Amino acid dipepetide frequency for Glycomyces buryatensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.277AlaAla: 20.277 ± 0.203
1.012AlaCys: 1.012 ± 0.026
8.528AlaAsp: 8.528 ± 0.083
9.524AlaGlu: 9.524 ± 0.101
3.741AlaPhe: 3.741 ± 0.06
11.331AlaGly: 11.331 ± 0.091
2.274AlaHis: 2.274 ± 0.038
5.403AlaIle: 5.403 ± 0.062
3.149AlaLys: 3.149 ± 0.056
12.6AlaLeu: 12.6 ± 0.107
2.733AlaMet: 2.733 ± 0.039
2.561AlaAsn: 2.561 ± 0.04
5.7AlaPro: 5.7 ± 0.069
3.413AlaGln: 3.413 ± 0.05
7.875AlaArg: 7.875 ± 0.079
6.549AlaSer: 6.549 ± 0.072
6.787AlaThr: 6.787 ± 0.074
10.694AlaVal: 10.694 ± 0.105
1.989AlaTrp: 1.989 ± 0.038
2.56AlaTyr: 2.56 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.023
0.1CysCys: 0.1 ± 0.009
0.57CysAsp: 0.57 ± 0.02
0.536CysGlu: 0.536 ± 0.021
0.224CysPhe: 0.224 ± 0.012
0.941CysGly: 0.941 ± 0.029
0.183CysHis: 0.183 ± 0.011
0.245CysIle: 0.245 ± 0.012
0.12CysLys: 0.12 ± 0.009
0.707CysLeu: 0.707 ± 0.021
0.134CysMet: 0.134 ± 0.009
0.197CysAsn: 0.197 ± 0.012
0.423CysPro: 0.423 ± 0.017
0.177CysGln: 0.177 ± 0.011
0.54CysArg: 0.54 ± 0.019
0.474CysSer: 0.474 ± 0.017
0.418CysThr: 0.418 ± 0.015
0.592CysVal: 0.592 ± 0.019
0.113CysTrp: 0.113 ± 0.009
0.178CysTyr: 0.178 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.734AspAla: 7.734 ± 0.073
0.519AspCys: 0.519 ± 0.02
4.169AspAsp: 4.169 ± 0.059
4.633AspGlu: 4.633 ± 0.064
2.157AspPhe: 2.157 ± 0.038
6.236AspGly: 6.236 ± 0.073
1.399AspHis: 1.399 ± 0.032
2.436AspIle: 2.436 ± 0.041
1.244AspLys: 1.244 ± 0.029
6.87AspLeu: 6.87 ± 0.068
1.085AspMet: 1.085 ± 0.028
1.292AspAsn: 1.292 ± 0.03
4.489AspPro: 4.489 ± 0.054
1.953AspGln: 1.953 ± 0.033
4.692AspArg: 4.692 ± 0.063
3.187AspSer: 3.187 ± 0.052
3.221AspThr: 3.221 ± 0.047
4.448AspVal: 4.448 ± 0.056
1.243AspTrp: 1.243 ± 0.028
1.634AspTyr: 1.634 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
8.67GluAla: 8.67 ± 0.086
0.448GluCys: 0.448 ± 0.017
3.569GluAsp: 3.569 ± 0.054
3.854GluGlu: 3.854 ± 0.066
2.099GluPhe: 2.099 ± 0.037
4.777GluGly: 4.777 ± 0.059
1.69GluHis: 1.69 ± 0.034
2.928GluIle: 2.928 ± 0.046
1.396GluLys: 1.396 ± 0.033
6.888GluLeu: 6.888 ± 0.065
1.137GluMet: 1.137 ± 0.026
1.441GluAsn: 1.441 ± 0.032
3.839GluPro: 3.839 ± 0.061
2.371GluGln: 2.371 ± 0.044
5.253GluArg: 5.253 ± 0.067
3.725GluSer: 3.725 ± 0.056
3.809GluThr: 3.809 ± 0.054
4.934GluVal: 4.934 ± 0.063
1.06GluTrp: 1.06 ± 0.028
1.567GluTyr: 1.567 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.092PheAla: 4.092 ± 0.064
0.274PheCys: 0.274 ± 0.011
2.555PheAsp: 2.555 ± 0.038
2.045PheGlu: 2.045 ± 0.04
0.952PhePhe: 0.952 ± 0.026
3.305PheGly: 3.305 ± 0.046
0.617PheHis: 0.617 ± 0.021
1.22PheIle: 1.22 ± 0.03
0.725PheLys: 0.725 ± 0.023
2.64PheLeu: 2.64 ± 0.052
0.545PheMet: 0.545 ± 0.016
0.864PheAsn: 0.864 ± 0.024
1.355PhePro: 1.355 ± 0.029
0.805PheGln: 0.805 ± 0.022
1.718PheArg: 1.718 ± 0.036
1.728PheSer: 1.728 ± 0.037
2.184PheThr: 2.184 ± 0.037
2.188PheVal: 2.188 ± 0.037
0.508PheTrp: 0.508 ± 0.019
0.712PheTyr: 0.712 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
9.773GlyAla: 9.773 ± 0.093
0.751GlyCys: 0.751 ± 0.023
5.637GlyAsp: 5.637 ± 0.068
5.823GlyGlu: 5.823 ± 0.066
3.07GlyPhe: 3.07 ± 0.047
7.86GlyGly: 7.86 ± 0.093
1.993GlyHis: 1.993 ± 0.037
4.105GlyIle: 4.105 ± 0.057
2.445GlyLys: 2.445 ± 0.043
8.787GlyLeu: 8.787 ± 0.086
1.97GlyMet: 1.97 ± 0.03
2.125GlyAsn: 2.125 ± 0.043
4.378GlyPro: 4.378 ± 0.054
2.643GlyGln: 2.643 ± 0.039
6.373GlyArg: 6.373 ± 0.065
5.268GlySer: 5.268 ± 0.055
5.635GlyThr: 5.635 ± 0.062
6.626GlyVal: 6.626 ± 0.062
1.7GlyTrp: 1.7 ± 0.035
2.292GlyTyr: 2.292 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.194HisAla: 2.194 ± 0.042
0.202HisCys: 0.202 ± 0.013
1.269HisAsp: 1.269 ± 0.029
1.124HisGlu: 1.124 ± 0.028
0.694HisPhe: 0.694 ± 0.02
1.96HisGly: 1.96 ± 0.039
0.639HisHis: 0.639 ± 0.021
0.757HisIle: 0.757 ± 0.023
0.373HisLys: 0.373 ± 0.013
2.392HisLeu: 2.392 ± 0.039
0.329HisMet: 0.329 ± 0.013
0.449HisAsn: 0.449 ± 0.016
1.496HisPro: 1.496 ± 0.025
0.685HisGln: 0.685 ± 0.021
1.936HisArg: 1.936 ± 0.039
1.072HisSer: 1.072 ± 0.025
1.102HisThr: 1.102 ± 0.026
1.482HisVal: 1.482 ± 0.031
0.389HisTrp: 0.389 ± 0.015
0.565HisTyr: 0.565 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
6.468IleAla: 6.468 ± 0.077
0.336IleCys: 0.336 ± 0.012
3.501IleAsp: 3.501 ± 0.048
3.169IleGlu: 3.169 ± 0.046
1.042IlePhe: 1.042 ± 0.029
4.497IleGly: 4.497 ± 0.054
0.762IleHis: 0.762 ± 0.021
1.578IleIle: 1.578 ± 0.042
0.905IleLys: 0.905 ± 0.029
3.365IleLeu: 3.365 ± 0.052
0.684IleMet: 0.684 ± 0.021
0.97IleAsn: 0.97 ± 0.025
2.227IlePro: 2.227 ± 0.039
0.913IleGln: 0.913 ± 0.024
2.633IleArg: 2.633 ± 0.041
2.078IleSer: 2.078 ± 0.038
2.559IleThr: 2.559 ± 0.039
3.551IleVal: 3.551 ± 0.046
0.604IleTrp: 0.604 ± 0.018
0.751IleTyr: 0.751 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.986LysAla: 2.986 ± 0.052
0.132LysCys: 0.132 ± 0.009
1.211LysAsp: 1.211 ± 0.028
1.198LysGlu: 1.198 ± 0.029
0.61LysPhe: 0.61 ± 0.019
1.697LysGly: 1.697 ± 0.035
0.53LysHis: 0.53 ± 0.02
1.029LysIle: 1.029 ± 0.03
0.683LysLys: 0.683 ± 0.033
2.321LysLeu: 2.321 ± 0.042
0.463LysMet: 0.463 ± 0.016
0.512LysAsn: 0.512 ± 0.018
1.407LysPro: 1.407 ± 0.032
0.792LysGln: 0.792 ± 0.027
1.994LysArg: 1.994 ± 0.038
1.389LysSer: 1.389 ± 0.031
1.452LysThr: 1.452 ± 0.034
1.856LysVal: 1.856 ± 0.04
0.367LysTrp: 0.367 ± 0.014
0.481LysTyr: 0.481 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
14.152LeuAla: 14.152 ± 0.104
0.786LeuCys: 0.786 ± 0.023
6.662LeuAsp: 6.662 ± 0.073
5.57LeuGlu: 5.57 ± 0.062
2.697LeuPhe: 2.697 ± 0.049
8.503LeuGly: 8.503 ± 0.087
2.043LeuHis: 2.043 ± 0.037
4.18LeuIle: 4.18 ± 0.065
2.18LeuLys: 2.18 ± 0.042
9.499LeuLeu: 9.499 ± 0.107
1.719LeuMet: 1.719 ± 0.035
2.135LeuAsn: 2.135 ± 0.036
5.432LeuPro: 5.432 ± 0.06
2.378LeuGln: 2.378 ± 0.044
7.302LeuArg: 7.302 ± 0.08
5.267LeuSer: 5.267 ± 0.059
6.062LeuThr: 6.062 ± 0.067
7.762LeuVal: 7.762 ± 0.079
1.356LeuTrp: 1.356 ± 0.033
1.884LeuTyr: 1.884 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.321MetAla: 2.321 ± 0.039
0.134MetCys: 0.134 ± 0.01
0.931MetAsp: 0.931 ± 0.023
0.951MetGlu: 0.951 ± 0.029
0.629MetPhe: 0.629 ± 0.022
1.434MetGly: 1.434 ± 0.032
0.367MetHis: 0.367 ± 0.015
0.908MetIle: 0.908 ± 0.026
0.505MetLys: 0.505 ± 0.017
1.968MetLeu: 1.968 ± 0.03
0.406MetMet: 0.406 ± 0.016
0.6MetAsn: 0.6 ± 0.016
1.145MetPro: 1.145 ± 0.025
0.551MetGln: 0.551 ± 0.018
1.567MetArg: 1.567 ± 0.029
1.522MetSer: 1.522 ± 0.027
1.53MetThr: 1.53 ± 0.031
1.408MetVal: 1.408 ± 0.029
0.316MetTrp: 0.316 ± 0.014
0.363MetTyr: 0.363 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.643AsnAla: 2.643 ± 0.041
0.196AsnCys: 0.196 ± 0.011
1.326AsnAsp: 1.326 ± 0.028
1.321AsnGlu: 1.321 ± 0.033
0.703AsnPhe: 0.703 ± 0.023
2.343AsnGly: 2.343 ± 0.043
0.522AsnHis: 0.522 ± 0.018
0.879AsnIle: 0.879 ± 0.022
0.413AsnLys: 0.413 ± 0.018
2.315AsnLeu: 2.315 ± 0.039
0.381AsnMet: 0.381 ± 0.016
0.551AsnAsn: 0.551 ± 0.022
1.772AsnPro: 1.772 ± 0.033
0.76AsnGln: 0.76 ± 0.025
1.569AsnArg: 1.569 ± 0.035
1.137AsnSer: 1.137 ± 0.029
1.291AsnThr: 1.291 ± 0.03
1.669AsnVal: 1.669 ± 0.038
0.434AsnTrp: 0.434 ± 0.017
0.564AsnTyr: 0.564 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.47ProAla: 6.47 ± 0.069
0.3ProCys: 0.3 ± 0.014
4.214ProAsp: 4.214 ± 0.057
4.64ProGlu: 4.64 ± 0.055
1.518ProPhe: 1.518 ± 0.028
5.473ProGly: 5.473 ± 0.065
1.114ProHis: 1.114 ± 0.026
2.07ProIle: 2.07 ± 0.035
1.292ProLys: 1.292 ± 0.028
4.472ProLeu: 4.472 ± 0.056
1.019ProMet: 1.019 ± 0.024
1.298ProAsn: 1.298 ± 0.03
2.922ProPro: 2.922 ± 0.058
1.689ProGln: 1.689 ± 0.036
3.162ProArg: 3.162 ± 0.047
3.025ProSer: 3.025 ± 0.047
3.243ProThr: 3.243 ± 0.051
4.596ProVal: 4.596 ± 0.056
0.899ProTrp: 0.899 ± 0.022
1.193ProTyr: 1.193 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.713GlnAla: 3.713 ± 0.05
0.194GlnCys: 0.194 ± 0.01
1.316GlnAsp: 1.316 ± 0.029
1.366GlnGlu: 1.366 ± 0.028
0.932GlnPhe: 0.932 ± 0.023
2.069GlnGly: 2.069 ± 0.034
0.602GlnHis: 0.602 ± 0.021
1.483GlnIle: 1.483 ± 0.029
0.563GlnLys: 0.563 ± 0.017
3.019GlnLeu: 3.019 ± 0.054
0.653GlnMet: 0.653 ± 0.02
0.621GlnAsn: 0.621 ± 0.02
1.587GlnPro: 1.587 ± 0.042
1.213GlnGln: 1.213 ± 0.04
2.415GlnArg: 2.415 ± 0.039
1.57GlnSer: 1.57 ± 0.032
1.675GlnThr: 1.675 ± 0.032
2.429GlnVal: 2.429 ± 0.039
0.65GlnTrp: 0.65 ± 0.021
0.74GlnTyr: 0.74 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.695ArgAla: 7.695 ± 0.083
0.543ArgCys: 0.543 ± 0.016
3.949ArgAsp: 3.949 ± 0.051
4.438ArgGlu: 4.438 ± 0.061
2.468ArgPhe: 2.468 ± 0.045
4.917ArgGly: 4.917 ± 0.062
1.878ArgHis: 1.878 ± 0.038
3.484ArgIle: 3.484 ± 0.054
1.848ArgLys: 1.848 ± 0.038
7.786ArgLeu: 7.786 ± 0.084
1.687ArgMet: 1.687 ± 0.026
1.497ArgAsn: 1.497 ± 0.035
3.911ArgPro: 3.911 ± 0.058
2.169ArgGln: 2.169 ± 0.04
6.563ArgArg: 6.563 ± 0.089
4.083ArgSer: 4.083 ± 0.052
4.034ArgThr: 4.034 ± 0.043
4.801ArgVal: 4.801 ± 0.059
1.27ArgTrp: 1.27 ± 0.031
1.813ArgTyr: 1.813 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.479SerAla: 6.479 ± 0.07
0.409SerCys: 0.409 ± 0.016
3.461SerAsp: 3.461 ± 0.053
3.639SerGlu: 3.639 ± 0.049
1.728SerPhe: 1.728 ± 0.031
6.138SerGly: 6.138 ± 0.069
1.063SerHis: 1.063 ± 0.023
2.305SerIle: 2.305 ± 0.037
1.333SerLys: 1.333 ± 0.03
4.953SerLeu: 4.953 ± 0.058
1.26SerMet: 1.26 ± 0.027
1.314SerAsn: 1.314 ± 0.03
3.029SerPro: 3.029 ± 0.044
1.598SerGln: 1.598 ± 0.038
3.557SerArg: 3.557 ± 0.042
3.119SerSer: 3.119 ± 0.053
3.216SerThr: 3.216 ± 0.041
4.133SerVal: 4.133 ± 0.047
1.038SerTrp: 1.038 ± 0.025
1.31SerTyr: 1.31 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
7.894ThrAla: 7.894 ± 0.091
0.452ThrCys: 0.452 ± 0.019
3.912ThrAsp: 3.912 ± 0.056
3.993ThrGlu: 3.993 ± 0.053
1.746ThrPhe: 1.746 ± 0.031
6.299ThrGly: 6.299 ± 0.059
0.981ThrHis: 0.981 ± 0.025
2.482ThrIle: 2.482 ± 0.04
1.192ThrLys: 1.192 ± 0.027
5.141ThrLeu: 5.141 ± 0.056
1.117ThrMet: 1.117 ± 0.025
1.176ThrAsn: 1.176 ± 0.028
3.223ThrPro: 3.223 ± 0.045
1.37ThrGln: 1.37 ± 0.032
3.351ThrArg: 3.351 ± 0.044
3.106ThrSer: 3.106 ± 0.047
3.481ThrThr: 3.481 ± 0.05
5.719ThrVal: 5.719 ± 0.052
1.088ThrTrp: 1.088 ± 0.028
1.331ThrTyr: 1.331 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
9.852ValAla: 9.852 ± 0.091
0.679ValCys: 0.679 ± 0.019
5.345ValAsp: 5.345 ± 0.061
5.261ValGlu: 5.261 ± 0.072
2.639ValPhe: 2.639 ± 0.042
6.086ValGly: 6.086 ± 0.069
1.631ValHis: 1.631 ± 0.031
3.53ValIle: 3.53 ± 0.048
1.841ValLys: 1.841 ± 0.038
7.773ValLeu: 7.773 ± 0.071
1.465ValMet: 1.465 ± 0.029
1.95ValAsn: 1.95 ± 0.04
4.257ValPro: 4.257 ± 0.053
1.94ValGln: 1.94 ± 0.036
5.082ValArg: 5.082 ± 0.066
4.43ValSer: 4.43 ± 0.052
4.788ValThr: 4.788 ± 0.054
6.629ValVal: 6.629 ± 0.083
1.199ValTrp: 1.199 ± 0.029
1.785ValTyr: 1.785 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.79TrpAla: 1.79 ± 0.033
0.174TrpCys: 0.174 ± 0.011
1.037TrpAsp: 1.037 ± 0.026
0.955TrpGlu: 0.955 ± 0.022
0.551TrpPhe: 0.551 ± 0.021
1.244TrpGly: 1.244 ± 0.031
0.401TrpHis: 0.401 ± 0.015
0.806TrpIle: 0.806 ± 0.026
0.46TrpLys: 0.46 ± 0.016
1.725TrpLeu: 1.725 ± 0.031
0.398TrpMet: 0.398 ± 0.015
0.623TrpAsn: 0.623 ± 0.02
0.823TrpPro: 0.823 ± 0.026
0.626TrpGln: 0.626 ± 0.018
1.332TrpArg: 1.332 ± 0.03
1.072TrpSer: 1.072 ± 0.032
1.22TrpThr: 1.22 ± 0.03
1.043TrpVal: 1.043 ± 0.027
0.412TrpTrp: 0.412 ± 0.017
0.373TrpTyr: 0.373 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.534TyrAla: 2.534 ± 0.04
0.193TyrCys: 0.193 ± 0.011
1.478TyrAsp: 1.478 ± 0.034
1.415TyrGlu: 1.415 ± 0.033
0.834TyrPhe: 0.834 ± 0.022
2.145TyrGly: 2.145 ± 0.037
0.418TyrHis: 0.418 ± 0.015
0.763TyrIle: 0.763 ± 0.023
0.445TyrLys: 0.445 ± 0.017
2.345TyrLeu: 2.345 ± 0.036
0.371TyrMet: 0.371 ± 0.015
0.612TyrAsn: 0.612 ± 0.024
1.191TyrPro: 1.191 ± 0.03
0.766TyrGln: 0.766 ± 0.021
1.922TyrArg: 1.922 ± 0.034
1.281TyrSer: 1.281 ± 0.025
1.346TyrThr: 1.346 ± 0.029
1.606TyrVal: 1.606 ± 0.031
0.43TyrTrp: 0.43 ± 0.016
0.647TyrTyr: 0.647 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5187 proteins (1676623 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski