Amino acid dipepetide frequency for Pelagibacterium lacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.122AlaAla: 17.122 ± 0.214	0.888AlaCys: 0.888 ± 0.034	7.202AlaAsp: 7.202 ± 0.093	8.355AlaGlu: 8.355 ± 0.121	4.516AlaPhe: 4.516 ± 0.067	11.027AlaGly: 11.027 ± 0.108	2.351AlaHis: 2.351 ± 0.049	7.427AlaIle: 7.427 ± 0.106	3.006AlaLys: 3.006 ± 0.063	14.593AlaLeu: 14.593 ± 0.17	3.82AlaMet: 3.82 ± 0.061	2.973AlaAsn: 2.973 ± 0.053	5.928AlaPro: 5.928 ± 0.103	4.32AlaGln: 4.32 ± 0.072	9.504AlaArg: 9.504 ± 0.122	6.161AlaSer: 6.161 ± 0.093	5.863AlaThr: 5.863 ± 0.082	8.903AlaVal: 8.903 ± 0.112	1.366AlaTrp: 1.366 ± 0.042	2.684AlaTyr: 2.684 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.898CysAla: 0.898 ± 0.029	0.093CysCys: 0.093 ± 0.01	0.495CysAsp: 0.495 ± 0.025	0.39CysGlu: 0.39 ± 0.022	0.281CysPhe: 0.281 ± 0.016	0.788CysGly: 0.788 ± 0.03	0.214CysHis: 0.214 ± 0.016	0.337CysIle: 0.337 ± 0.019	0.119CysLys: 0.119 ± 0.011	0.706CysLeu: 0.706 ± 0.028	0.127CysMet: 0.127 ± 0.012	0.174CysAsn: 0.174 ± 0.013	0.376CysPro: 0.376 ± 0.022	0.196CysGln: 0.196 ± 0.015	0.537CysArg: 0.537 ± 0.025	0.395CysSer: 0.395 ± 0.021	0.336CysThr: 0.336 ± 0.02	0.522CysVal: 0.522 ± 0.026	0.09CysTrp: 0.09 ± 0.009	0.183CysTyr: 0.183 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.45AspAla: 7.45 ± 0.092	0.421AspCys: 0.421 ± 0.021	3.131AspAsp: 3.131 ± 0.068	3.418AspGlu: 3.418 ± 0.068	2.36AspPhe: 2.36 ± 0.056	5.11AspGly: 5.11 ± 0.081	1.268AspHis: 1.268 ± 0.036	3.558AspIle: 3.558 ± 0.066	1.559AspLys: 1.559 ± 0.049	6.095AspLeu: 6.095 ± 0.079	1.477AspMet: 1.477 ± 0.044	1.364AspAsn: 1.364 ± 0.036	3.598AspPro: 3.598 ± 0.053	1.589AspGln: 1.589 ± 0.041	4.202AspArg: 4.202 ± 0.078	2.303AspSer: 2.303 ± 0.053	2.777AspThr: 2.777 ± 0.062	3.881AspVal: 3.881 ± 0.062	1.01AspTrp: 1.01 ± 0.036	1.567AspTyr: 1.567 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.193GluAla: 8.193 ± 0.107	0.294GluCys: 0.294 ± 0.016	3.227GluAsp: 3.227 ± 0.064	3.382GluGlu: 3.382 ± 0.071	1.767GluPhe: 1.767 ± 0.039	4.796GluGly: 4.796 ± 0.087	1.197GluHis: 1.197 ± 0.038	3.857GluIle: 3.857 ± 0.065	2.081GluLys: 2.081 ± 0.049	5.266GluLeu: 5.266 ± 0.075	1.712GluMet: 1.712 ± 0.041	1.561GluAsn: 1.561 ± 0.046	2.778GluPro: 2.778 ± 0.062	2.004GluGln: 2.004 ± 0.054	4.87GluArg: 4.87 ± 0.072	2.388GluSer: 2.388 ± 0.056	3.914GluThr: 3.914 ± 0.069	3.87GluVal: 3.87 ± 0.078	0.635GluTrp: 0.635 ± 0.025	1.012GluTyr: 1.012 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	5.012PheAla: 5.012 ± 0.08	0.373PheCys: 0.373 ± 0.021	2.726PheAsp: 2.726 ± 0.05	2.319PheGlu: 2.319 ± 0.046	1.421PhePhe: 1.421 ± 0.043	3.836PheGly: 3.836 ± 0.066	0.734PheHis: 0.734 ± 0.029	1.827PheIle: 1.827 ± 0.045	0.809PheLys: 0.809 ± 0.031	3.357PheLeu: 3.357 ± 0.064	0.81PheMet: 0.81 ± 0.03	1.071PheAsn: 1.071 ± 0.035	1.608PhePro: 1.608 ± 0.042	0.92PheGln: 0.92 ± 0.03	2.107PheArg: 2.107 ± 0.047	2.363PheSer: 2.363 ± 0.056	2.099PheThr: 2.099 ± 0.051	2.927PheVal: 2.927 ± 0.059	0.588PheTrp: 0.588 ± 0.026	0.921PheTyr: 0.921 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.706GlyAla: 9.706 ± 0.111	0.713GlyCys: 0.713 ± 0.026	4.482GlyAsp: 4.482 ± 0.073	5.175GlyGlu: 5.175 ± 0.07	3.826GlyPhe: 3.826 ± 0.061	7.243GlyGly: 7.243 ± 0.111	1.955GlyHis: 1.955 ± 0.049	4.94GlyIle: 4.94 ± 0.077	2.957GlyLys: 2.957 ± 0.06	9.45GlyLeu: 9.45 ± 0.102	2.341GlyMet: 2.341 ± 0.052	2.201GlyAsn: 2.201 ± 0.049	3.643GlyPro: 3.643 ± 0.063	3.076GlyGln: 3.076 ± 0.047	6.156GlyArg: 6.156 ± 0.084	4.407GlySer: 4.407 ± 0.071	4.873GlyThr: 4.873 ± 0.078	6.256GlyVal: 6.256 ± 0.091	1.326GlyTrp: 1.326 ± 0.039	2.252GlyTyr: 2.252 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.312HisAla: 2.312 ± 0.054	0.193HisCys: 0.193 ± 0.014	1.203HisAsp: 1.203 ± 0.036	1.054HisGlu: 1.054 ± 0.034	0.869HisPhe: 0.869 ± 0.031	1.805HisGly: 1.805 ± 0.044	0.543HisHis: 0.543 ± 0.029	1.13HisIle: 1.13 ± 0.033	0.552HisLys: 0.552 ± 0.024	2.076HisLeu: 2.076 ± 0.048	0.587HisMet: 0.587 ± 0.023	0.517HisAsn: 0.517 ± 0.026	1.312HisPro: 1.312 ± 0.042	0.583HisGln: 0.583 ± 0.024	1.337HisArg: 1.337 ± 0.04	0.917HisSer: 0.917 ± 0.035	0.821HisThr: 0.821 ± 0.028	1.445HisVal: 1.445 ± 0.036	0.3HisTrp: 0.3 ± 0.018	0.577HisTyr: 0.577 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.595IleAla: 8.595 ± 0.093	0.516IleCys: 0.516 ± 0.021	3.915IleAsp: 3.915 ± 0.079	3.953IleGlu: 3.953 ± 0.076	1.909IlePhe: 1.909 ± 0.05	5.445IleGly: 5.445 ± 0.081	0.924IleHis: 0.924 ± 0.027	2.635IleIle: 2.635 ± 0.057	1.331IleLys: 1.331 ± 0.039	4.938IleLeu: 4.938 ± 0.078	1.114IleMet: 1.114 ± 0.04	1.464IleAsn: 1.464 ± 0.041	2.393IlePro: 2.393 ± 0.054	1.188IleGln: 1.188 ± 0.031	3.125IleArg: 3.125 ± 0.055	3.088IleSer: 3.088 ± 0.052	2.89IleThr: 2.89 ± 0.054	4.919IleVal: 4.919 ± 0.073	0.63IleTrp: 0.63 ± 0.026	1.132IleTyr: 1.132 