Amino acid dipepetide frequency for Acinetobacter phage WCHABP12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.152AlaAla: 5.152 ± 0.825
0.847AlaCys: 0.847 ± 0.216
3.67AlaAsp: 3.67 ± 0.505
4.093AlaGlu: 4.093 ± 0.5
2.611AlaPhe: 2.611 ± 0.511
3.741AlaGly: 3.741 ± 0.559
1.2AlaHis: 1.2 ± 0.25
5.082AlaIle: 5.082 ± 0.641
5.082AlaLys: 5.082 ± 0.656
6.211AlaLeu: 6.211 ± 0.728
2.329AlaMet: 2.329 ± 0.471
3.176AlaAsn: 3.176 ± 0.501
2.541AlaPro: 2.541 ± 0.408
3.388AlaGln: 3.388 ± 0.599
2.4AlaArg: 2.4 ± 0.321
4.517AlaSer: 4.517 ± 0.554
4.87AlaThr: 4.87 ± 0.745
3.811AlaVal: 3.811 ± 0.576
0.847AlaTrp: 0.847 ± 0.212
3.105AlaTyr: 3.105 ± 0.405
0.0AlaXaa: 0.0 ± 0.0
Cys
0.847CysAla: 0.847 ± 0.228
0.071CysCys: 0.071 ± 0.073
1.059CysAsp: 1.059 ± 0.306
1.059CysGlu: 1.059 ± 0.256
0.423CysPhe: 0.423 ± 0.178
0.917CysGly: 0.917 ± 0.228
0.071CysHis: 0.071 ± 0.068
0.706CysIle: 0.706 ± 0.236
1.27CysLys: 1.27 ± 0.293
1.553CysLeu: 1.553 ± 0.362
0.282CysMet: 0.282 ± 0.146
0.353CysAsn: 0.353 ± 0.169
0.282CysPro: 0.282 ± 0.136
0.423CysGln: 0.423 ± 0.149
0.494CysArg: 0.494 ± 0.169
0.776CysSer: 0.776 ± 0.183
0.141CysThr: 0.141 ± 0.088
0.917CysVal: 0.917 ± 0.235
0.282CysTrp: 0.282 ± 0.13
0.776CysTyr: 0.776 ± 0.244
0.0CysXaa: 0.0 ± 0.0
Asp
4.235AspAla: 4.235 ± 0.473
1.129AspCys: 1.129 ± 0.303
4.305AspAsp: 4.305 ± 0.735
4.587AspGlu: 4.587 ± 0.634
3.599AspPhe: 3.599 ± 0.463
5.223AspGly: 5.223 ± 0.65
0.635AspHis: 0.635 ± 0.207
3.176AspIle: 3.176 ± 0.494
4.729AspLys: 4.729 ± 0.771
4.658AspLeu: 4.658 ± 0.562
1.482AspMet: 1.482 ± 0.322
2.752AspAsn: 2.752 ± 0.453
1.764AspPro: 1.764 ± 0.297
2.47AspGln: 2.47 ± 0.403
2.611AspArg: 2.611 ± 0.358
3.741AspSer: 3.741 ± 0.549
2.258AspThr: 2.258 ± 0.428
4.446AspVal: 4.446 ± 0.617
1.412AspTrp: 1.412 ± 0.353
2.47AspTyr: 2.47 ± 0.407
0.0AspXaa: 0.0 ± 0.0
Glu
4.376GluAla: 4.376 ± 0.533
0.565GluCys: 0.565 ± 0.183
3.388GluAsp: 3.388 ± 0.747
3.741GluGlu: 3.741 ± 0.512
3.317GluPhe: 3.317 ± 0.608
4.023GluGly: 4.023 ± 0.573
1.27GluHis: 1.27 ± 0.27
5.434GluIle: 5.434 ± 0.722
5.505GluLys: 5.505 ± 0.635
6.281GluLeu: 6.281 ± 0.882
2.258GluMet: 2.258 ± 0.423
3.529GluAsn: 3.529 ± 0.453
1.482GluPro: 1.482 ± 0.339
3.035GluGln: 3.035 ± 0.497
2.047GluArg: 2.047 ± 0.374
5.011GluSer: 5.011 ± 0.638
2.541GluThr: 2.541 ± 0.486
4.87GluVal: 4.87 ± 0.593
0.917GluTrp: 0.917 ± 0.272
3.247GluTyr: 3.247 ± 0.496
0.0GluXaa: 0.0 ± 0.0
Phe
3.247PheAla: 3.247 ± 0.523
0.776PheCys: 0.776 ± 0.228
3.388PheAsp: 3.388 ± 0.415
2.541PheGlu: 2.541 ± 0.47
1.694PhePhe: 1.694 ± 0.357
3.458PheGly: 3.458 ± 0.553
0.494PheHis: 0.494 ± 0.192
3.599PheIle: 3.599 ± 0.556
3.529PheLys: 3.529 ± 0.404
2.682PheLeu: 2.682 ± 0.457
1.764PheMet: 1.764 ± 0.338
2.752PheAsn: 2.752 ± 0.459
0.776PhePro: 0.776 ± 0.208
1.2PheGln: 1.2 ± 0.339
1.553PheArg: 1.553 ± 0.335
2.329PheSer: 2.329 ± 0.395
2.752PheThr: 2.752 ± 0.438
2.47PheVal: 2.47 ± 0.422
0.565PheTrp: 0.565 ± 0.268
2.47PheTyr: 2.47 ± 0.475
0.0PheXaa: 0.0 ± 0.0
Gly
5.717GlyAla: 5.717 ± 0.71
0.776GlyCys: 0.776 ± 0.206
3.176GlyAsp: 3.176 ± 0.537
3.741GlyGlu: 3.741 ± 0.503
4.658GlyPhe: 4.658 ± 0.637
4.658GlyGly: 4.658 ± 0.669
1.341GlyHis: 1.341 ± 0.298
5.152GlyIle: 5.152 ± 0.434
4.799GlyLys: 4.799 ± 0.481
6.07GlyLeu: 6.07 ± 0.676
2.117GlyMet: 2.117 ± 0.403
4.093GlyAsn: 4.093 ± 0.601
0.776GlyPro: 0.776 ± 0.293
2.047GlyGln: 2.047 ± 0.4
2.964GlyArg: 2.964 ± 0.43
4.446GlySer: 4.446 ± 0.654
3.741GlyThr: 3.741 ± 0.661
5.858GlyVal: 5.858 ± 0.701
1.059GlyTrp: 1.059 ± 0.291
2.752GlyTyr: 2.752 ± 0.446
0.0GlyXaa: 0.0 ± 0.0
His
1.059HisAla: 1.059 ± 0.242
0.141HisCys: 0.141 ± 0.1
0.988HisAsp: 0.988 ± 0.244
1.694HisGlu: 1.694 ± 0.358
0.494HisPhe: 0.494 ± 0.179
0.917HisGly: 0.917 ± 0.267
0.353HisHis: 0.353 ± 0.16
1.129HisIle: 1.129 ± 0.295
1.129HisLys: 1.129 ± 0.313
1.341HisLeu: 1.341 ± 0.289
0.635HisMet: 0.635 ± 0.159
1.2HisAsn: 1.2 ± 0.29
0.282HisPro: 0.282 ± 0.153
0.776HisGln: 0.776 ± 0.197
0.353HisArg: 0.353 ± 0.153
0.706HisSer: 0.706 ± 0.198
1.059HisThr: 1.059 ± 0.323
0.988HisVal: 0.988 ± 0.301
0.141HisTrp: 0.141 ± 0.102
0.988HisTyr: 0.988 ± 0.293
0.0HisXaa: 0.0 ± 0.0
Ile
4.729IleAla: 4.729 ± 0.711
0.988IleCys: 0.988 ± 0.292
4.94IleAsp: 4.94 ± 0.502
7.411IleGlu: 7.411 ± 0.764
2.188IlePhe: 2.188 ± 0.37
5.223IleGly: 5.223 ± 0.664
1.553IleHis: 1.553 ± 0.347
3.952IleIle: 3.952 ± 0.517
6.705IleLys: 6.705 ± 0.843
4.658IleLeu: 4.658 ± 0.609
0.988IleMet: 0.988 ± 0.281
4.376IleAsn: 4.376 ± 0.584
3.67IlePro: 3.67 ± 0.454
2.329IleGln: 2.329 ± 0.362
2.188IleArg: 2.188 ± 0.4
5.152IleSer: 5.152 ± 0.653
4.164IleThr: 4.164 ± 0.656
4.164IleVal: 4.164 ± 0.44
0.917IleTrp: 0.917 ± 0.209
1.623IleTyr: 1.623 ± 0.32
0.0IleXaa: 0.0 ± 0.0
Lys
5.646LysAla: 5.646 ± 0.863
1.341LysCys: 1.341 ± 0.379
4.87LysAsp: 4.87 ± 0.689
4.446LysGlu: 4.446 ± 0.678
2.047LysPhe: 2.047 ± 0.408
5.787LysGly: 5.787 ± 0.634
0.847LysHis: 0.847 ± 0.265
5.434LysIle: 5.434 ± 0.746
6.211LysLys: 6.211 ± 0.959
6.564LysLeu: 6.564 ± 0.588
2.611LysMet: 2.611 ± 0.396
4.517LysAsn: 4.517 ± 0.456
2.258LysPro: 2.258 ± 0.384
2.823LysGln: 2.823 ± 0.527
3.741LysArg: 3.741 ± 0.509
4.235LysSer: 4.235 ± 0.66
4.587LysThr: 4.587 ± 0.461
5.011LysVal: 5.011 ± 0.712
1.059LysTrp: 1.059 ± 0.235
2.894LysTyr: 2.894 ± 0.434
0.0LysXaa: 0.0 ± 0.0
Leu
5.717LeuAla: 5.717 ± 0.69
1.27LeuCys: 1.27 ± 0.304
5.787LeuAsp: 5.787 ± 0.676
6.352LeuGlu: 6.352 ± 0.661
2.682LeuPhe: 2.682 ± 0.461
5.364LeuGly: 5.364 ± 0.667
1.059LeuHis: 1.059 ± 0.241
6.493LeuIle: 6.493 ± 0.817
6.987LeuLys: 6.987 ± 0.596
5.152LeuLeu: 5.152 ± 0.769
2.117LeuMet: 2.117 ± 0.371
6.211LeuAsn: 6.211 ± 0.705
2.117LeuPro: 2.117 ± 0.451
1.976LeuGln: 1.976 ± 0.401
3.317LeuArg: 3.317 ± 0.475
4.87LeuSer: 4.87 ± 0.423
4.517LeuThr: 4.517 ± 0.492
5.293LeuVal: 5.293 ± 0.637
0.847LeuTrp: 0.847 ± 0.244
2.47LeuTyr: 2.47 ± 0.421
0.0LeuXaa: 0.0 ± 0.0
Met
1.835MetAla: 1.835 ± 0.369
0.353MetCys: 0.353 ± 0.145
1.623MetAsp: 1.623 ± 0.37
1.764MetGlu: 1.764 ± 0.323
1.129MetPhe: 1.129 ± 0.318
1.553MetGly: 1.553 ± 0.436
0.494MetHis: 0.494 ± 0.189
1.694MetIle: 1.694 ± 0.346
2.823MetLys: 2.823 ± 0.45
2.258MetLeu: 2.258 ± 0.477
0.494MetMet: 0.494 ± 0.172
2.47MetAsn: 2.47 ± 0.349
1.059MetPro: 1.059 ± 0.225
1.553MetGln: 1.553 ± 0.387
0.847MetArg: 0.847 ± 0.302
2.894MetSer: 2.894 ± 0.479
2.188MetThr: 2.188 ± 0.332
1.059MetVal: 1.059 ± 0.328
0.212MetTrp: 0.212 ± 0.117
0.494MetTyr: 0.494 ± 0.188
0.0MetXaa: 0.0 ± 0.0
Asn
4.235AsnAla: 4.235 ± 0.614
0.494AsnCys: 0.494 ± 0.179
3.882AsnAsp: 3.882 ± 0.464
4.164AsnGlu: 4.164 ± 0.545
2.188AsnPhe: 2.188 ± 0.393
5.576AsnGly: 5.576 ± 0.759
1.059AsnHis: 1.059 ± 0.318
4.305AsnIle: 4.305 ± 0.549
2.964AsnLys: 2.964 ± 0.599
4.799AsnLeu: 4.799 ± 0.633
1.764AsnMet: 1.764 ± 0.351
3.247AsnAsn: 3.247 ± 0.654
2.047AsnPro: 2.047 ± 0.341
2.047AsnGln: 2.047 ± 0.388
2.329AsnArg: 2.329 ± 0.381
3.741AsnSer: 3.741 ± 0.569
3.811AsnThr: 3.811 ± 0.47
2.752AsnVal: 2.752 ± 0.539
0.565AsnTrp: 0.565 ± 0.176
2.752AsnTyr: 2.752 ± 0.409
0.0AsnXaa: 0.0 ± 0.0
Pro
1.623ProAla: 1.623 ± 0.286
0.494ProCys: 0.494 ± 0.204
2.117ProAsp: 2.117 ± 0.422
2.188ProGlu: 2.188 ± 0.324
1.2ProPhe: 1.2 ± 0.34
0.282ProGly: 0.282 ± 0.166
0.423ProHis: 0.423 ± 0.201
2.258ProIle: 2.258 ± 0.358
2.541ProLys: 2.541 ± 0.429
2.752ProLeu: 2.752 ± 0.42
1.129ProMet: 1.129 ± 0.339
2.47ProAsn: 2.47 ± 0.341
0.635ProPro: 0.635 ± 0.26
1.482ProGln: 1.482 ± 0.333
0.494ProArg: 0.494 ± 0.171
1.835ProSer: 1.835 ± 0.424
1.623ProThr: 1.623 ± 0.39
1.694ProVal: 1.694 ± 0.296
0.282ProTrp: 0.282 ± 0.142
1.764ProTyr: 1.764 ± 0.331
0.0ProXaa: 0.0 ± 0.0
Gln
2.823GlnAla: 2.823 ± 0.417
0.353GlnCys: 0.353 ± 0.145
2.117GlnAsp: 2.117 ± 0.384
2.329GlnGlu: 2.329 ± 0.415
1.906GlnPhe: 1.906 ± 0.393
2.682GlnGly: 2.682 ± 0.479
0.494GlnHis: 0.494 ± 0.164
2.752GlnIle: 2.752 ± 0.469
2.47GlnLys: 2.47 ± 0.379
3.599GlnLeu: 3.599 ± 0.595
1.059GlnMet: 1.059 ± 0.26
1.341GlnAsn: 1.341 ± 0.271
0.706GlnPro: 0.706 ± 0.204
1.341GlnGln: 1.341 ± 0.344
1.059GlnArg: 1.059 ± 0.285
3.317GlnSer: 3.317 ± 0.458
1.694GlnThr: 1.694 ± 0.33
2.541GlnVal: 2.541 ± 0.437
0.847GlnTrp: 0.847 ± 0.267
1.835GlnTyr: 1.835 ± 0.394
0.0GlnXaa: 0.0 ± 0.0
Arg
1.835ArgAla: 1.835 ± 0.406
0.423ArgCys: 0.423 ± 0.202
1.976ArgAsp: 1.976 ± 0.301
2.4ArgGlu: 2.4 ± 0.462
1.764ArgPhe: 1.764 ± 0.309
1.694ArgGly: 1.694 ± 0.311
1.2ArgHis: 1.2 ± 0.228
3.247ArgIle: 3.247 ± 0.642
3.599ArgLys: 3.599 ± 0.489
3.035ArgLeu: 3.035 ± 0.529
0.917ArgMet: 0.917 ± 0.23
1.835ArgAsn: 1.835 ± 0.352
1.129ArgPro: 1.129 ± 0.254
1.341ArgGln: 1.341 ± 0.328
1.694ArgArg: 1.694 ± 0.493
3.035ArgSer: 3.035 ± 0.438
1.764ArgThr: 1.764 ± 0.392
2.611ArgVal: 2.611 ± 0.393
0.494ArgTrp: 0.494 ± 0.153
1.553ArgTyr: 1.553 ± 0.407
0.0ArgXaa: 0.0 ± 0.0
Ser
3.388SerAla: 3.388 ± 0.451
0.706SerCys: 0.706 ± 0.245
4.235SerAsp: 4.235 ± 0.586
4.235SerGlu: 4.235 ± 0.53
3.176SerPhe: 3.176 ± 0.544
5.434SerGly: 5.434 ± 0.631
1.2SerHis: 1.2 ± 0.277
5.858SerIle: 5.858 ± 0.615
5.011SerLys: 5.011 ± 0.645
5.576SerLeu: 5.576 ± 0.55
1.412SerMet: 1.412 ± 0.306
3.882SerAsn: 3.882 ± 0.514
1.835SerPro: 1.835 ± 0.312
2.611SerGln: 2.611 ± 0.402
2.188SerArg: 2.188 ± 0.386
3.105SerSer: 3.105 ± 0.55
3.458SerThr: 3.458 ± 0.532
3.67SerVal: 3.67 ± 0.427
0.988SerTrp: 0.988 ± 0.254
2.329SerTyr: 2.329 ± 0.42
0.0SerXaa: 0.0 ± 0.0
Thr
3.811ThrAla: 3.811 ± 0.521
0.565ThrCys: 0.565 ± 0.194
