Amino acid dipepetide frequency for Gemmobacter aquatilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.452AlaAla: 20.452 ± 0.235	1.229AlaCys: 1.229 ± 0.032	7.431AlaAsp: 7.431 ± 0.105	9.238AlaGlu: 9.238 ± 0.108	4.437AlaPhe: 4.437 ± 0.067	11.958AlaGly: 11.958 ± 0.118	2.562AlaHis: 2.562 ± 0.051	5.519AlaIle: 5.519 ± 0.063	4.035AlaLys: 4.035 ± 0.082	16.199AlaLeu: 16.199 ± 0.175	4.018AlaMet: 4.018 ± 0.059	2.61AlaAsn: 2.61 ± 0.055	6.965AlaPro: 6.965 ± 0.107	5.188AlaGln: 5.188 ± 0.074	10.17AlaArg: 10.17 ± 0.116	5.379AlaSer: 5.379 ± 0.068	6.434AlaThr: 6.434 ± 0.084	9.189AlaVal: 9.189 ± 0.101	1.4AlaTrp: 1.4 ± 0.039	2.491AlaTyr: 2.491 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.176CysAla: 1.176 ± 0.037	0.115CysCys: 0.115 ± 0.012	0.625CysAsp: 0.625 ± 0.024	0.424CysGlu: 0.424 ± 0.02	0.343CysPhe: 0.343 ± 0.015	0.993CysGly: 0.993 ± 0.033	0.254CysHis: 0.254 ± 0.015	0.409CysIle: 0.409 ± 0.02	0.189CysLys: 0.189 ± 0.013	0.952CysLeu: 0.952 ± 0.028	0.164CysMet: 0.164 ± 0.013	0.204CysAsn: 0.204 ± 0.013	0.517CysPro: 0.517 ± 0.025	0.238CysGln: 0.238 ± 0.014	0.594CysArg: 0.594 ± 0.022	0.423CysSer: 0.423 ± 0.022	0.51CysThr: 0.51 ± 0.023	0.581CysVal: 0.581 ± 0.023	0.116CysTrp: 0.116 ± 0.01	0.185CysTyr: 0.185 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.08AspAla: 7.08 ± 0.088	0.527AspCys: 0.527 ± 0.021	2.888AspAsp: 2.888 ± 0.064	2.818AspGlu: 2.818 ± 0.058	2.249AspPhe: 2.249 ± 0.049	5.061AspGly: 5.061 ± 0.084	1.358AspHis: 1.358 ± 0.037	2.558AspIle: 2.558 ± 0.047	1.429AspLys: 1.429 ± 0.041	6.894AspLeu: 6.894 ± 0.083	1.484AspMet: 1.484 ± 0.038	1.026AspAsn: 1.026 ± 0.03	3.584AspPro: 3.584 ± 0.06	1.775AspGln: 1.775 ± 0.039	4.258AspArg: 4.258 ± 0.079	2.216AspSer: 2.216 ± 0.054	2.68AspThr: 2.68 ± 0.058	3.769AspVal: 3.769 ± 0.058	1.235AspTrp: 1.235 ± 0.036	1.454AspTyr: 1.454 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.698GluAla: 8.698 ± 0.108	0.337GluCys: 0.337 ± 0.016	2.925GluAsp: 2.925 ± 0.052	2.886GluGlu: 2.886 ± 0.065	1.69GluPhe: 1.69 ± 0.035	4.968GluGly: 4.968 ± 0.067	0.951GluHis: 0.951 ± 0.03	3.235GluIle: 3.235 ± 0.053	1.885GluLys: 1.885 ± 0.042	4.729GluLeu: 4.729 ± 0.069	1.67GluMet: 1.67 ± 0.038	1.388GluAsn: 1.388 ± 0.039	2.47GluPro: 2.47 ± 0.053	1.656GluGln: 1.656 ± 0.038	3.913GluArg: 3.913 ± 0.067	1.971GluSer: 1.971 ± 0.043	3.456GluThr: 3.456 ± 0.052	4.439GluVal: 4.439 ± 0.064	0.624GluTrp: 0.624 ± 0.023	0.957GluTyr: 0.957 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.78PheAla: 4.78 ± 0.073	0.429PheCys: 0.429 ± 0.018	2.657PheAsp: 2.657 ± 0.048	1.879PheGlu: 1.879 ± 0.039	1.307PhePhe: 1.307 ± 0.036	3.779PheGly: 3.779 ± 0.064	0.763PheHis: 0.763 ± 0.024	1.514PheIle: 1.514 ± 0.04	0.878PheLys: 0.878 ± 0.028	3.476PheLeu: 3.476 ± 0.064	0.718PheMet: 0.718 ± 0.025	0.983PheAsn: 0.983 ± 0.034	1.582PhePro: 1.582 ± 0.042	0.964PheGln: 0.964 ± 0.03	2.299PheArg: 2.299 ± 0.042	1.948PheSer: 1.948 ± 0.041	2.205PheThr: 2.205 ± 0.042	2.5PheVal: 2.5 ± 0.041	0.512PheTrp: 0.512 ± 0.023	0.832PheTyr: 0.832 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.279GlyAla: 11.279 ± 0.12	0.868GlyCys: 0.868 ± 0.028	4.609GlyAsp: 4.609 ± 0.088	4.491GlyGlu: 4.491 ± 0.065	3.825GlyPhe: 3.825 ± 0.063	8.24GlyGly: 8.24 ± 0.152	1.935GlyHis: 1.935 ± 0.036	4.339GlyIle: 4.339 ± 0.064	3.173GlyLys: 3.173 ± 0.055	9.956GlyLeu: 9.956 ± 0.116	2.627GlyMet: 2.627 ± 0.047	2.166GlyAsn: 2.166 ± 0.069	3.94GlyPro: 3.94 ± 0.059	3.406GlyGln: 3.406 ± 0.06	6.203GlyArg: 6.203 ± 0.085	4.122GlySer: 4.122 ± 0.067	4.72GlyThr: 4.72 ± 0.068	6.654GlyVal: 6.654 ± 0.082	1.701GlyTrp: 1.701 ± 0.039	2.238GlyTyr: 2.238 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.483HisAla: 2.483 ± 0.045	0.232HisCys: 0.232 ± 0.013	1.23HisAsp: 1.23 ± 0.03	0.978HisGlu: 0.978 ± 0.029	0.812HisPhe: 0.812 ± 0.027	1.943HisGly: 1.943 ± 0.045	0.542HisHis: 0.542 ± 0.025	0.905HisIle: 0.905 ± 0.029	0.46HisLys: 0.46 ± 0.019	2.395HisLeu: 2.395 ± 0.055	0.524HisMet: 0.524 ± 0.022	0.422HisAsn: 0.422 ± 0.019	1.517HisPro: 1.517 ± 0.039	0.561HisGln: 0.561 ± 0.02	1.447HisArg: 1.447 ± 0.037	0.895HisSer: 0.895 ± 0.029	0.772HisThr: 0.772 ± 0.025	1.526HisVal: 1.526 ± 0.034	0.374HisTrp: 0.374 ± 0.017	0.54HisTyr: 0.54 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.127IleAla: 7.127 ± 0.082	0.64IleCys: 0.64 ± 0.023	3.121IleAsp: 3.121 ± 0.053	3.06IleGlu: 3.06 ± 0.046	1.58IlePhe: 1.58 ± 0.04	4.732IleGly: 4.732 ± 0.077	1.006IleHis: 1.006 ± 0.03	1.876IleIle: 1.876 ± 0.046	1.186IleLys: 1.186 ± 0.036	4.553IleLeu: 4.553 ± 0.07	0.904IleMet: 0.904 ± 0.031	1.205IleAsn: 1.205 ± 0.036	2.21IlePro: 2.21 ± 0.044	0.967IleGln: 0.967 ± 0.029	3.257IleArg: 3.257 ± 0.059	2.593IleSer: 2.593 ± 0.052	2.886IleThr: 2.886 ± 0.052	3.37IleVal: 3.37 ± 0.06	0.704IleTrp: 0.704 ± 0.026	1.073IleTyr: 1.073 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.056LysAla: 4.056 ± 0.065	0.173LysCys: 0.173 ± 0.012	1.54LysAsp: 1.54 ± 0.041	1.331LysGlu: 1.331 ± 0.036	0.824LysPhe: 0.824 ± 0.027	2.887LysGly: 2.887 ± 0.049	0.552LysHis: 0.552 ± 0.021	1.541LysIle: 1.541 ± 0.038	1.051LysLys: 1.051 ± 0.039	3.01LysLeu: 3.01 ± 0.057	0.803LysMet: 0.803 ± 0.026	0.676LysAsn: 0.676 ± 0.023	1.868LysPro: 1.868 ± 0.046	0.828LysGln: 0.828 ± 0.029	2.019LysArg: 2.019 ± 0.044	1.519LysSer: 1.519 ± 0.035	1.742LysThr: 1.742 ± 0.045	2.272LysVal: 2.272 ± 0.047	0.346LysTrp: 0.346 ± 0.017	0.567LysTyr: 0.567 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.843LeuAla: 15.843 ± 0.161	1.069LeuCys: 1.069 ± 0.034	5.851LeuAsp: 5.851 ± 0.083	4.972LeuGlu: 4.972 ± 0.073	3.479LeuPhe: 3.479 ± 0.063	9.184LeuGly: 9.184 ± 0.107	2.144LeuHis: 2.144 ± 0.043	5.313LeuIle: 5.313 ± 0.078	3.121LeuLys: 3.121 ± 0.053	9.85LeuLeu: 9.85 ± 0.129	2.706LeuMet: 2.706 ± 0.056	2.471LeuAsn: 2.471 ± 0.046	6.545LeuPro: 6.545 ± 0.096	2.922LeuGln: 2.922 ± 0.054	8.005LeuArg: 8.005 ± 0.111	6.1LeuSer: 6.1 ± 0.074	6.208LeuThr: 6.208 ± 0.068	7.197LeuVal: 7.197 ± 0.1	1.406LeuTrp: 1.406 ± 0.032	1.934LeuTyr: 1.934 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.676MetAla: 3.676 ± 0.065	0.164MetCys: 0.164 ± 0.012	1.316MetAsp: 1.316 ± 0.03	1.358MetGlu: 1.358 ± 0.035	0.733MetPhe: 0.733 ± 0.025	2.392MetGly: 2.392 ± 0.054	0.394MetHis: 0.394 ± 0.018	1.451MetIle: 1.451 ± 0.035	1.002MetLys: 1.002 ± 0.028	2.508MetLeu: 2.508 ± 0.048	0.73MetMet: 0.73 ± 0.028	0.773MetAsn: 0.773 ± 0.027	1.479MetPro: 1.479 ± 0.039	0.977MetGln: 0.977 ± 0.025	1.831MetArg: 1.831 ± 0.043	1.434MetSer: 1.434 ± 0.035	2.027MetThr: 2.027 ± 0.044	1.871MetVal: 1.871 ± 0.043	0.233MetTrp: 0.233 ± 0.013	0.316MetTyr: 0.316 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.831AsnAla: 2.831 ± 0.051	0.25AsnCys: 0.25 ± 0.014	1.396AsnAsp: 1.396 ± 0.059	0.947AsnGlu: 0.947 ± 0.031	0.854AsnPhe: 0.854 ± 0.031	2.255AsnGly: 2.255 ± 0.054	0.46AsnHis: 0.46 ± 0.021	1.221AsnIle: 1.221 ± 0.032	0.542AsnLys: 0.542 ± 0.025	2.409AsnLeu: 2.409 ± 0.048	0.618AsnMet: 0.618 ± 0.024	0.52AsnAsn: 0.52 ± 0.021	1.783AsnPro: 1.783 ± 0.046	0.569AsnGln: 0.569 ± 0.023	1.662AsnArg: 1.662 ± 0.033	0.984AsnSer: 0.984 ± 0.03	1.209AsnThr: 1.209 ± 0.039	1.607AsnVal: 1.607 ± 0.04	0.398AsnTrp: 0.398 ± 0.019	0.545AsnTyr: 0.545 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.947ProAla: 6.947 ± 0.102	0.397ProCys: 0.397 ± 0.018	3.85ProAsp: 3.85 ± 0.067	4.285ProGlu: 4.285 ± 0.069	2.013ProPhe: 2.013 ± 0.041	5.171ProGly: 5.171 ± 0.073	1.14ProHis: 1.14 ± 0.031	2.016ProIle: 2.016 ± 0.04	1.668ProLys: 1.668 ± 0.039	5.274ProLeu: 5.274 ± 0.083	1.39ProMet: 1.39 ± 0.039	1.162ProAsn: 1.162 ± 0.033	2.709ProPro: 2.709 ± 0.063	1.892ProGln: 1.892 ± 0.046	3.036ProArg: 3.036 ± 0.06	2.118ProSer: 2.118 ± 0.047	2.4ProThr: 2.4 ± 0.046	4.679ProVal: 4.679 ± 0.064	0.721ProTrp: 0.721 ± 0.024	1.114ProTyr: 1.114 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.582GlnAla: 4.582 ± 0.064	0.194GlnCys: 0.194 ± 0.012	1.595GlnAsp: 1.595 ± 0.039	1.375GlnGlu: 1.375 ± 0.038	1.034GlnPhe: 1.034 ± 0.028	3.053GlnGly: 3.053 ± 0.051	0.603GlnHis: 0.603 ± 0.023	2.073GlnIle: 2.073 ± 0.044	0.988GlnLys: 0.988 ± 0.031	2.683GlnLeu: 2.683 ± 0.056	1.043GlnMet: 1.043 ± 0.03	0.823GlnAsn: 0.823 ± 0.025	1.825GlnPro: 1.825 ± 0.044	1.02GlnGln: 1.02 ± 0.033	2.309GlnArg: 2.309 ± 0.053	1.528GlnSer: 1.528 ± 0.036	1.685GlnThr: 1.685 ± 0.038	2.531GlnVal: 2.531 ± 0.052	0.401GlnTrp: 0.401 ± 0.02	0.532GlnTyr: 0.532 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.462ArgAla: 9.462 ± 0.11	0.527ArgCys: 0.527 ± 0.021	4.028ArgAsp: 4.028 ± 0.071	3.54ArgGlu: 3.54 ± 0.063	2.845ArgPhe: 2.845 ± 0.05	4.945ArgGly: 4.945 ± 0.065	1.704ArgHis: 1.704 ± 0.04	3.885ArgIle: 3.885 ± 0.066	2.125ArgLys: 2.125 ± 0.05	8.43ArgLeu: 8.43 ± 0.12	2.022ArgMet: 2.022 ± 0.039	1.64ArgAsn: 1.64 ± 0.038	3.577ArgPro: 3.577 ± 0.062	2.366ArgGln: 2.366 ± 0.049	5.183ArgArg: 5.183 ± 0.084	3.067ArgSer: 3.067 ± 0.055	2.689ArgThr: 2.689 ± 0.049	4.88ArgVal: 4.88 ± 0.062	1.009ArgTrp: 1.009 ± 0.033	1.496ArgTyr: 1.496 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.668SerAla: 5.668 ± 0.073	0.391SerCys: 0.391 ± 0.018	2.73SerAsp: 2.73 ± 0.051	2.199SerGlu: 2.199 ± 0.041	2.065SerPhe: 2.065 ± 0.042	5.245SerGly: 5.245 ± 0.093	0.993SerHis: 0.993 ± 0.03	2.063SerIle: 2.063 ± 0.044	1.255SerLys: 1.255 ± 0.035	4.854SerLeu: 4.854 ± 0.075	1.081SerMet: 1.081 ± 0.031	1.044SerAsn: 1.044 ± 0.034	2.49SerPro: 2.49 ± 0.045	1.361SerGln: 1.361 ± 0.043	3.097SerArg: 3.097 ± 0.055	2.15SerSer: 2.15 ± 0.045	2.258SerThr: 2.258 ± 0.043	3.395SerVal: 3.395 ± 0.055	0.62SerTrp: 0.62 ± 0.023	1.202SerTyr: 1.202 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.75ThrAla: 6.75 ± 0.085	0.486ThrCys: 0.486 ± 0.023	2.845ThrAsp: 2.845 ± 0.047	2.908ThrGlu: 2.908 ± 0.052	1.9ThrPhe: 1.9 ± 0.041	5.396ThrGly: 5.396 ± 0.075	1.13ThrHis: 1.13 ± 0.032	2.446ThrIle: 2.446 ± 0.047	1.281ThrLys: 1.281 ± 0.034	6.295ThrLeu: 6.295 ± 0.074	1.161ThrMet: 1.161 ± 0.033	1.116ThrAsn: 1.116 ± 0.027	3.545ThrPro: 3.545 ± 0.054	1.492ThrGln: 1.492 ± 0.035	3.506ThrArg: 3.506 ± 0.06	2.247ThrSer: 2.247 ± 0.049	2.787ThrThr: 2.787 ± 0.055	4.133ThrVal: 4.133 ± 0.061	0.631ThrTrp: 0.631 ± 0.024	1.162ThrTyr: 1.162 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.907ValAla: 9.907 ± 0.117	0.608ValCys: 0.608 ± 0.022	3.578ValAsp: 3.578 ± 0.062	4.366ValGlu: 4.366 ± 0.065	2.675ValPhe: 2.675 ± 0.05	5.125ValGly: 5.125 ± 0.082	1.21ValHis: 1.21 ± 0.031	4.182ValIle: 4.182 ± 0.055	2.33ValLys: 2.33 ± 0.053	7.911ValLeu: 7.911 ± 0.088	2.149ValMet: 2.149 ± 0.042	1.914ValAsn: 1.914 ± 0.046	3.619ValPro: 3.619 ± 0.058	2.38ValGln: 2.38 ± 0.045	3.961ValArg: 3.961 ± 0.063	3.732ValSer: 3.732 ± 0.056	4.788ValThr: 4.788 ± 0.066	5.692ValVal: 5.692 ± 0.088	1.075ValTrp: 1.075 ± 0.032	1.393ValTyr: 1.393 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.55TrpAla: 1.55 ± 0.036	0.144TrpCys: 0.144 ± 0.012	0.657TrpAsp: 0.657 ± 0.025	0.645TrpGlu: 0.645 ± 0.028	0.531TrpPhe: 0.531 ± 0.02	1.099TrpGly: 1.099 ± 0.031	0.363TrpHis: 0.363 ± 0.019	0.654TrpIle: 0.654 ± 0.024	0.463TrpLys: 0.463 ± 0.02	1.766TrpLeu: 1.766 ± 0.041	0.393TrpMet: 0.393 ± 0.018	0.407TrpAsn: 0.407 ± 0.02	0.72TrpPro: 0.72 ± 0.023	0.671TrpGln: 0.671 ± 0.027	1.142TrpArg: 1.142 ± 0.03	0.731TrpSer: 0.731 ± 0.025	0.689TrpThr: 0.689 ± 0.026	0.92TrpVal: 0.92 ± 0.028	0.214TrpTrp: 0.214 ± 0.013	0.289TrpTyr: 0.289 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.556TyrAla: 2.556 ± 0.05	0.231TyrCys: 0.231 ± 0.013	1.471TyrAsp: 1.471 ± 0.039	1.147TyrGlu: 1.147 ± 0.034	0.813TyrPhe: 0.813 ± 0.025	2.065TyrGly: 2.065 ± 0.046	0.494TyrHis: 0.494 ± 0.022	0.852TyrIle: 0.852 ± 0.026	0.546TyrLys: 0.546 ± 0.026	2.173TyrLeu: 2.173 ± 0.044	0.459TyrMet: 0.459 ± 0.025	0.509TyrAsn: 0.509 ± 0.022	1.041TyrPro: 1.041 ± 0.027	0.643TyrGln: 0.643 ± 0.025	1.527TyrArg: 1.527 ± 0.037	1.003TyrSer: 1.003 ± 0.031	1.073TyrThr: 1.073 ± 0.029	1.39TyrVal: 1.39 ± 0.033	0.328TyrTrp: 0.328 ± 0.016	0.514TyrTyr: 0.514 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3845 proteins (1190717 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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