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.491LysAla: 3.491 ± 0.069	0.132LysCys: 0.132 ± 0.012	1.385LysAsp: 1.385 ± 0.045	1.157LysGlu: 1.157 ± 0.041	0.851LysPhe: 0.851 ± 0.032	2.394LysGly: 2.394 ± 0.058	0.458LysHis: 0.458 ± 0.021	1.514LysIle: 1.514 ± 0.041	1.003LysLys: 1.003 ± 0.041	2.705LysLeu: 2.705 ± 0.056	0.612LysMet: 0.612 ± 0.024	0.678LysAsn: 0.678 ± 0.025	1.622LysPro: 1.622 ± 0.045	0.754LysGln: 0.754 ± 0.031	2.095LysArg: 2.095 ± 0.052	1.634LysSer: 1.634 ± 0.037	1.66LysThr: 1.66 ± 0.043	2.066LysVal: 2.066 ± 0.051	0.334LysTrp: 0.334 ± 0.018	0.517LysTyr: 0.517 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.701LeuAla: 14.701 ± 0.162	0.79LeuCys: 0.79 ± 0.029	6.612LeuAsp: 6.612 ± 0.109	5.709LeuGlu: 5.709 ± 0.08	3.678LeuPhe: 3.678 ± 0.071	8.86LeuGly: 8.86 ± 0.114	1.746LeuHis: 1.746 ± 0.045	5.355LeuIle: 5.355 ± 0.082	2.883LeuLys: 2.883 ± 0.064	9.424LeuLeu: 9.424 ± 0.116	2.45LeuMet: 2.45 ± 0.05	2.441LeuAsn: 2.441 ± 0.053	5.29LeuPro: 5.29 ± 0.079	2.362LeuGln: 2.362 ± 0.053	6.702LeuArg: 6.702 ± 0.088	6.501LeuSer: 6.501 ± 0.086	5.278LeuThr: 5.278 ± 0.089	8.071LeuVal: 8.071 ± 0.102	1.119LeuTrp: 1.119 ± 0.034	2.208LeuTyr: 2.208 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.486MetAla: 3.486 ± 0.063	0.146MetCys: 0.146 ± 0.012	1.227MetAsp: 1.227 ± 0.032	1.215MetGlu: 1.215 ± 0.033	0.755MetPhe: 0.755 ± 0.029	2.183MetGly: 2.183 ± 0.054	0.425MetHis: 0.425 ± 0.021	1.392MetIle: 1.392 ± 0.046	0.759MetLys: 0.759 ± 0.03	2.617MetLeu: 2.617 ± 0.056	0.669MetMet: 0.669 ± 0.026	0.696MetAsn: 0.696 ± 0.03	1.508MetPro: 1.508 ± 0.044	0.797MetGln: 0.797 ± 0.032	1.788MetArg: 1.788 ± 0.042	1.641MetSer: 1.641 ± 0.039	1.888MetThr: 1.888 ± 0.044	1.998MetVal: 1.998 ± 0.046	0.207MetTrp: 0.207 ± 0.015	0.302MetTyr: 0.302 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.25AsnAla: 3.25 ± 0.061	0.195AsnCys: 0.195 ± 0.014	1.293AsnAsp: 1.293 ± 0.042	1.172AsnGlu: 1.172 ± 0.04	0.994AsnPhe: 0.994 ± 0.031	2.245AsnGly: 2.245 ± 0.051	0.489AsnHis: 0.489 ± 0.027	1.452AsnIle: 1.452 ± 0.04	0.605AsnLys: 0.605 ± 0.029	2.487AsnLeu: 2.487 ± 0.052	0.599AsnMet: 0.599 ± 0.024	0.67AsnAsn: 0.67 ± 0.029	1.754AsnPro: 1.754 ± 0.048	0.729AsnGln: 0.729 ± 0.026	1.79AsnArg: 1.79 ± 0.047	1.215AsnSer: 1.215 ± 0.04	1.303AsnThr: 1.303 ± 0.038	1.878AsnVal: 1.878 ± 0.048	0.447AsnTrp: 0.447 ± 0.02	0.659AsnTyr: 0.659 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.327ProAla: 6.327 ± 0.099	0.261ProCys: 0.261 ± 0.018	3.818ProAsp: 3.818 ± 0.064	3.897ProGlu: 3.897 ± 0.074	2.008ProPhe: 2.008 ± 0.042	4.501ProGly: 4.501 ± 0.07	1.136ProHis: 1.136 ± 0.033	2.57ProIle: 2.57 ± 0.053	1.247ProLys: 1.247 ± 0.04	4.864ProLeu: 4.864 ± 0.07	1.297ProMet: 1.297 ± 0.04	1.314ProAsn: 1.314 ± 0.038	2.23ProPro: 2.23 ± 0.062	1.774ProGln: 1.774 ± 0.047	3.033ProArg: 3.033 ± 0.057	2.639ProSer: 2.639 ± 0.06	2.259ProThr: 2.259 ± 0.052	4.191ProVal: 4.191 ± 0.072	0.59ProTrp: 0.59 ± 0.027	1.179ProTyr: 1.179 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.961GlnAla: 3.961 ± 0.07	0.206GlnCys: 0.206 ± 0.014	1.47GlnAsp: 1.47 ± 0.039	1.354GlnGlu: 1.354 ± 0.041	1.15GlnPhe: 1.15 ± 0.034	2.349GlnGly: 2.349 ± 0.047	0.589GlnHis: 0.589 ± 0.028	1.901GlnIle: 1.901 ± 0.049	0.879GlnLys: 0.879 ± 0.031	2.898GlnLeu: 2.898 ± 0.066	1.029GlnMet: 1.029 ± 0.033	0.746GlnAsn: 0.746 ± 0.029	1.742GlnPro: 1.742 ± 0.049	1.09GlnGln: 1.09 ± 0.046	2.427GlnArg: 2.427 ± 0.058	1.86GlnSer: 1.86 ± 0.051	1.75GlnThr: 1.75 ± 0.044	2.105GlnVal: 2.105 ± 0.053	0.377GlnTrp: 0.377 ± 0.021	0.624GlnTyr: 0.624 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.964ArgAla: 7.964 ± 0.096	0.433ArgCys: 0.433 ± 0.023	4.028ArgAsp: 4.028 ± 0.071	4.127ArgGlu: 4.127 ± 0.064	2.966ArgPhe: 2.966 ± 0.058	4.767ArgGly: 4.767 ± 0.064	1.722ArgHis: 1.722 ± 0.05	4.166ArgIle: 4.166 ± 0.062	2.163ArgLys: 2.163 ± 0.051	7.7ArgLeu: 7.7 ± 0.106	1.866ArgMet: 1.866 ± 0.045	1.786ArgAsn: 1.786 ± 0.044	3.692ArgPro: 3.692 ± 0.077	2.737ArgGln: 2.737 ± 0.057	5.415ArgArg: 5.415 ± 0.095	3.48ArgSer: 3.48 ± 0.059	3.553ArgThr: 3.553 ± 0.069	4.5ArgVal: 4.5 ± 0.079	0.939ArgTrp: 0.939 ± 0.033	1.719ArgTyr: 1.719 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.261SerAla: 6.261 ± 0.09	0.345SerCys: 0.345 ± 0.025	2.882SerAsp: 2.882 ± 0.056	2.817SerGlu: 2.817 ± 0.057	2.344SerPhe: 2.344 ± 0.048	5.694SerGly: 5.694 ± 0.084	1.083SerHis: 1.083 ± 0.038	2.928SerIle: 2.928 ± 0.053	1.268SerLys: 1.268 ± 0.038	5.202SerLeu: 5.202 ± 0.078	1.311SerMet: 1.311 ± 0.035	1.33SerAsn: 1.33 ± 0.04	2.673SerPro: 2.673 ± 0.053	1.691SerGln: 1.691 ± 0.037	3.511SerArg: 3.511 ± 0.062	2.795SerSer: 2.795 ± 0.057	2.674SerThr: 2.674 ± 0.055	4.098SerVal: 4.098 ± 0.065	0.641SerTrp: 0.641 ± 0.028	1.315SerTyr: 1.315 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.214ThrAla: 6.214 ± 0.083	0.341ThrCys: 0.341 ± 0.02	2.801ThrAsp: 2.801 ± 0.058	2.749ThrGlu: 2.749 ± 0.06	1.841ThrPhe: 1.841 ± 0.044	5.166ThrGly: 5.166 ± 0.079	1.123ThrHis: 1.123 ± 0.032	3.228ThrIle: 3.228 ± 0.062	1.118ThrLys: 1.118 ± 0.037	6.182ThrLeu: 6.182 ± 0.089	1.15ThrMet: 1.15 ± 0.036	1.344ThrAsn: 1.344 ± 0.038	3.277ThrPro: 3.277 ± 0.07	1.511ThrGln: 1.511 ± 0.041	3.504ThrArg: 3.504 ± 0.064	2.729ThrSer: 2.729 ± 0.053	2.709ThrThr: 2.709 ± 0.056	4.218ThrVal: 4.218 ± 0.073	0.525ThrTrp: 0.525 ± 0.023	1.178ThrTyr: 1.178 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.306ValAla: 9.306 ± 0.112	0.605ValCys: 0.605 ± 0.027	4.15ValAsp: 4.15 ± 0.07	4.738ValGlu: 4.738 ± 0.075	2.86ValPhe: 2.86 ± 0.058	5.663ValGly: 5.663 ± 0.08	1.379ValHis: 1.379 ± 0.035	4.301ValIle: 4.301 ± 0.077	1.826ValLys: 1.826 ± 0.049	7.885ValLeu: 7.885 ± 0.095	1.925ValMet: 1.925 ± 0.042	1.895ValAsn: 1.895 ± 0.046	3.89ValPro: 3.89 ± 0.064	1.942ValGln: 1.942 ± 0.046	4.773ValArg: 4.773 ± 0.069	4.444ValSer: 4.444 ± 0.065	4.403ValThr: 4.403 ± 0.075	6.055ValVal: 6.055 ± 0.096	0.906ValTrp: 0.906 ± 0.033	1.529ValTyr: 1.529 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.209TrpAla: 1.209 ± 0.038	0.116TrpCys: 0.116 ± 0.011	0.64TrpAsp: 0.64 ± 0.029	0.54TrpGlu: 0.54 ± 0.023	0.486TrpPhe: 0.486 ± 0.025	0.899TrpGly: 0.899 ± 0.034	0.318TrpHis: 0.318 ± 0.019	0.645TrpIle: 0.645 ± 0.029	0.326TrpLys: 0.326 ± 0.02	1.504TrpLeu: 1.504 ± 0.038	0.351TrpMet: 0.351 ± 0.02	0.399TrpAsn: 0.399 ± 0.02	0.707TrpPro: 0.707 ± 0.03	0.539TrpGln: 0.539 ± 0.024	1.071TrpArg: 1.071 ± 0.036	0.739TrpSer: 0.739 ± 0.029	0.727TrpThr: 0.727 ± 0.028	0.89TrpVal: 0.89 ± 0.029	0.2TrpTrp: 0.2 ± 0.014	0.247TrpTyr: 0.247 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.549TyrAla: 2.549 ± 0.045	0.195TyrCys: 0.195 ± 0.016	1.451TyrAsp: 1.451 ± 0.041	1.286TyrGlu: 1.286 ± 0.037	0.95TyrPhe: 0.95 ± 0.03	2.211TyrGly: 2.211 ± 0.046	0.477TyrHis: 0.477 ± 0.022	0.939TyrIle: 0.939 ± 0.032	0.571TyrLys: 0.571 ± 0.024	2.228TyrLeu: 2.228 ± 0.045	0.451TyrMet: 0.451 ± 0.022	0.598TyrAsn: 0.598 ± 0.026	1.113TyrPro: 1.113 ± 0.039	0.704TyrGln: 0.704 ± 0.027	1.775TyrArg: 1.775 ± 0.04	1.165TyrSer: 1.165 ± 0.032	1.132TyrThr: 1.132 ± 0.039	1.685TyrVal: 1.685 ± 0.044	0.324TyrTrp: 0.324 ± 0.02	0.617TyrTyr: 0.617 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3129 proteins (967114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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