Amino acid dipepetide frequency for Diaminobutyricimonas aerilata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.939AlaAla: 19.939 ± 0.217	0.545AlaCys: 0.545 ± 0.025	8.455AlaAsp: 8.455 ± 0.103	8.157AlaGlu: 8.157 ± 0.109	3.858AlaPhe: 3.858 ± 0.061	12.095AlaGly: 12.095 ± 0.127	2.409AlaHis: 2.409 ± 0.051	5.716AlaIle: 5.716 ± 0.074	2.09AlaLys: 2.09 ± 0.052	14.511AlaLeu: 14.511 ± 0.168	2.466AlaMet: 2.466 ± 0.051	2.194AlaAsn: 2.194 ± 0.049	6.825AlaPro: 6.825 ± 0.104	3.512AlaGln: 3.512 ± 0.058	9.9AlaArg: 9.9 ± 0.136	6.924AlaSer: 6.924 ± 0.078	7.813AlaThr: 7.813 ± 0.174	12.292AlaVal: 12.292 ± 0.119	1.866AlaTrp: 1.866 ± 0.042	2.289AlaTyr: 2.289 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.642CysAla: 0.642 ± 0.028	0.028CysCys: 0.028 ± 0.004	0.298CysAsp: 0.298 ± 0.019	0.21CysGlu: 0.21 ± 0.015	0.169CysPhe: 0.169 ± 0.012	0.449CysGly: 0.449 ± 0.025	0.102CysHis: 0.102 ± 0.01	0.148CysIle: 0.148 ± 0.012	0.038CysLys: 0.038 ± 0.007	0.392CysLeu: 0.392 ± 0.022	0.061CysMet: 0.061 ± 0.008	0.092CysAsn: 0.092 ± 0.009	0.26CysPro: 0.26 ± 0.02	0.081CysGln: 0.081 ± 0.01	0.267CysArg: 0.267 ± 0.015	0.29CysSer: 0.29 ± 0.016	0.324CysThr: 0.324 ± 0.028	0.368CysVal: 0.368 ± 0.021	0.048CysTrp: 0.048 ± 0.007	0.092CysTyr: 0.092 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.342AspAla: 9.342 ± 0.109	0.239AspCys: 0.239 ± 0.021	4.909AspAsp: 4.909 ± 0.095	4.673AspGlu: 4.673 ± 0.069	1.731AspPhe: 1.731 ± 0.05	6.413AspGly: 6.413 ± 0.11	1.162AspHis: 1.162 ± 0.034	2.251AspIle: 2.251 ± 0.049	0.765AspLys: 0.765 ± 0.029	6.19AspLeu: 6.19 ± 0.079	0.716AspMet: 0.716 ± 0.028	0.934AspAsn: 0.934 ± 0.035	4.463AspPro: 4.463 ± 0.078	1.361AspGln: 1.361 ± 0.039	5.045AspArg: 5.045 ± 0.087	2.629AspSer: 2.629 ± 0.063	3.089AspThr: 3.089 ± 0.058	5.544AspVal: 5.544 ± 0.074	1.009AspTrp: 1.009 ± 0.034	1.381AspTyr: 1.381 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.864GluAla: 6.864 ± 0.106	0.25GluCys: 0.25 ± 0.014	2.39GluAsp: 2.39 ± 0.051	3.075GluGlu: 3.075 ± 0.075	1.929GluPhe: 1.929 ± 0.042	4.229GluGly: 4.229 ± 0.08	1.656GluHis: 1.656 ± 0.045	2.401GluIle: 2.401 ± 0.055	1.319GluLys: 1.319 ± 0.045	7.081GluLeu: 7.081 ± 0.093	0.846GluMet: 0.846 ± 0.029	1.285GluAsn: 1.285 ± 0.037	3.327GluPro: 3.327 ± 0.074	2.438GluGln: 2.438 ± 0.05	5.966GluArg: 5.966 ± 0.104	2.997GluSer: 2.997 ± 0.053	2.98GluThr: 2.98 ± 0.054	5.148GluVal: 5.148 ± 0.072	1.009GluTrp: 1.009 ± 0.031	1.29GluTyr: 1.29 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.294PheAla: 4.294 ± 0.07	0.142PheCys: 0.142 ± 0.012	2.443PheAsp: 2.443 ± 0.049	1.947PheGlu: 1.947 ± 0.044	1.093PhePhe: 1.093 ± 0.037	3.432PheGly: 3.432 ± 0.067	0.513PheHis: 0.513 ± 0.024	1.089PheIle: 1.089 ± 0.032	0.388PheLys: 0.388 ± 0.02	2.754PheLeu: 2.754 ± 0.069	0.41PheMet: 0.41 ± 0.018	0.618PheAsn: 0.618 ± 0.024	1.395PhePro: 1.395 ± 0.04	0.76PheGln: 0.76 ± 0.029	1.892PheArg: 1.892 ± 0.047	1.741PheSer: 1.741 ± 0.047	2.153PheThr: 2.153 ± 0.048	2.994PheVal: 2.994 ± 0.061	0.482PheTrp: 0.482 ± 0.022	0.687PheTyr: 0.687 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.964GlyAla: 10.964 ± 0.125	0.577GlyCys: 0.577 ± 0.027	5.603GlyAsp: 5.603 ± 0.093	5.21GlyGlu: 5.21 ± 0.069	3.137GlyPhe: 3.137 ± 0.054	7.816GlyGly: 7.816 ± 0.105	1.778GlyHis: 1.778 ± 0.043	4.36GlyIle: 4.36 ± 0.064	1.727GlyLys: 1.727 ± 0.048	8.637GlyLeu: 8.637 ± 0.116	1.89GlyMet: 1.89 ± 0.045	1.808GlyAsn: 1.808 ± 0.056	3.829GlyPro: 3.829 ± 0.063	2.197GlyGln: 2.197 ± 0.05	6.639GlyArg: 6.639 ± 0.094	5.364GlySer: 5.364 ± 0.074	5.816GlyThr: 5.816 ± 0.105	8.261GlyVal: 8.261 ± 0.112	1.705GlyTrp: 1.705 ± 0.04	2.285GlyTyr: 2.285 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.25HisAla: 2.25 ± 0.056	0.084HisCys: 0.084 ± 0.008	1.379HisAsp: 1.379 ± 0.04	1.148HisGlu: 1.148 ± 0.033	0.521HisPhe: 0.521 ± 0.023	1.96HisGly: 1.96 ± 0.051	0.565HisHis: 0.565 ± 0.031	0.696HisIle: 0.696 ± 0.024	0.242HisLys: 0.242 ± 0.015	2.06HisLeu: 2.06 ± 0.056	0.275HisMet: 0.275 ± 0.017	0.344HisAsn: 0.344 ± 0.022	1.539HisPro: 1.539 ± 0.044	0.426HisGln: 0.426 ± 0.021	1.592HisArg: 1.592 ± 0.039	0.924HisSer: 0.924 ± 0.03	0.936HisThr: 0.936 ± 0.033	1.698HisVal: 1.698 ± 0.044	0.33HisTrp: 0.33 ± 0.017	0.445HisTyr: 0.445 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.767IleAla: 6.767 ± 0.079	0.192IleCys: 0.192 ± 0.012	3.443IleAsp: 3.443 ± 0.065	2.885IleGlu: 2.885 ± 0.063	1.056IlePhe: 1.056 ± 0.039	4.44IleGly: 4.44 ± 0.085	0.555IleHis: 0.555 ± 0.022	1.449IleIle: 1.449 ± 0.045	0.657IleLys: 0.657 ± 0.026	3.114IleLeu: 3.114 ± 0.063	0.535IleMet: 0.535 ± 0.023	0.763IleAsn: 0.763 ± 0.031	2.252IlePro: 2.252 ± 0.047	0.864IleGln: 0.864 ± 0.027	2.819IleArg: 2.819 ± 0.054	2.019IleSer: 2.019 ± 0.046	2.765IleThr: 2.765 ± 0.064	4.421IleVal: 4.421 ± 0.067	0.48IleTrp: 0.48 ± 0.022	0.667IleTyr: 0.667 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	1.879LysAla: 1.879 ± 0.049	0.048LysCys: 0.048 ± 0.006	0.864LysAsp: 0.864 ± 0.034	0.814LysGlu: 0.814 ± 0.032	0.433LysPhe: 0.433 ± 0.021	1.252LysGly: 1.252 ± 0.04	0.381LysHis: 0.381 ± 0.02	0.742LysIle: 0.742 ± 0.031	0.551LysLys: 0.551 ± 0.026	1.598LysLeu: 1.598 ± 0.047	0.276LysMet: 0.276 ± 0.017	0.426LysAsn: 0.426 ± 0.022	0.966LysPro: 0.966 ± 0.03	0.597LysGln: 0.597 ± 0.023	1.379LysArg: 1.379 ± 0.037	0.965LysSer: 0.965 ± 0.035	1.158LysThr: 1.158 ± 0.044	1.429LysVal: 1.429 ± 0.044	0.229LysTrp: 0.229 ± 0.015	0.416LysTyr: 0.416 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.917LeuAla: 14.917 ± 0.157	0.399LeuCys: 0.399 ± 0.02	7.233LeuAsp: 7.233 ± 0.09	5.747LeuGlu: 5.747 ± 0.075	2.935LeuPhe: 2.935 ± 0.069	9.304LeuGly: 9.304 ± 0.117	1.905LeuHis: 1.905 ± 0.05	4.037LeuIle: 4.037 ± 0.07	1.536LeuLys: 1.536 ± 0.04	10.763LeuLeu: 10.763 ± 0.169	1.479LeuMet: 1.479 ± 0.037	1.71LeuAsn: 1.71 ± 0.044	5.883LeuPro: 5.883 ± 0.075	2.471LeuGln: 2.471 ± 0.052	7.556LeuArg: 7.556 ± 0.094	5.271LeuSer: 5.271 ± 0.074	6.365LeuThr: 6.365 ± 0.095	9.931LeuVal: 9.931 ± 0.123	1.22LeuTrp: 1.22 ± 0.035	1.71LeuTyr: 1.71 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.883MetAla: 1.883 ± 0.042	0.078MetCys: 0.078 ± 0.007	0.739MetAsp: 0.739 ± 0.03	0.608MetGlu: 0.608 ± 0.024	0.521MetPhe: 0.521 ± 0.022	1.13MetGly: 1.13 ± 0.032	0.322MetHis: 0.322 ± 0.018	0.773MetIle: 0.773 ± 0.028	0.331MetLys: 0.331 ± 0.018	1.719MetLeu: 1.719 ± 0.045	0.253MetMet: 0.253 ± 0.016	0.434MetAsn: 0.434 ± 0.019	1.097MetPro: 1.097 ± 0.033	0.427MetGln: 0.427 ± 0.021	1.408MetArg: 1.408 ± 0.038	1.33MetSer: 1.33 ± 0.037	1.727MetThr: 1.727 ± 0.04	1.153MetVal: 1.153 ± 0.037	0.193MetTrp: 0.193 ± 0.014	0.274MetTyr: 0.274 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.461AsnAla: 2.461 ± 0.05	0.114AsnCys: 0.114 ± 0.014	1.14AsnAsp: 1.14 ± 0.042	0.94AsnGlu: 0.94 ± 0.03	0.654AsnPhe: 0.654 ± 0.027	1.937AsnGly: 1.937 ± 0.049	0.326AsnHis: 0.326 ± 0.018	0.744AsnIle: 0.744 ± 0.023	0.333AsnLys: 0.333 ± 0.019	1.818AsnLeu: 1.818 ± 0.041	0.29AsnMet: 0.29 ± 0.018	0.467AsnAsn: 0.467 ± 0.025	1.495AsnPro: 1.495 ± 0.039	0.515AsnGln: 0.515 ± 0.022	1.282AsnArg: 1.282 ± 0.034	0.981AsnSer: 0.981 ± 0.04	1.232AsnThr: 1.232 ± 0.073	1.748AsnVal: 1.748 ± 0.051	0.285AsnTrp: 0.285 ± 0.018	0.475AsnTyr: 0.475 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.646ProAla: 7.646 ± 0.119	0.167ProCys: 0.167 ± 0.012	4.115ProAsp: 4.115 ± 0.056	3.985ProGlu: 3.985 ± 0.064	1.76ProPhe: 1.76 ± 0.047	5.351ProGly: 5.351 ± 0.126	1.144ProHis: 1.144 ± 0.032	2.024ProIle: 2.024 ± 0.047	0.841ProLys: 0.841 ± 0.031	5.151ProLeu: 5.151 ± 0.084	0.823ProMet: 0.823 ± 0.026	1.029ProAsn: 1.029 ± 0.029	2.517ProPro: 2.517 ± 0.069	1.511ProGln: 1.511 ± 0.041	3.646ProArg: 3.646 ± 0.07	3.21ProSer: 3.21 ± 0.062	3.558ProThr: 3.558 ± 0.062	5.257ProVal: 5.257 ± 0.071	0.836ProTrp: 0.836 ± 0.032	1.109ProTyr: 1.109 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.163GlnAla: 3.163 ± 0.064	0.09GlnCys: 0.09 ± 0.009	1.05GlnAsp: 1.05 ± 0.033	1.268GlnGlu: 1.268 ± 0.036	0.891GlnPhe: 0.891 ± 0.027	1.85GlnGly: 1.85 ± 0.045	0.623GlnHis: 0.623 ± 0.028	1.207GlnIle: 1.207 ± 0.032	0.583GlnLys: 0.583 ± 0.026	3.17GlnLeu: 3.17 ± 0.057	0.411GlnMet: 0.411 ± 0.022	0.642GlnAsn: 0.642 ± 0.028	1.518GlnPro: 1.518 ± 0.044	1.256GlnGln: 1.256 ± 0.041	2.413GlnArg: 2.413 ± 0.047	1.424GlnSer: 1.424 ± 0.038	1.376GlnThr: 1.376 ± 0.038	2.266GlnVal: 2.266 ± 0.052	0.443GlnTrp: 0.443 ± 0.022	0.623GlnTyr: 0.623 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.297ArgAla: 9.297 ± 0.136	0.239ArgCys: 0.239 ± 0.015	4.544ArgAsp: 4.544 ± 0.073	4.757ArgGlu: 4.757 ± 0.094	2.603ArgPhe: 2.603 ± 0.056	5.648ArgGly: 5.648 ± 0.083	1.666ArgHis: 1.666 ± 0.041	3.917ArgIle: 3.917 ± 0.068	1.166ArgLys: 1.166 ± 0.042	8.035ArgLeu: 8.035 ± 0.122	1.914ArgMet: 1.914 ± 0.048	1.457ArgAsn: 1.457 ± 0.041	3.935ArgPro: 3.935 ± 0.077	1.928ArgGln: 1.928 ± 0.048	7.471ArgArg: 7.471 ± 0.129	4.222ArgSer: 4.222 ± 0.069	4.264ArgThr: 4.264 ± 0.069	6.753ArgVal: 6.753 ± 0.095	1.286ArgTrp: 1.286 ± 0.04	1.656ArgTyr: 1.656 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.031SerAla: 7.031 ± 0.088	0.236SerCys: 0.236 ± 0.016	3.176SerAsp: 3.176 ± 0.049	2.669SerGlu: 2.669 ± 0.055	1.835SerPhe: 1.835 ± 0.045	5.808SerGly: 5.808 ± 0.096	0.862SerHis: 0.862 ± 0.031	2.451SerIle: 2.451 ± 0.057	0.888SerLys: 0.888 ± 0.028	5.048SerLeu: 5.048 ± 0.068	0.971SerMet: 0.971 ± 0.031	1.065SerAsn: 1.065 ± 0.034	2.983SerPro: 2.983 ± 0.052	1.203SerGln: 1.203 ± 0.034	3.757SerArg: 3.757 ± 0.063	3.162SerSer: 3.162 ± 0.065	3.807SerThr: 3.807 ± 0.071	4.75SerVal: 4.75 ± 0.074	0.913SerTrp: 0.913 ± 0.029	1.172SerTyr: 1.172 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	8.363ThrAla: 8.363 ± 0.167	0.242ThrCys: 0.242 ± 0.02	3.786ThrAsp: 3.786 ± 0.07	3.213ThrGlu: 3.213 ± 0.06	1.863ThrPhe: 1.863 ± 0.053	6.158ThrGly: 6.158 ± 0.14	1.072ThrHis: 1.072 ± 0.031	2.74ThrIle: 2.74 ± 0.06	1.02ThrLys: 1.02 ± 0.034	6.163ThrLeu: 6.163 ± 0.101	0.871ThrMet: 0.871 ± 0.026	1.177ThrAsn: 1.177 ± 0.052	4.12ThrPro: 4.12 ± 0.08	1.383ThrGln: 1.383 ± 0.05	3.957ThrArg: 3.957 ± 0.062	3.271ThrSer: 3.271 ± 0.061	4.046ThrThr: 4.046 ± 0.082	6.43ThrVal: 6.43 ± 0.147	0.924ThrTrp: 0.924 ± 0.034	1.213ThrTyr: 1.213 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	12.075ValAla: 12.075 ± 0.139	0.469ValCys: 0.469 ± 0.025	6.187ValAsp: 6.187 ± 0.086	5.271ValGlu: 5.271 ± 0.069	2.936ValPhe: 2.936 ± 0.053	7.386ValGly: 7.386 ± 0.09	1.734ValHis: 1.734 ± 0.045	4.104ValIle: 4.104 ± 0.072	1.379ValLys: 1.379 ± 0.039	10.218ValLeu: 10.218 ± 0.132	1.334ValMet: 1.334 ± 0.039	1.834ValAsn: 1.834 ± 0.038	5.378ValPro: 5.378 ± 0.081	2.262ValGln: 2.262 ± 0.054	6.64ValArg: 6.64 ± 0.083	4.934ValSer: 4.934 ± 0.072	6.271ValThr: 6.271 ± 0.173	9.478ValVal: 9.478 ± 0.13	1.184ValTrp: 1.184 ± 0.035	1.683ValTyr: 1.683 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.679TrpAla: 1.679 ± 0.042	0.099TrpCys: 0.099 ± 0.009	0.783TrpAsp: 0.783 ± 0.026	0.682TrpGlu: 0.682 ± 0.024	0.582TrpPhe: 0.582 ± 0.027	1.051TrpGly: 1.051 ± 0.034	0.342TrpHis: 0.342 ± 0.017	0.638TrpIle: 0.638 ± 0.025	0.252TrpLys: 0.252 ± 0.014	1.671TrpLeu: 1.671 ± 0.044	0.336TrpMet: 0.336 ± 0.019	0.48TrpAsn: 0.48 ± 0.024	0.825TrpPro: 0.825 ± 0.046	0.516TrpGln: 0.516 ± 0.021	1.36TrpArg: 1.36 ± 0.043	0.985TrpSer: 0.985 ± 0.028	0.994TrpThr: 0.994 ± 0.034	1.196TrpVal: 1.196 ± 0.033	0.376TrpTrp: 0.376 ± 0.022	0.313TrpTyr: 0.313 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.05	0.121TyrCys: 0.121 ± 0.012	1.306TyrAsp: 1.306 ± 0.038	1.22TyrGlu: 1.22 ± 0.036	0.721TyrPhe: 0.721 ± 0.028	1.893TyrGly: 1.893 ± 0.046	0.295TyrHis: 0.295 ± 0.016	0.658TyrIle: 0.658 ± 0.024	0.295TyrLys: 0.295 ± 0.017	2.28TyrLeu: 2.28 ± 0.046	0.244TyrMet: 0.244 ± 0.016	0.475TyrAsn: 0.475 ± 0.026	1.076TyrPro: 1.076 ± 0.033	0.56TyrGln: 0.56 ± 0.024	1.766TyrArg: 1.766 ± 0.045	1.147TyrSer: 1.147 ± 0.033	1.339TyrThr: 1.339 ± 0.071	1.638TyrVal: 1.638 ± 0.042	0.342TyrTrp: 0.342 ± 0.017	0.463TyrTyr: 0.463 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3263 proteins (1073911 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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