Amino acid dipepetide frequency for Synechococcus virus P60

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.309AlaAla: 11.309 ± 1.431
0.827AlaCys: 0.827 ± 0.285
5.861AlaAsp: 5.861 ± 0.924
7.723AlaGlu: 7.723 ± 1.191
2.896AlaPhe: 2.896 ± 0.425
7.792AlaGly: 7.792 ± 0.635
0.896AlaHis: 0.896 ± 0.276
4.827AlaIle: 4.827 ± 0.538
5.034AlaLys: 5.034 ± 0.672
8.826AlaLeu: 8.826 ± 0.899
2.345AlaMet: 2.345 ± 0.411
4.137AlaAsn: 4.137 ± 0.799
4.62AlaPro: 4.62 ± 0.724
5.448AlaGln: 5.448 ± 0.707
5.654AlaArg: 5.654 ± 0.805
5.723AlaSer: 5.723 ± 0.551
5.448AlaThr: 5.448 ± 0.84
4.413AlaVal: 4.413 ± 0.675
1.172AlaTrp: 1.172 ± 0.369
2.758AlaTyr: 2.758 ± 0.426
0.0AlaXaa: 0.0 ± 0.0
Cys
0.483CysAla: 0.483 ± 0.254
0.069CysCys: 0.069 ± 0.089
0.621CysAsp: 0.621 ± 0.31
0.483CysGlu: 0.483 ± 0.195
0.414CysPhe: 0.414 ± 0.193
0.621CysGly: 0.621 ± 0.226
0.138CysHis: 0.138 ± 0.124
0.621CysIle: 0.621 ± 0.269
0.276CysLys: 0.276 ± 0.205
0.965CysLeu: 0.965 ± 0.321
0.207CysMet: 0.207 ± 0.127
0.345CysAsn: 0.345 ± 0.174
0.414CysPro: 0.414 ± 0.202
0.276CysGln: 0.276 ± 0.148
0.759CysArg: 0.759 ± 0.23
0.069CysSer: 0.069 ± 0.076
0.552CysThr: 0.552 ± 0.2
0.414CysVal: 0.414 ± 0.157
0.069CysTrp: 0.069 ± 0.067
0.276CysTyr: 0.276 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
7.309AspAla: 7.309 ± 0.814
0.345AspCys: 0.345 ± 0.18
3.655AspAsp: 3.655 ± 0.415
5.034AspGlu: 5.034 ± 0.388
2.827AspPhe: 2.827 ± 0.518
6.896AspGly: 6.896 ± 1.345
0.621AspHis: 0.621 ± 0.271
2.62AspIle: 2.62 ± 0.483
2.551AspLys: 2.551 ± 0.377
5.654AspLeu: 5.654 ± 0.642
1.586AspMet: 1.586 ± 0.242
2.413AspAsn: 2.413 ± 0.459
3.724AspPro: 3.724 ± 0.527
2.413AspGln: 2.413 ± 0.398
3.034AspArg: 3.034 ± 0.459
3.379AspSer: 3.379 ± 0.592
3.655AspThr: 3.655 ± 0.755
4.413AspVal: 4.413 ± 0.507
1.034AspTrp: 1.034 ± 0.276
2.758AspTyr: 2.758 ± 0.507
0.0AspXaa: 0.0 ± 0.0
Glu
6.965GluAla: 6.965 ± 1.105
0.414GluCys: 0.414 ± 0.208
3.655GluAsp: 3.655 ± 0.465
4.62GluGlu: 4.62 ± 0.869
2.758GluPhe: 2.758 ± 0.541
4.62GluGly: 4.62 ± 0.569
0.896GluHis: 0.896 ± 0.314
3.93GluIle: 3.93 ± 0.645
2.551GluLys: 2.551 ± 0.571
6.62GluLeu: 6.62 ± 0.799
1.379GluMet: 1.379 ± 0.29
2.207GluAsn: 2.207 ± 0.45
1.793GluPro: 1.793 ± 0.38
3.241GluGln: 3.241 ± 0.524
3.586GluArg: 3.586 ± 0.528
3.31GluSer: 3.31 ± 0.415
4.206GluThr: 4.206 ± 0.485
3.93GluVal: 3.93 ± 0.499
0.965GluTrp: 0.965 ± 0.254
2.069GluTyr: 2.069 ± 0.466
0.0GluXaa: 0.0 ± 0.0
Phe
1.724PheAla: 1.724 ± 0.382
0.483PheCys: 0.483 ± 0.231
3.379PheAsp: 3.379 ± 0.49
2.207PheGlu: 2.207 ± 0.396
1.241PhePhe: 1.241 ± 0.332
1.517PheGly: 1.517 ± 0.377
0.965PheHis: 0.965 ± 0.291
1.448PheIle: 1.448 ± 0.315
1.862PheLys: 1.862 ± 0.332
2.413PheLeu: 2.413 ± 0.421
1.586PheMet: 1.586 ± 0.38
2.413PheAsn: 2.413 ± 0.334
1.379PhePro: 1.379 ± 0.279
1.448PheGln: 1.448 ± 0.308
2.689PheArg: 2.689 ± 0.406
2.276PheSer: 2.276 ± 0.434
2.758PheThr: 2.758 ± 0.445
2.758PheVal: 2.758 ± 0.405
0.345PheTrp: 0.345 ± 0.186
0.827PheTyr: 0.827 ± 0.241
0.0PheXaa: 0.0 ± 0.0
Gly
7.999GlyAla: 7.999 ± 1.41
0.483GlyCys: 0.483 ± 0.22
5.585GlyAsp: 5.585 ± 1.078
3.241GlyGlu: 3.241 ± 0.509
3.103GlyPhe: 3.103 ± 0.531
4.758GlyGly: 4.758 ± 0.616
1.034GlyHis: 1.034 ± 0.378
3.517GlyIle: 3.517 ± 0.532
4.275GlyLys: 4.275 ± 0.763
6.827GlyLeu: 6.827 ± 0.849
1.172GlyMet: 1.172 ± 0.245
3.999GlyAsn: 3.999 ± 0.616
4.689GlyPro: 4.689 ± 1.864
3.793GlyGln: 3.793 ± 0.605
4.137GlyArg: 4.137 ± 0.609
5.585GlySer: 5.585 ± 0.913
5.172GlyThr: 5.172 ± 0.7
4.896GlyVal: 4.896 ± 0.535
1.448GlyTrp: 1.448 ± 0.373
3.448GlyTyr: 3.448 ± 0.482
0.0GlyXaa: 0.0 ± 0.0
His
0.552HisAla: 0.552 ± 0.188
0.276HisCys: 0.276 ± 0.146
0.827HisAsp: 0.827 ± 0.298
1.448HisGlu: 1.448 ± 0.41
0.414HisPhe: 0.414 ± 0.154
0.896HisGly: 0.896 ± 0.225
0.621HisHis: 0.621 ± 0.38
0.552HisIle: 0.552 ± 0.228
1.103HisLys: 1.103 ± 0.292
1.448HisLeu: 1.448 ± 0.392
0.276HisMet: 0.276 ± 0.206
0.621HisAsn: 0.621 ± 0.19
0.827HisPro: 0.827 ± 0.232
0.965HisGln: 0.965 ± 0.316
1.379HisArg: 1.379 ± 0.34
0.965HisSer: 0.965 ± 0.293
0.69HisThr: 0.69 ± 0.262
1.034HisVal: 1.034 ± 0.26
0.276HisTrp: 0.276 ± 0.143
0.69HisTyr: 0.69 ± 0.26
0.0HisXaa: 0.0 ± 0.0
Ile
4.344IleAla: 4.344 ± 0.515
0.276IleCys: 0.276 ± 0.161
3.999IleAsp: 3.999 ± 0.573
3.034IleGlu: 3.034 ± 0.427
1.241IlePhe: 1.241 ± 0.321
2.965IleGly: 2.965 ± 0.49
0.827IleHis: 0.827 ± 0.341
1.724IleIle: 1.724 ± 0.304
2.413IleLys: 2.413 ± 0.425
3.724IleLeu: 3.724 ± 0.496
1.241IleMet: 1.241 ± 0.323
2.207IleAsn: 2.207 ± 0.394
2.482IlePro: 2.482 ± 0.408
2.413IleGln: 2.413 ± 0.356
3.241IleArg: 3.241 ± 0.601
3.448IleSer: 3.448 ± 0.543
2.62IleThr: 2.62 ± 0.429
2.896IleVal: 2.896 ± 0.621
0.345IleTrp: 0.345 ± 0.159
2.069IleTyr: 2.069 ± 0.396
0.0IleXaa: 0.0 ± 0.0
Lys
4.827LysAla: 4.827 ± 0.62
0.483LysCys: 0.483 ± 0.192
2.827LysAsp: 2.827 ± 0.487
2.965LysGlu: 2.965 ± 0.52
2.069LysPhe: 2.069 ± 0.375
4.275LysGly: 4.275 ± 0.535
1.172LysHis: 1.172 ± 0.279
1.517LysIle: 1.517 ± 0.331
2.276LysLys: 2.276 ± 0.518
5.034LysLeu: 5.034 ± 0.729
1.034LysMet: 1.034 ± 0.226
2.207LysAsn: 2.207 ± 0.424
3.241LysPro: 3.241 ± 0.523
2.413LysGln: 2.413 ± 0.504
2.482LysArg: 2.482 ± 0.482
2.896LysSer: 2.896 ± 0.527
2.276LysThr: 2.276 ± 0.286
3.31LysVal: 3.31 ± 0.443
0.552LysTrp: 0.552 ± 0.193
2.069LysTyr: 2.069 ± 0.523
0.0LysXaa: 0.0 ± 0.0
Leu
7.654LeuAla: 7.654 ± 0.774
0.621LeuCys: 0.621 ± 0.23
5.723LeuAsp: 5.723 ± 0.598
5.241LeuGlu: 5.241 ± 0.963
2.758LeuPhe: 2.758 ± 0.389
5.585LeuGly: 5.585 ± 0.702
1.724LeuHis: 1.724 ± 0.399
4.275LeuIle: 4.275 ± 0.54
4.827LeuLys: 4.827 ± 0.47
5.516LeuLeu: 5.516 ± 0.715
1.931LeuMet: 1.931 ± 0.378
3.862LeuAsn: 3.862 ± 0.69
3.31LeuPro: 3.31 ± 0.528
4.206LeuGln: 4.206 ± 0.564
5.034LeuArg: 5.034 ± 0.715
5.861LeuSer: 5.861 ± 0.64
5.792LeuThr: 5.792 ± 0.755
5.034LeuVal: 5.034 ± 0.822
1.103LeuTrp: 1.103 ± 0.292
1.793LeuTyr: 1.793 ± 0.422
0.0LeuXaa: 0.0 ± 0.0
Met
3.103MetAla: 3.103 ± 0.484
0.276MetCys: 0.276 ± 0.203
1.517MetAsp: 1.517 ± 0.304
0.965MetGlu: 0.965 ± 0.284
0.552MetPhe: 0.552 ± 0.288
1.655MetGly: 1.655 ± 0.304
0.069MetHis: 0.069 ± 0.054
1.448MetIle: 1.448 ± 0.415
1.793MetLys: 1.793 ± 0.522
1.31MetLeu: 1.31 ± 0.337
0.759MetMet: 0.759 ± 0.181
1.31MetAsn: 1.31 ± 0.373
0.621MetPro: 0.621 ± 0.217
1.241MetGln: 1.241 ± 0.218
1.103MetArg: 1.103 ± 0.234
1.31MetSer: 1.31 ± 0.337
1.793MetThr: 1.793 ± 0.36
1.448MetVal: 1.448 ± 0.318
0.069MetTrp: 0.069 ± 0.081
0.69MetTyr: 0.69 ± 0.24
0.0MetXaa: 0.0 ± 0.0
Asn
4.068AsnAla: 4.068 ± 0.741
0.207AsnCys: 0.207 ± 0.114
3.034AsnAsp: 3.034 ± 0.614
2.138AsnGlu: 2.138 ± 0.364
1.379AsnPhe: 1.379 ± 0.359
3.379AsnGly: 3.379 ± 0.537
0.896AsnHis: 0.896 ± 0.333
2.276AsnIle: 2.276 ± 0.428
1.31AsnLys: 1.31 ± 0.268
3.586AsnLeu: 3.586 ± 0.449
0.896AsnMet: 0.896 ± 0.223
2.482AsnAsn: 2.482 ± 0.437
3.172AsnPro: 3.172 ± 0.462
2.138AsnGln: 2.138 ± 0.471
2.413AsnArg: 2.413 ± 0.406
3.379AsnSer: 3.379 ± 0.489
3.31AsnThr: 3.31 ± 0.448
2.62AsnVal: 2.62 ± 0.42
1.103AsnTrp: 1.103 ± 0.371
1.655AsnTyr: 1.655 ± 0.415
0.0AsnXaa: 0.0 ± 0.0
Pro
3.999ProAla: 3.999 ± 0.649
0.345ProCys: 0.345 ± 0.191
2.827ProAsp: 2.827 ± 0.491
3.999ProGlu: 3.999 ± 0.619
1.379ProPhe: 1.379 ± 0.221
3.448ProGly: 3.448 ± 0.89
0.965ProHis: 0.965 ± 0.242
2.276ProIle: 2.276 ± 0.458
2.896ProLys: 2.896 ± 0.608
3.034ProLeu: 3.034 ± 0.472
0.896ProMet: 0.896 ± 0.29
2.345ProAsn: 2.345 ± 0.345
1.586ProPro: 1.586 ± 0.728
2.482ProGln: 2.482 ± 1.226
1.655ProArg: 1.655 ± 0.299
3.586ProSer: 3.586 ± 0.559
3.586ProThr: 3.586 ± 0.406
2.551ProVal: 2.551 ± 0.401
0.759ProTrp: 0.759 ± 0.256
1.103ProTyr: 1.103 ± 0.34
0.0ProXaa: 0.0 ± 0.0
Gln
5.93GlnAla: 5.93 ± 0.873
0.276GlnCys: 0.276 ± 0.157
2.896GlnAsp: 2.896 ± 0.466
3.448GlnGlu: 3.448 ± 0.71
1.586GlnPhe: 1.586 ± 0.355
5.172GlnGly: 5.172 ± 1.959
0.69GlnHis: 0.69 ± 0.235
2.138GlnIle: 2.138 ± 0.41
2.207GlnLys: 2.207 ± 0.461
3.93GlnLeu: 3.93 ± 0.64
1.241GlnMet: 1.241 ± 0.301
1.172GlnAsn: 1.172 ± 0.22
1.517GlnPro: 1.517 ± 0.308
4.206GlnGln: 4.206 ± 0.939
2.827GlnArg: 2.827 ± 0.615
2.413GlnSer: 2.413 ± 0.34
2.62GlnThr: 2.62 ± 0.505
2.62GlnVal: 2.62 ± 0.437
0.896GlnTrp: 0.896 ± 0.248
1.862GlnTyr: 1.862 ± 0.424
0.0GlnXaa: 0.0 ± 0.0
Arg
5.172ArgAla: 5.172 ± 0.596
0.552ArgCys: 0.552 ± 0.292
3.034ArgAsp: 3.034 ± 0.39
3.172ArgGlu: 3.172 ± 0.63
1.724ArgPhe: 1.724 ± 0.32
3.655ArgGly: 3.655 ± 0.595
0.896ArgHis: 0.896 ± 0.344
2.62ArgIle: 2.62 ± 0.351
3.379ArgLys: 3.379 ± 0.588
5.31ArgLeu: 5.31 ± 0.68
1.379ArgMet: 1.379 ± 0.303
3.103ArgAsn: 3.103 ± 0.598
2.138ArgPro: 2.138 ± 0.413
2.276ArgGln: 2.276 ± 0.462
3.034ArgArg: 3.034 ± 0.473
3.379ArgSer: 3.379 ± 0.389
3.103ArgThr: 3.103 ± 0.565
3.586ArgVal: 3.586 ± 0.597
0.69ArgTrp: 0.69 ± 0.214
2.413ArgTyr: 2.413 ± 0.415
0.0ArgXaa: 0.0 ± 0.0
Ser
6.275SerAla: 6.275 ± 0.708
0.345SerCys: 0.345 ± 0.209
4.413SerAsp: 4.413 ± 0.686
2.482SerGlu: 2.482 ± 0.415
2.689SerPhe: 2.689 ± 0.395
6.413SerGly: 6.413 ± 0.866
0.896SerHis: 0.896 ± 0.301
3.379SerIle: 3.379 ± 0.483
3.172SerLys: 3.172 ± 0.595
4.827SerLeu: 4.827 ± 0.572
1.034SerMet: 1.034 ± 0.307
3.103SerAsn: 3.103 ± 0.493
2.276SerPro: 2.276 ± 0.344
2.069SerGln: 2.069 ± 0.312
3.517SerArg: 3.517 ± 0.563
3.379SerSer: 3.379 ± 0.524
4.689SerThr: 4.689 ± 0.749
4.551SerVal: 4.551 ± 0.543
1.103SerTrp: 1.103 ± 0.337
1.517SerTyr: 1.517 ± 0.282
0.0SerXaa: 0.0 ± 0.0
Thr
5.654ThrAla: 5.654 ± 1.076
0.138ThrCys: 0.138 ± 0.105
4.206ThrAsp: 4.206 ± 0.484
4.206ThrGlu: 4.206 ± 0.504
2.62ThrPhe: 2.62 ± 0.566
7.516ThrGly: 7.516 ± 1.142
0.827ThrHis: 0.827 ± 0.209
2.689ThrIle: 2.689 ± 0.601
2.551ThrLys: 2.551 ± 0.446
4.965ThrLeu: 4.965 ± 0.541
0.965ThrMet: 0.965 ± 0.34
2.758ThrAsn: 2.758 ± 0.617
3.724ThrPro: 3.724 ± 0.487
2.965ThrGln: 2.965 ± 0.465
2.138ThrArg: 2.138 ± 0.353
3.655ThrSer: 3.655 ± 0.57
5.034ThrThr: 5.034 ± 1.004
4.068ThrVal: 4.068 ± 0.753
0.896ThrTrp: 0.896 ± 0.372
2.62ThrTyr: 2.62 ± 0.484
0.0ThrXaa: 0.0 ± 0.0
Val
6.344ValAla: 6.344 ± 0.871
0.759ValCys: 0.759 ± 0.28
4.206ValAsp: 4.206 ± 0.677
4.551ValGlu: 4.551 ± 0.668
2.827ValPhe: 2.827 ± 0.466
4.482ValGly: 4.482 ± 0.538
0.965ValHis: 0.965 ± 0.231
2.551ValIle: 2.551 ± 0.425
3.31ValLys: 3.31 ± 0.594
3.793ValLeu: 3.793 ± 0.522
1.724ValMet: 1.724 ± 0.349
2.276ValAsn: 2.276 ± 0.351
2.413ValPro: 2.413 ± 0.379
3.034ValGln: 3.034 ± 0.546
2.896ValArg: 2.896 ± 0.486
4.068ValSer: 4.068 ± 0.589
4.413ValThr: 4.413 ± 0.677
3.724ValVal: 3.724 ± 0.506
0.69ValTrp: 0.69 ± 0.379
2.069ValTyr: 2.069 ± 0.428
0.0ValXaa: 0.0 ± 0.0
Trp
1.172TrpAla: 1.172 ± 0.281
0.345TrpCys: 0.345 ± 0.123
1.31TrpAsp: 1.31 ± 0.306
0.759TrpGlu: 0.759 ± 0.24
0.207TrpPhe: 0.207 ± 0.144
0.896TrpGly: 0.896 ± 0.216
0.276TrpHis: 0.276 ± 0.137
1.034TrpIle: 1.034 ± 0.233
0.621TrpLys: 0.621 ± 0.23
1.31TrpLeu: 1.31 ± 0.389
0.483TrpMet: 0.483 ± 0.203
0.69TrpAsn: 0.69 ± 0.243
0.414TrpPro: 0.414 ± 0.207
0.827TrpGln: 0.827 ± 0.245
0.552TrpArg: 0.552 ± 0.229
1.172TrpSer: 1.172 ± 0.292
0.896TrpThr: 0.896 ± 0.353
0.69TrpVal: 0.69 ± 0.251
0.207TrpTrp: 0.207 ± 0.108
0.483TrpTyr: 0.483 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.827TyrAla: 2.827 ± 0.472
0.552TyrCys: 0.552 ± 0.266
2.345TyrAsp: 2.345 ± 0.521
2.0TyrGlu: 2.0 ± 0.426
1.034TyrPhe: 1.034 ± 0.263
2.62TyrGly: 2.62 ± 0.365
0.483TyrHis: 0.483 ± 0.187
2.069TyrIle: 2.069 ± 0.348
1.517TyrLys: 1.517 ± 0.375
2.827TyrLeu: 2.827 ± 0.54
0.827TyrMet: 0.827 ± 0.236
1.793TyrAsn: 1.793 ± 0.404
1.379TyrPro: 1.379 ± 0.375
1.793TyrGln: 1.793 ± 0.316
2.482TyrArg: 2.482 ± 0.432
2.276TyrSer: 2.276 ± 0.44
1.586TyrThr: 1.586 ± 0.313
2.138TyrVal: 2.138 ± 0.513
0.621TyrTrp: 0.621 ± 0.209
1.172TyrTyr: 1.172 ± 0.284
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (14503 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski