306GlnLys: 2.306 ± 0.033
4.495GlnLeu: 4.495 ± 0.046
0.964GlnMet: 0.964 ± 0.022
1.788GlnAsn: 1.788 ± 0.031
1.717GlnPro: 1.717 ± 0.029
2.63GlnGln: 2.63 ± 0.037
1.618GlnArg: 1.618 ± 0.026
2.281GlnSer: 2.281 ± 0.033
2.17GlnThr: 2.17 ± 0.031
2.5GlnVal: 2.5 ± 0.04
0.557GlnTrp: 0.557 ± 0.017
1.832GlnTyr: 1.832 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
2.493ArgAla: 2.493 ± 0.037
0.282ArgCys: 0.282 ± 0.011
1.914ArgAsp: 1.914 ± 0.029
2.307ArgGlu: 2.307 ± 0.035
2.099ArgPhe: 2.099 ± 0.031
2.14ArgGly: 2.14 ± 0.036
0.78ArgHis: 0.78 ± 0.019
3.188ArgIle: 3.188 ± 0.033
2.821ArgLys: 2.821 ± 0.038
3.997ArgLeu: 3.997 ± 0.047
1.13ArgMet: 1.13 ± 0.018
2.376ArgAsn: 2.376 ± 0.041
1.44ArgPro: 1.44 ± 0.03
1.704ArgGln: 1.704 ± 0.03
1.695ArgArg: 1.695 ± 0.031
2.342ArgSer: 2.342 ± 0.04
2.252ArgThr: 2.252 ± 0.036
2.464ArgVal: 2.464 ± 0.031
0.643ArgTrp: 0.643 ± 0.016
2.008ArgTyr: 2.008 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
4.972SerAla: 4.972 ± 0.067
0.618SerCys: 0.618 ± 0.018
3.209SerAsp: 3.209 ± 0.04
2.815SerGlu: 2.815 ± 0.04
3.507SerPhe: 3.507 ± 0.043
5.309SerGly: 5.309 ± 0.066
1.1SerHis: 1.1 ± 0.021
4.468SerIle: 4.468 ± 0.042
3.477SerLys: 3.477 ± 0.041
6.424SerLeu: 6.424 ± 0.052
1.38SerMet: 1.38 ± 0.025
3.388SerAsn: 3.388 ± 0.04
2.492SerPro: 2.492 ± 0.032
2.077SerGln: 2.077 ± 0.029
2.518SerArg: 2.518 ± 0.039
4.528SerSer: 4.528 ± 0.052
4.139SerThr: 4.139 ± 0.072
4.402SerVal: 4.402 ± 0.074
0.919SerTrp: 0.919 ± 0.02
2.917SerTyr: 2.917 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.638ThrAla: 5.638 ± 0.094
0.474ThrCys: 0.474 ± 0.027
3.716ThrAsp: 3.716 ± 0.046
2.838ThrGlu: 2.838 ± 0.041
2.86ThrPhe: 2.86 ± 0.043
5.616ThrGly: 5.616 ± 0.073
1.088ThrHis: 1.088 ± 0.022
4.577ThrIle: 4.577 ± 0.077
3.086ThrLys: 3.086 ± 0.041
5.928ThrLeu: 5.928 ± 0.058
1.139ThrMet: 1.139 ± 0.019
3.112ThrAsn: 3.112 ± 0.046
3.115ThrPro: 3.115 ± 0.062
2.026ThrGln: 2.026 ± 0.031
2.259ThrArg: 2.259 ± 0.033
4.113ThrSer: 4.113 ± 0.069
4.544ThrThr: 4.544 ± 0.114
4.615ThrVal: 4.615 ± 0.093
0.803ThrTrp: 0.803 ± 0.026
2.738ThrTyr: 2.738 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
4.788ValAla: 4.788 ± 0.05
0.576ValCys: 0.576 ± 0.018
3.179ValAsp: 3.179 ± 0.038
3.049ValGlu: 3.049 ± 0.041
2.957ValPhe: 2.957 ± 0.037
3.543ValGly: 3.543 ± 0.047
1.189ValHis: 1.189 ± 0.024
4.854ValIle: 4.854 ± 0.045
4.411ValLys: 4.411 ± 0.046
6.039ValLeu: 6.039 ± 0.066
1.516ValMet: 1.516 ± 0.028
3.769ValAsn: 3.769 ± 0.042
2.703ValPro: 2.703 ± 0.038
2.298ValGln: 2.298 ± 0.032
2.462ValArg: 2.462 ± 0.035
4.638ValSer: 4.638 ± 0.06
4.656ValThr: 4.656 ± 0.104
4.297ValVal: 4.297 ± 0.052
0.731ValTrp: 0.731 ± 0.022
2.701ValTyr: 2.701 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.797TrpAla: 0.797 ± 0.018
0.114TrpCys: 0.114 ± 0.007
0.718TrpAsp: 0.718 ± 0.019
0.736TrpGlu: 0.736 ± 0.019
0.569TrpPhe: 0.569 ± 0.018
0.887TrpGly: 0.887 ± 0.02
0.291TrpHis: 0.291 ± 0.012
0.819TrpIle: 0.819 ± 0.023
0.897TrpLys: 0.897 ± 0.022
1.281TrpLeu: 1.281 ± 0.024
0.386TrpMet: 0.386 ± 0.012
0.761TrpAsn: 0.761 ± 0.02
0.37TrpPro: 0.37 ± 0.012
0.698TrpGln: 0.698 ± 0.019
0.539TrpArg: 0.539 ± 0.016
0.762TrpSer: 0.762 ± 0.022
0.79TrpThr: 0.79 ± 0.037
0.728TrpVal: 0.728 ± 0.017
0.259TrpTrp: 0.259 ± 0.011
0.568TrpTyr: 0.568 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.107TyrAla: 3.107 ± 0.04
0.377TyrCys: 0.377 ± 0.013
2.468TyrAsp: 2.468 ± 0.038
2.017TyrGlu: 2.017 ± 0.035
2.19TyrPhe: 2.19 ± 0.034
2.935TyrGly: 2.935 ± 0.039
0.9TyrHis: 0.9 ± 0.021
2.652TyrIle: 2.652 ± 0.035
2.734TyrLys: 2.734 ± 0.041
4.026TyrLeu: 4.026 ± 0.042
0.886TyrMet: 0.886 ± 0.019
2.741TyrAsn: 2.741 ± 0.033
1.867TyrPro: 1.867 ± 0.029
1.701TyrGln: 1.701 ± 0.029
1.953TyrArg: 1.953 ± 0.026
2.848TyrSer: 2.848 ± 0.041
3.016TyrThr: 3.016 ± 0.051
2.313TyrVal: 2.313 ± 0.032
0.58TyrTrp: 0.58 ± 0.016
2.209TyrTyr: 2.209 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6483 proteins (2436871 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski