Amino acid dipepetide frequency for Legionella israelensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.876AlaAla: 5.876 ± 0.093	1.065AlaCys: 1.065 ± 0.035	3.399AlaAsp: 3.399 ± 0.068	4.527AlaGlu: 4.527 ± 0.092	3.314AlaPhe: 3.314 ± 0.061	4.912AlaGly: 4.912 ± 0.095	1.735AlaHis: 1.735 ± 0.049	5.901AlaIle: 5.901 ± 0.088	4.796AlaLys: 4.796 ± 0.076	8.786AlaLeu: 8.786 ± 0.119	2.151AlaMet: 2.151 ± 0.055	3.011AlaAsn: 3.011 ± 0.065	2.172AlaPro: 2.172 ± 0.052	3.003AlaGln: 3.003 ± 0.058	3.558AlaArg: 3.558 ± 0.07	4.617AlaSer: 4.617 ± 0.084	3.355AlaThr: 3.355 ± 0.069	4.779AlaVal: 4.779 ± 0.08	0.811AlaTrp: 0.811 ± 0.028	2.563AlaTyr: 2.563 ± 0.058	0.002AlaXaa: 0.002 ± 0.002
Cys	0.723CysAla: 0.723 ± 0.035	0.199CysCys: 0.199 ± 0.017	0.527CysAsp: 0.527 ± 0.028	0.737CysGlu: 0.737 ± 0.029	0.716CysPhe: 0.716 ± 0.033	0.868CysGly: 0.868 ± 0.036	0.368CysHis: 0.368 ± 0.022	0.795CysIle: 0.795 ± 0.034	0.637CysLys: 0.637 ± 0.026	1.38CysLeu: 1.38 ± 0.039	0.305CysMet: 0.305 ± 0.018	0.41CysAsn: 0.41 ± 0.024	0.517CysPro: 0.517 ± 0.028	0.606CysGln: 0.606 ± 0.03	0.544CysArg: 0.544 ± 0.025	0.818CysSer: 0.818 ± 0.029	0.501CysThr: 0.501 ± 0.025	0.637CysVal: 0.637 ± 0.028	0.169CysTrp: 0.169 ± 0.015	0.49CysTyr: 0.49 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.371AspAla: 3.371 ± 0.073	0.584AspCys: 0.584 ± 0.026	2.399AspAsp: 2.399 ± 0.058	3.724AspGlu: 3.724 ± 0.078	2.605AspPhe: 2.605 ± 0.056	2.547AspGly: 2.547 ± 0.07	1.079AspHis: 1.079 ± 0.034	4.121AspIle: 4.121 ± 0.061	3.921AspLys: 3.921 ± 0.068	4.779AspLeu: 4.779 ± 0.081	1.225AspMet: 1.225 ± 0.034	2.151AspAsn: 2.151 ± 0.053	1.795AspPro: 1.795 ± 0.052	1.511AspGln: 1.511 ± 0.042	1.946AspArg: 1.946 ± 0.048	2.949AspSer: 2.949 ± 0.061	2.104AspThr: 2.104 ± 0.054	3.105AspVal: 3.105 ± 0.056	0.686AspTrp: 0.686 ± 0.028	2.133AspTyr: 2.133 ± 0.055	0.002AspXaa: 0.002 ± 0.002
Glu	4.679GluAla: 4.679 ± 0.088	0.62GluCys: 0.62 ± 0.032	2.991GluAsp: 2.991 ± 0.066	4.664GluGlu: 4.664 ± 0.098	2.36GluPhe: 2.36 ± 0.06	3.205GluGly: 3.205 ± 0.06	1.839GluHis: 1.839 ± 0.045	4.455GluIle: 4.455 ± 0.077	5.64GluLys: 5.64 ± 0.096	6.55GluLeu: 6.55 ± 0.09	1.62GluMet: 1.62 ± 0.04	3.441GluAsn: 3.441 ± 0.073	1.871GluPro: 1.871 ± 0.044	3.449GluGln: 3.449 ± 0.067	3.085GluArg: 3.085 ± 0.069	3.457GluSer: 3.457 ± 0.07	3.042GluThr: 3.042 ± 0.061	3.448GluVal: 3.448 ± 0.071	0.675GluTrp: 0.675 ± 0.03	1.925GluTyr: 1.925 ± 0.052	0.002GluXaa: 0.002 ± 0.002
