Amino acid dipepetide frequency for Spiribacter sp. 2438

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.734AlaAla: 14.734 ± 0.248	1.03AlaCys: 1.03 ± 0.043	7.262AlaAsp: 7.262 ± 0.131	8.263AlaGlu: 8.263 ± 0.136	3.604AlaPhe: 3.604 ± 0.085	11.178AlaGly: 11.178 ± 0.143	2.311AlaHis: 2.311 ± 0.062	5.598AlaIle: 5.598 ± 0.103	1.798AlaLys: 1.798 ± 0.056	14.121AlaLeu: 14.121 ± 0.212	3.215AlaMet: 3.215 ± 0.085	2.375AlaAsn: 2.375 ± 0.072	4.807AlaPro: 4.807 ± 0.098	3.435AlaGln: 3.435 ± 0.081	9.449AlaArg: 9.449 ± 0.147	5.541AlaSer: 5.541 ± 0.104	5.125AlaThr: 5.125 ± 0.118	9.229AlaVal: 9.229 ± 0.15	1.657AlaTrp: 1.657 ± 0.059	2.279AlaTyr: 2.279 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.82CysAla: 0.82 ± 0.042	0.126CysCys: 0.126 ± 0.016	0.476CysAsp: 0.476 ± 0.027	0.444CysGlu: 0.444 ± 0.026	0.295CysPhe: 0.295 ± 0.021	0.911CysGly: 0.911 ± 0.049	0.282CysHis: 0.282 ± 0.023	0.413CysIle: 0.413 ± 0.023	0.124CysLys: 0.124 ± 0.015	1.0CysLeu: 1.0 ± 0.041	0.179CysMet: 0.179 ± 0.017	0.22CysAsn: 0.22 ± 0.02	0.589CysPro: 0.589 ± 0.039	0.339CysGln: 0.339 ± 0.024	0.735CysArg: 0.735 ± 0.041	0.446CysSer: 0.446 ± 0.024	0.421CysThr: 0.421 ± 0.026	0.604CysVal: 0.604 ± 0.033	0.119CysTrp: 0.119 ± 0.014	0.22CysTyr: 0.22 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	6.766AspAla: 6.766 ± 0.123	0.605AspCys: 0.605 ± 0.035	3.623AspAsp: 3.623 ± 0.093	4.248AspGlu: 4.248 ± 0.089	2.172AspPhe: 2.172 ± 0.069	5.172AspGly: 5.172 ± 0.099	1.536AspHis: 1.536 ± 0.063	2.843AspIle: 2.843 ± 0.07	0.973AspLys: 0.973 ± 0.045	6.199AspLeu: 6.199 ± 0.098	1.254AspMet: 1.254 ± 0.049	1.437AspAsn: 1.437 ± 0.049	3.846AspPro: 3.846 ± 0.088	2.397AspGln: 2.397 ± 0.065	5.057AspArg: 5.057 ± 0.102	2.655AspSer: 2.655 ± 0.068	2.838AspThr: 2.838 ± 0.069	3.926AspVal: 3.926 ± 0.083	1.12AspTrp: 1.12 ± 0.042	1.699AspTyr: 1.699 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	9.271GluAla: 9.271 ± 0.16	0.434GluCys: 0.434 ± 0.027	3.265GluAsp: 3.265 ± 0.088	3.579GluGlu: 3.579 ± 0.089	1.738GluPhe: 1.738 ± 0.062	4.793GluGly: 4.793 ± 0.086	1.518GluHis: 1.518 ± 0.056	2.999GluIle: 2.999 ± 0.075	1.491GluLys: 1.491 ± 0.066	6.142GluLeu: 6.142 ± 0.118	1.441GluMet: 1.441 ± 0.046	1.486GluAsn: 1.486 ± 0.05	3.457GluPro: 3.457 ± 0.077	3.039GluGln: 3.039 ± 0.092	5.962GluArg: 5.962 ± 0.107	3.535GluSer: 3.535 ± 0.097	3.502GluThr: 3.502 ± 0.081	4.877GluVal: 4.877 ± 0.101	0.862GluTrp: 0.862 ± 0.036	1.224GluTyr: 1.224 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.381PheAla: 3.381 ± 0.071	0.382PheCys: 0.382 ± 0.028	2.215PheAsp: 2.215 ± 0.062	2.269PheGlu: 2.269 ± 0.065	1.323PhePhe: 1.323 ± 0.059	2.918PheGly: 2.918 ± 0.075	0.765PheHis: 0.765 ± 0.035	1.56PheIle: 1.56 ± 0.059	0.547PheLys: 0.547 ± 0.03	3.242PheLeu: 3.242 ± 0.097	0.835PheMet: 0.835 ± 0.042	0.983PheAsn: 0.983 ± 0.043	1.437PhePro: 1.437 ± 0.051	1.172PheGln: 1.172 ± 0.044	2.222PheArg: 2.222 ± 0.064	1.966PheSer: 1.966 ± 0.069	1.768PheThr: 1.768 ± 0.056	2.35PheVal: 2.35 ± 0.074	0.486PheTrp: 0.486 ± 0.031	0.822PheTyr: 0.822 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	8.347GlyAla: 8.347 ± 0.142	0.909GlyCys: 0.909 ± 0.042	5.068GlyAsp: 5.068 ± 0.102	5.966GlyGlu: 5.966 ± 0.108	3.348GlyPhe: 3.348 ± 0.082	7.218GlyGly: 7.218 ± 0.136	2.314GlyHis: 2.314 ± 0.077	4.465GlyIle: 4.465 ± 0.094	2.019GlyLys: 2.019 ± 0.068	9.939GlyLeu: 9.939 ± 0.155	2.358GlyMet: 2.358 ± 0.072	1.907GlyAsn: 1.907 ± 0.058	3.648GlyPro: 3.648 ± 0.075	3.297GlyGln: 3.297 ± 0.079	6.858GlyArg: 6.858 ± 0.12	4.498GlySer: 4.498 ± 0.089	4.042GlyThr: 4.042 ± 0.078	6.982GlyVal: 6.982 ± 0.115	1.444GlyTrp: 1.444 ± 0.052	2.378GlyTyr: 2.378 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.273HisAla: 2.273 ± 0.058	0.337HisCys: 0.337 ± 0.025	1.369HisAsp: 1.369 ± 0.064	1.246HisGlu: 1.246 ± 0.048	0.83HisPhe: 0.83 ± 0.045	2.376HisGly: 2.376 ± 0.075	0.761HisHis: 0.761 ± 0.04	0.872HisIle: 0.872 ± 0.044	0.396HisLys: 0.396 ± 0.027	2.408HisLeu: 2.408 ± 0.066	0.528HisMet: 0.528 ± 0.031	0.55HisAsn: 0.55 ± 0.03	1.649HisPro: 1.649 ± 0.057	1.047HisGln: 1.047 ± 0.039	2.212HisArg: 2.212 ± 0.063	1.03HisSer: 1.03 ± 0.041	0.924HisThr: 0.924 ± 0.04	1.525HisVal: 1.525 ± 0.053	0.533HisTrp: 0.533 ± 0.032	0.701HisTyr: 0.701 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.836IleAla: 5.836 ± 0.098	0.391IleCys: 0.391 ± 0.026	3.163IleAsp: 3.163 ± 0.076	3.368IleGlu: 3.368 ± 0.083	1.283IlePhe: 1.283 ± 0.057	4.505IleGly: 4.505 ± 0.093	1.172IleHis: 1.172 ± 0.05	2.004IleIle: 2.004 ± 0.069	1.023IleLys: 1.023 ± 0.045	3.987IleLeu: 3.987 ± 0.089	0.874IleMet: 0.874 ± 0.036	1.523IleAsn: 1.523 ± 0.061	2.454IlePro: 2.454 ± 0.065	1.607IleGln: 1.607 ± 0.055	3.681IleArg: 3.681 ± 0.075	2.373IleSer: 2.373 ± 0.064	2.588IleThr: 2.588 ± 0.076	3.114IleVal: 3.114 ± 0.07	0.491IleTrp: 0.491 ± 0.027	1.028IleTyr: 1.028 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	2.425LysAla: 2.425 ± 0.072	0.138LysCys: 0.138 ± 0.014	1.045LysAsp: 1.045 ± 0.044	0.963LysGlu: 0.963 ± 0.055	0.431LysPhe: 0.431 ± 0.03	1.667LysGly: 1.667 ± 0.048	0.408LysHis: 0.408 ± 0.024	0.82LysIle: 0.82 ± 0.035	0.703LysLys: 0.703 ± 0.048	1.853LysLeu: 1.853 ± 0.063	0.424LysMet: 0.424 ± 0.027	0.475LysAsn: 0.475 ± 0.031	1.171LysPro: 1.171 ± 0.051	0.689LysGln: 0.689 ± 0.041	1.778LysArg: 1.778 ± 0.063	1.156LysSer: 1.156 ± 0.042	1.134LysThr: 1.134 ± 0.041	1.441LysVal: 1.441 ± 0.055	0.198LysTrp: 0.198 ± 0.019	0.379LysTyr: 0.379 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.867LeuAla: 13.867 ± 0.203	0.904LeuCys: 0.904 ± 0.043	6.683LeuAsp: 6.683 ± 0.108	7.509LeuGlu: 7.509 ± 0.127	3.348LeuPhe: 3.348 ± 0.098	9.32LeuGly: 9.32 ± 0.147	2.348LeuHis: 2.348 ± 0.079	4.944LeuIle: 4.944 ± 0.112	2.42LeuLys: 2.42 ± 0.076	11.099LeuLeu: 11.099 ± 0.22	2.601LeuMet: 2.601 ± 0.069	2.564LeuAsn: 2.564 ± 0.06	6.083LeuPro: 6.083 ± 0.117	3.965LeuGln: 3.965 ± 0.08	8.444LeuArg: 8.444 ± 0.124	5.878LeuSer: 5.878 ± 0.098	5.687LeuThr: 5.687 ± 0.105	8.092LeuVal: 8.092 ± 0.134	1.157LeuTrp: 1.157 ± 0.049	2.112LeuTyr: 2.112 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	3.44MetAla: 3.44 ± 0.082	0.121MetCys: 0.121 ± 0.015	1.389MetAsp: 1.389 ± 0.051	1.337MetGlu: 1.337 ± 0.045	0.562MetPhe: 0.562 ± 0.035	1.919MetGly: 1.919 ± 0.059	0.444MetHis: 0.444 ± 0.024	1.124MetIle: 1.124 ± 0.045	0.703MetLys: 0.703 ± 0.035	2.314MetLeu: 2.314 ± 0.068	0.533MetMet: 0.533 ± 0.03	0.76MetAsn: 0.76 ± 0.038	1.392MetPro: 1.392 ± 0.043	0.948MetGln: 0.948 ± 0.041	1.68MetArg: 1.68 ± 0.047	1.473MetSer: 1.473 ± 0.053	1.635MetThr: 1.635 ± 0.051	1.722MetVal: 1.722 ± 0.058	0.148MetTrp: 0.148 ± 0.016	0.292MetTyr: 0.292 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.695AsnAla: 2.695 ± 0.067	0.211AsnCys: 0.211 ± 0.019	1.256AsnAsp: 1.256 ± 0.05	1.283AsnGlu: 1.283 ± 0.049	0.726AsnPhe: 0.726 ± 0.034	2.002AsnGly: 2.002 ± 0.066	0.595AsnHis: 0.595 ± 0.038	1.211AsnIle: 1.211 ± 0.055	0.414AsnLys: 0.414 ± 0.03	2.548AsnLeu: 2.548 ± 0.071	0.47AsnMet: 0.47 ± 0.029	0.627AsnAsn: 0.627 ± 0.035	1.826AsnPro: 1.826 ± 0.057	0.839AsnGln: 0.839 ± 0.042	2.12AsnArg: 2.12 ± 0.066	0.961AsnSer: 0.961 ± 0.04	1.196AsnThr: 1.196 ± 0.047	1.628AsnVal: 1.628 ± 0.06	0.369AsnTrp: 0.369 ± 0.025	0.567AsnTyr: 0.567 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.526ProAla: 6.526 ± 0.129	0.339ProCys: 0.339 ± 0.025	3.931ProAsp: 3.931 ± 0.082	4.164ProGlu: 4.164 ± 0.086	1.672ProPhe: 1.672 ± 0.054	5.179ProGly: 5.179 ± 0.092	1.028ProHis: 1.028 ± 0.042	1.929ProIle: 1.929 ± 0.056	0.849ProLys: 0.849 ± 0.036	5.541ProLeu: 5.541 ± 0.102	1.387ProMet: 1.387 ± 0.049	1.06ProAsn: 1.06 ± 0.045	2.754ProPro: 2.754 ± 0.072	1.457ProGln: 1.457 ± 0.047	3.509ProArg: 3.509 ± 0.086	2.524ProSer: 2.524 ± 0.065	2.439ProThr: 2.439 ± 0.063	4.654ProVal: 4.654 ± 0.094	0.839ProTrp: 0.839 ± 0.04	1.03ProTyr: 1.03 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	5.077GlnAla: 5.077 ± 0.113	0.265GlnCys: 0.265 ± 0.019	1.684GlnAsp: 1.684 ± 0.056	1.682GlnGlu: 1.682 ± 0.06	1.11GlnPhe: 1.11 ± 0.047	2.826GlnGly: 2.826 ± 0.063	0.865GlnHis: 0.865 ± 0.038	1.575GlnIle: 1.575 ± 0.054	0.787GlnLys: 0.787 ± 0.041	3.77GlnLeu: 3.77 ± 0.083	0.823GlnMet: 0.823 ± 0.037	0.652GlnAsn: 0.652 ± 0.032	2.098GlnPro: 2.098 ± 0.052	1.707GlnGln: 1.707 ± 0.061	4.057GlnArg: 4.057 ± 0.094	1.929GlnSer: 1.929 ± 0.056	1.776GlnThr: 1.776 ± 0.055	2.836GlnVal: 2.836 ± 0.06	0.572GlnTrp: 0.572 ± 0.033	0.716GlnTyr: 0.716 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.908ArgAla: 7.908 ± 0.144	0.758ArgCys: 0.758 ± 0.038	4.907ArgAsp: 4.907 ± 0.084	5.533ArgGlu: 5.533 ± 0.128	3.161ArgPhe: 3.161 ± 0.073	5.88ArgGly: 5.88 ± 0.105	2.345ArgHis: 2.345 ± 0.065	3.992ArgIle: 3.992 ± 0.087	1.432ArgLys: 1.432 ± 0.054	10.075ArgLeu: 10.075 ± 0.168	2.034ArgMet: 2.034 ± 0.055	1.845ArgAsn: 1.845 ± 0.061	3.867ArgPro: 3.867 ± 0.078	3.935ArgGln: 3.935 ± 0.075	7.7ArgArg: 7.7 ± 0.147	3.923ArgSer: 3.923 ± 0.075	3.208ArgThr: 3.208 ± 0.076	6.199ArgVal: 6.199 ± 0.12	1.322ArgTrp: 1.322 ± 0.06	2.271ArgTyr: 2.271 ± 0.065	0.0ArgXaa: 0.0 ± 0.0
Ser	5.857SerAla: 5.857 ± 0.105	0.351SerCys: 0.351 ± 0.029	3.027SerAsp: 3.027 ± 0.072	3.01SerGlu: 3.01 ± 0.077	1.54SerPhe: 1.54 ± 0.056	5.28SerGly: 5.28 ± 0.107	1.196SerHis: 1.196 ± 0.047	2.17SerIle: 2.17 ± 0.066	0.818SerLys: 0.818 ± 0.04	5.748SerLeu: 5.748 ± 0.115	1.266SerMet: 1.266 ± 0.045	1.132SerAsn: 1.132 ± 0.044	2.802SerPro: 2.802 ± 0.079	1.62SerGln: 1.62 ± 0.057	4.094SerArg: 4.094 ± 0.077	2.447SerSer: 2.447 ± 0.071	2.397SerThr: 2.397 ± 0.069	4.03SerVal: 4.03 ± 0.09	0.627SerTrp: 0.627 ± 0.033	1.018SerTyr: 1.018 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.568ThrAla: 5.568 ± 0.103	0.392ThrCys: 0.392 ± 0.032	3.101ThrAsp: 3.101 ± 0.075	2.844ThrGlu: 2.844 ± 0.06	1.449ThrPhe: 1.449 ± 0.051	5.065ThrGly: 5.065 ± 0.11	1.11ThrHis: 1.11 ± 0.042	1.915ThrIle: 1.915 ± 0.055	0.696ThrLys: 0.696 ± 0.038	6.185ThrLeu: 6.185 ± 0.123	0.926ThrMet: 0.926 ± 0.042	1.015ThrAsn: 1.015 ± 0.048	3.301ThrPro: 3.301 ± 0.092	1.34ThrGln: 1.34 ± 0.044	3.809ThrArg: 3.809 ± 0.088	2.091ThrSer: 2.091 ± 0.065	2.407ThrThr: 2.407 ± 0.068	4.169ThrVal: 4.169 ± 0.077	0.585ThrTrp: 0.585 ± 0.031	0.958ThrTyr: 0.958 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.701ValAla: 8.701 ± 0.152	0.666ValCys: 0.666 ± 0.03	5.078ValAsp: 5.078 ± 0.098	5.06ValGlu: 5.06 ± 0.098	2.675ValPhe: 2.675 ± 0.076	5.937ValGly: 5.937 ± 0.113	1.645ValHis: 1.645 ± 0.055	4.411ValIle: 4.411 ± 0.091	1.511ValLys: 1.511 ± 0.052	8.057ValLeu: 8.057 ± 0.125	2.009ValMet: 2.009 ± 0.058	2.038ValAsn: 2.038 ± 0.059	3.675ValPro: 3.675 ± 0.087	2.138ValGln: 2.138 ± 0.061	5.447ValArg: 5.447 ± 0.108	4.176ValSer: 4.176 ± 0.089	4.161ValThr: 4.161 ± 0.098	6.452ValVal: 6.452 ± 0.124	0.887ValTrp: 0.887 ± 0.043	1.585ValTyr: 1.585 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.203TrpAla: 1.203 ± 0.047	0.131TrpCys: 0.131 ± 0.016	0.587TrpAsp: 0.587 ± 0.033	0.656TrpGlu: 0.656 ± 0.034	0.543TrpPhe: 0.543 ± 0.031	0.87TrpGly: 0.87 ± 0.042	0.381TrpHis: 0.381 ± 0.026	0.736TrpIle: 0.736 ± 0.048	0.243TrpLys: 0.243 ± 0.019	2.202TrpLeu: 2.202 ± 0.072	0.397TrpMet: 0.397 ± 0.028	0.34TrpAsn: 0.34 ± 0.022	0.708TrpPro: 0.708 ± 0.037	0.805TrpGln: 0.805 ± 0.039	1.312TrpArg: 1.312 ± 0.053	0.728TrpSer: 0.728 ± 0.037	0.616TrpThr: 0.616 ± 0.033	1.021TrpVal: 1.021 ± 0.048	0.243TrpTrp: 0.243 ± 0.022	0.3TrpTyr: 0.3 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.319TyrAla: 2.319 ± 0.066	0.272TyrCys: 0.272 ± 0.022	1.234TyrAsp: 1.234 ± 0.047	1.191TyrGlu: 1.191 ± 0.042	0.834TyrPhe: 0.834 ± 0.036	1.989TyrGly: 1.989 ± 0.066	0.542TyrHis: 0.542 ± 0.034	0.886TyrIle: 0.886 ± 0.042	0.349TyrLys: 0.349 ± 0.027	2.596TyrLeu: 2.596 ± 0.065	0.376TyrMet: 0.376 ± 0.026	0.557TyrAsn: 0.557 ± 0.028	1.248TyrPro: 1.248 ± 0.046	1.033TyrGln: 1.033 ± 0.049	2.169TyrArg: 2.169 ± 0.068	1.1TyrSer: 1.1 ± 0.046	1.065TyrThr: 1.065 ± 0.043	1.457TyrVal: 1.457 ± 0.052	0.362TyrTrp: 0.362 ± 0.022	0.587TyrTyr: 0.587 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1830 proteins (596256 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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