Amino acid dipepetide frequency for Sulfurovum sp. bin170

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.005AlaAla: 2.005 ± 0.081
0.687AlaCys: 0.687 ± 0.043
3.213AlaAsp: 3.213 ± 0.08
3.257AlaGlu: 3.257 ± 0.086
2.912AlaPhe: 2.912 ± 0.071
3.755AlaGly: 3.755 ± 0.087
1.156AlaHis: 1.156 ± 0.046
5.733AlaIle: 5.733 ± 0.101
5.758AlaLys: 5.758 ± 0.09
6.644AlaLeu: 6.644 ± 0.118
2.039AlaMet: 2.039 ± 0.069
3.142AlaAsn: 3.142 ± 0.077
1.794AlaPro: 1.794 ± 0.061
1.71AlaGln: 1.71 ± 0.05
2.113AlaArg: 2.113 ± 0.066
4.085AlaSer: 4.085 ± 0.091
3.896AlaThr: 3.896 ± 0.092
3.912AlaVal: 3.912 ± 0.093
0.472AlaTrp: 0.472 ± 0.032
2.405AlaTyr: 2.405 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.473CysAla: 0.473 ± 0.031
0.076CysCys: 0.076 ± 0.011
0.593CysAsp: 0.593 ± 0.033
0.622CysGlu: 0.622 ± 0.032
0.307CysPhe: 0.307 ± 0.024
0.771CysGly: 0.771 ± 0.035
0.273CysHis: 0.273 ± 0.026
0.465CysIle: 0.465 ± 0.028
0.583CysLys: 0.583 ± 0.031
0.472CysLeu: 0.472 ± 0.032
0.192CysMet: 0.192 ± 0.017
0.4CysAsn: 0.4 ± 0.026
0.366CysPro: 0.366 ± 0.03
0.287CysGln: 0.287 ± 0.022
0.34CysArg: 0.34 ± 0.024
0.683CysSer: 0.683 ± 0.036
0.416CysThr: 0.416 ± 0.024
0.422CysVal: 0.422 ± 0.025
0.067CysTrp: 0.067 ± 0.01
0.329CysTyr: 0.329 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.662AspAla: 3.662 ± 0.081
0.45AspCys: 0.45 ± 0.026
3.649AspAsp: 3.649 ± 0.091
5.457AspGlu: 5.457 ± 0.105
3.019AspPhe: 3.019 ± 0.07
4.262AspGly: 4.262 ± 0.096
0.694AspHis: 0.694 ± 0.029
6.289AspIle: 6.289 ± 0.125
5.159AspLys: 5.159 ± 0.098
4.296AspLeu: 4.296 ± 0.1
1.884AspMet: 1.884 ± 0.053
3.209AspAsn: 3.209 ± 0.079
1.339AspPro: 1.339 ± 0.048
0.794AspGln: 0.794 ± 0.034
2.968AspArg: 2.968 ± 0.08
4.29AspSer: 4.29 ± 0.102
3.179AspThr: 3.179 ± 0.077
3.057AspVal: 3.057 ± 0.069
0.5AspTrp: 0.5 ± 0.033
2.467AspTyr: 2.467 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
4.593GluAla: 4.593 ± 0.097
0.574GluCys: 0.574 ± 0.032
4.217GluAsp: 4.217 ± 0.084
5.636GluGlu: 5.636 ± 0.11
3.201GluPhe: 3.201 ± 0.077
3.859GluGly: 3.859 ± 0.087
1.376GluHis: 1.376 ± 0.051
6.438GluIle: 6.438 ± 0.112
6.241GluLys: 6.241 ± 0.117
7.468GluLeu: 7.468 ± 0.123
1.905GluMet: 1.905 ± 0.049
4.185GluAsn: 4.185 ± 0.084
1.778GluPro: 1.778 ± 0.058
2.509GluGln: 2.509 ± 0.067
2.979GluArg: 2.979 ± 0.075
4.836GluSer: 4.836 ± 0.096
3.223GluThr: 3.223 ± 0.079
4.52GluVal: 4.52 ± 0.097
0.618GluTrp: 0.618 ± 0.031
3.128GluTyr: 3.128 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
2.939PheAla: 2.939 ± 0.08
0.366PheCys: 0.366 ± 0.022
3.39PheAsp: 3.39 ± 0.076
3.331PheGlu: 3.331 ± 0.074
2.32PhePhe: 2.32 ± 0.073
3.251PheGly: 3.251 ± 0.082
0.726PheHis: 0.726 ± 0.034
3.989PheIle: 3.989 ± 0.093
3.224PheLys: 3.224 ± 0.074
4.27PheLeu: 4.27 ± 0.11
1.198PheMet: 1.198 ± 0.046
2.414PheAsn: 2.414 ± 0.063
1.254PhePro: 1.254 ± 0.047
1.103PheGln: 1.103 ± 0.041
1.803PheArg: 1.803 ± 0.057
3.767PheSer: 3.767 ± 0.076
2.452PheThr: 2.452 ± 0.062
3.068PheVal: 3.068 ± 0.077
0.408PheTrp: 0.408 ± 0.027
1.91PheTyr: 1.91 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
4.241GlyAla: 4.241 ± 0.113
0.788GlyCys: 0.788 ± 0.034
3.691GlyAsp: 3.691 ± 0.092
4.601GlyGlu: 4.601 ± 0.106
3.175GlyPhe: 3.175 ± 0.072
4.253GlyGly: 4.253 ± 0.111
1.215GlyHis: 1.215 ± 0.051
4.919GlyIle: 4.919 ± 0.092
4.754GlyLys: 4.754 ± 0.088
5.393GlyLeu: 5.393 ± 0.094
1.736GlyMet: 1.736 ± 0.057
2.452GlyAsn: 2.452 ± 0.066
0.746GlyPro: 0.746 ± 0.038
1.496GlyGln: 1.496 ± 0.05
2.427GlyArg: 2.427 ± 0.073
3.988GlySer: 3.988 ± 0.091
3.192GlyThr: 3.192 ± 0.083
4.815GlyVal: 4.815 ± 0.089
0.619GlyTrp: 0.619 ± 0.036
2.838GlyTyr: 2.838 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
0.985HisAla: 0.985 ± 0.046
0.186HisCys: 0.186 ± 0.017
0.849HisAsp: 0.849 ± 0.04
0.974HisGlu: 0.974 ± 0.036
0.929HisPhe: 0.929 ± 0.041
1.145HisGly: 1.145 ± 0.042
0.486HisHis: 0.486 ± 0.03
1.697HisIle: 1.697 ± 0.061
1.358HisLys: 1.358 ± 0.039
1.733HisLeu: 1.733 ± 0.046
0.424HisMet: 0.424 ± 0.03
0.917HisAsn: 0.917 ± 0.042
0.85HisPro: 0.85 ± 0.038
0.714HisGln: 0.714 ± 0.041
0.78HisArg: 0.78 ± 0.035
1.244HisSer: 1.244 ± 0.043
1.012HisThr: 1.012 ± 0.041
0.67HisVal: 0.67 ± 0.034
0.182HisTrp: 0.182 ± 0.02
0.867HisTyr: 0.867 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.958IleAla: 5.958 ± 0.089
0.653IleCys: 0.653 ± 0.033
6.546IleAsp: 6.546 ± 0.098
7.814IleGlu: 7.814 ± 0.123
4.002IlePhe: 4.002 ± 0.089
5.522IleGly: 5.522 ± 0.105
1.339IleHis: 1.339 ± 0.048
6.511IleIle: 6.511 ± 0.127
6.857IleLys: 6.857 ± 0.117
7.873IleLeu: 7.873 ± 0.143
1.736IleMet: 1.736 ± 0.058
4.064IleAsn: 4.064 ± 0.075
2.867IlePro: 2.867 ± 0.072
2.056IleGln: 2.056 ± 0.06
2.858IleArg: 2.858 ± 0.064
6.189IleSer: 6.189 ± 0.108
4.652IleThr: 4.652 ± 0.098
5.53IleVal: 5.53 ± 0.113
0.664IleTrp: 0.664 ± 0.038
3.33IleTyr: 3.33 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
4.874LysAla: 4.874 ± 0.093
0.438LysCys: 0.438 ± 0.027
4.705LysAsp: 4.705 ± 0.084
7.612LysGlu: 7.612 ± 0.144
3.049LysPhe: 3.049 ± 0.077
4.056LysGly: 4.056 ± 0.087
1.311LysHis: 1.311 ± 0.048
7.262LysIle: 7.262 ± 0.112
7.822LysLys: 7.822 ± 0.164
7.496LysLeu: 7.496 ± 0.12
2.056LysMet: 2.056 ± 0.057
4.728LysAsn: 4.728 ± 0.087
2.358LysPro: 2.358 ± 0.067
2.371LysGln: 2.371 ± 0.066
3.769LysArg: 3.769 ± 0.08
5.774LysSer: 5.774 ± 0.113
4.025LysThr: 4.025 ± 0.08
4.77LysVal: 4.77 ± 0.084
0.583LysTrp: 0.583 ± 0.03
3.091LysTyr: 3.091 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
6.037LeuAla: 6.037 ± 0.106
0.619LeuCys: 0.619 ± 0.03
5.78LeuAsp: 5.78 ± 0.103
6.776LeuGlu: 6.776 ± 0.124
5.11LeuPhe: 5.11 ± 0.123
5.539LeuGly: 5.539 ± 0.104
1.665LeuHis: 1.665 ± 0.045
7.182LeuIle: 7.182 ± 0.125
8.289LeuLys: 8.289 ± 0.121
9.451LeuLeu: 9.451 ± 0.185
2.296LeuMet: 2.296 ± 0.07
4.822LeuAsn: 4.822 ± 0.082
3.153LeuPro: 3.153 ± 0.071
2.757LeuGln: 2.757 ± 0.072
3.203LeuArg: 3.203 ± 0.072
7.164LeuSer: 7.164 ± 0.118
4.922LeuThr: 4.922 ± 0.093
4.976LeuVal: 4.976 ± 0.092
0.735LeuTrp: 0.735 ± 0.041
3.761LeuTyr: 3.761 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.814MetAla: 1.814 ± 0.066
0.132MetCys: 0.132 ± 0.016
1.435MetAsp: 1.435 ± 0.049
1.652MetGlu: 1.652 ± 0.049
1.066MetPhe: 1.066 ± 0.046
1.918MetGly: 1.918 ± 0.062
0.438MetHis: 0.438 ± 0.025
2.155MetIle: 2.155 ± 0.057
2.203MetLys: 2.203 ± 0.06
2.506MetLeu: 2.506 ± 0.065
0.884MetMet: 0.884 ± 0.043
1.235MetAsn: 1.235 ± 0.039
1.021MetPro: 1.021 ± 0.04
0.943MetGln: 0.943 ± 0.04
1.206MetArg: 1.206 ± 0.042
1.825MetSer: 1.825 ± 0.053
1.227MetThr: 1.227 ± 0.05
1.749MetVal: 1.749 ± 0.053
0.168MetTrp: 0.168 ± 0.014
0.588MetTyr: 0.588 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.653AsnAla: 2.653 ± 0.063
0.358AsnCys: 0.358 ± 0.022
2.428AsnAsp: 2.428 ± 0.069
3.016AsnGlu: 3.016 ± 0.074
2.501AsnPhe: 2.501 ± 0.062
3.203AsnGly: 3.203 ± 0.083
1.019AsnHis: 1.019 ± 0.044
5.525AsnIle: 5.525 ± 0.103
3.004AsnLys: 3.004 ± 0.072
4.995AsnLeu: 4.995 ± 0.088
1.212AsnMet: 1.212 ± 0.04
2.501AsnAsn: 2.501 ± 0.078
2.129AsnPro: 2.129 ± 0.067
1.797AsnGln: 1.797 ± 0.059
3.01AsnArg: 3.01 ± 0.075
4.506AsnSer: 4.506 ± 0.102
2.076AsnThr: 2.076 ± 0.054
2.123AsnVal: 2.123 ± 0.069
0.399AsnTrp: 0.399 ± 0.024
2.217AsnTyr: 2.217 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.507ProAla: 1.507 ± 0.057
0.214ProCys: 0.214 ± 0.018
1.6ProAsp: 1.6 ± 0.051
1.791ProGlu: 1.791 ± 0.055
1.682ProPhe: 1.682 ± 0.058
0.943ProGly: 0.943 ± 0.043
0.642ProHis: 0.642 ± 0.031
2.905ProIle: 2.905 ± 0.072
2.875ProLys: 2.875 ± 0.073
2.954ProLeu: 2.954 ± 0.068
0.818ProMet: 0.818 ± 0.034
1.784ProAsn: 1.784 ± 0.048
0.78ProPro: 0.78 ± 0.042
0.928ProGln: 0.928 ± 0.042
0.985ProArg: 0.985 ± 0.039
2.132ProSer: 2.132 ± 0.054
2.2ProThr: 2.2 ± 0.072
1.71ProVal: 1.71 ± 0.058
0.267ProTrp: 0.267 ± 0.02
1.272ProTyr: 1.272 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.665GlnAla: 1.665 ± 0.051
0.178GlnCys: 0.178 ± 0.017
1.387GlnAsp: 1.387 ± 0.052
2.23GlnGlu: 2.23 ± 0.064
1.203GlnPhe: 1.203 ± 0.042
1.522GlnGly: 1.522 ± 0.058
0.489GlnHis: 0.489 ± 0.027
2.36GlnIle: 2.36 ± 0.06
3.17GlnLys: 3.17 ± 0.071
2.497GlnLeu: 2.497 ± 0.065
0.757GlnMet: 0.757 ± 0.034
1.932GlnAsn: 1.932 ± 0.066
0.816GlnPro: 0.816 ± 0.04
0.993GlnGln: 0.993 ± 0.044
1.223GlnArg: 1.223 ± 0.043
1.938GlnSer: 1.938 ± 0.059
1.508GlnThr: 1.508 ± 0.056
1.474GlnVal: 1.474 ± 0.056
0.241GlnTrp: 0.241 ± 0.021
1.06GlnTyr: 1.06 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.579ArgAla: 2.579 ± 0.074
0.377ArgCys: 0.377 ± 0.025
2.964ArgAsp: 2.964 ± 0.077
3.693ArgGlu: 3.693 ± 0.083
2.023ArgPhe: 2.023 ± 0.052
2.551ArgGly: 2.551 ± 0.072
0.726ArgHis: 0.726 ± 0.033
2.737ArgIle: 2.737 ± 0.07
2.736ArgLys: 2.736 ± 0.06
3.749ArgLeu: 3.749 ± 0.084
0.974ArgMet: 0.974 ± 0.039
1.628ArgAsn: 1.628 ± 0.052
1.085ArgPro: 1.085 ± 0.045
1.072ArgGln: 1.072 ± 0.043
1.682ArgArg: 1.682 ± 0.061
1.936ArgSer: 1.936 ± 0.06
1.718ArgThr: 1.718 ± 0.046
3.533ArgVal: 3.533 ± 0.089
0.382ArgTrp: 0.382 ± 0.025
1.899ArgTyr: 1.899 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.152SerAla: 4.152 ± 0.079
0.684SerCys: 0.684 ± 0.035
4.103SerAsp: 4.103 ± 0.085
4.059SerGlu: 4.059 ± 0.08
3.93SerPhe: 3.93 ± 0.095
4.49SerGly: 4.49 ± 0.096
1.241SerHis: 1.241 ± 0.048
6.225SerIle: 6.225 ± 0.109
5.764SerLys: 5.764 ± 0.102
6.751SerLeu: 6.751 ± 0.127
1.898SerMet: 1.898 ± 0.057
3.525SerAsn: 3.525 ± 0.082
1.854SerPro: 1.854 ± 0.05
2.178SerGln: 2.178 ± 0.06
2.622SerArg: 2.622 ± 0.071
5.712SerSer: 5.712 ± 0.119
3.721SerThr: 3.721 ± 0.078
4.124SerVal: 4.124 ± 0.076
0.641SerTrp: 0.641 ± 0.031
3.018SerTyr: 3.018 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
3.353ThrAla: 3.353 ± 0.075
0.341ThrCys: 0.341 ± 0.021
2.867ThrAsp: 2.867 ± 0.076
2.822ThrGlu: 2.822 ± 0.068
2.022ThrPhe: 2.022 ± 0.057
3.111ThrGly: 3.111 ± 0.096
1.139ThrHis: 1.139 ± 0.044
5.572ThrIle: 5.572 ± 0.098
4.276ThrLys: 4.276 ± 0.092
5.735ThrLeu: 5.735 ± 0.109
1.199ThrMet: 1.199 ± 0.042
2.405ThrAsn: 2.405 ± 0.065
2.441ThrPro: 2.441 ± 0.073
1.769ThrGln: 1.769 ± 0.057
1.601ThrArg: 1.601 ± 0.047
2.987ThrSer: 2.987 ± 0.067
3.459ThrThr: 3.459 ± 0.093
3.383ThrVal: 3.383 ± 0.072
0.304ThrTrp: 0.304 ± 0.026
1.851ThrTyr: 1.851 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
4.439ValAla: 4.439 ± 0.084
0.61ValCys: 0.61 ± 0.032
4.135ValAsp: 4.135 ± 0.086
4.874ValGlu: 4.874 ± 0.097
2.258ValPhe: 2.258 ± 0.057
4.107ValGly: 4.107 ± 0.09
0.976ValHis: 0.976 ± 0.034
4.852ValIle: 4.852 ± 0.092
4.478ValLys: 4.478 ± 0.095
5.17ValLeu: 5.17 ± 0.095
1.626ValMet: 1.626 ± 0.05
2.774ValAsn: 2.774 ± 0.068
1.901ValPro: 1.901 ± 0.054
1.468ValGln: 1.468 ± 0.046
1.992ValArg: 1.992 ± 0.055
4.065ValSer: 4.065 ± 0.068
3.477ValThr: 3.477 ± 0.078
4.323ValVal: 4.323 ± 0.108
0.478ValTrp: 0.478 ± 0.037
2.076ValTyr: 2.076 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.458TrpAla: 0.458 ± 0.03
0.056TrpCys: 0.056 ± 0.01
0.493TrpAsp: 0.493 ± 0.031
0.514TrpGlu: 0.514 ± 0.032
0.434TrpPhe: 0.434 ± 0.028
0.582TrpGly: 0.582 ± 0.03
0.185TrpHis: 0.185 ± 0.018
0.762TrpIle: 0.762 ± 0.035
0.47TrpLys: 0.47 ± 0.029
0.836TrpLeu: 0.836 ± 0.038
0.293TrpMet: 0.293 ± 0.024
0.411TrpAsn: 0.411 ± 0.029
0.081TrpPro: 0.081 ± 0.012
0.267TrpGln: 0.267 ± 0.024
0.383TrpArg: 0.383 ± 0.026
0.597TrpSer: 0.597 ± 0.034
0.352TrpThr: 0.352 ± 0.024
0.515TrpVal: 0.515 ± 0.031
0.078TrpTrp: 0.078 ± 0.011
0.4TrpTyr: 0.4 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.303TyrAla: 2.303 ± 0.062
0.349TyrCys: 0.349 ± 0.025
2.579TyrAsp: 2.579 ± 0.072
2.552TyrGlu: 2.552 ± 0.056
2.04TyrPhe: 2.04 ± 0.067
2.497TyrGly: 2.497 ± 0.067
0.908TyrHis: 0.908 ± 0.037
3.443TyrIle: 3.443 ± 0.08
3.127TyrLys: 3.127 ± 0.076
3.949TyrLeu: 3.949 ± 0.081
1.035TyrMet: 1.035 ± 0.039
2.144TyrAsn: 2.144 ± 0.076
1.376TyrPro: 1.376 ± 0.043
1.429TyrGln: 1.429 ± 0.04
2.098TyrArg: 2.098 ± 0.063
2.976TyrSer: 2.976 ± 0.08
1.932TyrThr: 1.932 ± 0.057
1.407TyrVal: 1.407 ± 0.047
0.365TyrTrp: 0.365 ± 0.024
1.735TyrTyr: 1.735 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2107 proteins (644486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski