Amino acid dipepetide frequency for Apibacter mensalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.181AlaAla: 3.181 ± 0.094
0.54AlaCys: 0.54 ± 0.027
2.644AlaAsp: 2.644 ± 0.061
3.353AlaGlu: 3.353 ± 0.083
2.406AlaPhe: 2.406 ± 0.063
3.672AlaGly: 3.672 ± 0.089
0.967AlaHis: 0.967 ± 0.039
4.726AlaIle: 4.726 ± 0.091
4.428AlaLys: 4.428 ± 0.09
5.293AlaLeu: 5.293 ± 0.095
1.214AlaMet: 1.214 ± 0.041
2.653AlaAsn: 2.653 ± 0.069
1.525AlaPro: 1.525 ± 0.057
2.098AlaGln: 2.098 ± 0.053
1.829AlaArg: 1.829 ± 0.055
3.267AlaSer: 3.267 ± 0.078
2.726AlaThr: 2.726 ± 0.07
3.109AlaVal: 3.109 ± 0.081
0.504AlaTrp: 0.504 ± 0.026
2.27AlaTyr: 2.27 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.461CysAla: 0.461 ± 0.026
0.108CysCys: 0.108 ± 0.013
0.377CysAsp: 0.377 ± 0.025
0.447CysGlu: 0.447 ± 0.027
0.467CysPhe: 0.467 ± 0.027
0.599CysGly: 0.599 ± 0.034
0.156CysHis: 0.156 ± 0.016
0.85CysIle: 0.85 ± 0.043
0.667CysLys: 0.667 ± 0.037
0.816CysLeu: 0.816 ± 0.042
0.181CysMet: 0.181 ± 0.019
0.533CysAsn: 0.533 ± 0.028
0.356CysPro: 0.356 ± 0.022
0.227CysGln: 0.227 ± 0.017
0.245CysArg: 0.245 ± 0.019
0.585CysSer: 0.585 ± 0.028
0.413CysThr: 0.413 ± 0.025
0.426CysVal: 0.426 ± 0.027
0.061CysTrp: 0.061 ± 0.01
0.371CysTyr: 0.371 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
2.526AspAla: 2.526 ± 0.058
0.397AspCys: 0.397 ± 0.028
2.325AspAsp: 2.325 ± 0.064
3.497AspGlu: 3.497 ± 0.078
3.12AspPhe: 3.12 ± 0.068
2.833AspGly: 2.833 ± 0.083
0.905AspHis: 0.905 ± 0.038
4.926AspIle: 4.926 ± 0.09
4.625AspLys: 4.625 ± 0.087
5.007AspLeu: 5.007 ± 0.095
1.046AspMet: 1.046 ± 0.042
2.927AspAsn: 2.927 ± 0.079
1.781AspPro: 1.781 ± 0.058
1.552AspGln: 1.552 ± 0.049
1.757AspArg: 1.757 ± 0.056
3.297AspSer: 3.297 ± 0.075
2.581AspThr: 2.581 ± 0.063
2.738AspVal: 2.738 ± 0.069
0.625AspTrp: 0.625 ± 0.034
2.658AspTyr: 2.658 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
3.506GluAla: 3.506 ± 0.081
0.42GluCys: 0.42 ± 0.031
3.32GluAsp: 3.32 ± 0.072
5.028GluGlu: 5.028 ± 0.115
3.114GluPhe: 3.114 ± 0.068
3.668GluGly: 3.668 ± 0.086
0.949GluHis: 0.949 ± 0.039
6.532GluIle: 6.532 ± 0.111
7.036GluLys: 7.036 ± 0.137
6.065GluLeu: 6.065 ± 0.1
1.44GluMet: 1.44 ± 0.05
4.859GluAsn: 4.859 ± 0.093
1.377GluPro: 1.377 ± 0.052
2.059GluGln: 2.059 ± 0.061
2.224GluArg: 2.224 ± 0.065
3.365GluSer: 3.365 ± 0.079
2.869GluThr: 2.869 ± 0.061
3.741GluVal: 3.741 ± 0.085
0.655GluTrp: 0.655 ± 0.033
2.946GluTyr: 2.946 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
2.415PheAla: 2.415 ± 0.062
0.483PheCys: 0.483 ± 0.028
2.789PheAsp: 2.789 ± 0.059
2.925PheGlu: 2.925 ± 0.072
2.887PhePhe: 2.887 ± 0.072
3.231PheGly: 3.231 ± 0.073
0.881PheHis: 0.881 ± 0.034
5.237PheIle: 5.237 ± 0.107
3.867PheLys: 3.867 ± 0.088
4.874PheLeu: 4.874 ± 0.098
1.041PheMet: 1.041 ± 0.047
3.308PheAsn: 3.308 ± 0.081
1.697PhePro: 1.697 ± 0.053
1.495PheGln: 1.495 ± 0.042
1.489PheArg: 1.489 ± 0.046
4.259PheSer: 4.259 ± 0.092
3.075PheThr: 3.075 ± 0.073
2.435PheVal: 2.435 ± 0.064
0.516PheTrp: 0.516 ± 0.026
2.436PheTyr: 2.436 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
3.675GlyAla: 3.675 ± 0.092
0.561GlyCys: 0.561 ± 0.031
2.904GlyAsp: 2.904 ± 0.069
3.6GlyGlu: 3.6 ± 0.072
3.181GlyPhe: 3.181 ± 0.075
4.256GlyGly: 4.256 ± 0.099
0.985GlyHis: 0.985 ± 0.042
6.306GlyIle: 6.306 ± 0.107
5.819GlyLys: 5.819 ± 0.104
5.252GlyLeu: 5.252 ± 0.107
1.505GlyMet: 1.505 ± 0.05
3.772GlyAsn: 3.772 ± 0.084
1.086GlyPro: 1.086 ± 0.045
1.639GlyGln: 1.639 ± 0.045
1.98GlyArg: 1.98 ± 0.063
3.663GlySer: 3.663 ± 0.097
3.416GlyThr: 3.416 ± 0.075
3.727GlyVal: 3.727 ± 0.09
0.717GlyTrp: 0.717 ± 0.042
2.963GlyTyr: 2.963 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
0.943HisAla: 0.943 ± 0.036
0.181HisCys: 0.181 ± 0.015
0.724HisAsp: 0.724 ± 0.036
0.995HisGlu: 0.995 ± 0.039
1.018HisPhe: 1.018 ± 0.04
1.0HisGly: 1.0 ± 0.038
0.392HisHis: 0.392 ± 0.029
1.662HisIle: 1.662 ± 0.049
1.261HisLys: 1.261 ± 0.043
1.697HisLeu: 1.697 ± 0.058
0.356HisMet: 0.356 ± 0.023
0.959HisAsn: 0.959 ± 0.04
0.811HisPro: 0.811 ± 0.039
0.67HisGln: 0.67 ± 0.032
0.606HisArg: 0.606 ± 0.033
1.175HisSer: 1.175 ± 0.042
1.047HisThr: 1.047 ± 0.039
0.901HisVal: 0.901 ± 0.036
0.156HisTrp: 0.156 ± 0.017
0.866HisTyr: 0.866 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
4.99IleAla: 4.99 ± 0.098
0.85IleCys: 0.85 ± 0.043
5.101IleAsp: 5.101 ± 0.087
5.761IleGlu: 5.761 ± 0.106
4.69IlePhe: 4.69 ± 0.111
5.495IleGly: 5.495 ± 0.109
1.836IleHis: 1.836 ± 0.055
8.718IleIle: 8.718 ± 0.153
7.995IleLys: 7.995 ± 0.126
8.618IleLeu: 8.618 ± 0.144
1.649IleMet: 1.649 ± 0.057
6.195IleAsn: 6.195 ± 0.106
3.796IlePro: 3.796 ± 0.083
3.21IleGln: 3.21 ± 0.078
2.879IleArg: 2.879 ± 0.067
7.313IleSer: 7.313 ± 0.11
5.164IleThr: 5.164 ± 0.091
4.848IleVal: 4.848 ± 0.103
0.75IleTrp: 0.75 ± 0.035
4.028IleTyr: 4.028 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
4.28LysAla: 4.28 ± 0.098
0.44LysCys: 0.44 ± 0.027
4.953LysAsp: 4.953 ± 0.089
7.216LysGlu: 7.216 ± 0.113
3.689LysPhe: 3.689 ± 0.082
5.005LysGly: 5.005 ± 0.098
1.27LysHis: 1.27 ± 0.044
8.944LysIle: 8.944 ± 0.129
9.035LysLys: 9.035 ± 0.141
7.62LysLeu: 7.62 ± 0.119
2.144LysMet: 2.144 ± 0.059
7.287LysAsn: 7.287 ± 0.112
2.399LysPro: 2.399 ± 0.065
2.834LysGln: 2.834 ± 0.074
2.913LysArg: 2.913 ± 0.068
5.116LysSer: 5.116 ± 0.083
4.432LysThr: 4.432 ± 0.084
4.703LysVal: 4.703 ± 0.087
0.783LysTrp: 0.783 ± 0.038
4.176LysTyr: 4.176 ± 0.095
0.0LysXaa: 0.0 ± 0.0
Leu
5.086LeuAla: 5.086 ± 0.097
0.82LeuCys: 0.82 ± 0.034
4.744LeuAsp: 4.744 ± 0.085
5.794LeuGlu: 5.794 ± 0.117
4.978LeuPhe: 4.978 ± 0.115
5.942LeuGly: 5.942 ± 0.102
1.652LeuHis: 1.652 ± 0.05
8.215LeuIle: 8.215 ± 0.122
8.312LeuLys: 8.312 ± 0.125
9.254LeuLeu: 9.254 ± 0.162
2.013LeuMet: 2.013 ± 0.059
5.953LeuAsn: 5.953 ± 0.097
3.458LeuPro: 3.458 ± 0.081
3.235LeuGln: 3.235 ± 0.068
2.975LeuArg: 2.975 ± 0.065
7.307LeuSer: 7.307 ± 0.12
5.107LeuThr: 5.107 ± 0.09
4.785LeuVal: 4.785 ± 0.089
0.799LeuTrp: 0.799 ± 0.041
3.841LeuTyr: 3.841 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.232MetAla: 1.232 ± 0.051
0.126MetCys: 0.126 ± 0.012
1.119MetAsp: 1.119 ± 0.044
1.377MetGlu: 1.377 ± 0.044
0.848MetPhe: 0.848 ± 0.037
1.405MetGly: 1.405 ± 0.055
0.328MetHis: 0.328 ± 0.023
1.82MetIle: 1.82 ± 0.056
2.297MetLys: 2.297 ± 0.062
1.781MetLeu: 1.781 ± 0.05
0.533MetMet: 0.533 ± 0.029
1.481MetAsn: 1.481 ± 0.042
0.765MetPro: 0.765 ± 0.034
0.693MetGln: 0.693 ± 0.035
0.747MetArg: 0.747 ± 0.033
1.357MetSer: 1.357 ± 0.047
0.988MetThr: 0.988 ± 0.033
1.267MetVal: 1.267 ± 0.045
0.154MetTrp: 0.154 ± 0.016
0.723MetTyr: 0.723 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.023AsnAla: 3.023 ± 0.078
0.486AsnCys: 0.486 ± 0.029
2.91AsnAsp: 2.91 ± 0.076
3.937AsnGlu: 3.937 ± 0.079
3.621AsnPhe: 3.621 ± 0.076
3.606AsnGly: 3.606 ± 0.086
1.232AsnHis: 1.232 ± 0.043
5.878AsnIle: 5.878 ± 0.11
5.981AsnLys: 5.981 ± 0.105
6.116AsnLeu: 6.116 ± 0.106
1.266AsnMet: 1.266 ± 0.046
4.467AsnAsn: 4.467 ± 0.104
2.927AsnPro: 2.927 ± 0.07
2.37AsnGln: 2.37 ± 0.058
2.131AsnArg: 2.131 ± 0.053
4.533AsnSer: 4.533 ± 0.102
3.383AsnThr: 3.383 ± 0.079
3.05AsnVal: 3.05 ± 0.066
0.718AsnTrp: 0.718 ± 0.032
3.543AsnTyr: 3.543 ± 0.082
0.0AsnXaa: 0.0 ± 0.0
Pro
1.495ProAla: 1.495 ± 0.052
0.274ProCys: 0.274 ± 0.022
1.891ProAsp: 1.891 ± 0.054
2.628ProGlu: 2.628 ± 0.06
1.838ProPhe: 1.838 ± 0.053
1.817ProGly: 1.817 ± 0.06
0.606ProHis: 0.606 ± 0.027
3.092ProIle: 3.092 ± 0.073
2.608ProLys: 2.608 ± 0.068
2.967ProLeu: 2.967 ± 0.063
0.672ProMet: 0.672 ± 0.031
2.087ProAsn: 2.087 ± 0.06
0.832ProPro: 0.832 ± 0.044
1.184ProGln: 1.184 ± 0.047
0.871ProArg: 0.871 ± 0.037
2.266ProSer: 2.266 ± 0.066
1.775ProThr: 1.775 ± 0.056
2.252ProVal: 2.252 ± 0.067
0.314ProTrp: 0.314 ± 0.021
1.577ProTyr: 1.577 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.98GlnAla: 1.98 ± 0.059
0.214GlnCys: 0.214 ± 0.017
1.505GlnAsp: 1.505 ± 0.046
2.273GlnGlu: 2.273 ± 0.065
1.399GlnPhe: 1.399 ± 0.047
1.832GlnGly: 1.832 ± 0.052
0.519GlnHis: 0.519 ± 0.026
3.084GlnIle: 3.084 ± 0.07
3.285GlnLys: 3.285 ± 0.085
3.246GlnLeu: 3.246 ± 0.075
0.781GlnMet: 0.781 ± 0.033
2.339GlnAsn: 2.339 ± 0.058
0.944GlnPro: 0.944 ± 0.037
1.254GlnGln: 1.254 ± 0.053
1.22GlnArg: 1.22 ± 0.042
1.981GlnSer: 1.981 ± 0.055
1.74GlnThr: 1.74 ± 0.051
1.939GlnVal: 1.939 ± 0.053
0.413GlnTrp: 0.413 ± 0.027
1.498GlnTyr: 1.498 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
1.794ArgAla: 1.794 ± 0.057
0.236ArgCys: 0.236 ± 0.02
1.601ArgAsp: 1.601 ± 0.048
2.234ArgGlu: 2.234 ± 0.073
1.621ArgPhe: 1.621 ± 0.049
1.751ArgGly: 1.751 ± 0.058
0.485ArgHis: 0.485 ± 0.03
3.087ArgIle: 3.087 ± 0.073
3.115ArgLys: 3.115 ± 0.065
2.966ArgLeu: 2.966 ± 0.073
0.853ArgMet: 0.853 ± 0.034
2.225ArgAsn: 2.225 ± 0.057
1.079ArgPro: 1.079 ± 0.038
1.034ArgGln: 1.034 ± 0.039
1.291ArgArg: 1.291 ± 0.048
1.788ArgSer: 1.788 ± 0.056
1.562ArgThr: 1.562 ± 0.055
1.887ArgVal: 1.887 ± 0.062
0.331ArgTrp: 0.331 ± 0.025
1.535ArgTyr: 1.535 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
3.347SerAla: 3.347 ± 0.076
0.678SerCys: 0.678 ± 0.032
3.404SerAsp: 3.404 ± 0.072
4.202SerGlu: 4.202 ± 0.089
3.775SerPhe: 3.775 ± 0.091
4.393SerGly: 4.393 ± 0.082
1.23SerHis: 1.23 ± 0.045
6.265SerIle: 6.265 ± 0.103
5.652SerLys: 5.652 ± 0.093
6.886SerLeu: 6.886 ± 0.118
1.276SerMet: 1.276 ± 0.046
4.006SerAsn: 4.006 ± 0.086
2.216SerPro: 2.216 ± 0.06
2.351SerGln: 2.351 ± 0.064
1.981SerArg: 1.981 ± 0.05
4.865SerSer: 4.865 ± 0.097
3.394SerThr: 3.394 ± 0.072
3.763SerVal: 3.763 ± 0.083
0.706SerTrp: 0.706 ± 0.031
3.153SerTyr: 3.153 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
2.765ThrAla: 2.765 ± 0.067
0.482ThrCys: 0.482 ± 0.026
2.91ThrAsp: 2.91 ± 0.072
2.976ThrGlu: 2.976 ± 0.075
2.758ThrPhe: 2.758 ± 0.063
3.653ThrGly: 3.653 ± 0.08
1.097ThrHis: 1.097 ± 0.049
4.96ThrIle: 4.96 ± 0.08
3.686ThrLys: 3.686 ± 0.079
5.282ThrLeu: 5.282 ± 0.096
0.872ThrMet: 0.872 ± 0.04
2.999ThrAsn: 2.999 ± 0.07
2.164ThrPro: 2.164 ± 0.058
1.885ThrGln: 1.885 ± 0.068
1.553ThrArg: 1.553 ± 0.044
3.533ThrSer: 3.533 ± 0.065
2.813ThrThr: 2.813 ± 0.082
3.141ThrVal: 3.141 ± 0.072
0.465ThrTrp: 0.465 ± 0.028
2.432ThrTyr: 2.432 ± 0.084
0.001ThrXaa: 0.001 ± 0.001
Val
2.94ValAla: 2.94 ± 0.074
0.525ValCys: 0.525 ± 0.032
3.003ValAsp: 3.003 ± 0.077
3.647ValGlu: 3.647 ± 0.079
2.68ValPhe: 2.68 ± 0.069
3.509ValGly: 3.509 ± 0.083
0.904ValHis: 0.904 ± 0.036
4.863ValIle: 4.863 ± 0.092
4.648ValLys: 4.648 ± 0.082
5.177ValLeu: 5.177 ± 0.085
1.107ValMet: 1.107 ± 0.045
3.326ValAsn: 3.326 ± 0.077
1.863ValPro: 1.863 ± 0.056
1.57ValGln: 1.57 ± 0.048
1.836ValArg: 1.836 ± 0.051
4.108ValSer: 4.108 ± 0.076
2.937ValThr: 2.937 ± 0.069
3.258ValVal: 3.258 ± 0.071
0.518ValTrp: 0.518 ± 0.028
2.267ValTyr: 2.267 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.507TrpAla: 0.507 ± 0.033
0.079TrpCys: 0.079 ± 0.012
0.54TrpAsp: 0.54 ± 0.026
0.594TrpGlu: 0.594 ± 0.032
0.53TrpPhe: 0.53 ± 0.03
0.709TrpGly: 0.709 ± 0.04
0.171TrpHis: 0.171 ± 0.015
0.875TrpIle: 0.875 ± 0.039
0.986TrpLys: 0.986 ± 0.042
0.908TrpLeu: 0.908 ± 0.038
0.281TrpMet: 0.281 ± 0.02
0.732TrpAsn: 0.732 ± 0.036
0.196TrpPro: 0.196 ± 0.017
0.341TrpGln: 0.341 ± 0.024
0.34TrpArg: 0.34 ± 0.019
0.543TrpSer: 0.543 ± 0.032
0.417TrpThr: 0.417 ± 0.03
0.537TrpVal: 0.537 ± 0.03
0.12TrpTrp: 0.12 ± 0.015
0.446TrpTyr: 0.446 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.258TyrAla: 2.258 ± 0.058
0.446TyrCys: 0.446 ± 0.028
2.354TyrAsp: 2.354 ± 0.076
2.687TyrGlu: 2.687 ± 0.063
2.722TyrPhe: 2.722 ± 0.073
2.635TyrGly: 2.635 ± 0.074
0.857TyrHis: 0.857 ± 0.037
3.847TyrIle: 3.847 ± 0.068
3.935TyrLys: 3.935 ± 0.078
4.447TyrLeu: 4.447 ± 0.094
0.807TyrMet: 0.807 ± 0.037
3.069TyrAsn: 3.069 ± 0.073
1.772TyrPro: 1.772 ± 0.064
1.745TyrGln: 1.745 ± 0.047
1.61TyrArg: 1.61 ± 0.049
3.226TyrSer: 3.226 ± 0.081
2.587TyrThr: 2.587 ± 0.068
2.177TyrVal: 2.177 ± 0.057
0.548TyrTrp: 0.548 ± 0.031
2.342TyrTyr: 2.342 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.021XaaXaa: 0.021 ± 0.019
Statistics based on 2083 proteins (668283 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski