Amino acid dipepetide frequency for Maricaulis salignorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.741AlaAla: 18.741 ± 0.199	1.278AlaCys: 1.278 ± 0.038	7.663AlaAsp: 7.663 ± 0.101	7.776AlaGlu: 7.776 ± 0.124	4.426AlaPhe: 4.426 ± 0.076	11.873AlaGly: 11.873 ± 0.133	2.323AlaHis: 2.323 ± 0.049	6.638AlaIle: 6.638 ± 0.09	3.112AlaLys: 3.112 ± 0.088	14.162AlaLeu: 14.162 ± 0.18	3.723AlaMet: 3.723 ± 0.07	3.052AlaAsn: 3.052 ± 0.063	6.091AlaPro: 6.091 ± 0.101	4.081AlaGln: 4.081 ± 0.077	9.743AlaArg: 9.743 ± 0.143	7.259AlaSer: 7.259 ± 0.105	5.644AlaThr: 5.644 ± 0.08	8.493AlaVal: 8.493 ± 0.09	1.768AlaTrp: 1.768 ± 0.044	2.567AlaTyr: 2.567 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.014CysAla: 1.014 ± 0.034	0.091CysCys: 0.091 ± 0.011	0.602CysAsp: 0.602 ± 0.026	0.473CysGlu: 0.473 ± 0.028	0.289CysPhe: 0.289 ± 0.017	0.893CysGly: 0.893 ± 0.032	0.213CysHis: 0.213 ± 0.014	0.328CysIle: 0.328 ± 0.02	0.178CysLys: 0.178 ± 0.012	0.776CysLeu: 0.776 ± 0.027	0.121CysMet: 0.121 ± 0.012	0.174CysAsn: 0.174 ± 0.014	0.443CysPro: 0.443 ± 0.022	0.27CysGln: 0.27 ± 0.017	0.594CysArg: 0.594 ± 0.027	0.51CysSer: 0.51 ± 0.027	0.386CysThr: 0.386 ± 0.023	0.605CysVal: 0.605 ± 0.027	0.12CysTrp: 0.12 ± 0.011	0.171CysTyr: 0.171 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.131AspAla: 8.131 ± 0.091	0.501AspCys: 0.501 ± 0.028	3.557AspAsp: 3.557 ± 0.072	3.906AspGlu: 3.906 ± 0.07	2.44AspPhe: 2.44 ± 0.047	6.049AspGly: 6.049 ± 0.098	1.228AspHis: 1.228 ± 0.039	3.193AspIle: 3.193 ± 0.065	1.358AspLys: 1.358 ± 0.042	6.191AspLeu: 6.191 ± 0.085	1.521AspMet: 1.521 ± 0.043	1.387AspAsn: 1.387 ± 0.044	3.711AspPro: 3.711 ± 0.067	2.078AspGln: 2.078 ± 0.047	4.524AspArg: 4.524 ± 0.078	2.681AspSer: 2.681 ± 0.058	2.921AspThr: 2.921 ± 0.066	4.119AspVal: 4.119 ± 0.076	1.162AspTrp: 1.162 ± 0.036	1.604AspTyr: 1.604 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.729GluAla: 8.729 ± 0.128	0.338GluCys: 0.338 ± 0.018	3.251GluAsp: 3.251 ± 0.061	2.891GluGlu: 2.891 ± 0.073	2.055GluPhe: 2.055 ± 0.05	4.255GluGly: 4.255 ± 0.073	1.276GluHis: 1.276 ± 0.041	3.793GluIle: 3.793 ± 0.065	1.52GluLys: 1.52 ± 0.048	5.748GluLeu: 5.748 ± 0.092	1.68GluMet: 1.68 ± 0.045	1.668GluAsn: 1.668 ± 0.039	2.925GluPro: 2.925 ± 0.062	2.059GluGln: 2.059 ± 0.055	5.011GluArg: 5.011 ± 0.083	2.742GluSer: 2.742 ± 0.055	4.072GluThr: 4.072 ± 0.073	3.572GluVal: 3.572 ± 0.079	0.714GluTrp: 0.714 ± 0.03	1.178GluTyr: 1.178 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.812PheAla: 4.812 ± 0.083	0.327PheCys: 0.327 ± 0.018	2.943PheAsp: 2.943 ± 0.05	2.474PheGlu: 2.474 ± 0.057	1.363PhePhe: 1.363 ± 0.046	3.645PheGly: 3.645 ± 0.069	0.768PheHis: 0.768 ± 0.03	1.794PheIle: 1.794 ± 0.044	0.881PheLys: 0.881 ± 0.032	3.234PheLeu: 3.234 ± 0.071	0.84PheMet: 0.84 ± 0.034	1.155PheAsn: 1.155 ± 0.034	1.466PhePro: 1.466 ± 0.036	0.989PheGln: 0.989 ± 0.032	2.082PheArg: 2.082 ± 0.05	2.187PheSer: 2.187 ± 0.065	2.05PheThr: 2.05 ± 0.058	2.42PheVal: 2.42 ± 0.057	0.529PheTrp: 0.529 ± 0.023	0.863PheTyr: 0.863 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.869GlyAla: 9.869 ± 0.135	0.77GlyCys: 0.77 ± 0.03	5.15GlyAsp: 5.15 ± 0.077	5.742GlyGlu: 5.742 ± 0.083	3.764GlyPhe: 3.764 ± 0.073	7.614GlyGly: 7.614 ± 0.142	1.959GlyHis: 1.959 ± 0.05	4.202GlyIle: 4.202 ± 0.075	2.437GlyLys: 2.437 ± 0.057	9.442GlyLeu: 9.442 ± 0.124	2.298GlyMet: 2.298 ± 0.05	2.17GlyAsn: 2.17 ± 0.079	3.741GlyPro: 3.741 ± 0.059	3.116GlyGln: 3.116 ± 0.06	6.154GlyArg: 6.154 ± 0.101	4.802GlySer: 4.802 ± 0.086	3.983GlyThr: 3.983 ± 0.085	6.265GlyVal: 6.265 ± 0.08	1.439GlyTrp: 1.439 ± 0.044	2.342GlyTyr: 2.342 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.462HisAla: 2.462 ± 0.05	0.236HisCys: 0.236 ± 0.016	1.227HisAsp: 1.227 ± 0.037	1.084HisGlu: 1.084 ± 0.038	0.812HisPhe: 0.812 ± 0.031	1.872HisGly: 1.872 ± 0.053	0.534HisHis: 0.534 ± 0.025	0.976HisIle: 0.976 ± 0.033	0.427HisLys: 0.427 ± 0.023	1.903HisLeu: 1.903 ± 0.044	0.446HisMet: 0.446 ± 0.021	0.439HisAsn: 0.439 ± 0.023	1.215HisPro: 1.215 ± 0.04	0.576HisGln: 0.576 ± 0.025	1.348HisArg: 1.348 ± 0.036	0.971HisSer: 0.971 ± 0.028	0.88HisThr: 0.88 ± 0.032	1.397HisVal: 1.397 ± 0.04	0.365HisTrp: 0.365 ± 0.019	0.569HisTyr: 0.569 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.704IleAla: 7.704 ± 0.093	0.445IleCys: 0.445 ± 0.025	3.862IleAsp: 3.862 ± 0.073	3.925IleGlu: 3.925 ± 0.08	1.708IlePhe: 1.708 ± 0.046	4.913IleGly: 4.913 ± 0.078	1.002IleHis: 1.002 ± 0.031	2.564IleIle: 2.564 ± 0.066	1.175IleLys: 1.175 ± 0.041	4.693IleLeu: 4.693 ± 0.08	0.996IleMet: 0.996 ± 0.032	1.492IleAsn: 1.492 ± 0.045	2.209IlePro: 2.209 ± 0.049	1.279IleGln: 1.279 ± 0.039	3.291IleArg: 3.291 ± 0.053	2.978IleSer: 2.978 ± 0.057	2.675IleThr: 2.675 ± 0.08	3.66IleVal: 3.66 ± 0.07	0.721IleTrp: 0.721 ± 0.03	1.136IleTyr: 1.136 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.315LysAla: 3.315 ± 0.085	0.136LysCys: 0.136 ± 0.011	1.233LysAsp: 1.233 ± 0.043	0.99LysGlu: 0.99 ± 0.037	0.766LysPhe: 0.766 ± 0.029	1.855LysGly: 1.855 ± 0.056	0.537LysHis: 0.537 ± 0.023	1.326LysIle: 1.326 ± 0.042	0.904LysLys: 0.904 ± 0.042	2.523LysLeu: 2.523 ± 0.064	0.626LysMet: 0.626 ± 0.028	0.599LysAsn: 0.599 ± 0.024	1.717LysPro: 1.717 ± 0.049	0.768LysGln: 0.768 ± 0.031	2.053LysArg: 2.053 ± 0.053	1.531LysSer: 1.531 ± 0.048	1.696LysThr: 1.696 ± 0.046	1.549LysVal: 1.549 ± 0.042	0.301LysTrp: 0.301 ± 0.018	0.473LysTyr: 0.473 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.296LeuAla: 14.296 ± 0.185	0.819LeuCys: 0.819 ± 0.029	6.763LeuAsp: 6.763 ± 0.094	5.934LeuGlu: 5.934 ± 0.086	3.466LeuPhe: 3.466 ± 0.069	8.376LeuGly: 8.376 ± 0.109	1.87LeuHis: 1.87 ± 0.044	5.36LeuIle: 5.36 ± 0.089	2.729LeuLys: 2.729 ± 0.061	8.779LeuLeu: 8.779 ± 0.139	2.334LeuMet: 2.334 ± 0.052	2.745LeuAsn: 2.745 ± 0.054	5.16LeuPro: 5.16 ± 0.083	2.859LeuGln: 2.859 ± 0.054	6.794LeuArg: 6.794 ± 0.089	6.106LeuSer: 6.106 ± 0.09	5.73LeuThr: 5.73 ± 0.087	7.286LeuVal: 7.286 ± 0.098	1.108LeuTrp: 1.108 ± 0.036	2.062LeuTyr: 2.062 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.348MetAla: 3.348 ± 0.055	0.165MetCys: 0.165 ± 0.015	1.293MetAsp: 1.293 ± 0.041	1.094MetGlu: 1.094 ± 0.033	0.787MetPhe: 0.787 ± 0.031	1.819MetGly: 1.819 ± 0.045	0.437MetHis: 0.437 ± 0.023	1.453MetIle: 1.453 ± 0.039	0.903MetLys: 0.903 ± 0.03	2.419MetLeu: 2.419 ± 0.06	0.765MetMet: 0.765 ± 0.026	0.699MetAsn: 0.699 ± 0.028	1.445MetPro: 1.445 ± 0.047	0.86MetGln: 0.86 ± 0.03	1.905MetArg: 1.905 ± 0.045	1.817MetSer: 1.817 ± 0.046	1.932MetThr: 1.932 ± 0.041	1.547MetVal: 1.547 ± 0.04	0.247MetTrp: 0.247 ± 0.015	0.286MetTyr: 0.286 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.293AsnAla: 3.293 ± 0.056	0.219AsnCys: 0.219 ± 0.016	1.41AsnAsp: 1.41 ± 0.048	1.223AsnGlu: 1.223 ± 0.031	1.017AsnPhe: 1.017 ± 0.035	2.33AsnGly: 2.33 ± 0.049	0.455AsnHis: 0.455 ± 0.02	1.338AsnIle: 1.338 ± 0.04	0.501AsnLys: 0.501 ± 0.025	2.585AsnLeu: 2.585 ± 0.051	0.625AsnMet: 0.625 ± 0.025	0.696AsnAsn: 0.696 ± 0.031	1.783AsnPro: 1.783 ± 0.043	0.814AsnGln: 0.814 ± 0.031	1.814AsnArg: 1.814 ± 0.049	1.351AsnSer: 1.351 ± 0.042	1.281AsnThr: 1.281 ± 0.044	1.704AsnVal: 1.704 ± 0.041	0.466AsnTrp: 0.466 ± 0.021	0.663AsnTyr: 0.663 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.705ProAla: 6.705 ± 0.091	0.288ProCys: 0.288 ± 0.02	4.166ProAsp: 4.166 ± 0.076	3.672ProGlu: 3.672 ± 0.074	1.799ProPhe: 1.799 ± 0.04	4.956ProGly: 4.956 ± 0.071	1.002ProHis: 1.002 ± 0.032	2.213ProIle: 2.213 ± 0.05	1.217ProLys: 1.217 ± 0.041	4.314ProLeu: 4.314 ± 0.064	1.222ProMet: 1.222 ± 0.035	1.116ProAsn: 1.116 ± 0.038	2.266ProPro: 2.266 ± 0.062	1.682ProGln: 1.682 ± 0.043	2.877ProArg: 2.877 ± 0.063	2.507ProSer: 2.507 ± 0.055	2.148ProThr: 2.148 ± 0.058	4.338ProVal: 4.338 ± 0.073	0.655ProTrp: 0.655 ± 0.026	1.077ProTyr: 1.077 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.68GlnAla: 4.68 ± 0.084	0.229GlnCys: 0.229 ± 0.014	1.685GlnAsp: 1.685 ± 0.046	1.301GlnGlu: 1.301 ± 0.043	1.086GlnPhe: 1.086 ± 0.034	2.311GlnGly: 2.311 ± 0.05	0.596GlnHis: 0.596 ± 0.027	1.895GlnIle: 1.895 ± 0.048	0.672GlnLys: 0.672 ± 0.026	3.178GlnLeu: 3.178 ± 0.059	0.863GlnMet: 0.863 ± 0.029	0.733GlnAsn: 0.733 ± 0.031	1.715GlnPro: 1.715 ± 0.049	1.076GlnGln: 1.076 ± 0.037	2.54GlnArg: 2.54 ± 0.056	2.007GlnSer: 2.007 ± 0.048	2.017GlnThr: 2.017 ± 0.04	2.115GlnVal: 2.115 ± 0.049	0.403GlnTrp: 0.403 ± 0.02	0.634GlnTyr: 0.634 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.491ArgAla: 8.491 ± 0.128	0.553ArgCys: 0.553 ± 0.022	4.363ArgAsp: 4.363 ± 0.062	4.377ArgGlu: 4.377 ± 0.078	2.995ArgPhe: 2.995 ± 0.054	5.097ArgGly: 5.097 ± 0.075	1.556ArgHis: 1.556 ± 0.04	4.174ArgIle: 4.174 ± 0.069	1.86ArgLys: 1.86 ± 0.053	8.192ArgLeu: 8.192 ± 0.105	1.789ArgMet: 1.789 ± 0.044	1.818ArgAsn: 1.818 ± 0.05	3.567ArgPro: 3.567 ± 0.069	2.553ArgGln: 2.553 ± 0.056	5.489ArgArg: 5.489 ± 0.106	3.884ArgSer: 3.884 ± 0.063	3.401ArgThr: 3.401 ± 0.061	4.771ArgVal: 4.771 ± 0.067	1.015ArgTrp: 1.015 ± 0.037	1.783ArgTyr: 1.783 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.699SerAla: 6.699 ± 0.106	0.389SerCys: 0.389 ± 0.024	3.499SerAsp: 3.499 ± 0.065	3.209SerGlu: 3.209 ± 0.057	2.152SerPhe: 2.152 ± 0.053	5.745SerGly: 5.745 ± 0.103	1.058SerHis: 1.058 ± 0.032	2.784SerIle: 2.784 ± 0.052	1.341SerLys: 1.341 ± 0.041	5.724SerLeu: 5.724 ± 0.078	1.404SerMet: 1.404 ± 0.04	1.437SerAsn: 1.437 ± 0.042	2.764SerPro: 2.764 ± 0.055	1.824SerGln: 1.824 ± 0.048	3.784SerArg: 3.784 ± 0.059	2.981SerSer: 2.981 ± 0.07	2.699SerThr: 2.699 ± 0.059	3.992SerVal: 3.992 ± 0.072	0.85SerTrp: 0.85 ± 0.034	1.315SerTyr: 1.315 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.515ThrAla: 6.515 ± 0.1	0.397ThrCys: 0.397 ± 0.021	3.079ThrAsp: 3.079 ± 0.056	2.809ThrGlu: 2.809 ± 0.064	1.572ThrPhe: 1.572 ± 0.048	5.624ThrGly: 5.624 ± 0.101	0.977ThrHis: 0.977 ± 0.031	2.743ThrIle: 2.743 ± 0.072	1.059ThrLys: 1.059 ± 0.035	5.611ThrLeu: 5.611 ± 0.081	1.061ThrMet: 1.061 ± 0.035	1.241ThrAsn: 1.241 ± 0.042	3.446ThrPro: 3.446 ± 0.069	1.551ThrGln: 1.551 ± 0.048	3.628ThrArg: 3.628 ± 0.06	2.829ThrSer: 2.829 ± 0.06	2.707ThrThr: 2.707 ± 0.061	3.992ThrVal: 3.992 ± 0.083	0.553ThrTrp: 0.553 ± 0.022	1.084ThrTyr: 1.084 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.669ValAla: 7.669 ± 0.094	0.713ValCys: 0.713 ± 0.033	4.302ValAsp: 4.302 ± 0.079	4.721ValGlu: 4.721 ± 0.075	2.908ValPhe: 2.908 ± 0.061	4.963ValGly: 4.963 ± 0.077	1.225ValHis: 1.225 ± 0.041	4.016ValIle: 4.016 ± 0.068	1.779ValLys: 1.779 ± 0.057	7.086ValLeu: 7.086 ± 0.092	2.051ValMet: 2.051 ± 0.048	1.966ValAsn: 1.966 ± 0.046	2.847ValPro: 2.847 ± 0.057	1.955ValGln: 1.955 ± 0.043	4.991ValArg: 4.991 ± 0.086	4.233ValSer: 4.233 ± 0.082	4.341ValThr: 4.341 ± 0.093	4.756ValVal: 4.756 ± 0.081	1.065ValTrp: 1.065 ± 0.036	1.476ValTyr: 1.476 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.411TrpAla: 1.411 ± 0.044	0.126TrpCys: 0.126 ± 0.012	0.736TrpAsp: 0.736 ± 0.027	0.609TrpGlu: 0.609 ± 0.027	0.516TrpPhe: 0.516 ± 0.023	0.966TrpGly: 0.966 ± 0.035	0.319TrpHis: 0.319 ± 0.02	0.728TrpIle: 0.728 ± 0.03	0.361TrpLys: 0.361 ± 0.02	1.65TrpLeu: 1.65 ± 0.052	0.398TrpMet: 0.398 ± 0.023	0.401TrpAsn: 0.401 ± 0.022	0.713TrpPro: 0.713 ± 0.029	0.537TrpGln: 0.537 ± 0.023	1.344TrpArg: 1.344 ± 0.039	0.973TrpSer: 0.973 ± 0.034	0.885TrpThr: 0.885 ± 0.033	0.9TrpVal: 0.9 ± 0.034	0.224TrpTrp: 0.224 ± 0.016	0.283TrpTyr: 0.283 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.529TyrAla: 2.529 ± 0.057	0.231TyrCys: 0.231 ± 0.017	1.477TyrAsp: 1.477 ± 0.048	1.267TyrGlu: 1.267 ± 0.036	0.901TyrPhe: 0.901 ± 0.034	2.104TyrGly: 2.104 ± 0.05	0.404TyrHis: 0.404 ± 0.02	0.909TyrIle: 0.909 ± 0.033	0.488TyrLys: 0.488 ± 0.024	2.366TyrLeu: 2.366 ± 0.058	0.457TyrMet: 0.457 ± 0.023	0.579TyrAsn: 0.579 ± 0.026	0.997TyrPro: 0.997 ± 0.031	0.809TyrGln: 0.809 ± 0.033	1.765TyrArg: 1.765 ± 0.046	1.301TyrSer: 1.301 ± 0.044	1.028TyrThr: 1.028 ± 0.041	1.581TyrVal: 1.581 ± 0.045	0.373TyrTrp: 0.373 ± 0.02	0.563TyrTyr: 0.563 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2949 proteins (939932 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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