Phe	3.303PheAla: 3.303 ± 0.069	0.638PheCys: 0.638 ± 0.029	2.476PheAsp: 2.476 ± 0.055	2.33PheGlu: 2.33 ± 0.06	2.672PhePhe: 2.672 ± 0.07	2.675PheGly: 2.675 ± 0.063	1.101PheHis: 1.101 ± 0.035	3.952PheIle: 3.952 ± 0.079	2.671PheLys: 2.671 ± 0.056	4.886PheLeu: 4.886 ± 0.08	1.116PheMet: 1.116 ± 0.038	2.409PheAsn: 2.409 ± 0.052	1.722PhePro: 1.722 ± 0.046	1.548PheGln: 1.548 ± 0.043	1.629PheArg: 1.629 ± 0.045	3.689PheSer: 3.689 ± 0.073	2.31PheThr: 2.31 ± 0.052	2.491PheVal: 2.491 ± 0.05	0.567PheTrp: 0.567 ± 0.028	1.852PheTyr: 1.852 ± 0.046	0.001PheXaa: 0.001 ± 0.001
Gly	3.984GlyAla: 3.984 ± 0.075	0.806GlyCys: 0.806 ± 0.034	2.618GlyAsp: 2.618 ± 0.064	3.387GlyGlu: 3.387 ± 0.066	3.202GlyPhe: 3.202 ± 0.066	3.785GlyGly: 3.785 ± 0.086	1.691GlyHis: 1.691 ± 0.047	4.821GlyIle: 4.821 ± 0.081	3.994GlyLys: 3.994 ± 0.077	6.476GlyLeu: 6.476 ± 0.088	1.702GlyMet: 1.702 ± 0.047	2.231GlyAsn: 2.231 ± 0.06	1.54GlyPro: 1.54 ± 0.046	2.532GlyGln: 2.532 ± 0.059	2.714GlyArg: 2.714 ± 0.06	3.502GlySer: 3.502 ± 0.066	2.733GlyThr: 2.733 ± 0.059	3.832GlyVal: 3.832 ± 0.077	0.874GlyTrp: 0.874 ± 0.038	2.446GlyTyr: 2.446 ± 0.052	0.002GlyXaa: 0.002 ± 0.002
His	1.773HisAla: 1.773 ± 0.052	0.435HisCys: 0.435 ± 0.024	1.156HisAsp: 1.156 ± 0.035	1.44HisGlu: 1.44 ± 0.038	1.461HisPhe: 1.461 ± 0.037	1.654HisGly: 1.654 ± 0.045	1.049HisHis: 1.049 ± 0.042	1.732HisIle: 1.732 ± 0.041	1.268HisLys: 1.268 ± 0.041	3.067HisLeu: 3.067 ± 0.072	0.602HisMet: 0.602 ± 0.027	0.949HisAsn: 0.949 ± 0.03	1.408HisPro: 1.408 ± 0.034	1.591HisGln: 1.591 ± 0.047	1.263HisArg: 1.263 ± 0.043	1.682HisSer: 1.682 ± 0.041	1.071HisThr: 1.071 ± 0.037	1.343HisVal: 1.343 ± 0.041	0.478HisTrp: 0.478 ± 0.023	1.303HisTyr: 1.303 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.108IleAla: 6.108 ± 0.092	0.845IleCys: 0.845 ± 0.031	4.253IleAsp: 4.253 ± 0.077	5.115IleGlu: 5.115 ± 0.073	3.05IlePhe: 3.05 ± 0.069	4.569IleGly: 4.569 ± 0.086	2.089IleHis: 2.089 ± 0.048	5.372IleIle: 5.372 ± 0.093	5.053IleLys: 5.053 ± 0.078	7.2IleLeu: 7.2 ± 0.117	1.585IleMet: 1.585 ± 0.045	3.798IleAsn: 3.798 ± 0.076	3.241IlePro: 3.241 ± 0.059	3.001IleGln: 3.001 ± 0.06	3.26IleArg: 3.26 ± 0.06	5.249IleSer: 5.249 ± 0.086	3.787IleThr: 3.787 ± 0.063	3.88IleVal: 3.88 ± 0.08	0.67IleTrp: 0.67 ± 0.029	2.34IleTyr: 2.34 ± 0.051	0.003IleXaa: 0.003 ± 0.002
Lys	5.208LysAla: 5.208 ± 0.081	0.467LysCys: 0.467 ± 0.024	3.322LysAsp: 3.322 ± 0.072	5.179LysGlu: 5.179 ± 0.086	1.723LysPhe: 1.723 ± 0.046	3.578LysGly: 3.578 ± 0.077	1.686LysHis: 1.686 ± 0.047	5.024LysIle: 5.024 ± 0.085	5.832LysLys: 5.832 ± 0.109	6.278LysLeu: 6.278 ± 0.089	1.634LysMet: 1.634 ± 0.039	3.967LysAsn: 3.967 ± 0.083	2.889LysPro: 2.889 ± 0.061	3.416LysGln: 3.416 ± 0.066	3.17LysArg: 3.17 ± 0.058	4.009LysSer: 4.009 ± 0.073	3.78LysThr: 3.78 ± 0.069	3.163LysVal: 3.163 ± 0.062	0.628LysTrp: 0.628 ± 0.025	1.963LysTyr: 1.963 ± 0.045	0.002LysXaa: 0.002 ± 0.002
Leu	8.847LeuAla: 8.847 ± 0.114	1.352LeuCys: 1.352 ± 0.041	4.913LeuAsp: 4.913 ± 0.085	5.592LeuGlu: 5.592 ± 0.097	5.213LeuPhe: 5.213 ± 0.098	6.095LeuGly: 6.095 ± 0.099	2.543LeuHis: 2.543 ± 0.057	8.124LeuIle: 8.124 ± 0.123	7.472LeuLys: 7.472 ± 0.106	12.07LeuLeu: 12.07 ± 0.192	2.803LeuMet: 2.803 ± 0.064	5.394LeuAsn: 5.394 ± 0.087	4.886LeuPro: 4.886 ± 0.083	4.536LeuGln: 4.536 ± 0.072	4.626LeuArg: 4.626 ± 0.083	8.476LeuSer: 8.476 ± 0.107	5.788LeuThr: 5.788 ± 0.085	5.79LeuVal: 5.79 ± 0.09	1.112LeuTrp: 1.112 ± 0.041	3.262LeuTyr: 3.262 ± 0.067	0.002LeuXaa: 0.002 ± 0.002
Met	2.197MetAla: 2.197 ± 0.055	0.19MetCys: 0.19 ± 0.015	1.31MetAsp: 1.31 ± 0.043	1.371MetGlu: 1.371 ± 0.038	0.858MetPhe: 0.858 ± 0.033	1.466MetGly: 1.466 ± 0.045	0.543MetHis: 0.543 ± 0.023	1.722MetIle: 1.722 ± 0.045	1.682MetLys: 1.682 ± 0.045	2.622MetLeu: 2.622 ± 0.058	0.7MetMet: 0.7 ± 0.033	1.319MetAsn: 1.319 ± 0.037	1.147MetPro: 1.147 ± 0.036	1.191MetGln: 1.191 ± 0.038	1.189MetArg: 1.189 ± 0.041	1.688MetSer: 1.688 ± 0.046	1.444MetThr: 1.444 ± 0.039	1.482MetVal: 1.482 ± 0.045	0.203MetTrp: 0.203 ± 0.016	0.574MetTyr: 0.574 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.262AsnAla: 3.262 ± 0.065	0.556AsnCys: 0.556 ± 0.03	2.288AsnAsp: 2.288 ± 0.054	3.304AsnGlu: 3.304 ± 0.069	1.79AsnPhe: 1.79 ± 0.043	2.499AsnGly: 2.499 ± 0.061	1.419AsnHis: 1.419 ± 0.042	3.599AsnIle: 3.599 ± 0.073	3.142AsnLys: 3.142 ± 0.06	4.371AsnLeu: 4.371 ± 0.08	1.005AsnMet: 1.005 ± 0.031	2.245AsnAsn: 2.245 ± 0.053	2.372AsnPro: 2.372 ± 0.043	2.417AsnGln: 2.417 ± 0.064	2.081AsnArg: 2.081 ± 0.047	2.61AsnSer: 2.61 ± 0.052	2.249AsnThr: 2.249 ± 0.052	2.289AsnVal: 2.289 ± 0.046	0.618AsnTrp: 0.618 ± 0.028	1.728AsnTyr: 1.728 ± 0.045	0.002AsnXaa: 0.002 ± 0.002
Pro	2.735ProAla: 2.735 ± 0.053	0.41ProCys: 0.41 ± 0.024	2.262ProAsp: 2.262 ± 0.053	3.318ProGlu: 3.318 ± 0.075	1.966ProPhe: 1.966 ± 0.043	2.426ProGly: 2.426 ± 0.06	0.982ProHis: 0.982 ± 0.029	2.437ProIle: 2.437 ± 0.057	2.167ProLys: 2.167 ± 0.05	4.377ProLeu: 4.377 ± 0.069	0.91ProMet: 0.91 ± 0.033	1.502ProAsn: 1.502 ± 0.045	1.449ProPro: 1.449 ± 0.043	1.732ProGln: 1.732 ± 0.051	1.385ProArg: 1.385 ± 0.044	2.568ProSer: 2.568 ± 0.054	1.68ProThr: 1.68 ± 0.048	3.153ProVal: 3.153 ± 0.06	0.522ProTrp: 0.522 ± 0.026	1.402ProTyr: 1.402 ± 0.042	0.001ProXaa: 0.001 ± 0.001
Gln	3.594GlnAla: 3.594 ± 0.072	0.526GlnCys: 0.526 ± 0.025	1.889GlnAsp: 1.889 ± 0.057	2.592GlnGlu: 2.592 ± 0.064	2.026GlnPhe: 2.026 ± 0.045	2.446GlnGly: 2.446 ± 0.055	1.19GlnHis: 1.19 ± 0.04	3.094GlnIle: 3.094 ± 0.05	3.244GlnLys: 3.244 ± 0.068	5.379GlnLeu: 5.379 ± 0.088	1.092GlnMet: 1.092 ± 0.036	1.997GlnAsn: 1.997 ± 0.061	1.588GlnPro: 1.588 ± 0.051	2.955GlnGln: 2.955 ± 0.09	2.184GlnArg: 2.184 ± 0.061	2.798GlnSer: 2.798 ± 0.059	2.206GlnThr: 2.206 ± 0.052	2.4GlnVal: 2.4 ± 0.052	0.716GlnTrp: 0.716 ± 0.03	1.763GlnTyr: 1.763 ± 0.053	0.0GlnXaa: 0.0 ± 0.0
Arg	2.99ArgAla: 2.99 ± 0.075	0.494ArgCys: 0.494 ± 0.023	2.063ArgAsp: 2.063 ± 0.048	2.993ArgGlu: 2.993 ± 0.065	2.355ArgPhe: 2.355 ± 0.055	2.284ArgGly: 2.284 ± 0.052	1.4ArgHis: 1.4 ± 0.052	3.309ArgIle: 3.309 ± 0.063	3.016ArgLys: 3.016 ± 0.06	5.26ArgLeu: 5.26 ± 0.084	1.128ArgMet: 1.128 ± 0.041	1.891ArgAsn: 1.891 ± 0.044	1.511ArgPro: 1.511 ± 0.041	2.383ArgGln: 2.383 ± 0.065	2.256ArgArg: 2.256 ± 0.059	2.487ArgSer: 2.487 ± 0.052	1.994ArgThr: 1.994 ± 0.052	2.56ArgVal: 2.56 ± 0.059	0.641ArgTrp: 0.641 ± 0.027	1.978ArgTyr: 1.978 ± 0.054	0.002ArgXaa: 0.002 ± 0.002
Ser	4.481SerAla: 4.481 ± 0.079	0.861SerCys: 0.861 ± 0.031	3.146SerAsp: 3.146 ± 0.062	4.048SerGlu: 4.048 ± 0.067	3.366SerPhe: 3.366 ± 0.061	4.242SerGly: 4.242 ± 0.071	1.904SerHis: 1.904 ± 0.064	4.696SerIle: 4.696 ± 0.078	3.761SerLys: 3.761 ± 0.072	7.832SerLeu: 7.832 ± 0.108	1.719SerMet: 1.719 ± 0.042	2.623SerAsn: 2.623 ± 0.058	2.666SerPro: 2.666 ± 0.051	2.889SerGln: 2.889 ± 0.052	2.963SerArg: 2.963 ± 0.058	4.676SerSer: 4.676 ± 0.082	3.002SerThr: 3.002 ± 0.07	3.788SerVal: 3.788 ± 0.063	0.814SerTrp: 0.814 ± 0.036	2.309SerTyr: 2.309 ± 0.053	0.002SerXaa: 0.002 ± 0.002
Thr	3.873ThrAla: 3.873 ± 0.079	0.5ThrCys: 0.5 ± 0.026	2.399ThrAsp: 2.399 ± 0.051	2.86ThrGlu: 2.86 ± 0.055	1.97ThrPhe: 1.97 ± 0.055	3.564ThrGly: 3.564 ± 0.069	1.321ThrHis: 1.321 ± 0.038	3.561ThrIle: 3.561 ± 0.065	2.418ThrLys: 2.418 ± 0.056	5.556ThrLeu: 5.556 ± 0.089	1.084ThrMet: 1.084 ± 0.035	1.877ThrAsn: 1.877 ± 0.045	2.344ThrPro: 2.344 ± 0.053	1.945ThrGln: 1.945 ± 0.044	2.149ThrArg: 2.149 ± 0.049	3.205ThrSer: 3.205 ± 0.059	2.449ThrThr: 2.449 ± 0.054	3.289ThrVal: 3.289 ± 0.066	0.454ThrTrp: 0.454 ± 0.023	1.574ThrTyr: 1.574 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.22ValAla: 4.22 ± 0.082	0.715ValCys: 0.715 ± 0.032	3.121ValAsp: 3.121 ± 0.069	3.331ValGlu: 3.331 ± 0.059	2.899ValPhe: 2.899 ± 0.055	3.263ValGly: 3.263 ± 0.074	1.354ValHis: 1.354 ± 0.034	4.659ValIle: 4.659 ± 0.089	3.683ValLys: 3.683 ± 0.067	6.171ValLeu: 6.171 ± 0.108	1.474ValMet: 1.474 ± 0.039	2.87ValAsn: 2.87 ± 0.063	2.182ValPro: 2.182 ± 0.052	1.823ValGln: 1.823 ± 0.05	2.432ValArg: 2.432 ± 0.052	4.246ValSer: 4.246 ± 0.069	2.845ValThr: 2.845 ± 0.064	3.648ValVal: 3.648 ± 0.086	0.596ValTrp: 0.596 ± 0.028	1.974ValTyr: 1.974 ± 0.055	0.005ValXaa: 0.005 ± 0.003
Trp	0.677TrpAla: 0.677 ± 0.025	0.147TrpCys: 0.147 ± 0.013	0.47TrpAsp: 0.47 ± 0.023	0.515TrpGlu: 0.515 ± 0.021	0.63TrpPhe: 0.63 ± 0.025	0.683TrpGly: 0.683 ± 0.028	0.376TrpHis: 0.376 ± 0.019	0.869TrpIle: 0.869 ± 0.037	0.616TrpLys: 0.616 ± 0.027	1.712TrpLeu: 1.712 ± 0.045	0.296TrpMet: 0.296 ± 0.017	0.449TrpAsn: 0.449 ± 0.025	0.474TrpPro: 0.474 ± 0.025	0.891TrpGln: 0.891 ± 0.032	0.638TrpArg: 0.638 ± 0.032	0.735TrpSer: 0.735 ± 0.03	0.489TrpThr: 0.489 ± 0.026	0.714TrpVal: 0.714 ± 0.03	0.163TrpTrp: 0.163 ± 0.012	0.405TrpTyr: 0.405 ± 0.023	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.428TyrAla: 2.428 ± 0.056	0.533TyrCys: 0.533 ± 0.025	1.736TyrAsp: 1.736 ± 0.093	1.989TyrGlu: 1.989 ± 0.049	1.861TyrPhe: 1.861 ± 0.055	2.109TyrGly: 2.109 ± 0.05	1.056TyrHis: 1.056 ± 0.037	2.224TyrIle: 2.224 ± 0.055	1.904TyrLys: 1.904 ± 0.057	4.143TyrLeu: 4.143 ± 0.073	0.741TyrMet: 0.741 ± 0.031	1.314TyrAsn: 1.314 ± 0.046	1.608TyrPro: 1.608 ± 0.044	2.262TyrGln: 2.262 ± 0.063	1.92TyrArg: 1.92 ± 0.054	2.325TyrSer: 2.325 ± 0.059	1.561TyrThr: 1.561 ± 0.047	1.717TyrVal: 1.717 ± 0.04	0.551TyrTrp: 0.551 ± 0.028	1.489TyrTyr: 1.489 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.002	0.003XaaCys: 0.003 ± 0.002	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.003XaaLeu: 0.003 ± 0.002	0.003XaaMet: 0.003 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.002	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.097XaaXaa: 0.097 ± 0.019

Statistics based on 2821 proteins (878026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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