Amino acid dipepetide frequency for Hibiscus green spot virus (isolate Citrus volkameriana /USA/WAI 1-1/2009)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.623AlaAla: 4.623 ± 1.833
0.462AlaCys: 0.462 ± 0.324
4.623AlaAsp: 4.623 ± 1.407
3.236AlaGlu: 3.236 ± 1.098
2.312AlaPhe: 2.312 ± 1.181
3.93AlaGly: 3.93 ± 0.768
1.156AlaHis: 1.156 ± 0.384
2.543AlaIle: 2.543 ± 1.082
2.312AlaLys: 2.312 ± 0.935
6.241AlaLeu: 6.241 ± 1.994
1.387AlaMet: 1.387 ± 0.511
1.618AlaAsn: 1.618 ± 0.363
2.543AlaPro: 2.543 ± 0.805
1.156AlaGln: 1.156 ± 0.602
3.005AlaArg: 3.005 ± 1.084
4.623AlaSer: 4.623 ± 0.438
5.086AlaThr: 5.086 ± 0.766
6.241AlaVal: 6.241 ± 0.916
1.156AlaTrp: 1.156 ± 0.38
2.543AlaTyr: 2.543 ± 0.466
0.0AlaXaa: 0.0 ± 0.0
Cys
1.387CysAla: 1.387 ± 0.485
0.925CysCys: 0.925 ± 0.488
3.005CysAsp: 3.005 ± 1.318
1.618CysGlu: 1.618 ± 0.628
2.543CysPhe: 2.543 ± 0.642
1.156CysGly: 1.156 ± 0.467
0.693CysHis: 0.693 ± 0.273
0.462CysIle: 0.462 ± 0.268
1.618CysLys: 1.618 ± 0.613
2.312CysLeu: 2.312 ± 1.283
0.925CysMet: 0.925 ± 0.414
0.462CysAsn: 0.462 ± 0.268
0.925CysPro: 0.925 ± 0.667
0.0CysGln: 0.0 ± 0.0
1.387CysArg: 1.387 ± 0.485
3.236CysSer: 3.236 ± 0.669
1.156CysThr: 1.156 ± 0.325
3.005CysVal: 3.005 ± 0.741
0.462CysTrp: 0.462 ± 0.587
1.156CysTyr: 1.156 ± 0.54
0.0CysXaa: 0.0 ± 0.0
Asp
3.93AspAla: 3.93 ± 1.01
0.693AspCys: 0.693 ± 0.366
3.699AspAsp: 3.699 ± 1.099
3.467AspGlu: 3.467 ± 0.774
2.543AspPhe: 2.543 ± 0.84
3.005AspGly: 3.005 ± 0.402
0.925AspHis: 0.925 ± 0.55
3.699AspIle: 3.699 ± 0.816
2.774AspLys: 2.774 ± 1.049
5.548AspLeu: 5.548 ± 1.18
3.236AspMet: 3.236 ± 0.821
2.08AspAsn: 2.08 ± 0.546
3.93AspPro: 3.93 ± 1.102
0.925AspGln: 0.925 ± 0.328
4.854AspArg: 4.854 ± 1.494
8.091AspSer: 8.091 ± 2.131
2.774AspThr: 2.774 ± 0.904
6.704AspVal: 6.704 ± 1.222
0.462AspTrp: 0.462 ± 0.244
2.774AspTyr: 2.774 ± 0.424
0.0AspXaa: 0.0 ± 0.0
Glu
3.467GluAla: 3.467 ± 0.928
2.08GluCys: 2.08 ± 0.679
3.93GluAsp: 3.93 ± 1.24
2.08GluGlu: 2.08 ± 0.788
2.312GluPhe: 2.312 ± 0.793
1.849GluGly: 1.849 ± 0.931
1.387GluHis: 1.387 ± 0.512
2.08GluIle: 2.08 ± 0.538
2.08GluLys: 2.08 ± 0.579
3.467GluLeu: 3.467 ± 0.767
1.849GluMet: 1.849 ± 0.557
1.849GluAsn: 1.849 ± 0.735
1.618GluPro: 1.618 ± 0.42
0.925GluGln: 0.925 ± 0.331
3.005GluArg: 3.005 ± 0.418
5.086GluSer: 5.086 ± 1.06
1.156GluThr: 1.156 ± 0.42
5.317GluVal: 5.317 ± 1.066
0.925GluTrp: 0.925 ± 0.353
2.774GluTyr: 2.774 ± 1.08
0.0GluXaa: 0.0 ± 0.0
Phe
2.312PheAla: 2.312 ± 0.458
2.543PheCys: 2.543 ± 0.643
3.699PheAsp: 3.699 ± 0.801
2.774PheGlu: 2.774 ± 0.832
3.236PhePhe: 3.236 ± 0.987
3.005PheGly: 3.005 ± 0.873
0.462PheHis: 0.462 ± 0.244
3.467PheIle: 3.467 ± 0.975
0.693PheLys: 0.693 ± 0.279
3.93PheLeu: 3.93 ± 1.116
2.543PheMet: 2.543 ± 0.74
3.236PheAsn: 3.236 ± 1.366
2.543PhePro: 2.543 ± 0.851
1.849PheGln: 1.849 ± 0.767
5.086PheArg: 5.086 ± 0.897
4.392PheSer: 4.392 ± 1.31
3.699PheThr: 3.699 ± 0.606
6.704PheVal: 6.704 ± 2.576
0.462PheTrp: 0.462 ± 0.545
1.156PheTyr: 1.156 ± 0.602
0.0PheXaa: 0.0 ± 0.0
Gly
5.548GlyAla: 5.548 ± 1.387
2.774GlyCys: 2.774 ± 0.832
4.854GlyAsp: 4.854 ± 1.4
3.699GlyGlu: 3.699 ± 0.899
3.93GlyPhe: 3.93 ± 1.104
5.317GlyGly: 5.317 ± 1.061
1.849GlyHis: 1.849 ± 0.413
2.774GlyIle: 2.774 ± 1.132
4.854GlyLys: 4.854 ± 1.254
5.317GlyLeu: 5.317 ± 1.431
1.849GlyMet: 1.849 ± 0.59
1.156GlyAsn: 1.156 ± 0.425
2.312GlyPro: 2.312 ± 0.891
0.925GlyGln: 0.925 ± 0.431
3.467GlyArg: 3.467 ± 0.89
3.236GlySer: 3.236 ± 1.02
3.93GlyThr: 3.93 ± 1.308
4.854GlyVal: 4.854 ± 1.167
0.231GlyTrp: 0.231 ± 0.433
2.312GlyTyr: 2.312 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
1.387HisAla: 1.387 ± 0.563
0.231HisCys: 0.231 ± 0.122
2.312HisAsp: 2.312 ± 1.074
0.925HisGlu: 0.925 ± 0.328
0.925HisPhe: 0.925 ± 0.488
0.462HisGly: 0.462 ± 0.324
0.0HisHis: 0.0 ± 0.0
1.387HisIle: 1.387 ± 0.301
1.387HisLys: 1.387 ± 0.732
2.543HisLeu: 2.543 ± 0.75
1.387HisMet: 1.387 ± 0.563
0.693HisAsn: 0.693 ± 0.366
0.462HisPro: 0.462 ± 0.307
0.693HisGln: 0.693 ± 0.366
2.08HisArg: 2.08 ± 0.638
1.618HisSer: 1.618 ± 0.62
1.156HisThr: 1.156 ± 0.61
1.849HisVal: 1.849 ± 0.484
0.231HisTrp: 0.231 ± 0.433
0.693HisTyr: 0.693 ± 0.366
0.0HisXaa: 0.0 ± 0.0
Ile
2.543IleAla: 2.543 ± 0.88
0.925IleCys: 0.925 ± 0.673
4.854IleAsp: 4.854 ± 0.951
3.005IleGlu: 3.005 ± 0.696
2.08IlePhe: 2.08 ± 0.686
3.699IleGly: 3.699 ± 0.748
1.387IleHis: 1.387 ± 0.512
1.618IleIle: 1.618 ± 0.559
2.08IleLys: 2.08 ± 0.551
4.854IleLeu: 4.854 ± 2.776
1.618IleMet: 1.618 ± 0.751
0.462IleAsn: 0.462 ± 0.337
1.387IlePro: 1.387 ± 0.301
0.925IleGln: 0.925 ± 0.488
3.699IleArg: 3.699 ± 0.618
2.774IleSer: 2.774 ± 0.761
2.312IleThr: 2.312 ± 0.44
4.392IleVal: 4.392 ± 0.958
0.231IleTrp: 0.231 ± 0.122
2.774IleTyr: 2.774 ± 1.464
0.0IleXaa: 0.0 ± 0.0
Lys
4.161LysAla: 4.161 ± 0.927
1.156LysCys: 1.156 ± 0.414
3.467LysAsp: 3.467 ± 1.073
2.08LysGlu: 2.08 ± 0.846
4.161LysPhe: 4.161 ± 0.961
2.774LysGly: 2.774 ± 0.722
1.156LysHis: 1.156 ± 0.43
1.156LysIle: 1.156 ± 0.43
2.543LysLys: 2.543 ± 0.777
5.779LysLeu: 5.779 ± 1.315
1.156LysMet: 1.156 ± 0.677
0.693LysAsn: 0.693 ± 0.366
1.618LysPro: 1.618 ± 0.57
0.925LysGln: 0.925 ± 0.331
2.774LysArg: 2.774 ± 0.332
4.854LysSer: 4.854 ± 0.753
1.618LysThr: 1.618 ± 0.413
4.854LysVal: 4.854 ± 2.285
0.693LysTrp: 0.693 ± 0.299
4.161LysTyr: 4.161 ± 0.783
0.0LysXaa: 0.0 ± 0.0
Leu
4.161LeuAla: 4.161 ± 0.583
2.774LeuCys: 2.774 ± 0.702
6.472LeuAsp: 6.472 ± 0.823
3.699LeuGlu: 3.699 ± 0.934
7.628LeuPhe: 7.628 ± 1.391
6.472LeuGly: 6.472 ± 1.254
2.312LeuHis: 2.312 ± 0.525
5.086LeuIle: 5.086 ± 1.099
6.935LeuLys: 6.935 ± 1.754
10.171LeuLeu: 10.171 ± 2.539
2.543LeuMet: 2.543 ± 0.663
2.08LeuAsn: 2.08 ± 0.424
3.93LeuPro: 3.93 ± 1.524
1.849LeuGln: 1.849 ± 0.761
5.779LeuArg: 5.779 ± 1.391
7.628LeuSer: 7.628 ± 2.299
2.543LeuThr: 2.543 ± 0.955
9.478LeuVal: 9.478 ± 2.892
1.387LeuTrp: 1.387 ± 1.507
3.005LeuTyr: 3.005 ± 0.813
0.0LeuXaa: 0.0 ± 0.0
Met
1.156MetAla: 1.156 ± 0.44
0.693MetCys: 0.693 ± 0.366
1.387MetAsp: 1.387 ± 0.615
1.618MetGlu: 1.618 ± 0.528
1.387MetPhe: 1.387 ± 0.524
0.693MetGly: 0.693 ± 0.743
0.462MetHis: 0.462 ± 0.244
1.156MetIle: 1.156 ± 0.66
0.925MetLys: 0.925 ± 0.322
4.161MetLeu: 4.161 ± 0.572
0.231MetMet: 0.231 ± 0.323
0.925MetAsn: 0.925 ± 0.384
1.618MetPro: 1.618 ± 0.667
0.462MetGln: 0.462 ± 0.268
1.849MetArg: 1.849 ± 0.861
1.387MetSer: 1.387 ± 0.355
0.925MetThr: 0.925 ± 0.351
3.699MetVal: 3.699 ± 1.059
0.231MetTrp: 0.231 ± 0.122
2.543MetTyr: 2.543 ± 1.539
0.0MetXaa: 0.0 ± 0.0
Asn
1.156AsnAla: 1.156 ± 0.468
0.693AsnCys: 0.693 ± 0.362
1.156AsnAsp: 1.156 ± 0.384
1.849AsnGlu: 1.849 ± 0.31
1.849AsnPhe: 1.849 ± 1.078
1.849AsnGly: 1.849 ± 0.446
0.925AsnHis: 0.925 ± 0.488
1.618AsnIle: 1.618 ± 0.592
1.849AsnLys: 1.849 ± 0.339
2.543AsnLeu: 2.543 ± 1.403
1.618AsnMet: 1.618 ± 0.515
0.231AsnAsn: 0.231 ± 0.122
2.312AsnPro: 2.312 ± 0.904
0.693AsnGln: 0.693 ± 0.279
2.543AsnArg: 2.543 ± 0.922
1.387AsnSer: 1.387 ± 0.4
1.618AsnThr: 1.618 ± 0.522
3.236AsnVal: 3.236 ± 0.568
0.0AsnTrp: 0.0 ± 0.0
1.156AsnTyr: 1.156 ± 0.808
0.0AsnXaa: 0.0 ± 0.0
Pro
0.462ProAla: 0.462 ± 0.642
0.462ProCys: 0.462 ± 0.487
3.467ProAsp: 3.467 ± 1.092
2.774ProGlu: 2.774 ± 1.135
2.08ProPhe: 2.08 ± 0.622
3.005ProGly: 3.005 ± 0.978
1.156ProHis: 1.156 ± 0.384
2.543ProIle: 2.543 ± 0.675
2.312ProLys: 2.312 ± 0.65
2.543ProLeu: 2.543 ± 0.803
0.925ProMet: 0.925 ± 0.561
0.693ProAsn: 0.693 ± 0.455
1.156ProPro: 1.156 ± 0.489
0.693ProGln: 0.693 ± 0.299
2.543ProArg: 2.543 ± 1.027
4.623ProSer: 4.623 ± 0.884
1.849ProThr: 1.849 ± 0.463
5.317ProVal: 5.317 ± 1.53
0.231ProTrp: 0.231 ± 0.351
0.925ProTyr: 0.925 ± 0.503
0.0ProXaa: 0.0 ± 0.0
Gln
1.387GlnAla: 1.387 ± 0.408
0.925GlnCys: 0.925 ± 0.34
0.462GlnAsp: 0.462 ± 0.244
1.849GlnGlu: 1.849 ± 0.976
1.156GlnPhe: 1.156 ± 0.334
1.618GlnGly: 1.618 ± 0.572
0.462GlnHis: 0.462 ± 0.268
1.156GlnIle: 1.156 ± 0.414
0.231GlnLys: 0.231 ± 0.122
1.387GlnLeu: 1.387 ± 0.599
0.462GlnMet: 0.462 ± 0.702
0.231GlnAsn: 0.231 ± 0.122
0.462GlnPro: 0.462 ± 0.275
0.925GlnGln: 0.925 ± 0.488
0.693GlnArg: 0.693 ± 0.366
1.387GlnSer: 1.387 ± 0.416
0.693GlnThr: 0.693 ± 0.533
2.08GlnVal: 2.08 ± 0.659
0.231GlnTrp: 0.231 ± 0.122
0.693GlnTyr: 0.693 ± 0.279
0.0GlnXaa: 0.0 ± 0.0
Arg
4.161ArgAla: 4.161 ± 0.718
0.925ArgCys: 0.925 ± 0.34
4.623ArgAsp: 4.623 ± 0.992
1.618ArgGlu: 1.618 ± 1.078
3.93ArgPhe: 3.93 ± 1.276
6.241ArgGly: 6.241 ± 1.309
0.925ArgHis: 0.925 ± 0.331
4.623ArgIle: 4.623 ± 1.059
2.543ArgLys: 2.543 ± 0.803
7.628ArgLeu: 7.628 ± 2.026
0.693ArgMet: 0.693 ± 0.254
3.467ArgAsn: 3.467 ± 1.04
1.618ArgPro: 1.618 ± 0.374
0.693ArgGln: 0.693 ± 0.366
3.467ArgArg: 3.467 ± 0.874
5.548ArgSer: 5.548 ± 1.14
2.08ArgThr: 2.08 ± 0.554
4.854ArgVal: 4.854 ± 2.006
0.462ArgTrp: 0.462 ± 0.244
2.312ArgTyr: 2.312 ± 0.515
0.0ArgXaa: 0.0 ± 0.0
Ser
6.241SerAla: 6.241 ± 1.289
3.236SerCys: 3.236 ± 0.578
1.849SerAsp: 1.849 ± 0.965
1.849SerGlu: 1.849 ± 0.463
5.779SerPhe: 5.779 ± 1.812
7.628SerGly: 7.628 ± 0.671
1.618SerHis: 1.618 ± 0.42
2.774SerIle: 2.774 ± 0.999
4.623SerLys: 4.623 ± 1.061
7.859SerLeu: 7.859 ± 1.496
2.312SerMet: 2.312 ± 0.544
3.467SerAsn: 3.467 ± 0.868
2.543SerPro: 2.543 ± 0.655
0.693SerGln: 0.693 ± 0.366
4.854SerArg: 4.854 ± 0.776
4.161SerSer: 4.161 ± 0.994
3.005SerThr: 3.005 ± 1.003
11.096SerVal: 11.096 ± 0.721
0.231SerTrp: 0.231 ± 0.314
2.08SerTyr: 2.08 ± 0.607
0.0SerXaa: 0.0 ± 0.0
Thr
3.236ThrAla: 3.236 ± 1.44
1.387ThrCys: 1.387 ± 0.558
3.005ThrAsp: 3.005 ± 0.676
1.849ThrGlu: 1.849 ± 0.714
0.925ThrPhe: 0.925 ± 0.387
3.467ThrGly: 3.467 ± 0.455
0.693ThrHis: 0.693 ± 0.333
2.08ThrIle: 2.08 ± 1.021
4.623ThrLys: 4.623 ± 1.526
3.467ThrLeu: 3.467 ± 0.592
1.156ThrMet: 1.156 ± 0.393
0.462ThrAsn: 0.462 ± 0.268
1.618ThrPro: 1.618 ± 0.443
1.156ThrGln: 1.156 ± 0.42
1.387ThrArg: 1.387 ± 0.557
3.467ThrSer: 3.467 ± 0.521
1.387ThrThr: 1.387 ± 0.547
4.392ThrVal: 4.392 ± 1.233
0.462ThrTrp: 0.462 ± 0.628
3.467ThrTyr: 3.467 ± 1.29
0.0ThrXaa: 0.0 ± 0.0
Val
5.779ValAla: 5.779 ± 1.265
3.005ValCys: 3.005 ± 1.033
5.779ValAsp: 5.779 ± 0.601
5.317ValGlu: 5.317 ± 0.903
5.779ValPhe: 5.779 ± 1.217
6.704ValGly: 6.704 ± 1.475
2.774ValHis: 2.774 ± 0.981
4.161ValIle: 4.161 ± 1.355
3.93ValLys: 3.93 ± 0.802
11.558ValLeu: 11.558 ± 1.522
0.693ValMet: 0.693 ± 0.322
4.161ValAsn: 4.161 ± 0.468
5.548ValPro: 5.548 ± 0.313
2.312ValGln: 2.312 ± 0.513
6.935ValArg: 6.935 ± 1.181
6.935ValSer: 6.935 ± 1.288
4.854ValThr: 4.854 ± 1.077
10.171ValVal: 10.171 ± 1.912
0.462ValTrp: 0.462 ± 0.508
4.854ValTyr: 4.854 ± 1.256
0.0ValXaa: 0.0 ± 0.0
Trp
0.693TrpAla: 0.693 ± 0.299
0.693TrpCys: 0.693 ± 0.342
0.693TrpAsp: 0.693 ± 0.455
0.0TrpGlu: 0.0 ± 0.0
1.387TrpPhe: 1.387 ± 0.674
0.231TrpGly: 0.231 ± 0.433
0.231TrpHis: 0.231 ± 0.122
0.925TrpIle: 0.925 ± 0.34
1.156TrpLys: 1.156 ± 0.733
0.693TrpLeu: 0.693 ± 0.726
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.693TrpArg: 0.693 ± 0.942
0.693TrpSer: 0.693 ± 0.455
0.0TrpThr: 0.0 ± 0.0
0.462TrpVal: 0.462 ± 0.307
0.0TrpTrp: 0.0 ± 0.0
0.231TrpTyr: 0.231 ± 0.122
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.005TyrAla: 3.005 ± 0.996
1.849TyrCys: 1.849 ± 0.614
2.774TyrAsp: 2.774 ± 0.602
3.93TyrGlu: 3.93 ± 0.728
1.849TyrPhe: 1.849 ± 0.918
2.08TyrGly: 2.08 ± 0.49
1.849TyrHis: 1.849 ± 0.442
2.312TyrIle: 2.312 ± 0.714
2.312TyrLys: 2.312 ± 0.653
3.93TyrLeu: 3.93 ± 0.905
0.693TyrMet: 0.693 ± 0.307
2.312TyrAsn: 2.312 ± 0.66
1.618TyrPro: 1.618 ± 0.551
0.693TyrGln: 0.693 ± 0.455
2.312TyrArg: 2.312 ± 1.13
2.774TyrSer: 2.774 ± 0.847
1.849TyrThr: 1.849 ± 0.48
3.236TyrVal: 3.236 ± 0.973
0.231TyrTrp: 0.231 ± 0.433
2.543TyrTyr: 2.543 ± 1.082
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (4327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski