Amino acid dipepetide frequency for Acidomonas methanolica NBRC 104435

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.967AlaAla: 17.967 ± 0.22	1.297AlaCys: 1.297 ± 0.038	6.418AlaAsp: 6.418 ± 0.074	7.239AlaGlu: 7.239 ± 0.095	4.325AlaPhe: 4.325 ± 0.069	10.826AlaGly: 10.826 ± 0.113	2.753AlaHis: 2.753 ± 0.061	5.833AlaIle: 5.833 ± 0.084	2.777AlaLys: 2.777 ± 0.064	14.873AlaLeu: 14.873 ± 0.158	3.454AlaMet: 3.454 ± 0.055	2.447AlaAsn: 2.447 ± 0.051	6.873AlaPro: 6.873 ± 0.11	4.045AlaGln: 4.045 ± 0.074	10.79AlaArg: 10.79 ± 0.122	6.396AlaSer: 6.396 ± 0.089	6.371AlaThr: 6.371 ± 0.088	8.52AlaVal: 8.52 ± 0.086	1.787AlaTrp: 1.787 ± 0.041	2.511AlaTyr: 2.511 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.213CysAla: 1.213 ± 0.033	0.144CysCys: 0.144 ± 0.012	0.537CysAsp: 0.537 ± 0.023	0.409CysGlu: 0.409 ± 0.018	0.378CysPhe: 0.378 ± 0.02	1.028CysGly: 1.028 ± 0.035	0.251CysHis: 0.251 ± 0.018	0.368CysIle: 0.368 ± 0.02	0.141CysLys: 0.141 ± 0.012	0.919CysLeu: 0.919 ± 0.03	0.151CysMet: 0.151 ± 0.012	0.192CysAsn: 0.192 ± 0.011	0.509CysPro: 0.509 ± 0.023	0.206CysGln: 0.206 ± 0.014	0.73CysArg: 0.73 ± 0.028	0.458CysSer: 0.458 ± 0.021	0.445CysThr: 0.445 ± 0.022	0.724CysVal: 0.724 ± 0.025	0.144CysTrp: 0.144 ± 0.013	0.2CysTyr: 0.2 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.344AspAla: 7.344 ± 0.089	0.471AspCys: 0.471 ± 0.022	3.083AspAsp: 3.083 ± 0.062	3.188AspGlu: 3.188 ± 0.066	2.029AspPhe: 2.029 ± 0.05	5.512AspGly: 5.512 ± 0.077	1.426AspHis: 1.426 ± 0.038	2.767AspIle: 2.767 ± 0.057	1.085AspLys: 1.085 ± 0.036	5.934AspLeu: 5.934 ± 0.084	1.259AspMet: 1.259 ± 0.03	1.147AspAsn: 1.147 ± 0.033	3.757AspPro: 3.757 ± 0.063	1.524AspGln: 1.524 ± 0.039	4.645AspArg: 4.645 ± 0.066	2.371AspSer: 2.371 ± 0.048	2.658AspThr: 2.658 ± 0.055	4.024AspVal: 4.024 ± 0.075	1.015AspTrp: 1.015 ± 0.035	1.384AspTyr: 1.384 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.5GluAla: 7.5 ± 0.107	0.331GluCys: 0.331 ± 0.018	2.708GluAsp: 2.708 ± 0.052	2.991GluGlu: 2.991 ± 0.076	1.466GluPhe: 1.466 ± 0.039	4.086GluGly: 4.086 ± 0.067	1.27GluHis: 1.27 ± 0.036	3.207GluIle: 3.207 ± 0.061	1.776GluLys: 1.776 ± 0.048	4.415GluLeu: 4.415 ± 0.07	1.454GluMet: 1.454 ± 0.041	1.502GluAsn: 1.502 ± 0.037	2.414GluPro: 2.414 ± 0.051	1.884GluGln: 1.884 ± 0.046	5.019GluArg: 5.019 ± 0.072	2.621GluSer: 2.621 ± 0.05	3.668GluThr: 3.668 ± 0.059	3.16GluVal: 3.16 ± 0.058	0.671GluTrp: 0.671 ± 0.024	0.902GluTyr: 0.902 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.373PheAla: 4.373 ± 0.066	0.436PheCys: 0.436 ± 0.02	2.474PheAsp: 2.474 ± 0.051	1.76PheGlu: 1.76 ± 0.047	1.329PhePhe: 1.329 ± 0.045	3.612PheGly: 3.612 ± 0.064	0.834PheHis: 0.834 ± 0.029	1.451PheIle: 1.451 ± 0.044	0.659PheLys: 0.659 ± 0.027	3.473PheLeu: 3.473 ± 0.068	0.804PheMet: 0.804 ± 0.029	0.9PheAsn: 0.9 ± 0.031	1.688PhePro: 1.688 ± 0.042	0.887PheGln: 0.887 ± 0.03	2.536PheArg: 2.536 ± 0.052	2.195PheSer: 2.195 ± 0.052	1.939PheThr: 1.939 ± 0.044	2.517PheVal: 2.517 ± 0.054	0.511PheTrp: 0.511 ± 0.022	0.88PheTyr: 0.88 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.788GlyAla: 9.788 ± 0.11	0.899GlyCys: 0.899 ± 0.031	4.285GlyAsp: 4.285 ± 0.071	4.517GlyGlu: 4.517 ± 0.07	3.407GlyPhe: 3.407 ± 0.051	7.705GlyGly: 7.705 ± 0.106	2.171GlyHis: 2.171 ± 0.044	4.185GlyIle: 4.185 ± 0.072	2.747GlyLys: 2.747 ± 0.058	9.054GlyLeu: 9.054 ± 0.11	2.485GlyMet: 2.485 ± 0.053	2.101GlyAsn: 2.101 ± 0.057	3.84GlyPro: 3.84 ± 0.067	2.921GlyGln: 2.921 ± 0.061	6.877GlyArg: 6.877 ± 0.09	4.561GlySer: 4.561 ± 0.077	4.841GlyThr: 4.841 ± 0.08	6.677GlyVal: 6.677 ± 0.078	1.602GlyTrp: 1.602 ± 0.046	2.255GlyTyr: 2.255 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.868HisAla: 2.868 ± 0.062	0.227HisCys: 0.227 ± 0.018	1.591HisAsp: 1.591 ± 0.044	1.201HisGlu: 1.201 ± 0.033	0.918HisPhe: 0.918 ± 0.03	2.252HisGly: 2.252 ± 0.051	0.747HisHis: 0.747 ± 0.029	1.044HisIle: 1.044 ± 0.032	0.481HisLys: 0.481 ± 0.022	2.357HisLeu: 2.357 ± 0.054	0.501HisMet: 0.501 ± 0.026	0.507HisAsn: 0.507 ± 0.024	1.607HisPro: 1.607 ± 0.041	0.617HisGln: 0.617 ± 0.024	1.756HisArg: 1.756 ± 0.044	1.003HisSer: 1.003 ± 0.027	0.904HisThr: 0.904 ± 0.028	1.94HisVal: 1.94 ± 0.043	0.427HisTrp: 0.427 ± 0.019	0.637HisTyr: 0.637 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.884IleAla: 6.884 ± 0.078	0.485IleCys: 0.485 ± 0.022	3.159IleAsp: 3.159 ± 0.055	3.106IleGlu: 3.106 ± 0.058	1.55IlePhe: 1.55 ± 0.041	4.761IleGly: 4.761 ± 0.075	0.947IleHis: 0.947 ± 0.031	1.718IleIle: 1.718 ± 0.05	0.865IleLys: 0.865 ± 0.033	4.316IleLeu: 4.316 ± 0.073	0.9IleMet: 0.9 ± 0.033	1.079IleAsn: 1.079 ± 0.035	2.404IlePro: 2.404 ± 0.049	1.166IleGln: 1.166 ± 0.036	3.504IleArg: 3.504 ± 0.054	2.574IleSer: 2.574 ± 0.058	2.38IleThr: 2.38 ± 0.05	3.997IleVal: 3.997 ± 0.07	0.62IleTrp: 0.62 ± 0.028	1.011IleTyr: 1.011 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.079LysAla: 3.079 ± 0.07	0.143LysCys: 0.143 ± 0.013	1.233LysAsp: 1.233 ± 0.035	1.141LysGlu: 1.141 ± 0.036	0.634LysPhe: 0.634 ± 0.027	2.049LysGly: 2.049 ± 0.051	0.465LysHis: 0.465 ± 0.02	1.34LysIle: 1.34 ± 0.032	0.834LysLys: 0.834 ± 0.034	2.492LysLeu: 2.492 ± 0.053	0.595LysMet: 0.595 ± 0.026	0.631LysAsn: 0.631 ± 0.029	1.635LysPro: 1.635 ± 0.044	0.736LysGln: 0.736 ± 0.03	1.891LysArg: 1.891 ± 0.051	1.397LysSer: 1.397 ± 0.046	1.575LysThr: 1.575 ± 0.037	1.552LysVal: 1.552 ± 0.041	0.295LysTrp: 0.295 ± 0.018	0.46LysTyr: 0.46 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.209LeuAla: 14.209 ± 0.151	1.142LeuCys: 1.142 ± 0.034	6.522LeuAsp: 6.522 ± 0.09	4.651LeuGlu: 4.651 ± 0.069	3.629LeuPhe: 3.629 ± 0.065	8.459LeuGly: 8.459 ± 0.106	2.565LeuHis: 2.565 ± 0.051	4.525LeuIle: 4.525 ± 0.07	2.61LeuLys: 2.61 ± 0.055	10.426LeuLeu: 10.426 ± 0.156	2.251LeuMet: 2.251 ± 0.053	2.516LeuAsn: 2.516 ± 0.048	6.748LeuPro: 6.748 ± 0.091	2.576LeuGln: 2.576 ± 0.058	8.76LeuArg: 8.76 ± 0.116	6.439LeuSer: 6.439 ± 0.084	6.16LeuThr: 6.16 ± 0.089	7.106LeuVal: 7.106 ± 0.095	1.324LeuTrp: 1.324 ± 0.035	2.124LeuTyr: 2.124 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.061MetAla: 3.061 ± 0.056	0.139MetCys: 0.139 ± 0.011	1.086MetAsp: 1.086 ± 0.035	1.099MetGlu: 1.099 ± 0.029	0.629MetPhe: 0.629 ± 0.025	1.768MetGly: 1.768 ± 0.04	0.449MetHis: 0.449 ± 0.018	1.257MetIle: 1.257 ± 0.032	0.752MetLys: 0.752 ± 0.03	2.54MetLeu: 2.54 ± 0.066	0.62MetMet: 0.62 ± 0.028	0.781MetAsn: 0.781 ± 0.03	1.545MetPro: 1.545 ± 0.038	0.785MetGln: 0.785 ± 0.028	1.947MetArg: 1.947 ± 0.043	1.617MetSer: 1.617 ± 0.042	2.133MetThr: 2.133 ± 0.046	1.493MetVal: 1.493 ± 0.039	0.196MetTrp: 0.196 ± 0.014	0.277MetTyr: 0.277 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.956AsnAla: 2.956 ± 0.063	0.206AsnCys: 0.206 ± 0.013	1.384AsnAsp: 1.384 ± 0.043	1.064AsnGlu: 1.064 ± 0.032	0.881AsnPhe: 0.881 ± 0.036	2.427AsnGly: 2.427 ± 0.06	0.506AsnHis: 0.506 ± 0.022	1.185AsnIle: 1.185 ± 0.042	0.473AsnLys: 0.473 ± 0.025	2.194AsnLeu: 2.194 ± 0.052	0.544AsnMet: 0.544 ± 0.024	0.638AsnAsn: 0.638 ± 0.027	1.664AsnPro: 1.664 ± 0.039	0.67AsnGln: 0.67 ± 0.031	1.725AsnArg: 1.725 ± 0.04	1.09AsnSer: 1.09 ± 0.038	1.255AsnThr: 1.255 ± 0.044	1.753AsnVal: 1.753 ± 0.045	0.437AsnTrp: 0.437 ± 0.023	0.705AsnTyr: 0.705 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	7.175ProAla: 7.175 ± 0.105	0.401ProCys: 0.401 ± 0.022	4.388ProAsp: 4.388 ± 0.076	3.924ProGlu: 3.924 ± 0.08	2.043ProPhe: 2.043 ± 0.04	5.469ProGly: 5.469 ± 0.077	1.383ProHis: 1.383 ± 0.038	2.019ProIle: 2.019 ± 0.045	1.238ProLys: 1.238 ± 0.042	5.436ProLeu: 5.436 ± 0.074	1.318ProMet: 1.318 ± 0.037	1.18ProAsn: 1.18 ± 0.033	3.68ProPro: 3.68 ± 0.085	1.628ProGln: 1.628 ± 0.037	3.48ProArg: 3.48 ± 0.066	3.11ProSer: 3.11 ± 0.054	2.558ProThr: 2.558 ± 0.051	4.909ProVal: 4.909 ± 0.075	0.819ProTrp: 0.819 ± 0.029	1.309ProTyr: 1.309 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.009GlnAla: 4.009 ± 0.075	0.198GlnCys: 0.198 ± 0.016	1.675GlnAsp: 1.675 ± 0.041	1.533GlnGlu: 1.533 ± 0.038	1.08GlnPhe: 1.08 ± 0.033	2.38GlnGly: 2.38 ± 0.047	0.649GlnHis: 0.649 ± 0.023	1.949GlnIle: 1.949 ± 0.049	0.846GlnLys: 0.846 ± 0.03	2.48GlnLeu: 2.48 ± 0.047	0.756GlnMet: 0.756 ± 0.029	0.83GlnAsn: 0.83 ± 0.037	1.707GlnPro: 1.707 ± 0.041	1.051GlnGln: 1.051 ± 0.044	2.256GlnArg: 2.256 ± 0.053	1.74GlnSer: 1.74 ± 0.042	1.768GlnThr: 1.768 ± 0.041	2.025GlnVal: 2.025 ± 0.05	0.358GlnTrp: 0.358 ± 0.019	0.624GlnTyr: 0.624 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	9.646ArgAla: 9.646 ± 0.114	0.618ArgCys: 0.618 ± 0.024	4.676ArgAsp: 4.676 ± 0.072	4.518ArgGlu: 4.518 ± 0.075	3.16ArgPhe: 3.16 ± 0.057	5.429ArgGly: 5.429 ± 0.08	2.345ArgHis: 2.345 ± 0.058	4.087ArgIle: 4.087 ± 0.066	2.116ArgLys: 2.116 ± 0.05	9.294ArgLeu: 9.294 ± 0.119	1.955ArgMet: 1.955 ± 0.046	1.893ArgAsn: 1.893 ± 0.046	4.242ArgPro: 4.242 ± 0.076	2.863ArgGln: 2.863 ± 0.05	7.392ArgArg: 7.392 ± 0.122	3.736ArgSer: 3.736 ± 0.064	3.658ArgThr: 3.658 ± 0.06	5.221ArgVal: 5.221 ± 0.07	1.156ArgTrp: 1.156 ± 0.034	1.894ArgTyr: 1.894 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.255SerAla: 6.255 ± 0.08	0.502SerCys: 0.502 ± 0.021	2.872SerAsp: 2.872 ± 0.059	2.549SerGlu: 2.549 ± 0.054	2.247SerPhe: 2.247 ± 0.048	5.713SerGly: 5.713 ± 0.094	1.136SerHis: 1.136 ± 0.033	2.366SerIle: 2.366 ± 0.048	1.051SerLys: 1.051 ± 0.037	5.706SerLeu: 5.706 ± 0.08	1.233SerMet: 1.233 ± 0.035	1.233SerAsn: 1.233 ± 0.037	3.268SerPro: 3.268 ± 0.056	1.45SerGln: 1.45 ± 0.041	3.914SerArg: 3.914 ± 0.065	3.011SerSer: 3.011 ± 0.072	2.686SerThr: 2.686 ± 0.063	4.057SerVal: 4.057 ± 0.065	0.821SerTrp: 0.821 ± 0.026	1.367SerTyr: 1.367 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.291ThrAla: 6.291 ± 0.091	0.435ThrCys: 0.435 ± 0.024	2.796ThrAsp: 2.796 ± 0.054	2.472ThrGlu: 2.472 ± 0.046	1.658ThrPhe: 1.658 ± 0.041	5.358ThrGly: 5.358 ± 0.077	1.286ThrHis: 1.286 ± 0.039	2.801ThrIle: 2.801 ± 0.058	1.123ThrLys: 1.123 ± 0.039	6.778ThrLeu: 6.778 ± 0.098	1.192ThrMet: 1.192 ± 0.032	1.298ThrAsn: 1.298 ± 0.039	3.964ThrPro: 3.964 ± 0.061	1.587ThrGln: 1.587 ± 0.042	3.974ThrArg: 3.974 ± 0.065	2.786ThrSer: 2.786 ± 0.064	2.887ThrThr: 2.887 ± 0.056	4.167ThrVal: 4.167 ± 0.072	0.624ThrTrp: 0.624 ± 0.028	1.196ThrTyr: 1.196 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.028ValAla: 9.028 ± 0.107	0.703ValCys: 0.703 ± 0.024	3.55ValAsp: 3.55 ± 0.065	3.988ValGlu: 3.988 ± 0.065	2.586ValPhe: 2.586 ± 0.051	4.966ValGly: 4.966 ± 0.081	1.473ValHis: 1.473 ± 0.042	3.76ValIle: 3.76 ± 0.067	1.705ValLys: 1.705 ± 0.045	8.027ValLeu: 8.027 ± 0.093	1.897ValMet: 1.897 ± 0.046	1.795ValAsn: 1.795 ± 0.057	4.069ValPro: 4.069 ± 0.074	2.024ValGln: 2.024 ± 0.046	5.243ValArg: 5.243 ± 0.087	4.348ValSer: 4.348 ± 0.071	4.844ValThr: 4.844 ± 0.068	5.537ValVal: 5.537 ± 0.078	0.932ValTrp: 0.932 ± 0.028	1.375ValTyr: 1.375 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.309TrpAla: 1.309 ± 0.034	0.147TrpCys: 0.147 ± 0.013	0.668TrpAsp: 0.668 ± 0.025	0.581TrpGlu: 0.581 ± 0.026	0.519TrpPhe: 0.519 ± 0.021	0.948TrpGly: 0.948 ± 0.036	0.397TrpHis: 0.397 ± 0.021	0.71TrpIle: 0.71 ± 0.03	0.438TrpLys: 0.438 ± 0.021	1.823TrpLeu: 1.823 ± 0.044	0.365TrpMet: 0.365 ± 0.019	0.442TrpAsn: 0.442 ± 0.021	0.766TrpPro: 0.766 ± 0.031	0.553TrpGln: 0.553 ± 0.026	1.526TrpArg: 1.526 ± 0.041	0.899TrpSer: 0.899 ± 0.03	0.855TrpThr: 0.855 ± 0.03	0.836TrpVal: 0.836 ± 0.029	0.26TrpTrp: 0.26 ± 0.018	0.298TrpTyr: 0.298 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.546TyrAla: 2.546 ± 0.052	0.223TyrCys: 0.223 ± 0.014	1.519TyrAsp: 1.519 ± 0.038	1.113TyrGlu: 1.113 ± 0.035	0.792TyrPhe: 0.792 ± 0.026	2.167TyrGly: 2.167 ± 0.062	0.535TyrHis: 0.535 ± 0.023	0.858TyrIle: 0.858 ± 0.032	0.462TyrLys: 0.462 ± 0.024	2.206TyrLeu: 2.206 ± 0.045	0.44TyrMet: 0.44 ± 0.022	0.645TyrAsn: 0.645 ± 0.034	1.085TyrPro: 1.085 ± 0.036	0.738TyrGln: 0.738 ± 0.027	1.932TyrArg: 1.932 ± 0.035	1.082TyrSer: 1.082 ± 0.037	1.087TyrThr: 1.087 ± 0.04	1.635TyrVal: 1.635 ± 0.045	0.343TyrTrp: 0.343 ± 0.019	0.652TyrTyr: 0.652 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3270 proteins (1036497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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