3.247ThrAsp: 3.247 ± 0.415
2.117ThrGlu: 2.117 ± 0.343
1.976ThrPhe: 1.976 ± 0.4
4.658ThrGly: 4.658 ± 0.771
0.917ThrHis: 0.917 ± 0.291
3.811ThrIle: 3.811 ± 0.46
3.67ThrLys: 3.67 ± 0.599
3.882ThrLeu: 3.882 ± 0.483
1.694ThrMet: 1.694 ± 0.4
3.247ThrAsn: 3.247 ± 0.63
2.047ThrPro: 2.047 ± 0.409
1.906ThrGln: 1.906 ± 0.48
2.258ThrArg: 2.258 ± 0.411
2.894ThrSer: 2.894 ± 0.502
3.811ThrThr: 3.811 ± 0.655
4.446ThrVal: 4.446 ± 0.776
1.553ThrTrp: 1.553 ± 0.41
1.835ThrTyr: 1.835 ± 0.351
0.0ThrXaa: 0.0 ± 0.0
Val
4.658ValAla: 4.658 ± 0.578
0.212ValCys: 0.212 ± 0.166
3.741ValAsp: 3.741 ± 0.384
4.446ValGlu: 4.446 ± 0.702
3.529ValPhe: 3.529 ± 0.52
4.587ValGly: 4.587 ± 0.535
0.917ValHis: 0.917 ± 0.266
4.587ValIle: 4.587 ± 0.588
4.305ValLys: 4.305 ± 0.47
5.576ValLeu: 5.576 ± 0.746
2.047ValMet: 2.047 ± 0.486
3.952ValAsn: 3.952 ± 0.616
1.694ValPro: 1.694 ± 0.318
2.47ValGln: 2.47 ± 0.434
2.117ValArg: 2.117 ± 0.377
3.952ValSer: 3.952 ± 0.466
3.388ValThr: 3.388 ± 0.589
4.164ValVal: 4.164 ± 0.637
1.059ValTrp: 1.059 ± 0.258
3.317ValTyr: 3.317 ± 0.545
0.0ValXaa: 0.0 ± 0.0
Trp
1.129TrpAla: 1.129 ± 0.286
0.635TrpCys: 0.635 ± 0.22
0.776TrpAsp: 0.776 ± 0.249
0.988TrpGlu: 0.988 ± 0.203
1.129TrpPhe: 1.129 ± 0.284
0.706TrpGly: 0.706 ± 0.211
0.353TrpHis: 0.353 ± 0.167
0.847TrpIle: 0.847 ± 0.322
0.635TrpLys: 0.635 ± 0.234
1.2TrpLeu: 1.2 ± 0.362
0.423TrpMet: 0.423 ± 0.162
0.917TrpAsn: 0.917 ± 0.228
0.071TrpPro: 0.071 ± 0.083
0.565TrpGln: 0.565 ± 0.174
0.988TrpArg: 0.988 ± 0.244
1.2TrpSer: 1.2 ± 0.338
0.494TrpThr: 0.494 ± 0.202
1.2TrpVal: 1.2 ± 0.275
0.212TrpTrp: 0.212 ± 0.123
0.353TrpTyr: 0.353 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.611TyrAla: 2.611 ± 0.405
0.565TyrCys: 0.565 ± 0.224
2.4TyrAsp: 2.4 ± 0.47
2.541TyrGlu: 2.541 ± 0.41
2.329TyrPhe: 2.329 ± 0.406
3.458TyrGly: 3.458 ± 0.549
0.494TyrHis: 0.494 ± 0.152
2.4TyrIle: 2.4 ± 0.463
2.964TyrLys: 2.964 ± 0.445
2.752TyrLeu: 2.752 ± 0.496
1.2TyrMet: 1.2 ± 0.295
2.4TyrAsn: 2.4 ± 0.436
2.117TyrPro: 2.117 ± 0.398
1.553TyrGln: 1.553 ± 0.394
1.906TyrArg: 1.906 ± 0.442
2.541TyrSer: 2.541 ± 0.416
1.482TyrThr: 1.482 ± 0.295
2.752TyrVal: 2.752 ± 0.438
0.565TyrTrp: 0.565 ± 0.231
1.482TyrTyr: 1.482 ± 0.348
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 88 proteins (14170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski