Amino acid dipepetide frequency for Ectothiorhodosinus mongolicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.395AlaAla: 12.395 ± 0.203
1.092AlaCys: 1.092 ± 0.056
6.221AlaAsp: 6.221 ± 0.174
7.046AlaGlu: 7.046 ± 0.179
3.412AlaPhe: 3.412 ± 0.08
9.136AlaGly: 9.136 ± 0.426
2.359AlaHis: 2.359 ± 0.089
5.459AlaIle: 5.459 ± 0.126
3.151AlaLys: 3.151 ± 0.108
12.771AlaLeu: 12.771 ± 0.265
3.137AlaMet: 3.137 ± 0.115
2.914AlaAsn: 2.914 ± 0.174
4.032AlaPro: 4.032 ± 0.114
5.059AlaGln: 5.059 ± 0.125
7.285AlaArg: 7.285 ± 0.177
5.754AlaSer: 5.754 ± 0.155
4.931AlaThr: 4.931 ± 0.252
7.356AlaVal: 7.356 ± 0.12
1.465AlaTrp: 1.465 ± 0.055
2.424AlaTyr: 2.424 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
0.924CysAla: 0.924 ± 0.059
0.121CysCys: 0.121 ± 0.018
0.534CysAsp: 0.534 ± 0.032
0.532CysGlu: 0.532 ± 0.034
0.327CysPhe: 0.327 ± 0.029
0.87CysGly: 0.87 ± 0.055
0.296CysHis: 0.296 ± 0.025
0.448CysIle: 0.448 ± 0.032
0.179CysLys: 0.179 ± 0.017
0.932CysLeu: 0.932 ± 0.047
0.171CysMet: 0.171 ± 0.016
0.209CysAsn: 0.209 ± 0.02
0.515CysPro: 0.515 ± 0.034
0.41CysGln: 0.41 ± 0.028
0.66CysArg: 0.66 ± 0.042
0.505CysSer: 0.505 ± 0.035
0.408CysThr: 0.408 ± 0.03
0.655CysVal: 0.655 ± 0.041
0.112CysTrp: 0.112 ± 0.012
0.206CysTyr: 0.206 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
6.336AspAla: 6.336 ± 0.136
0.534AspCys: 0.534 ± 0.038
2.922AspAsp: 2.922 ± 0.091
3.701AspGlu: 3.701 ± 0.094
2.268AspPhe: 2.268 ± 0.066
4.498AspGly: 4.498 ± 0.298
1.278AspHis: 1.278 ± 0.05
3.314AspIle: 3.314 ± 0.101
1.587AspLys: 1.587 ± 0.07
6.471AspLeu: 6.471 ± 0.125
1.315AspMet: 1.315 ± 0.055
1.584AspAsn: 1.584 ± 0.103
3.024AspPro: 3.024 ± 0.074
2.319AspGln: 2.319 ± 0.067
3.498AspArg: 3.498 ± 0.08
2.834AspSer: 2.834 ± 0.087
2.647AspThr: 2.647 ± 0.096
4.217AspVal: 4.217 ± 0.111
1.028AspTrp: 1.028 ± 0.046
1.694AspTyr: 1.694 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
7.08GluAla: 7.08 ± 0.21
0.432GluCys: 0.432 ± 0.031
3.135GluAsp: 3.135 ± 0.087
3.353GluGlu: 3.353 ± 0.139
2.002GluPhe: 2.002 ± 0.062
4.181GluGly: 4.181 ± 0.09
1.646GluHis: 1.646 ± 0.074
3.302GluIle: 3.302 ± 0.083
2.043GluLys: 2.043 ± 0.084
6.525GluLeu: 6.525 ± 0.12
1.584GluMet: 1.584 ± 0.063
1.662GluAsn: 1.662 ± 0.05
2.659GluPro: 2.659 ± 0.098
3.382GluGln: 3.382 ± 0.112
4.885GluArg: 4.885 ± 0.163
3.073GluSer: 3.073 ± 0.088
3.172GluThr: 3.172 ± 0.065
4.491GluVal: 4.491 ± 0.09
0.735GluTrp: 0.735 ± 0.041
1.339GluTyr: 1.339 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.836PheAla: 3.836 ± 0.075
0.406PheCys: 0.406 ± 0.027
2.443PheAsp: 2.443 ± 0.082
2.176PheGlu: 2.176 ± 0.061
1.425PhePhe: 1.425 ± 0.066
2.941PheGly: 2.941 ± 0.076
0.743PheHis: 0.743 ± 0.038
1.742PheIle: 1.742 ± 0.074
0.923PheLys: 0.923 ± 0.043
3.455PheLeu: 3.455 ± 0.126
0.912PheMet: 0.912 ± 0.049
1.253PheAsn: 1.253 ± 0.062
1.39PhePro: 1.39 ± 0.069
1.14PheGln: 1.14 ± 0.047
1.929PheArg: 1.929 ± 0.062
2.356PheSer: 2.356 ± 0.08
2.062PheThr: 2.062 ± 0.094
2.541PheVal: 2.541 ± 0.082
0.524PheTrp: 0.524 ± 0.037
0.971PheTyr: 0.971 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
7.576GlyAla: 7.576 ± 0.363
0.859GlyCys: 0.859 ± 0.05
4.802GlyAsp: 4.802 ± 0.286
4.903GlyGlu: 4.903 ± 0.097
3.373GlyPhe: 3.373 ± 0.073
7.462GlyGly: 7.462 ± 0.894
1.898GlyHis: 1.898 ± 0.053
4.646GlyIle: 4.646 ± 0.097
2.698GlyLys: 2.698 ± 0.085
8.918GlyLeu: 8.918 ± 0.127
2.356GlyMet: 2.356 ± 0.082
2.628GlyAsn: 2.628 ± 0.309
2.749GlyPro: 2.749 ± 0.08
3.597GlyGln: 3.597 ± 0.093
5.298GlyArg: 5.298 ± 0.113
5.213GlySer: 5.213 ± 0.329
4.546GlyThr: 4.546 ± 0.539
6.183GlyVal: 6.183 ± 0.134
1.108GlyTrp: 1.108 ± 0.047
2.128GlyTyr: 2.128 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.303HisAla: 2.303 ± 0.089
0.32HisCys: 0.32 ± 0.029
1.23HisAsp: 1.23 ± 0.05
1.344HisGlu: 1.344 ± 0.057
0.963HisPhe: 0.963 ± 0.046
1.995HisGly: 1.995 ± 0.063
0.716HisHis: 0.716 ± 0.043
1.232HisIle: 1.232 ± 0.054
0.536HisLys: 0.536 ± 0.034
2.48HisLeu: 2.48 ± 0.091
0.575HisMet: 0.575 ± 0.034
0.625HisAsn: 0.625 ± 0.028
1.468HisPro: 1.468 ± 0.072
1.007HisGln: 1.007 ± 0.047
1.551HisArg: 1.551 ± 0.067
1.168HisSer: 1.168 ± 0.046
1.055HisThr: 1.055 ± 0.042
1.552HisVal: 1.552 ± 0.058
0.491HisTrp: 0.491 ± 0.033
0.752HisTyr: 0.752 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.888IleAla: 5.888 ± 0.105
0.534IleCys: 0.534 ± 0.034
3.624IleAsp: 3.624 ± 0.085
3.718IleGlu: 3.718 ± 0.086
1.709IlePhe: 1.709 ± 0.07
4.315IleGly: 4.315 ± 0.093
1.219IleHis: 1.219 ± 0.057
2.816IleIle: 2.816 ± 0.073
1.68IleLys: 1.68 ± 0.065
4.659IleLeu: 4.659 ± 0.124
1.117IleMet: 1.117 ± 0.059
1.956IleAsn: 1.956 ± 0.099
2.345IlePro: 2.345 ± 0.095
1.968IleGln: 1.968 ± 0.053
3.285IleArg: 3.285 ± 0.086
3.412IleSer: 3.412 ± 0.133
3.736IleThr: 3.736 ± 0.313
3.245IleVal: 3.245 ± 0.074
0.571IleTrp: 0.571 ± 0.033
1.309IleTyr: 1.309 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
3.567LysAla: 3.567 ± 0.107
0.171LysCys: 0.171 ± 0.017
1.63LysAsp: 1.63 ± 0.063
1.481LysGlu: 1.481 ± 0.06
0.712LysPhe: 0.712 ± 0.038
2.172LysGly: 2.172 ± 0.066
0.709LysHis: 0.709 ± 0.038
1.454LysIle: 1.454 ± 0.05
1.317LysLys: 1.317 ± 0.072
2.871LysLeu: 2.871 ± 0.08
0.673LysMet: 0.673 ± 0.044
0.896LysAsn: 0.896 ± 0.036
1.862LysPro: 1.862 ± 0.082
1.331LysGln: 1.331 ± 0.053
2.211LysArg: 2.211 ± 0.096
1.637LysSer: 1.637 ± 0.062
1.814LysThr: 1.814 ± 0.051
2.031LysVal: 2.031 ± 0.074
0.253LysTrp: 0.253 ± 0.022
0.548LysTyr: 0.548 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
12.513LeuAla: 12.513 ± 0.248
0.894LeuCys: 0.894 ± 0.049
6.581LeuAsp: 6.581 ± 0.103
6.924LeuGlu: 6.924 ± 0.164
3.588LeuPhe: 3.588 ± 0.131
8.992LeuGly: 8.992 ± 0.135
2.362LeuHis: 2.362 ± 0.096
5.582LeuIle: 5.582 ± 0.119
3.752LeuLys: 3.752 ± 0.129
11.855LeuLeu: 11.855 ± 0.327
2.796LeuMet: 2.796 ± 0.102
3.277LeuAsn: 3.277 ± 0.101
5.698LeuPro: 5.698 ± 0.182
4.555LeuGln: 4.555 ± 0.134
7.456LeuArg: 7.456 ± 0.193
7.215LeuSer: 7.215 ± 0.123
5.601LeuThr: 5.601 ± 0.262
7.517LeuVal: 7.517 ± 0.135
1.337LeuTrp: 1.337 ± 0.064
2.284LeuTyr: 2.284 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
3.035MetAla: 3.035 ± 0.103
0.14MetCys: 0.14 ± 0.016
1.438MetAsp: 1.438 ± 0.063
1.194MetGlu: 1.194 ± 0.056
0.614MetPhe: 0.614 ± 0.044
2.15MetGly: 2.15 ± 0.08
0.574MetHis: 0.574 ± 0.034
1.251MetIle: 1.251 ± 0.044
0.891MetLys: 0.891 ± 0.046
2.689MetLeu: 2.689 ± 0.104
0.599MetMet: 0.599 ± 0.038
0.832MetAsn: 0.832 ± 0.033
1.396MetPro: 1.396 ± 0.057
1.301MetGln: 1.301 ± 0.063
1.924MetArg: 1.924 ± 0.082
1.686MetSer: 1.686 ± 0.075
1.458MetThr: 1.458 ± 0.043
1.755MetVal: 1.755 ± 0.069
0.169MetTrp: 0.169 ± 0.017
0.368MetTyr: 0.368 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.221AsnAla: 3.221 ± 0.175
0.23AsnCys: 0.23 ± 0.021
1.503AsnAsp: 1.503 ± 0.104
1.46AsnGlu: 1.46 ± 0.056
0.987AsnPhe: 0.987 ± 0.052
2.274AsnGly: 2.274 ± 0.2
0.588AsnHis: 0.588 ± 0.031
1.871AsnIle: 1.871 ± 0.114
0.719AsnLys: 0.719 ± 0.036
3.082AsnLeu: 3.082 ± 0.101
0.674AsnMet: 0.674 ± 0.033
1.01AsnAsn: 1.01 ± 0.117
1.929AsnPro: 1.929 ± 0.051
1.242AsnGln: 1.242 ± 0.048
1.836AsnArg: 1.836 ± 0.053
1.514AsnSer: 1.514 ± 0.107
1.753AsnThr: 1.753 ± 0.177
2.171AsnVal: 2.171 ± 0.136
0.39AsnTrp: 0.39 ± 0.025
0.877AsnTyr: 0.877 ± 0.107
0.0AsnXaa: 0.0 ± 0.0
Pro
4.576ProAla: 4.576 ± 0.13
0.371ProCys: 0.371 ± 0.032
2.915ProAsp: 2.915 ± 0.087
4.061ProGlu: 4.061 ± 0.148
1.525ProPhe: 1.525 ± 0.068
4.032ProGly: 4.032 ± 0.116
1.109ProHis: 1.109 ± 0.053
2.3ProIle: 2.3 ± 0.071
1.468ProLys: 1.468 ± 0.06
4.901ProLeu: 4.901 ± 0.146
1.269ProMet: 1.269 ± 0.057
1.288ProAsn: 1.288 ± 0.046
2.018ProPro: 2.018 ± 0.079
2.015ProGln: 2.015 ± 0.073
2.593ProArg: 2.593 ± 0.078
2.517ProSer: 2.517 ± 0.073
2.064ProThr: 2.064 ± 0.057
3.72ProVal: 3.72 ± 0.12
0.671ProTrp: 0.671 ± 0.04
1.082ProTyr: 1.082 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
5.566GlnAla: 5.566 ± 0.128
0.347GlnCys: 0.347 ± 0.028
1.962GlnAsp: 1.962 ± 0.055
2.384GlnGlu: 2.384 ± 0.098
1.36GlnPhe: 1.36 ± 0.045
3.709GlnGly: 3.709 ± 0.086
1.079GlnHis: 1.079 ± 0.052
2.268GlnIle: 2.268 ± 0.058
1.264GlnLys: 1.264 ± 0.061
4.707GlnLeu: 4.707 ± 0.132
1.066GlnMet: 1.066 ± 0.048
1.061GlnAsn: 1.061 ± 0.041
2.019GlnPro: 2.019 ± 0.071
2.584GlnGln: 2.584 ± 0.099
3.722GlnArg: 3.722 ± 0.138
2.388GlnSer: 2.388 ± 0.077
2.19GlnThr: 2.19 ± 0.064
3.259GlnVal: 3.259 ± 0.075
0.719GlnTrp: 0.719 ± 0.042
0.918GlnTyr: 0.918 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
6.213ArgAla: 6.213 ± 0.181
0.61ArgCys: 0.61 ± 0.037
3.833ArgAsp: 3.833 ± 0.091
4.463ArgGlu: 4.463 ± 0.16
2.877ArgPhe: 2.877 ± 0.085
4.587ArgGly: 4.587 ± 0.087
1.799ArgHis: 1.799 ± 0.075
3.903ArgIle: 3.903 ± 0.089
1.744ArgLys: 1.744 ± 0.069
8.478ArgLeu: 8.478 ± 0.222
1.855ArgMet: 1.855 ± 0.064
1.731ArgAsn: 1.731 ± 0.066
2.866ArgPro: 2.866 ± 0.103
3.468ArgGln: 3.468 ± 0.123
4.978ArgArg: 4.978 ± 0.17
3.618ArgSer: 3.618 ± 0.089
2.506ArgThr: 2.506 ± 0.068
4.978ArgVal: 4.978 ± 0.123
0.98ArgTrp: 0.98 ± 0.055
1.94ArgTyr: 1.94 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.924SerAla: 5.924 ± 0.148
0.457SerCys: 0.457 ± 0.032
3.127SerAsp: 3.127 ± 0.115
3.119SerGlu: 3.119 ± 0.098
2.144SerPhe: 2.144 ± 0.07
6.183SerGly: 6.183 ± 0.447
1.262SerHis: 1.262 ± 0.052
2.947SerIle: 2.947 ± 0.101
1.447SerLys: 1.447 ± 0.043
6.606SerLeu: 6.606 ± 0.123
1.532SerMet: 1.532 ± 0.057
1.629SerAsn: 1.629 ± 0.128
2.517SerPro: 2.517 ± 0.075
2.333SerGln: 2.333 ± 0.066
3.624SerArg: 3.624 ± 0.076
3.44SerSer: 3.44 ± 0.158
2.674SerThr: 2.674 ± 0.145
4.163SerVal: 4.163 ± 0.104
0.735SerTrp: 0.735 ± 0.04
1.35SerTyr: 1.35 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.461ThrAla: 5.461 ± 0.254
0.413ThrCys: 0.413 ± 0.031
2.743ThrAsp: 2.743 ± 0.109
2.721ThrGlu: 2.721 ± 0.058
1.672ThrPhe: 1.672 ± 0.15
5.078ThrGly: 5.078 ± 0.474
1.27ThrHis: 1.27 ± 0.049
2.662ThrIle: 2.662 ± 0.277
1.012ThrLys: 1.012 ± 0.046
6.627ThrLeu: 6.627 ± 0.336
0.956ThrMet: 0.956 ± 0.048
1.414ThrAsn: 1.414 ± 0.153
3.068ThrPro: 3.068 ± 0.073
2.38ThrGln: 2.38 ± 0.065
3.119ThrArg: 3.119 ± 0.085
2.442ThrSer: 2.442 ± 0.117
2.789ThrThr: 2.789 ± 0.292
3.981ThrVal: 3.981 ± 0.258
0.539ThrTrp: 0.539 ± 0.033
1.164ThrTyr: 1.164 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
7.392ValAla: 7.392 ± 0.124
0.706ValCys: 0.706 ± 0.039
4.38ValAsp: 4.38 ± 0.093
4.088ValGlu: 4.088 ± 0.095
2.732ValPhe: 2.732 ± 0.074
5.507ValGly: 5.507 ± 0.146
1.535ValHis: 1.535 ± 0.061
4.372ValIle: 4.372 ± 0.085
2.045ValLys: 2.045 ± 0.068
8.068ValLeu: 8.068 ± 0.153
2.029ValMet: 2.029 ± 0.078
2.337ValAsn: 2.337 ± 0.102
3.169ValPro: 3.169 ± 0.117
2.474ValGln: 2.474 ± 0.063
4.627ValArg: 4.627 ± 0.114
4.44ValSer: 4.44 ± 0.111
4.297ValThr: 4.297 ± 0.224
5.633ValVal: 5.633 ± 0.108
0.669ValTrp: 0.669 ± 0.036
1.632ValTyr: 1.632 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.103TrpAla: 1.103 ± 0.043
0.129TrpCys: 0.129 ± 0.014
0.617TrpAsp: 0.617 ± 0.034
0.665TrpGlu: 0.665 ± 0.036
0.5TrpPhe: 0.5 ± 0.031
0.878TrpGly: 0.878 ± 0.041
0.324TrpHis: 0.324 ± 0.023
0.625TrpIle: 0.625 ± 0.039
0.344TrpLys: 0.344 ± 0.027
1.876TrpLeu: 1.876 ± 0.078
0.362TrpMet: 0.362 ± 0.026
0.365TrpAsn: 0.365 ± 0.023
0.628TrpPro: 0.628 ± 0.043
0.904TrpGln: 0.904 ± 0.043
0.993TrpArg: 0.993 ± 0.046
0.671TrpSer: 0.671 ± 0.033
0.539TrpThr: 0.539 ± 0.029
1.066TrpVal: 1.066 ± 0.056
0.233TrpTrp: 0.233 ± 0.023
0.304TrpTyr: 0.304 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.491TyrAla: 2.491 ± 0.061
0.245TyrCys: 0.245 ± 0.022
1.428TyrAsp: 1.428 ± 0.097
1.35TyrGlu: 1.35 ± 0.054
0.979TyrPhe: 0.979 ± 0.047
1.98TyrGly: 1.98 ± 0.057
0.596TyrHis: 0.596 ± 0.035
0.912TyrIle: 0.912 ± 0.041
0.54TyrLys: 0.54 ± 0.035
2.807TyrLeu: 2.807 ± 0.089
0.485TyrMet: 0.485 ± 0.028
0.661TyrAsn: 0.661 ± 0.041
1.146TyrPro: 1.146 ± 0.063
1.105TyrGln: 1.105 ± 0.044
1.952TyrArg: 1.952 ± 0.081
1.331TyrSer: 1.331 ± 0.055
1.267TyrThr: 1.267 ± 0.09
1.618TyrVal: 1.618 ± 0.06
0.397TyrTrp: 0.397 ± 0.027
0.587TyrTyr: 0.587 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1835 proteins (627416 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski