Amino acid dipepetide frequency for Trichoderma longibrachiatum ATCC 18648

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.819AlaAla: 10.819 ± 0.078	1.189AlaCys: 1.189 ± 0.02	4.548AlaAsp: 4.548 ± 0.036	5.463AlaGlu: 5.463 ± 0.053	3.148AlaPhe: 3.148 ± 0.031	6.0AlaGly: 6.0 ± 0.044	1.904AlaHis: 1.904 ± 0.021	4.242AlaIle: 4.242 ± 0.039	4.324AlaLys: 4.324 ± 0.042	8.047AlaLeu: 8.047 ± 0.047	2.144AlaMet: 2.144 ± 0.024	2.963AlaAsn: 2.963 ± 0.024	5.216AlaPro: 5.216 ± 0.046	3.655AlaGln: 3.655 ± 0.039	5.455AlaArg: 5.455 ± 0.043	8.058AlaSer: 8.058 ± 0.052	5.265AlaThr: 5.265 ± 0.035	5.711AlaVal: 5.711 ± 0.047	1.264AlaTrp: 1.264 ± 0.025	2.177AlaTyr: 2.177 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.019CysAla: 1.019 ± 0.018	0.337CysCys: 0.337 ± 0.011	0.69CysAsp: 0.69 ± 0.017	0.62CysGlu: 0.62 ± 0.015	0.622CysPhe: 0.622 ± 0.015	0.986CysGly: 0.986 ± 0.022	0.381CysHis: 0.381 ± 0.011	0.728CysIle: 0.728 ± 0.013	0.522CysLys: 0.522 ± 0.011	1.433CysLeu: 1.433 ± 0.021	0.3CysMet: 0.3 ± 0.008	0.441CysAsn: 0.441 ± 0.01	0.746CysPro: 0.746 ± 0.015	0.5CysGln: 0.5 ± 0.011	0.922CysArg: 0.922 ± 0.016	1.073CysSer: 1.073 ± 0.015	0.7CysThr: 0.7 ± 0.014	0.848CysVal: 0.848 ± 0.018	0.229CysTrp: 0.229 ± 0.008	0.371CysTyr: 0.371 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.334AspAla: 5.334 ± 0.041	0.658AspCys: 0.658 ± 0.014	4.651AspAsp: 4.651 ± 0.048	4.766AspGlu: 4.766 ± 0.045	2.164AspPhe: 2.164 ± 0.023	4.42AspGly: 4.42 ± 0.035	1.171AspHis: 1.171 ± 0.015	2.869AspIle: 2.869 ± 0.029	2.536AspLys: 2.536 ± 0.026	4.846AspLeu: 4.846 ± 0.032	1.31AspMet: 1.31 ± 0.019	1.758AspAsn: 1.758 ± 0.019	3.117AspPro: 3.117 ± 0.03	1.766AspGln: 1.766 ± 0.018	3.056AspArg: 3.056 ± 0.031	3.932AspSer: 3.932 ± 0.038	2.68AspThr: 2.68 ± 0.024	3.82AspVal: 3.82 ± 0.035	0.861AspTrp: 0.861 ± 0.015	1.513AspTyr: 1.513 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	6.079GluAla: 6.079 ± 0.051	0.627GluCys: 0.627 ± 0.013	4.2GluAsp: 4.2 ± 0.042	5.534GluGlu: 5.534 ± 0.065	1.834GluPhe: 1.834 ± 0.017	3.719GluGly: 3.719 ± 0.029	1.41GluHis: 1.41 ± 0.02	2.723GluIle: 2.723 ± 0.026	3.486GluLys: 3.486 ± 0.042	5.165GluLeu: 5.165 ± 0.045	1.511GluMet: 1.511 ± 0.017	1.943GluAsn: 1.943 ± 0.025	2.892GluPro: 2.892 ± 0.031	2.511GluGln: 2.511 ± 0.028	4.013GluArg: 4.013 ± 0.041	4.064GluSer: 4.064 ± 0.038	3.349GluThr: 3.349 ± 0.028	3.406GluVal: 3.406 ± 0.033	0.88GluTrp: 0.88 ± 0.014	1.592GluTyr: 1.592 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.15PheAla: 3.15 ± 0.029	0.607PheCys: 0.607 ± 0.013	2.258PheAsp: 2.258 ± 0.022	2.021PheGlu: 2.021 ± 0.023	1.735PhePhe: 1.735 ± 0.025	2.777PheGly: 2.777 ± 0.029	0.902PheHis: 0.902 ± 0.013	1.718PheIle: 1.718 ± 0.023	1.428PheLys: 1.428 ± 0.02	3.425PheLeu: 3.425 ± 0.035	0.797PheMet: 0.797 ± 0.013	1.338PheAsn: 1.338 ± 0.018	1.934PhePro: 1.934 ± 0.021	1.361PheGln: 1.361 ± 0.019	1.974PheArg: 1.974 ± 0.023	2.973PheSer: 2.973 ± 0.032	2.027PheThr: 2.027 ± 0.024	2.425PheVal: 2.425 ± 0.028	0.642PheTrp: 0.642 ± 0.012	1.053PheTyr: 1.053 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.437GlyAla: 5.437 ± 0.038	0.934GlyCys: 0.934 ± 0.017	3.804GlyAsp: 3.804 ± 0.027	3.748GlyGlu: 3.748 ± 0.03	2.709GlyPhe: 2.709 ± 0.027	5.941GlyGly: 5.941 ± 0.06	1.731GlyHis: 1.731 ± 0.024	3.405GlyIle: 3.405 ± 0.032	3.386GlyLys: 3.386 ± 0.032	6.102GlyLeu: 6.102 ± 0.044	1.574GlyMet: 1.574 ± 0.02	2.434GlyAsn: 2.434 ± 0.03	3.335GlyPro: 3.335 ± 0.031	2.595GlyGln: 2.595 ± 0.029	4.426GlyArg: 4.426 ± 0.036	5.806GlySer: 5.806 ± 0.043	3.817GlyThr: 3.817 ± 0.034	4.283GlyVal: 4.283 ± 0.035	1.183GlyTrp: 1.183 ± 0.018	1.987GlyTyr: 1.987 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.927HisAla: 1.927 ± 0.021	0.373HisCys: 0.373 ± 0.011	1.378HisAsp: 1.378 ± 0.019	1.33HisGlu: 1.33 ± 0.019	0.9HisPhe: 0.9 ± 0.014	1.789HisGly: 1.789 ± 0.023	1.008HisHis: 1.008 ± 0.019	1.178HisIle: 1.178 ± 0.018	0.912HisLys: 0.912 ± 0.016	2.329HisLeu: 2.329 ± 0.023	0.524HisMet: 0.524 ± 0.011	0.799HisAsn: 0.799 ± 0.011	1.655HisPro: 1.655 ± 0.021	1.07HisGln: 1.07 ± 0.021	1.654HisArg: 1.654 ± 0.021	1.796HisSer: 1.796 ± 0.022	1.223HisThr: 1.223 ± 0.018	1.496HisVal: 1.496 ± 0.02	0.359HisTrp: 0.359 ± 0.009	0.665HisTyr: 0.665 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.057IleAla: 4.057 ± 0.035	0.754IleCys: 0.754 ± 0.015	2.702IleAsp: 2.702 ± 0.026	2.683IleGlu: 2.683 ± 0.029	1.863IlePhe: 1.863 ± 0.022	2.947IleGly: 2.947 ± 0.033	1.176IleHis: 1.176 ± 0.016	2.29IleIle: 2.29 ± 0.028	2.106IleLys: 2.106 ± 0.026	4.329IleLeu: 4.329 ± 0.041	0.983IleMet: 0.983 ± 0.015	1.662IleAsn: 1.662 ± 0.019	2.858IlePro: 2.858 ± 0.025	1.827IleGln: 1.827 ± 0.025	2.847IleArg: 2.847 ± 0.024	3.598IleSer: 3.598 ± 0.028	2.613IleThr: 2.613 ± 0.025	3.049IleVal: 3.049 ± 0.033	0.715IleTrp: 0.715 ± 0.014	1.289IleTyr: 1.289 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.536LysAla: 4.536 ± 0.04	0.488LysCys: 0.488 ± 0.011	2.691LysAsp: 2.691 ± 0.025	3.24LysGlu: 3.24 ± 0.04	1.375LysPhe: 1.375 ± 0.02	2.984LysGly: 2.984 ± 0.029	1.117LysHis: 1.117 ± 0.016	2.033LysIle: 2.033 ± 0.02	3.365LysLys: 3.365 ± 0.049	4.063LysLeu: 4.063 ± 0.03	1.042LysMet: 1.042 ± 0.013	1.558LysAsn: 1.558 ± 0.019	2.809LysPro: 2.809 ± 0.029	1.883LysGln: 1.883 ± 0.023	3.481LysArg: 3.481 ± 0.038	3.334LysSer: 3.334 ± 0.027	2.704LysThr: 2.704 ± 0.027	2.695LysVal: 2.695 ± 0.027	0.642LysTrp: 0.642 ± 0.012	1.265LysTyr: 1.265 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.286LeuAla: 8.286 ± 0.049	1.329LeuCys: 1.329 ± 0.019	5.235LeuAsp: 5.235 ± 0.038	5.414LeuGlu: 5.414 ± 0.049	3.404LeuPhe: 3.404 ± 0.031	5.914LeuGly: 5.914 ± 0.05	2.248LeuHis: 2.248 ± 0.028	3.829LeuIle: 3.829 ± 0.038	4.05LeuLys: 4.05 ± 0.033	8.773LeuLeu: 8.773 ± 0.061	1.841LeuMet: 1.841 ± 0.02	2.945LeuAsn: 2.945 ± 0.028	5.622LeuPro: 5.622 ± 0.042	3.875LeuGln: 3.875 ± 0.036	6.037LeuArg: 6.037 ± 0.038	7.434LeuSer: 7.434 ± 0.049	4.69LeuThr: 4.69 ± 0.038	5.609LeuVal: 5.609 ± 0.048	1.253LeuTrp: 1.253 ± 0.016	2.294LeuTyr: 2.294 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.448MetAla: 2.448 ± 0.026	0.264MetCys: 0.264 ± 0.007	1.276MetAsp: 1.276 ± 0.018	1.286MetGlu: 1.286 ± 0.02	0.716MetPhe: 0.716 ± 0.013	1.475MetGly: 1.475 ± 0.018	0.489MetHis: 0.489 ± 0.009	0.935MetIle: 0.935 ± 0.015	0.984MetLys: 0.984 ± 0.015	1.971MetLeu: 1.971 ± 0.021	0.638MetMet: 0.638 ± 0.013	0.767MetAsn: 0.767 ± 0.013	1.433MetPro: 1.433 ± 0.02	0.882MetGln: 0.882 ± 0.017	1.371MetArg: 1.371 ± 0.017	1.869MetSer: 1.869 ± 0.024	1.297MetThr: 1.297 ± 0.015	1.278MetVal: 1.278 ± 0.016	0.261MetTrp: 0.261 ± 0.008	0.532MetTyr: 0.532 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.976AsnAla: 2.976 ± 0.03	0.446AsnCys: 0.446 ± 0.01	1.829AsnAsp: 1.829 ± 0.021	1.801AsnGlu: 1.801 ± 0.02	1.228AsnPhe: 1.228 ± 0.02	2.84AsnGly: 2.84 ± 0.036	0.805AsnHis: 0.805 ± 0.014	1.8AsnIle: 1.8 ± 0.023	1.507AsnLys: 1.507 ± 0.02	3.027AsnLeu: 3.027 ± 0.028	0.805AsnMet: 0.805 ± 0.014	1.392AsnAsn: 1.392 ± 0.023	2.259AsnPro: 2.259 ± 0.023	1.231AsnGln: 1.231 ± 0.018	1.899AsnArg: 1.899 ± 0.022	2.481AsnSer: 2.481 ± 0.023	1.84AsnThr: 1.84 ± 0.021	2.178AsnVal: 2.178 ± 0.022	0.528AsnTrp: 0.528 ± 0.011	0.958AsnTyr: 0.958 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	5.569ProAla: 5.569 ± 0.043	0.682ProCys: 0.682 ± 0.016	3.239ProAsp: 3.239 ± 0.027	3.774ProGlu: 3.774 ± 0.03	2.113ProPhe: 2.113 ± 0.025	3.989ProGly: 3.989 ± 0.033	1.362ProHis: 1.362 ± 0.019	2.353ProIle: 2.353 ± 0.024	2.614ProLys: 2.614 ± 0.027	5.014ProLeu: 5.014 ± 0.038	1.144ProMet: 1.144 ± 0.02	2.019ProAsn: 2.019 ± 0.022	5.524ProPro: 5.524 ± 0.07	2.504ProGln: 2.504 ± 0.035	3.728ProArg: 3.728 ± 0.032	6.179ProSer: 6.179 ± 0.052	3.684ProThr: 3.684 ± 0.032	3.631ProVal: 3.631 ± 0.034	0.787ProTrp: 0.787 ± 0.013	1.495ProTyr: 1.495 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.711GlnAla: 3.711 ± 0.037	0.46GlnCys: 0.46 ± 0.012	2.07GlnAsp: 2.07 ± 0.022	2.332GlnGlu: 2.332 ± 0.027	1.276GlnPhe: 1.276 ± 0.017	2.486GlnGly: 2.486 ± 0.025	1.106GlnHis: 1.106 ± 0.018	1.731GlnIle: 1.731 ± 0.021	1.915GlnLys: 1.915 ± 0.022	3.623GlnLeu: 3.623 ± 0.03	0.904GlnMet: 0.904 ± 0.016	1.316GlnAsn: 1.316 ± 0.02	2.71GlnPro: 2.71 ± 0.038	2.789GlnGln: 2.789 ± 0.065	2.844GlnArg: 2.844 ± 0.031	3.028GlnSer: 3.028 ± 0.028	2.278GlnThr: 2.278 ± 0.026	2.194GlnVal: 2.194 ± 0.025	0.568GlnTrp: 0.568 ± 0.011	1.094GlnTyr: 1.094 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.119ArgAla: 5.119 ± 0.039	0.893ArgCys: 0.893 ± 0.016	3.595ArgAsp: 3.595 ± 0.036	4.016ArgGlu: 4.016 ± 0.044	2.225ArgPhe: 2.225 ± 0.021	4.063ArgGly: 4.063 ± 0.037	1.754ArgHis: 1.754 ± 0.022	2.984ArgIle: 2.984 ± 0.028	3.383ArgLys: 3.383 ± 0.035	5.966ArgLeu: 5.966 ± 0.047	1.393ArgMet: 1.393 ± 0.017	2.199ArgAsn: 2.199 ± 0.026	3.88ArgPro: 3.88 ± 0.038	2.805ArgGln: 2.805 ± 0.027	5.762ArgArg: 5.762 ± 0.06	4.932ArgSer: 4.932 ± 0.042	3.285ArgThr: 3.285 ± 0.029	3.459ArgVal: 3.459 ± 0.029	0.993ArgTrp: 0.993 ± 0.014	1.689ArgTyr: 1.689 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.934SerAla: 6.934 ± 0.046	1.036SerCys: 1.036 ± 0.016	4.149SerAsp: 4.149 ± 0.037	3.925SerGlu: 3.925 ± 0.036	3.039SerPhe: 3.039 ± 0.027	5.542SerGly: 5.542 ± 0.042	2.047SerHis: 2.047 ± 0.024	3.811SerIle: 3.811 ± 0.034	3.616SerLys: 3.616 ± 0.034	7.382SerLeu: 7.382 ± 0.044	1.738SerMet: 1.738 ± 0.021	2.709SerAsn: 2.709 ± 0.025	5.591SerPro: 5.591 ± 0.055	3.282SerGln: 3.282 ± 0.032	5.45SerArg: 5.45 ± 0.046	9.26SerSer: 9.26 ± 0.086	5.186SerThr: 5.186 ± 0.042	4.534SerVal: 4.534 ± 0.036	1.185SerTrp: 1.185 ± 0.019	1.974SerTyr: 1.974 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.288ThrAla: 5.288 ± 0.034	0.799ThrCys: 0.799 ± 0.016	2.662ThrAsp: 2.662 ± 0.021	2.879ThrGlu: 2.879 ± 0.024	2.086ThrPhe: 2.086 ± 0.022	3.952ThrGly: 3.952 ± 0.034	1.239ThrHis: 1.239 ± 0.017	2.848ThrIle: 2.848 ± 0.029	2.49ThrLys: 2.49 ± 0.028	5.002ThrLeu: 5.002 ± 0.038	1.186ThrMet: 1.186 ± 0.017	1.868ThrAsn: 1.868 ± 0.021	4.106ThrPro: 4.106 ± 0.039	1.972ThrGln: 1.972 ± 0.021	3.219ThrArg: 3.219 ± 0.027	4.985ThrSer: 4.985 ± 0.04	4.085ThrThr: 4.085 ± 0.045	3.549ThrVal: 3.549 ± 0.036	0.822ThrTrp: 0.822 ± 0.014	1.511ThrTyr: 1.511 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.585ValAla: 5.585 ± 0.038	0.949ValCys: 0.949 ± 0.018	3.726ValAsp: 3.726 ± 0.029	3.774ValGlu: 3.774 ± 0.03	2.436ValPhe: 2.436 ± 0.028	3.896ValGly: 3.896 ± 0.034	1.402ValHis: 1.402 ± 0.017	2.831ValIle: 2.831 ± 0.026	2.841ValLys: 2.841 ± 0.031	5.633ValLeu: 5.633 ± 0.044	1.34ValMet: 1.34 ± 0.017	2.105ValAsn: 2.105 ± 0.027	3.633ValPro: 3.633 ± 0.034	2.306ValGln: 2.306 ± 0.024	3.576ValArg: 3.576 ± 0.03	4.6ValSer: 4.6 ± 0.035	3.454ValThr: 3.454 ± 0.03	4.385ValVal: 4.385 ± 0.041	0.87ValTrp: 0.87 ± 0.015	1.643ValTyr: 1.643 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.204TrpAla: 1.204 ± 0.021	0.213TrpCys: 0.213 ± 0.006	0.915TrpAsp: 0.915 ± 0.018	0.854TrpGlu: 0.854 ± 0.016	0.544TrpPhe: 0.544 ± 0.01	0.93TrpGly: 0.93 ± 0.015	0.379TrpHis: 0.379 ± 0.011	0.731TrpIle: 0.731 ± 0.013	0.778TrpLys: 0.778 ± 0.014	1.396TrpLeu: 1.396 ± 0.019	0.389TrpMet: 0.389 ± 0.009	0.601TrpAsn: 0.601 ± 0.012	0.661TrpPro: 0.661 ± 0.012	0.588TrpGln: 0.588 ± 0.011	1.031TrpArg: 1.031 ± 0.016	1.053TrpSer: 1.053 ± 0.015	0.922TrpThr: 0.922 ± 0.015	0.868TrpVal: 0.868 ± 0.015	0.299TrpTrp: 0.299 ± 0.008	0.406TrpTyr: 0.406 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.113TyrAla: 2.113 ± 0.02	0.428TyrCys: 0.428 ± 0.01	1.614TyrAsp: 1.614 ± 0.023	1.478TyrGlu: 1.478 ± 0.019	1.13TyrPhe: 1.13 ± 0.017	1.988TyrGly: 1.988 ± 0.028	0.733TyrHis: 0.733 ± 0.013	1.307TyrIle: 1.307 ± 0.018	1.062TyrLys: 1.062 ± 0.015	2.557TyrLeu: 2.557 ± 0.026	0.61TyrMet: 0.61 ± 0.013	1.013TyrAsn: 1.013 ± 0.014	1.423TyrPro: 1.423 ± 0.02	1.033TyrGln: 1.033 ± 0.018	1.649TyrArg: 1.649 ± 0.016	1.934TyrSer: 1.934 ± 0.022	1.453TyrThr: 1.453 ± 0.018	1.565TyrVal: 1.565 ± 0.018	0.422TyrTrp: 0.422 ± 0.011	0.887TyrTyr: 0.887 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.152XaaXaa: 0.152 ± 0.072

Statistics based on 10930 proteins (4672678 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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