Amino acid dipepetide frequency for Sediminicola sp. YIK13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.483AlaAla: 4.483 ± 0.098
0.505AlaCys: 0.505 ± 0.022
3.474AlaAsp: 3.474 ± 0.087
4.081AlaGlu: 4.081 ± 0.075
3.284AlaPhe: 3.284 ± 0.06
4.388AlaGly: 4.388 ± 0.101
1.203AlaHis: 1.203 ± 0.038
5.529AlaIle: 5.529 ± 0.084
4.775AlaLys: 4.775 ± 0.089
6.776AlaLeu: 6.776 ± 0.091
1.729AlaMet: 1.729 ± 0.053
3.492AlaAsn: 3.492 ± 0.072
2.123AlaPro: 2.123 ± 0.067
2.484AlaGln: 2.484 ± 0.045
2.065AlaArg: 2.065 ± 0.052
4.193AlaSer: 4.193 ± 0.073
3.835AlaThr: 3.835 ± 0.081
4.185AlaVal: 4.185 ± 0.078
0.595AlaTrp: 0.595 ± 0.024
2.535AlaTyr: 2.535 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.446CysAla: 0.446 ± 0.024
0.082CysCys: 0.082 ± 0.01
0.39CysAsp: 0.39 ± 0.023
0.416CysGlu: 0.416 ± 0.023
0.359CysPhe: 0.359 ± 0.019
0.598CysGly: 0.598 ± 0.028
0.151CysHis: 0.151 ± 0.014
0.538CysIle: 0.538 ± 0.021
0.407CysLys: 0.407 ± 0.019
0.595CysLeu: 0.595 ± 0.026
0.148CysMet: 0.148 ± 0.012
0.386CysAsn: 0.386 ± 0.023
0.315CysPro: 0.315 ± 0.019
0.211CysGln: 0.211 ± 0.014
0.199CysArg: 0.199 ± 0.014
0.499CysSer: 0.499 ± 0.029
0.432CysThr: 0.432 ± 0.03
0.377CysVal: 0.377 ± 0.019
0.055CysTrp: 0.055 ± 0.008
0.301CysTyr: 0.301 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.867AspAla: 3.867 ± 0.087
0.384AspCys: 0.384 ± 0.021
2.876AspAsp: 2.876 ± 0.08
3.529AspGlu: 3.529 ± 0.066
3.549AspPhe: 3.549 ± 0.066
4.022AspGly: 4.022 ± 0.127
1.086AspHis: 1.086 ± 0.031
4.524AspIle: 4.524 ± 0.072
4.076AspLys: 4.076 ± 0.078
5.36AspLeu: 5.36 ± 0.076
1.256AspMet: 1.256 ± 0.037
3.004AspAsn: 3.004 ± 0.104
1.937AspPro: 1.937 ± 0.043
1.818AspGln: 1.818 ± 0.046
2.063AspArg: 2.063 ± 0.046
3.294AspSer: 3.294 ± 0.069
2.903AspThr: 2.903 ± 0.058
3.512AspVal: 3.512 ± 0.061
0.746AspTrp: 0.746 ± 0.031
2.661AspTyr: 2.661 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
4.545GluAla: 4.545 ± 0.091
0.315GluCys: 0.315 ± 0.018
3.8GluAsp: 3.8 ± 0.082
5.283GluGlu: 5.283 ± 0.099
2.886GluPhe: 2.886 ± 0.059
4.124GluGly: 4.124 ± 0.074
1.324GluHis: 1.324 ± 0.042
5.399GluIle: 5.399 ± 0.073
5.591GluLys: 5.591 ± 0.103
6.498GluLeu: 6.498 ± 0.104
1.703GluMet: 1.703 ± 0.042
4.246GluAsn: 4.246 ± 0.071
1.691GluPro: 1.691 ± 0.046
2.383GluGln: 2.383 ± 0.057
2.778GluArg: 2.778 ± 0.059
3.237GluSer: 3.237 ± 0.058
3.534GluThr: 3.534 ± 0.071
4.638GluVal: 4.638 ± 0.076
0.687GluTrp: 0.687 ± 0.026
2.352GluTyr: 2.352 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
2.848PheAla: 2.848 ± 0.053
0.395PheCys: 0.395 ± 0.021
3.083PheAsp: 3.083 ± 0.059
3.309PheGlu: 3.309 ± 0.067
2.699PhePhe: 2.699 ± 0.076
3.816PheGly: 3.816 ± 0.067
0.836PheHis: 0.836 ± 0.03
3.712PheIle: 3.712 ± 0.079
3.626PheLys: 3.626 ± 0.061
4.763PheLeu: 4.763 ± 0.096
1.199PheMet: 1.199 ± 0.035
3.084PheAsn: 3.084 ± 0.063
1.715PhePro: 1.715 ± 0.038
1.591PheGln: 1.591 ± 0.039
1.66PheArg: 1.66 ± 0.049
3.775PheSer: 3.775 ± 0.063
3.011PheThr: 3.011 ± 0.074
2.973PheVal: 2.973 ± 0.067
0.569PheTrp: 0.569 ± 0.025
2.109PheTyr: 2.109 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.489GlyAla: 4.489 ± 0.088
0.641GlyCys: 0.641 ± 0.046
3.743GlyAsp: 3.743 ± 0.073
3.829GlyGlu: 3.829 ± 0.065
3.738GlyPhe: 3.738 ± 0.071
4.992GlyGly: 4.992 ± 0.115
1.226GlyHis: 1.226 ± 0.04
5.782GlyIle: 5.782 ± 0.087
5.089GlyLys: 5.089 ± 0.091
6.206GlyLeu: 6.206 ± 0.089
1.764GlyMet: 1.764 ± 0.043
3.757GlyAsn: 3.757 ± 0.1
1.566GlyPro: 1.566 ± 0.05
2.057GlyGln: 2.057 ± 0.048
2.262GlyArg: 2.262 ± 0.054
4.355GlySer: 4.355 ± 0.088
4.377GlyThr: 4.377 ± 0.167
4.585GlyVal: 4.585 ± 0.086
0.778GlyTrp: 0.778 ± 0.028
2.783GlyTyr: 2.783 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
0.968HisAla: 0.968 ± 0.03
0.171HisCys: 0.171 ± 0.014
0.823HisAsp: 0.823 ± 0.034
0.996HisGlu: 0.996 ± 0.035
1.098HisPhe: 1.098 ± 0.039
1.154HisGly: 1.154 ± 0.036
0.515HisHis: 0.515 ± 0.026
1.43HisIle: 1.43 ± 0.046
1.281HisLys: 1.281 ± 0.038
1.937HisLeu: 1.937 ± 0.051
0.386HisMet: 0.386 ± 0.021
0.886HisAsn: 0.886 ± 0.033
0.973HisPro: 0.973 ± 0.036
0.747HisGln: 0.747 ± 0.033
0.687HisArg: 0.687 ± 0.03
1.068HisSer: 1.068 ± 0.04
0.962HisThr: 0.962 ± 0.033
0.978HisVal: 0.978 ± 0.033
0.249HisTrp: 0.249 ± 0.015
0.816HisTyr: 0.816 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.642IleAla: 5.642 ± 0.084
0.556IleCys: 0.556 ± 0.022
4.494IleAsp: 4.494 ± 0.069
4.898IleGlu: 4.898 ± 0.077
3.599IlePhe: 3.599 ± 0.071
5.336IleGly: 5.336 ± 0.09
1.343IleHis: 1.343 ± 0.037
5.619IleIle: 5.619 ± 0.102
5.593IleLys: 5.593 ± 0.099
7.29IleLeu: 7.29 ± 0.104
1.59IleMet: 1.59 ± 0.039
4.235IleAsn: 4.235 ± 0.068
3.352IlePro: 3.352 ± 0.067
2.467IleGln: 2.467 ± 0.056
2.656IleArg: 2.656 ± 0.057
5.612IleSer: 5.612 ± 0.097
4.823IleThr: 4.823 ± 0.114
4.684IleVal: 4.684 ± 0.085
0.726IleTrp: 0.726 ± 0.03
2.69IleTyr: 2.69 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.018LysAla: 5.018 ± 0.082
0.303LysCys: 0.303 ± 0.017
4.641LysAsp: 4.641 ± 0.088
6.663LysGlu: 6.663 ± 0.111
2.768LysPhe: 2.768 ± 0.056
4.838LysGly: 4.838 ± 0.077
1.225LysHis: 1.225 ± 0.038
5.871LysIle: 5.871 ± 0.098
6.753LysLys: 6.753 ± 0.116
6.379LysLeu: 6.379 ± 0.11
2.071LysMet: 2.071 ± 0.05
4.833LysAsn: 4.833 ± 0.076
2.199LysPro: 2.199 ± 0.054
2.295LysGln: 2.295 ± 0.059
2.815LysArg: 2.815 ± 0.062
4.351LysSer: 4.351 ± 0.074
4.212LysThr: 4.212 ± 0.072
4.725LysVal: 4.725 ± 0.08
0.736LysTrp: 0.736 ± 0.027
2.822LysTyr: 2.822 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
6.322LeuAla: 6.322 ± 0.095
0.651LeuCys: 0.651 ± 0.026
5.415LeuAsp: 5.415 ± 0.068
6.86LeuGlu: 6.86 ± 0.099
4.82LeuPhe: 4.82 ± 0.081
6.368LeuGly: 6.368 ± 0.084
1.656LeuHis: 1.656 ± 0.052
6.668LeuIle: 6.668 ± 0.11
7.639LeuLys: 7.639 ± 0.111
9.274LeuLeu: 9.274 ± 0.144
2.374LeuMet: 2.374 ± 0.052
5.321LeuAsn: 5.321 ± 0.086
3.608LeuPro: 3.608 ± 0.069
3.342LeuGln: 3.342 ± 0.062
3.274LeuArg: 3.274 ± 0.066
6.496LeuSer: 6.496 ± 0.102
5.173LeuThr: 5.173 ± 0.104
5.972LeuVal: 5.972 ± 0.098
0.895LeuTrp: 0.895 ± 0.035
3.098LeuTyr: 3.098 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.888MetAla: 1.888 ± 0.044
0.135MetCys: 0.135 ± 0.01
1.593MetAsp: 1.593 ± 0.04
1.876MetGlu: 1.876 ± 0.043
0.844MetPhe: 0.844 ± 0.03
1.847MetGly: 1.847 ± 0.046
0.418MetHis: 0.418 ± 0.022
1.506MetIle: 1.506 ± 0.043
2.089MetLys: 2.089 ± 0.048
2.02MetLeu: 2.02 ± 0.044
0.593MetMet: 0.593 ± 0.025
1.227MetAsn: 1.227 ± 0.04
0.906MetPro: 0.906 ± 0.03
0.804MetGln: 0.804 ± 0.031
0.918MetArg: 0.918 ± 0.03
1.416MetSer: 1.416 ± 0.046
1.238MetThr: 1.238 ± 0.034
1.802MetVal: 1.802 ± 0.045
0.164MetTrp: 0.164 ± 0.012
0.707MetTyr: 0.707 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.73AsnAla: 3.73 ± 0.073
0.434AsnCys: 0.434 ± 0.029
2.932AsnAsp: 2.932 ± 0.05
3.449AsnGlu: 3.449 ± 0.062
2.92AsnPhe: 2.92 ± 0.059
4.112AsnGly: 4.112 ± 0.114
0.949AsnHis: 0.949 ± 0.033
4.519AsnIle: 4.519 ± 0.085
3.907AsnLys: 3.907 ± 0.081
5.152AsnLeu: 5.152 ± 0.099
1.329AsnMet: 1.329 ± 0.038
3.402AsnAsn: 3.402 ± 0.087
2.558AsnPro: 2.558 ± 0.053
1.909AsnGln: 1.909 ± 0.049
2.124AsnArg: 2.124 ± 0.046
3.648AsnSer: 3.648 ± 0.069
3.525AsnThr: 3.525 ± 0.092
3.358AsnVal: 3.358 ± 0.065
0.64AsnTrp: 0.64 ± 0.029
2.539AsnTyr: 2.539 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
1.941ProAla: 1.941 ± 0.052
0.201ProCys: 0.201 ± 0.014
2.017ProAsp: 2.017 ± 0.051
2.779ProGlu: 2.779 ± 0.055
1.948ProPhe: 1.948 ± 0.043
2.093ProGly: 2.093 ± 0.054
0.67ProHis: 0.67 ± 0.026
2.787ProIle: 2.787 ± 0.053
2.698ProLys: 2.698 ± 0.057
3.225ProLeu: 3.225 ± 0.061
0.868ProMet: 0.868 ± 0.032
2.27ProAsn: 2.27 ± 0.052
0.906ProPro: 0.906 ± 0.038
1.139ProGln: 1.139 ± 0.036
0.998ProArg: 0.998 ± 0.035
2.227ProSer: 2.227 ± 0.058
2.14ProThr: 2.14 ± 0.051
2.255ProVal: 2.255 ± 0.053
0.34ProTrp: 0.34 ± 0.02
1.465ProTyr: 1.465 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.978GlnAla: 1.978 ± 0.046
0.16GlnCys: 0.16 ± 0.013
1.743GlnAsp: 1.743 ± 0.041
2.499GlnGlu: 2.499 ± 0.056
1.607GlnPhe: 1.607 ± 0.037
1.951GlnGly: 1.951 ± 0.045
0.618GlnHis: 0.618 ± 0.025
2.612GlnIle: 2.612 ± 0.053
2.794GlnLys: 2.794 ± 0.057
3.647GlnLeu: 3.647 ± 0.071
0.922GlnMet: 0.922 ± 0.032
1.946GlnAsn: 1.946 ± 0.045
1.067GlnPro: 1.067 ± 0.036
1.348GlnGln: 1.348 ± 0.044
1.286GlnArg: 1.286 ± 0.036
1.798GlnSer: 1.798 ± 0.047
1.737GlnThr: 1.737 ± 0.045
1.957GlnVal: 1.957 ± 0.049
0.435GlnTrp: 0.435 ± 0.024
1.318GlnTyr: 1.318 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.157ArgAla: 2.157 ± 0.047
0.189ArgCys: 0.189 ± 0.015
1.91ArgAsp: 1.91 ± 0.047
2.413ArgGlu: 2.413 ± 0.057
1.857ArgPhe: 1.857 ± 0.05
2.054ArgGly: 2.054 ± 0.051
0.625ArgHis: 0.625 ± 0.027
2.904ArgIle: 2.904 ± 0.057
2.805ArgLys: 2.805 ± 0.055
3.353ArgLeu: 3.353 ± 0.065
0.92ArgMet: 0.92 ± 0.035
2.101ArgAsn: 2.101 ± 0.051
1.215ArgPro: 1.215 ± 0.035
1.169ArgGln: 1.169 ± 0.038
1.363ArgArg: 1.363 ± 0.041
2.048ArgSer: 2.048 ± 0.051
1.971ArgThr: 1.971 ± 0.048
2.165ArgVal: 2.165 ± 0.045
0.39ArgTrp: 0.39 ± 0.022
1.573ArgTyr: 1.573 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.807SerAla: 3.807 ± 0.065
0.539SerCys: 0.539 ± 0.024
3.45SerAsp: 3.45 ± 0.063
3.844SerGlu: 3.844 ± 0.07
3.679SerPhe: 3.679 ± 0.07
4.68SerGly: 4.68 ± 0.091
1.048SerHis: 1.048 ± 0.037
5.009SerIle: 5.009 ± 0.076
4.842SerLys: 4.842 ± 0.085
6.184SerLeu: 6.184 ± 0.106
1.38SerMet: 1.38 ± 0.039
3.618SerAsn: 3.618 ± 0.08
2.224SerPro: 2.224 ± 0.048
2.011SerGln: 2.011 ± 0.043
2.152SerArg: 2.152 ± 0.052
4.259SerSer: 4.259 ± 0.086
3.532SerThr: 3.532 ± 0.072
3.819SerVal: 3.819 ± 0.068
0.692SerTrp: 0.692 ± 0.03
2.711SerTyr: 2.711 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.883ThrAla: 3.883 ± 0.089
0.36ThrCys: 0.36 ± 0.025
3.358ThrAsp: 3.358 ± 0.119
3.38ThrGlu: 3.38 ± 0.06
2.998ThrPhe: 2.998 ± 0.066
4.073ThrGly: 4.073 ± 0.087
0.986ThrHis: 0.986 ± 0.034
4.853ThrIle: 4.853 ± 0.127
3.717ThrLys: 3.717 ± 0.059
5.45ThrLeu: 5.45 ± 0.116
1.144ThrMet: 1.144 ± 0.036
3.082ThrAsn: 3.082 ± 0.097
2.455ThrPro: 2.455 ± 0.058
1.793ThrGln: 1.793 ± 0.049
1.647ThrArg: 1.647 ± 0.042
3.805ThrSer: 3.805 ± 0.075
3.485ThrThr: 3.485 ± 0.098
4.01ThrVal: 4.01 ± 0.123
0.574ThrTrp: 0.574 ± 0.032
2.439ThrTyr: 2.439 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
4.643ValAla: 4.643 ± 0.097
0.486ValCys: 0.486 ± 0.021
3.81ValAsp: 3.81 ± 0.096
3.831ValGlu: 3.831 ± 0.079
3.299ValPhe: 3.299 ± 0.065
4.133ValGly: 4.133 ± 0.076
1.205ValHis: 1.205 ± 0.037
4.649ValIle: 4.649 ± 0.076
4.261ValLys: 4.261 ± 0.078
6.366ValLeu: 6.366 ± 0.087
1.496ValMet: 1.496 ± 0.041
3.281ValAsn: 3.281 ± 0.077
2.388ValPro: 2.388 ± 0.054
1.915ValGln: 1.915 ± 0.046
2.166ValArg: 2.166 ± 0.054
4.282ValSer: 4.282 ± 0.069
3.73ValThr: 3.73 ± 0.112
4.645ValVal: 4.645 ± 0.09
0.584ValTrp: 0.584 ± 0.027
2.327ValTyr: 2.327 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.639TrpAla: 0.639 ± 0.028
0.087TrpCys: 0.087 ± 0.01
0.628TrpAsp: 0.628 ± 0.025
0.736TrpGlu: 0.736 ± 0.032
0.563TrpPhe: 0.563 ± 0.025
0.687TrpGly: 0.687 ± 0.028
0.211TrpHis: 0.211 ± 0.016
0.726TrpIle: 0.726 ± 0.032
0.761TrpLys: 0.761 ± 0.034
0.98TrpLeu: 0.98 ± 0.035
0.31TrpMet: 0.31 ± 0.021
0.651TrpAsn: 0.651 ± 0.025
0.278TrpPro: 0.278 ± 0.016
0.425TrpGln: 0.425 ± 0.022
0.435TrpArg: 0.435 ± 0.021
0.598TrpSer: 0.598 ± 0.028
0.543TrpThr: 0.543 ± 0.026
0.645TrpVal: 0.645 ± 0.023
0.133TrpTrp: 0.133 ± 0.012
0.427TrpTyr: 0.427 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.44TyrAla: 2.44 ± 0.049
0.314TyrCys: 0.314 ± 0.02
2.288TyrAsp: 2.288 ± 0.056
2.342TyrGlu: 2.342 ± 0.054
2.255TyrPhe: 2.255 ± 0.052
2.753TyrGly: 2.753 ± 0.06
0.831TyrHis: 0.831 ± 0.031
2.567TyrIle: 2.567 ± 0.055
2.815TyrLys: 2.815 ± 0.056
3.767TyrLeu: 3.767 ± 0.062
0.809TyrMet: 0.809 ± 0.032
2.314TyrAsn: 2.314 ± 0.054
1.492TyrPro: 1.492 ± 0.039
1.517TyrGln: 1.517 ± 0.042
1.634TyrArg: 1.634 ± 0.041
2.518TyrSer: 2.518 ± 0.053
2.328TyrThr: 2.328 ± 0.075
2.213TyrVal: 2.213 ± 0.047
0.474TyrTrp: 0.474 ± 0.021
1.71TyrTyr: 1.71 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2966 proteins (1011104 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski