Amino acid dipepetide frequency for Pseudorhodobacter sp. PARRP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.555AlaAla: 19.555 ± 0.212
1.164AlaCys: 1.164 ± 0.033
7.496AlaAsp: 7.496 ± 0.082
8.332AlaGlu: 8.332 ± 0.095
4.485AlaPhe: 4.485 ± 0.053
11.906AlaGly: 11.906 ± 0.131
2.474AlaHis: 2.474 ± 0.045
6.119AlaIle: 6.119 ± 0.076
4.648AlaLys: 4.648 ± 0.065
15.078AlaLeu: 15.078 ± 0.145
4.176AlaMet: 4.176 ± 0.055
3.026AlaAsn: 3.026 ± 0.059
6.063AlaPro: 6.063 ± 0.093
5.328AlaGln: 5.328 ± 0.074
9.046AlaArg: 9.046 ± 0.124
6.133AlaSer: 6.133 ± 0.071
6.613AlaThr: 6.613 ± 0.087
9.286AlaVal: 9.286 ± 0.092
1.661AlaTrp: 1.661 ± 0.035
2.672AlaTyr: 2.672 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.087CysAla: 1.087 ± 0.035
0.107CysCys: 0.107 ± 0.009
0.618CysAsp: 0.618 ± 0.02
0.394CysGlu: 0.394 ± 0.02
0.331CysPhe: 0.331 ± 0.017
0.973CysGly: 0.973 ± 0.032
0.246CysHis: 0.246 ± 0.015
0.408CysIle: 0.408 ± 0.015
0.228CysLys: 0.228 ± 0.015
0.865CysLeu: 0.865 ± 0.029
0.172CysMet: 0.172 ± 0.013
0.22CysAsn: 0.22 ± 0.014
0.467CysPro: 0.467 ± 0.018
0.23CysGln: 0.23 ± 0.015
0.513CysArg: 0.513 ± 0.02
0.411CysSer: 0.411 ± 0.017
0.477CysThr: 0.477 ± 0.02
0.64CysVal: 0.64 ± 0.019
0.118CysTrp: 0.118 ± 0.01
0.206CysTyr: 0.206 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.506AspAla: 7.506 ± 0.09
0.506AspCys: 0.506 ± 0.018
2.926AspAsp: 2.926 ± 0.062
2.778AspGlu: 2.778 ± 0.057
2.301AspPhe: 2.301 ± 0.045
5.134AspGly: 5.134 ± 0.083
1.309AspHis: 1.309 ± 0.032
2.782AspIle: 2.782 ± 0.049
1.651AspLys: 1.651 ± 0.036
6.612AspLeu: 6.612 ± 0.085
1.509AspMet: 1.509 ± 0.035
1.24AspAsn: 1.24 ± 0.036
3.487AspPro: 3.487 ± 0.051
2.029AspGln: 2.029 ± 0.04
3.703AspArg: 3.703 ± 0.055
2.135AspSer: 2.135 ± 0.051
2.894AspThr: 2.894 ± 0.082
3.963AspVal: 3.963 ± 0.065
1.13AspTrp: 1.13 ± 0.032
1.453AspTyr: 1.453 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.84GluAla: 7.84 ± 0.101
0.323GluCys: 0.323 ± 0.016
2.606GluAsp: 2.606 ± 0.045
2.244GluGlu: 2.244 ± 0.049
1.621GluPhe: 1.621 ± 0.036
4.13GluGly: 4.13 ± 0.058
0.945GluHis: 0.945 ± 0.027
3.273GluIle: 3.273 ± 0.053
1.885GluLys: 1.885 ± 0.042
4.266GluLeu: 4.266 ± 0.066
1.652GluMet: 1.652 ± 0.036
1.488GluAsn: 1.488 ± 0.037
2.207GluPro: 2.207 ± 0.052
1.614GluGln: 1.614 ± 0.036
3.333GluArg: 3.333 ± 0.068
1.984GluSer: 1.984 ± 0.038
3.19GluThr: 3.19 ± 0.045
4.095GluVal: 4.095 ± 0.062
0.682GluTrp: 0.682 ± 0.024
0.969GluTyr: 0.969 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.876PheAla: 4.876 ± 0.063
0.408PheCys: 0.408 ± 0.018
2.637PheAsp: 2.637 ± 0.041
1.878PheGlu: 1.878 ± 0.041
1.304PhePhe: 1.304 ± 0.034
3.762PheGly: 3.762 ± 0.062
0.731PheHis: 0.731 ± 0.027
1.608PheIle: 1.608 ± 0.036
0.999PheLys: 0.999 ± 0.029
3.287PheLeu: 3.287 ± 0.058
0.835PheMet: 0.835 ± 0.027
1.087PheAsn: 1.087 ± 0.032
1.572PhePro: 1.572 ± 0.04
1.134PheGln: 1.134 ± 0.03
2.043PheArg: 2.043 ± 0.039
2.096PheSer: 2.096 ± 0.042
2.151PheThr: 2.151 ± 0.04
2.635PheVal: 2.635 ± 0.057
0.532PheTrp: 0.532 ± 0.022
0.906PheTyr: 0.906 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
10.596GlyAla: 10.596 ± 0.122
0.894GlyCys: 0.894 ± 0.03
4.58GlyAsp: 4.58 ± 0.094
3.996GlyGlu: 3.996 ± 0.062
3.814GlyPhe: 3.814 ± 0.054
7.713GlyGly: 7.713 ± 0.146
1.935GlyHis: 1.935 ± 0.039
4.409GlyIle: 4.409 ± 0.063
3.358GlyLys: 3.358 ± 0.053
9.632GlyLeu: 9.632 ± 0.097
2.613GlyMet: 2.613 ± 0.048
2.484GlyAsn: 2.484 ± 0.108
3.64GlyPro: 3.64 ± 0.051
3.38GlyGln: 3.38 ± 0.051
5.529GlyArg: 5.529 ± 0.072
4.311GlySer: 4.311 ± 0.069
4.558GlyThr: 4.558 ± 0.086
6.68GlyVal: 6.68 ± 0.074
1.572GlyTrp: 1.572 ± 0.038
2.345GlyTyr: 2.345 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.529HisAla: 2.529 ± 0.048
0.217HisCys: 0.217 ± 0.016
1.245HisAsp: 1.245 ± 0.035
0.918HisGlu: 0.918 ± 0.025
0.846HisPhe: 0.846 ± 0.026
1.92HisGly: 1.92 ± 0.046
0.585HisHis: 0.585 ± 0.021
1.019HisIle: 1.019 ± 0.029
0.558HisLys: 0.558 ± 0.022
2.267HisLeu: 2.267 ± 0.048
0.513HisMet: 0.513 ± 0.019
0.488HisAsn: 0.488 ± 0.019
1.415HisPro: 1.415 ± 0.039
0.611HisGln: 0.611 ± 0.022
1.359HisArg: 1.359 ± 0.031
0.967HisSer: 0.967 ± 0.027
0.88HisThr: 0.88 ± 0.027
1.376HisVal: 1.376 ± 0.029
0.36HisTrp: 0.36 ± 0.016
0.542HisTyr: 0.542 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.606IleAla: 7.606 ± 0.08
0.6IleCys: 0.6 ± 0.02
3.304IleAsp: 3.304 ± 0.051
3.136IleGlu: 3.136 ± 0.049
1.641IlePhe: 1.641 ± 0.042
4.977IleGly: 4.977 ± 0.073
0.925IleHis: 0.925 ± 0.03
2.23IleIle: 2.23 ± 0.05
1.493IleLys: 1.493 ± 0.038
4.707IleLeu: 4.707 ± 0.063
1.041IleMet: 1.041 ± 0.029
1.439IleAsn: 1.439 ± 0.036
2.396IlePro: 2.396 ± 0.04
1.118IleGln: 1.118 ± 0.027
3.043IleArg: 3.043 ± 0.05
3.033IleSer: 3.033 ± 0.054
3.136IleThr: 3.136 ± 0.045
3.441IleVal: 3.441 ± 0.06
0.767IleTrp: 0.767 ± 0.03
1.208IleTyr: 1.208 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.474LysAla: 4.474 ± 0.062
0.171LysCys: 0.171 ± 0.011
1.745LysAsp: 1.745 ± 0.041
1.234LysGlu: 1.234 ± 0.035
0.991LysPhe: 0.991 ± 0.029
2.949LysGly: 2.949 ± 0.058
0.644LysHis: 0.644 ± 0.024
1.743LysIle: 1.743 ± 0.038
1.165LysLys: 1.165 ± 0.042
3.369LysLeu: 3.369 ± 0.055
0.932LysMet: 0.932 ± 0.028
0.827LysAsn: 0.827 ± 0.026
2.071LysPro: 2.071 ± 0.046
0.955LysGln: 0.955 ± 0.027
2.13LysArg: 2.13 ± 0.043
1.886LysSer: 1.886 ± 0.04
2.019LysThr: 2.019 ± 0.048
2.461LysVal: 2.461 ± 0.049
0.395LysTrp: 0.395 ± 0.017
0.627LysTyr: 0.627 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.653LeuAla: 14.653 ± 0.115
0.985LeuCys: 0.985 ± 0.027
5.557LeuAsp: 5.557 ± 0.065
4.591LeuGlu: 4.591 ± 0.063
3.325LeuPhe: 3.325 ± 0.066
8.711LeuGly: 8.711 ± 0.1
2.193LeuHis: 2.193 ± 0.044
5.56LeuIle: 5.56 ± 0.069
3.319LeuLys: 3.319 ± 0.058
9.164LeuLeu: 9.164 ± 0.102
2.724LeuMet: 2.724 ± 0.048
2.761LeuAsn: 2.761 ± 0.043
6.078LeuPro: 6.078 ± 0.079
3.244LeuGln: 3.244 ± 0.054
7.175LeuArg: 7.175 ± 0.098
6.206LeuSer: 6.206 ± 0.077
6.357LeuThr: 6.357 ± 0.079
6.841LeuVal: 6.841 ± 0.077
1.385LeuTrp: 1.385 ± 0.04
2.009LeuTyr: 2.009 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.873MetAla: 3.873 ± 0.062
0.16MetCys: 0.16 ± 0.011
1.333MetAsp: 1.333 ± 0.034
1.168MetGlu: 1.168 ± 0.03
0.832MetPhe: 0.832 ± 0.023
2.246MetGly: 2.246 ± 0.044
0.463MetHis: 0.463 ± 0.018
1.604MetIle: 1.604 ± 0.039
1.047MetLys: 1.047 ± 0.031
2.762MetLeu: 2.762 ± 0.051
0.776MetMet: 0.776 ± 0.026
0.834MetAsn: 0.834 ± 0.028
1.566MetPro: 1.566 ± 0.035
1.127MetGln: 1.127 ± 0.03
1.845MetArg: 1.845 ± 0.039
1.552MetSer: 1.552 ± 0.036
2.05MetThr: 2.05 ± 0.035
1.979MetVal: 1.979 ± 0.039
0.257MetTrp: 0.257 ± 0.015
0.355MetTyr: 0.355 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.435AsnAla: 3.435 ± 0.059
0.237AsnCys: 0.237 ± 0.014
1.745AsnAsp: 1.745 ± 0.097
1.001AsnGlu: 1.001 ± 0.031
1.045AsnPhe: 1.045 ± 0.029
2.449AsnGly: 2.449 ± 0.054
0.547AsnHis: 0.547 ± 0.021
1.355AsnIle: 1.355 ± 0.041
0.665AsnLys: 0.665 ± 0.022
2.701AsnLeu: 2.701 ± 0.052
0.661AsnMet: 0.661 ± 0.024
0.675AsnAsn: 0.675 ± 0.026
1.979AsnPro: 1.979 ± 0.045
0.719AsnGln: 0.719 ± 0.024
1.693AsnArg: 1.693 ± 0.039
1.119AsnSer: 1.119 ± 0.031
1.357AsnThr: 1.357 ± 0.034
1.751AsnVal: 1.751 ± 0.046
0.439AsnTrp: 0.439 ± 0.019
0.627AsnTyr: 0.627 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.511ProAla: 6.511 ± 0.087
0.368ProCys: 0.368 ± 0.017
3.679ProAsp: 3.679 ± 0.061
3.571ProGlu: 3.571 ± 0.063
1.944ProPhe: 1.944 ± 0.043
4.481ProGly: 4.481 ± 0.071
1.157ProHis: 1.157 ± 0.035
2.322ProIle: 2.322 ± 0.045
1.793ProLys: 1.793 ± 0.038
4.887ProLeu: 4.887 ± 0.064
1.446ProMet: 1.446 ± 0.037
1.38ProAsn: 1.38 ± 0.031
2.285ProPro: 2.285 ± 0.054
1.901ProGln: 1.901 ± 0.043
2.713ProArg: 2.713 ± 0.052
2.495ProSer: 2.495 ± 0.044
2.537ProThr: 2.537 ± 0.044
4.077ProVal: 4.077 ± 0.063
0.67ProTrp: 0.67 ± 0.023
1.186ProTyr: 1.186 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.797GlnAla: 4.797 ± 0.062
0.206GlnCys: 0.206 ± 0.013
1.743GlnAsp: 1.743 ± 0.034
1.201GlnGlu: 1.201 ± 0.034
1.137GlnPhe: 1.137 ± 0.03
2.955GlnGly: 2.955 ± 0.051
0.685GlnHis: 0.685 ± 0.022
2.307GlnIle: 2.307 ± 0.043
1.113GlnLys: 1.113 ± 0.031
2.909GlnLeu: 2.909 ± 0.044
1.182GlnMet: 1.182 ± 0.032
0.973GlnAsn: 0.973 ± 0.025
1.844GlnPro: 1.844 ± 0.039
1.142GlnGln: 1.142 ± 0.037
2.302GlnArg: 2.302 ± 0.046
1.869GlnSer: 1.869 ± 0.034
1.981GlnThr: 1.981 ± 0.041
2.564GlnVal: 2.564 ± 0.049
0.405GlnTrp: 0.405 ± 0.019
0.606GlnTyr: 0.606 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
8.637ArgAla: 8.637 ± 0.109
0.486ArgCys: 0.486 ± 0.021
3.822ArgAsp: 3.822 ± 0.062
3.083ArgGlu: 3.083 ± 0.052
2.6ArgPhe: 2.6 ± 0.055
4.433ArgGly: 4.433 ± 0.07
1.458ArgHis: 1.458 ± 0.037
3.595ArgIle: 3.595 ± 0.05
2.086ArgLys: 2.086 ± 0.05
7.258ArgLeu: 7.258 ± 0.091
1.961ArgMet: 1.961 ± 0.044
1.624ArgAsn: 1.624 ± 0.038
3.08ArgPro: 3.08 ± 0.058
2.183ArgGln: 2.183 ± 0.042
4.404ArgArg: 4.404 ± 0.078
3.047ArgSer: 3.047 ± 0.052
2.633ArgThr: 2.633 ± 0.043
4.585ArgVal: 4.585 ± 0.065
0.887ArgTrp: 0.887 ± 0.028
1.442ArgTyr: 1.442 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.096SerAla: 6.096 ± 0.072
0.406SerCys: 0.406 ± 0.018
3.036SerAsp: 3.036 ± 0.048
2.45SerGlu: 2.45 ± 0.046
2.242SerPhe: 2.242 ± 0.042
5.44SerGly: 5.44 ± 0.086
1.076SerHis: 1.076 ± 0.028
2.364SerIle: 2.364 ± 0.041
1.545SerLys: 1.545 ± 0.043
5.187SerLeu: 5.187 ± 0.065
1.277SerMet: 1.277 ± 0.033
1.372SerAsn: 1.372 ± 0.033
2.517SerPro: 2.517 ± 0.044
1.568SerGln: 1.568 ± 0.036
2.982SerArg: 2.982 ± 0.053
2.368SerSer: 2.368 ± 0.059
2.444SerThr: 2.444 ± 0.047
3.872SerVal: 3.872 ± 0.056
0.629SerTrp: 0.629 ± 0.025
1.353SerTyr: 1.353 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
7.092ThrAla: 7.092 ± 0.084
0.474ThrCys: 0.474 ± 0.02
2.994ThrAsp: 2.994 ± 0.047
2.702ThrGlu: 2.702 ± 0.043
1.899ThrPhe: 1.899 ± 0.038
5.163ThrGly: 5.163 ± 0.089
1.123ThrHis: 1.123 ± 0.031
2.675ThrIle: 2.675 ± 0.054
1.614ThrLys: 1.614 ± 0.037
6.164ThrLeu: 6.164 ± 0.078
1.265ThrMet: 1.265 ± 0.031
1.318ThrAsn: 1.318 ± 0.039
3.539ThrPro: 3.539 ± 0.055
1.681ThrGln: 1.681 ± 0.037
3.244ThrArg: 3.244 ± 0.051
2.692ThrSer: 2.692 ± 0.045
3.055ThrThr: 3.055 ± 0.055
4.151ThrVal: 4.151 ± 0.055
0.711ThrTrp: 0.711 ± 0.025
1.21ThrTyr: 1.21 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
9.68ValAla: 9.68 ± 0.091
0.624ValCys: 0.624 ± 0.019
3.83ValAsp: 3.83 ± 0.057
4.064ValGlu: 4.064 ± 0.06
2.682ValPhe: 2.682 ± 0.053
5.399ValGly: 5.399 ± 0.071
1.255ValHis: 1.255 ± 0.036
4.262ValIle: 4.262 ± 0.063
2.515ValLys: 2.515 ± 0.048
7.721ValLeu: 7.721 ± 0.082
2.196ValMet: 2.196 ± 0.046
1.939ValAsn: 1.939 ± 0.043
3.372ValPro: 3.372 ± 0.052
2.465ValGln: 2.465 ± 0.043
3.765ValArg: 3.765 ± 0.065
4.011ValSer: 4.011 ± 0.058
4.59ValThr: 4.59 ± 0.068
5.895ValVal: 5.895 ± 0.078
1.008ValTrp: 1.008 ± 0.032
1.486ValTyr: 1.486 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.613TrpAla: 1.613 ± 0.038
0.143TrpCys: 0.143 ± 0.012
0.688TrpAsp: 0.688 ± 0.025
0.55TrpGlu: 0.55 ± 0.024
0.567TrpPhe: 0.567 ± 0.025
1.101TrpGly: 1.101 ± 0.03
0.352TrpHis: 0.352 ± 0.017
0.651TrpIle: 0.651 ± 0.025
0.456TrpLys: 0.456 ± 0.019
1.754TrpLeu: 1.754 ± 0.043
0.408TrpMet: 0.408 ± 0.016
0.429TrpAsn: 0.429 ± 0.019
0.745TrpPro: 0.745 ± 0.025
0.703TrpGln: 0.703 ± 0.021
1.079TrpArg: 1.079 ± 0.032
0.764TrpSer: 0.764 ± 0.027
0.709TrpThr: 0.709 ± 0.024
1.008TrpVal: 1.008 ± 0.033
0.234TrpTrp: 0.234 ± 0.014
0.258TrpTyr: 0.258 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.804TyrAla: 2.804 ± 0.047
0.231TyrCys: 0.231 ± 0.013
1.466TyrAsp: 1.466 ± 0.033
1.057TyrGlu: 1.057 ± 0.033
0.873TyrPhe: 0.873 ± 0.029
2.199TyrGly: 2.199 ± 0.058
0.519TyrHis: 0.519 ± 0.018
0.954TyrIle: 0.954 ± 0.025
0.651TyrLys: 0.651 ± 0.023
2.248TyrLeu: 2.248 ± 0.045
0.486TyrMet: 0.486 ± 0.021
0.594TyrAsn: 0.594 ± 0.022
1.082TyrPro: 1.082 ± 0.031
0.789TyrGln: 0.789 ± 0.024
1.404TyrArg: 1.404 ± 0.037
1.146TyrSer: 1.146 ± 0.031
1.13TyrThr: 1.13 ± 0.035
1.46TyrVal: 1.46 ± 0.036
0.369TyrTrp: 0.369 ± 0.018
0.554TyrTyr: 0.554 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4111 proteins (1288030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski