Amino acid dipepetide frequency for Andreprevotia lacus DSM 23236

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.315AlaAla: 17.315 ± 0.182
1.261AlaCys: 1.261 ± 0.031
6.885AlaAsp: 6.885 ± 0.066
6.672AlaGlu: 6.672 ± 0.08
3.704AlaPhe: 3.704 ± 0.055
10.737AlaGly: 10.737 ± 0.111
2.622AlaHis: 2.622 ± 0.051
5.367AlaIle: 5.367 ± 0.069
3.731AlaLys: 3.731 ± 0.066
14.84AlaLeu: 14.84 ± 0.162
3.0AlaMet: 3.0 ± 0.05
3.375AlaAsn: 3.375 ± 0.061
5.75AlaPro: 5.75 ± 0.107
5.977AlaGln: 5.977 ± 0.077
7.873AlaArg: 7.873 ± 0.092
6.68AlaSer: 6.68 ± 0.078
6.367AlaThr: 6.367 ± 0.1
8.164AlaVal: 8.164 ± 0.094
1.85AlaTrp: 1.85 ± 0.04
2.825AlaTyr: 2.825 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.014CysAla: 1.014 ± 0.028
0.139CysCys: 0.139 ± 0.009
0.495CysAsp: 0.495 ± 0.02
0.441CysGlu: 0.441 ± 0.019
0.348CysPhe: 0.348 ± 0.018
0.964CysGly: 0.964 ± 0.03
0.266CysHis: 0.266 ± 0.014
0.401CysIle: 0.401 ± 0.02
0.261CysLys: 0.261 ± 0.015
0.903CysLeu: 0.903 ± 0.03
0.202CysMet: 0.202 ± 0.013
0.326CysAsn: 0.326 ± 0.017
0.469CysPro: 0.469 ± 0.023
0.317CysGln: 0.317 ± 0.017
0.592CysArg: 0.592 ± 0.023
0.593CysSer: 0.593 ± 0.021
0.492CysThr: 0.492 ± 0.021
0.659CysVal: 0.659 ± 0.023
0.169CysTrp: 0.169 ± 0.011
0.277CysTyr: 0.277 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.31AspAla: 7.31 ± 0.085
0.523AspCys: 0.523 ± 0.021
3.21AspAsp: 3.21 ± 0.052
3.467AspGlu: 3.467 ± 0.062
2.209AspPhe: 2.209 ± 0.039
5.01AspGly: 5.01 ± 0.077
1.183AspHis: 1.183 ± 0.028
2.692AspIle: 2.692 ± 0.047
1.979AspLys: 1.979 ± 0.043
5.292AspLeu: 5.292 ± 0.057
1.104AspMet: 1.104 ± 0.029
1.543AspAsn: 1.543 ± 0.042
2.714AspPro: 2.714 ± 0.053
1.955AspGln: 1.955 ± 0.036
2.796AspArg: 2.796 ± 0.051
2.56AspSer: 2.56 ± 0.051
2.696AspThr: 2.696 ± 0.048
3.923AspVal: 3.923 ± 0.057
1.192AspTrp: 1.192 ± 0.033
1.799AspTyr: 1.799 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.177GluAla: 6.177 ± 0.079
0.381GluCys: 0.381 ± 0.019
1.978GluAsp: 1.978 ± 0.046
2.283GluGlu: 2.283 ± 0.054
1.766GluPhe: 1.766 ± 0.038
3.212GluGly: 3.212 ± 0.061
1.411GluHis: 1.411 ± 0.033
2.679GluIle: 2.679 ± 0.044
1.822GluLys: 1.822 ± 0.039
6.187GluLeu: 6.187 ± 0.08
1.143GluMet: 1.143 ± 0.029
1.329GluAsn: 1.329 ± 0.028
2.04GluPro: 2.04 ± 0.039
2.95GluGln: 2.95 ± 0.058
3.977GluArg: 3.977 ± 0.076
2.162GluSer: 2.162 ± 0.04
2.517GluThr: 2.517 ± 0.048
3.612GluVal: 3.612 ± 0.057
0.715GluTrp: 0.715 ± 0.027
1.302GluTyr: 1.302 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
4.397PheAla: 4.397 ± 0.062
0.413PheCys: 0.413 ± 0.017
2.548PheAsp: 2.548 ± 0.045
1.964PheGlu: 1.964 ± 0.043
1.322PhePhe: 1.322 ± 0.034
3.083PheGly: 3.083 ± 0.054
0.759PheHis: 0.759 ± 0.026
1.544PheIle: 1.544 ± 0.032
1.181PheLys: 1.181 ± 0.026
2.865PheLeu: 2.865 ± 0.056
0.751PheMet: 0.751 ± 0.026
1.318PheAsn: 1.318 ± 0.032
1.353PhePro: 1.353 ± 0.032
1.067PheGln: 1.067 ± 0.025
1.816PheArg: 1.816 ± 0.038
2.222PheSer: 2.222 ± 0.046
1.861PheThr: 1.861 ± 0.043
2.522PheVal: 2.522 ± 0.043
0.548PheTrp: 0.548 ± 0.021
1.002PheTyr: 1.002 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
7.748GlyAla: 7.748 ± 0.085
0.899GlyCys: 0.899 ± 0.031
4.274GlyAsp: 4.274 ± 0.063
4.4GlyGlu: 4.4 ± 0.065
3.045GlyPhe: 3.045 ± 0.055
6.378GlyGly: 6.378 ± 0.104
1.892GlyHis: 1.892 ± 0.041
4.005GlyIle: 4.005 ± 0.06
3.803GlyLys: 3.803 ± 0.065
8.282GlyLeu: 8.282 ± 0.08
2.22GlyMet: 2.22 ± 0.05
2.873GlyAsn: 2.873 ± 0.074
2.526GlyPro: 2.526 ± 0.046
3.599GlyGln: 3.599 ± 0.063
4.846GlyArg: 4.846 ± 0.069
4.727GlySer: 4.727 ± 0.073
4.132GlyThr: 4.132 ± 0.092
5.82GlyVal: 5.82 ± 0.071
1.631GlyTrp: 1.631 ± 0.035
2.437GlyTyr: 2.437 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
3.101HisAla: 3.101 ± 0.055
0.283HisCys: 0.283 ± 0.014
1.413HisAsp: 1.413 ± 0.037
1.147HisGlu: 1.147 ± 0.031
0.986HisPhe: 0.986 ± 0.029
2.125HisGly: 2.125 ± 0.044
0.729HisHis: 0.729 ± 0.028
1.072HisIle: 1.072 ± 0.03
0.661HisLys: 0.661 ± 0.022
2.301HisLeu: 2.301 ± 0.042
0.467HisMet: 0.467 ± 0.018
0.586HisAsn: 0.586 ± 0.019
1.359HisPro: 1.359 ± 0.032
0.816HisGln: 0.816 ± 0.026
1.299HisArg: 1.299 ± 0.036
1.018HisSer: 1.018 ± 0.028
1.167HisThr: 1.167 ± 0.03
1.527HisVal: 1.527 ± 0.033
0.504HisTrp: 0.504 ± 0.021
0.794HisTyr: 0.794 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.407IleAla: 6.407 ± 0.074
0.456IleCys: 0.456 ± 0.02
3.281IleAsp: 3.281 ± 0.05
2.906IleGlu: 2.906 ± 0.052
1.205IlePhe: 1.205 ± 0.035
4.147IleGly: 4.147 ± 0.065
0.907IleHis: 0.907 ± 0.031
1.773IleIle: 1.773 ± 0.044
1.762IleLys: 1.762 ± 0.041
3.501IleLeu: 3.501 ± 0.06
0.747IleMet: 0.747 ± 0.026
1.746IleAsn: 1.746 ± 0.042
2.048IlePro: 2.048 ± 0.04
1.404IleGln: 1.404 ± 0.032
2.579IleArg: 2.579 ± 0.045
2.687IleSer: 2.687 ± 0.052
2.603IleThr: 2.603 ± 0.051
3.428IleVal: 3.428 ± 0.051
0.562IleTrp: 0.562 ± 0.019
1.159IleTyr: 1.159 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.885LysAla: 3.885 ± 0.058
0.161LysCys: 0.161 ± 0.01
1.643LysAsp: 1.643 ± 0.038
1.462LysGlu: 1.462 ± 0.039
0.897LysPhe: 0.897 ± 0.028
2.269LysGly: 2.269 ± 0.046
0.716LysHis: 0.716 ± 0.026
1.588LysIle: 1.588 ± 0.038
1.407LysLys: 1.407 ± 0.04
4.301LysLeu: 4.301 ± 0.06
0.737LysMet: 0.737 ± 0.025
1.021LysAsn: 1.021 ± 0.027
2.325LysPro: 2.325 ± 0.051
1.836LysGln: 1.836 ± 0.039
2.14LysArg: 2.14 ± 0.041
1.727LysSer: 1.727 ± 0.046
2.007LysThr: 2.007 ± 0.045
2.523LysVal: 2.523 ± 0.045
0.397LysTrp: 0.397 ± 0.017
0.828LysTyr: 0.828 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
15.962LeuAla: 15.962 ± 0.175
1.056LeuCys: 1.056 ± 0.03
6.443LeuAsp: 6.443 ± 0.084
4.792LeuGlu: 4.792 ± 0.082
3.761LeuPhe: 3.761 ± 0.064
8.469LeuGly: 8.469 ± 0.083
2.549LeuHis: 2.549 ± 0.057
4.894LeuIle: 4.894 ± 0.057
3.904LeuLys: 3.904 ± 0.061
13.645LeuLeu: 13.645 ± 0.183
2.176LeuMet: 2.176 ± 0.049
3.255LeuAsn: 3.255 ± 0.049
6.864LeuPro: 6.864 ± 0.101
5.446LeuGln: 5.446 ± 0.074
7.036LeuArg: 7.036 ± 0.093
6.138LeuSer: 6.138 ± 0.07
5.765LeuThr: 5.765 ± 0.065
7.176LeuVal: 7.176 ± 0.079
1.423LeuTrp: 1.423 ± 0.032
2.473LeuTyr: 2.473 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.552MetAla: 2.552 ± 0.048
0.145MetCys: 0.145 ± 0.01
0.93MetAsp: 0.93 ± 0.025
0.755MetGlu: 0.755 ± 0.027
0.595MetPhe: 0.595 ± 0.021
1.415MetGly: 1.415 ± 0.033
0.556MetHis: 0.556 ± 0.021
0.861MetIle: 0.861 ± 0.027
0.859MetLys: 0.859 ± 0.027
2.778MetLeu: 2.778 ± 0.051
0.491MetMet: 0.491 ± 0.018
0.757MetAsn: 0.757 ± 0.025
1.315MetPro: 1.315 ± 0.033
1.254MetGln: 1.254 ± 0.03
1.486MetArg: 1.486 ± 0.035
1.527MetSer: 1.527 ± 0.034
1.375MetThr: 1.375 ± 0.035
1.416MetVal: 1.416 ± 0.035
0.195MetTrp: 0.195 ± 0.013
0.364MetTyr: 0.364 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.556AsnAla: 3.556 ± 0.057
0.267AsnCys: 0.267 ± 0.014
1.719AsnAsp: 1.719 ± 0.044
1.408AsnGlu: 1.408 ± 0.035
1.038AsnPhe: 1.038 ± 0.032
3.019AsnGly: 3.019 ± 0.072
0.637AsnHis: 0.637 ± 0.021
1.359AsnIle: 1.359 ± 0.031
1.018AsnLys: 1.018 ± 0.026
2.987AsnLeu: 2.987 ± 0.052
0.571AsnMet: 0.571 ± 0.019
1.04AsnAsn: 1.04 ± 0.031
1.991AsnPro: 1.991 ± 0.043
1.229AsnGln: 1.229 ± 0.036
1.892AsnArg: 1.892 ± 0.046
1.397AsnSer: 1.397 ± 0.037
1.708AsnThr: 1.708 ± 0.041
2.079AsnVal: 2.079 ± 0.045
0.537AsnTrp: 0.537 ± 0.021
0.945AsnTyr: 0.945 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
7.611ProAla: 7.611 ± 0.109
0.375ProCys: 0.375 ± 0.018
3.247ProAsp: 3.247 ± 0.049
2.858ProGlu: 2.858 ± 0.046
1.688ProPhe: 1.688 ± 0.038
3.958ProGly: 3.958 ± 0.067
1.177ProHis: 1.177 ± 0.029
1.827ProIle: 1.827 ± 0.043
1.494ProLys: 1.494 ± 0.037
5.576ProLeu: 5.576 ± 0.079
0.949ProMet: 0.949 ± 0.028
1.358ProAsn: 1.358 ± 0.03
2.338ProPro: 2.338 ± 0.06
2.398ProGln: 2.398 ± 0.047
2.479ProArg: 2.479 ± 0.05
2.416ProSer: 2.416 ± 0.044
3.101ProThr: 3.101 ± 0.123
4.269ProVal: 4.269 ± 0.066
0.761ProTrp: 0.761 ± 0.024
1.292ProTyr: 1.292 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
5.932GlnAla: 5.932 ± 0.083
0.331GlnCys: 0.331 ± 0.017
1.878GlnAsp: 1.878 ± 0.036
1.643GlnGlu: 1.643 ± 0.034
1.46GlnPhe: 1.46 ± 0.037
3.271GlnGly: 3.271 ± 0.05
1.32GlnHis: 1.32 ± 0.031
2.175GlnIle: 2.175 ± 0.041
1.288GlnLys: 1.288 ± 0.029
5.917GlnLeu: 5.917 ± 0.075
0.997GlnMet: 0.997 ± 0.028
1.122GlnAsn: 1.122 ± 0.032
2.755GlnPro: 2.755 ± 0.045
3.184GlnGln: 3.184 ± 0.065
3.599GlnArg: 3.599 ± 0.058
2.23GlnSer: 2.23 ± 0.042
2.368GlnThr: 2.368 ± 0.05
3.143GlnVal: 3.143 ± 0.052
0.721GlnTrp: 0.721 ± 0.025
1.173GlnTyr: 1.173 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
6.32ArgAla: 6.32 ± 0.085
0.568ArgCys: 0.568 ± 0.021
3.502ArgAsp: 3.502 ± 0.049
3.512ArgGlu: 3.512 ± 0.057
2.679ArgPhe: 2.679 ± 0.045
3.807ArgGly: 3.807 ± 0.054
1.771ArgHis: 1.771 ± 0.037
3.41ArgIle: 3.41 ± 0.053
2.061ArgLys: 2.061 ± 0.038
7.407ArgLeu: 7.407 ± 0.101
1.573ArgMet: 1.573 ± 0.038
2.011ArgAsn: 2.011 ± 0.043
2.652ArgPro: 2.652 ± 0.049
3.236ArgGln: 3.236 ± 0.052
4.014ArgArg: 4.014 ± 0.065
3.153ArgSer: 3.153 ± 0.056
2.732ArgThr: 2.732 ± 0.048
4.187ArgVal: 4.187 ± 0.059
1.206ArgTrp: 1.206 ± 0.035
2.21ArgTyr: 2.21 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
6.204SerAla: 6.204 ± 0.065
0.491SerCys: 0.491 ± 0.02
2.825SerAsp: 2.825 ± 0.055
2.445SerGlu: 2.445 ± 0.038
1.973SerPhe: 1.973 ± 0.043
5.134SerGly: 5.134 ± 0.079
1.211SerHis: 1.211 ± 0.03
2.366SerIle: 2.366 ± 0.046
1.787SerLys: 1.787 ± 0.035
5.591SerLeu: 5.591 ± 0.066
1.185SerMet: 1.185 ± 0.028
1.762SerAsn: 1.762 ± 0.048
2.648SerPro: 2.648 ± 0.046
2.136SerGln: 2.136 ± 0.042
3.109SerArg: 3.109 ± 0.055
3.342SerSer: 3.342 ± 0.066
3.013SerThr: 3.013 ± 0.068
3.729SerVal: 3.729 ± 0.064
0.848SerTrp: 0.848 ± 0.025
1.653SerTyr: 1.653 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.421ThrAla: 6.421 ± 0.102
0.398ThrCys: 0.398 ± 0.018
2.629ThrAsp: 2.629 ± 0.057
2.236ThrGlu: 2.236 ± 0.045
1.673ThrPhe: 1.673 ± 0.037
4.417ThrGly: 4.417 ± 0.068
1.163ThrHis: 1.163 ± 0.035
2.306ThrIle: 2.306 ± 0.055
1.205ThrLys: 1.205 ± 0.037
6.931ThrLeu: 6.931 ± 0.08
0.977ThrMet: 0.977 ± 0.03
1.331ThrAsn: 1.331 ± 0.039
4.189ThrPro: 4.189 ± 0.118
2.199ThrGln: 2.199 ± 0.05
3.058ThrArg: 3.058 ± 0.046
2.682ThrSer: 2.682 ± 0.06
2.961ThrThr: 2.961 ± 0.078
4.186ThrVal: 4.186 ± 0.069
0.627ThrTrp: 0.627 ± 0.022
1.297ThrTyr: 1.297 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
8.72ValAla: 8.72 ± 0.091
0.697ValCys: 0.697 ± 0.024
3.942ValAsp: 3.942 ± 0.053
3.61ValGlu: 3.61 ± 0.059
2.494ValPhe: 2.494 ± 0.049
4.939ValGly: 4.939 ± 0.063
1.444ValHis: 1.444 ± 0.033
3.437ValIle: 3.437 ± 0.051
2.392ValLys: 2.392 ± 0.049
8.359ValLeu: 8.359 ± 0.107
1.546ValMet: 1.546 ± 0.031
2.209ValAsn: 2.209 ± 0.051
3.629ValPro: 3.629 ± 0.062
2.897ValGln: 2.897 ± 0.048
4.153ValArg: 4.153 ± 0.06
4.002ValSer: 4.002 ± 0.071
3.881ValThr: 3.881 ± 0.075
5.458ValVal: 5.458 ± 0.075
0.989ValTrp: 0.989 ± 0.03
1.732ValTyr: 1.732 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.376TrpAla: 1.376 ± 0.033
0.169TrpCys: 0.169 ± 0.011
0.685TrpAsp: 0.685 ± 0.023
0.52TrpGlu: 0.52 ± 0.019
0.6TrpPhe: 0.6 ± 0.018
0.978TrpGly: 0.978 ± 0.03
0.477TrpHis: 0.477 ± 0.019
0.591TrpIle: 0.591 ± 0.021
0.405TrpLys: 0.405 ± 0.018
2.582TrpLeu: 2.582 ± 0.055
0.309TrpMet: 0.309 ± 0.016
0.491TrpAsn: 0.491 ± 0.019
0.794TrpPro: 0.794 ± 0.027
1.313TrpGln: 1.313 ± 0.034
1.284TrpArg: 1.284 ± 0.037
0.755TrpSer: 0.755 ± 0.024
0.651TrpThr: 0.651 ± 0.026
0.97TrpVal: 0.97 ± 0.029
0.364TrpTrp: 0.364 ± 0.018
0.396TrpTyr: 0.396 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.986TyrAla: 2.986 ± 0.047
0.315TyrCys: 0.315 ± 0.014
1.627TyrAsp: 1.627 ± 0.107
1.124TyrGlu: 1.124 ± 0.031
1.094TyrPhe: 1.094 ± 0.029
2.207TyrGly: 2.207 ± 0.041
0.564TyrHis: 0.564 ± 0.02
0.961TyrIle: 0.961 ± 0.024
0.849TyrLys: 0.849 ± 0.024
2.981TyrLeu: 2.981 ± 0.05
0.479TyrMet: 0.479 ± 0.019
0.944TyrAsn: 0.944 ± 0.041
1.413TyrPro: 1.413 ± 0.032
1.292TyrGln: 1.292 ± 0.032
1.981TyrArg: 1.981 ± 0.037
1.439TyrSer: 1.439 ± 0.04
1.489TyrThr: 1.489 ± 0.041
1.742TyrVal: 1.742 ± 0.037
0.469TyrTrp: 0.469 ± 0.019
0.789TyrTyr: 0.789 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4303 proteins (1369701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski