Amino acid dipepetide frequency for Candidatus Phycorickettsia trachydisci

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.907AlaAla: 5.907 ± 0.215
0.791AlaCys: 0.791 ± 0.043
3.563AlaAsp: 3.563 ± 0.105
3.861AlaGlu: 3.861 ± 0.125
2.634AlaPhe: 2.634 ± 0.093
3.778AlaGly: 3.778 ± 0.129
1.166AlaHis: 1.166 ± 0.057
5.749AlaIle: 5.749 ± 0.139
5.767AlaLys: 5.767 ± 0.139
7.148AlaLeu: 7.148 ± 0.147
1.544AlaMet: 1.544 ± 0.063
3.527AlaAsn: 3.527 ± 0.105
1.96AlaPro: 1.96 ± 0.099
2.688AlaGln: 2.688 ± 0.099
2.778AlaArg: 2.778 ± 0.104
4.711AlaSer: 4.711 ± 0.135
3.389AlaThr: 3.389 ± 0.119
3.687AlaVal: 3.687 ± 0.095
0.459AlaTrp: 0.459 ± 0.035
1.974AlaTyr: 1.974 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.642CysAla: 0.642 ± 0.048
0.197CysCys: 0.197 ± 0.023
0.685CysAsp: 0.685 ± 0.042
0.583CysGlu: 0.583 ± 0.046
0.581CysPhe: 0.581 ± 0.037
0.762CysGly: 0.762 ± 0.044
0.258CysHis: 0.258 ± 0.027
0.974CysIle: 0.974 ± 0.049
0.981CysLys: 0.981 ± 0.05
1.173CysLeu: 1.173 ± 0.054
0.271CysMet: 0.271 ± 0.027
0.642CysAsn: 0.642 ± 0.04
0.362CysPro: 0.362 ± 0.034
0.434CysGln: 0.434 ± 0.033
0.35CysArg: 0.35 ± 0.028
0.925CysSer: 0.925 ± 0.043
0.461CysThr: 0.461 ± 0.027
0.563CysVal: 0.563 ± 0.039
0.099CysTrp: 0.099 ± 0.015
0.463CysTyr: 0.463 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.212AspAla: 3.212 ± 0.099
0.52AspCys: 0.52 ± 0.038
2.701AspAsp: 2.701 ± 0.089
3.572AspGlu: 3.572 ± 0.097
2.824AspPhe: 2.824 ± 0.078
2.683AspGly: 2.683 ± 0.083
1.291AspHis: 1.291 ± 0.058
5.604AspIle: 5.604 ± 0.133
5.114AspLys: 5.114 ± 0.114
6.391AspLeu: 6.391 ± 0.121
1.103AspMet: 1.103 ± 0.052
3.187AspAsn: 3.187 ± 0.1
2.177AspPro: 2.177 ± 0.072
2.38AspGln: 2.38 ± 0.078
1.786AspArg: 1.786 ± 0.073
3.529AspSer: 3.529 ± 0.082
2.792AspThr: 2.792 ± 0.089
3.289AspVal: 3.289 ± 0.085
0.425AspTrp: 0.425 ± 0.03
2.322AspTyr: 2.322 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
4.548GluAla: 4.548 ± 0.145
0.631GluCys: 0.631 ± 0.039
3.373GluAsp: 3.373 ± 0.095
4.833GluGlu: 4.833 ± 0.15
2.783GluPhe: 2.783 ± 0.102
3.432GluGly: 3.432 ± 0.097
1.343GluHis: 1.343 ± 0.065
5.667GluIle: 5.667 ± 0.14
5.453GluLys: 5.453 ± 0.127
6.312GluLeu: 6.312 ± 0.118
1.433GluMet: 1.433 ± 0.059
3.531GluAsn: 3.531 ± 0.103
1.397GluPro: 1.397 ± 0.053
2.505GluGln: 2.505 ± 0.088
2.31GluArg: 2.31 ± 0.091
3.637GluSer: 3.637 ± 0.109
2.505GluThr: 2.505 ± 0.074
4.245GluVal: 4.245 ± 0.125
0.425GluTrp: 0.425 ± 0.035
2.344GluTyr: 2.344 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
3.206PheAla: 3.206 ± 0.101
0.656PheCys: 0.656 ± 0.047
3.09PheAsp: 3.09 ± 0.087
2.744PheGlu: 2.744 ± 0.099
2.306PhePhe: 2.306 ± 0.082
2.72PheGly: 2.72 ± 0.089
0.782PheHis: 0.782 ± 0.043
4.044PheIle: 4.044 ± 0.119
3.466PheLys: 3.466 ± 0.109
4.885PheLeu: 4.885 ± 0.141
1.001PheMet: 1.001 ± 0.045
2.55PheAsn: 2.55 ± 0.085
1.069PhePro: 1.069 ± 0.053
1.32PheGln: 1.32 ± 0.056
1.379PheArg: 1.379 ± 0.059
3.249PheSer: 3.249 ± 0.106
2.27PheThr: 2.27 ± 0.074
2.55PheVal: 2.55 ± 0.08
0.531PheTrp: 0.531 ± 0.035
1.818PheTyr: 1.818 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
4.695GlyAla: 4.695 ± 0.182
0.814GlyCys: 0.814 ± 0.046
2.819GlyAsp: 2.819 ± 0.085
2.948GlyGlu: 2.948 ± 0.09
2.824GlyPhe: 2.824 ± 0.088
3.859GlyGly: 3.859 ± 0.178
1.485GlyHis: 1.485 ± 0.088
5.071GlyIle: 5.071 ± 0.149
4.377GlyLys: 4.377 ± 0.11
5.324GlyLeu: 5.324 ± 0.127
1.456GlyMet: 1.456 ± 0.069
2.654GlyAsn: 2.654 ± 0.085
1.327GlyPro: 1.327 ± 0.063
2.17GlyGln: 2.17 ± 0.109
2.055GlyArg: 2.055 ± 0.084
3.924GlySer: 3.924 ± 0.126
2.46GlyThr: 2.46 ± 0.1
3.373GlyVal: 3.373 ± 0.111
0.524GlyTrp: 0.524 ± 0.037
2.451GlyTyr: 2.451 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
1.142HisAla: 1.142 ± 0.054
0.24HisCys: 0.24 ± 0.022
1.013HisAsp: 1.013 ± 0.051
1.189HisGlu: 1.189 ± 0.057
1.065HisPhe: 1.065 ± 0.05
1.103HisGly: 1.103 ± 0.058
0.604HisHis: 0.604 ± 0.035
1.854HisIle: 1.854 ± 0.081
1.707HisLys: 1.707 ± 0.064
2.518HisLeu: 2.518 ± 0.13
0.497HisMet: 0.497 ± 0.038
1.304HisAsn: 1.304 ± 0.058
0.843HisPro: 0.843 ± 0.052
0.845HisGln: 0.845 ± 0.047
0.685HisArg: 0.685 ± 0.042
1.445HisSer: 1.445 ± 0.056
0.909HisThr: 0.909 ± 0.046
1.051HisVal: 1.051 ± 0.056
0.212HisTrp: 0.212 ± 0.025
1.017HisTyr: 1.017 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
6.257IleAla: 6.257 ± 0.129
1.169IleCys: 1.169 ± 0.051
5.432IleAsp: 5.432 ± 0.13
5.762IleGlu: 5.762 ± 0.174
4.099IlePhe: 4.099 ± 0.148
4.571IleGly: 4.571 ± 0.124
1.558IleHis: 1.558 ± 0.06
7.078IleIle: 7.078 ± 0.164
7.51IleLys: 7.51 ± 0.167
8.129IleLeu: 8.129 ± 0.161
1.72IleMet: 1.72 ± 0.061
5.353IleAsn: 5.353 ± 0.136
3.018IlePro: 3.018 ± 0.091
3.022IleGln: 3.022 ± 0.089
2.819IleArg: 2.819 ± 0.08
7.019IleSer: 7.019 ± 0.135
4.347IleThr: 4.347 ± 0.108
4.521IleVal: 4.521 ± 0.114
0.708IleTrp: 0.708 ± 0.039
2.704IleTyr: 2.704 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
5.577LysAla: 5.577 ± 0.153
0.676LysCys: 0.676 ± 0.043
5.263LysAsp: 5.263 ± 0.128
5.814LysGlu: 5.814 ± 0.135
3.377LysPhe: 3.377 ± 0.104
4.713LysGly: 4.713 ± 0.129
1.637LysHis: 1.637 ± 0.063
7.668LysIle: 7.668 ± 0.144
6.061LysLys: 6.061 ± 0.159
8.118LysLeu: 8.118 ± 0.165
1.754LysMet: 1.754 ± 0.07
4.942LysAsn: 4.942 ± 0.099
2.747LysPro: 2.747 ± 0.092
3.124LysGln: 3.124 ± 0.091
2.717LysArg: 2.717 ± 0.076
5.31LysSer: 5.31 ± 0.122
3.97LysThr: 3.97 ± 0.099
5.161LysVal: 5.161 ± 0.134
0.61LysTrp: 0.61 ± 0.038
3.339LysTyr: 3.339 ± 0.09
0.0LysXaa: 0.0 ± 0.0
Leu
6.646LeuAla: 6.646 ± 0.136
1.239LeuCys: 1.239 ± 0.05
6.574LeuAsp: 6.574 ± 0.128
7.422LeuGlu: 7.422 ± 0.168
4.288LeuPhe: 4.288 ± 0.114
5.925LeuGly: 5.925 ± 0.148
2.778LeuHis: 2.778 ± 0.132
8.387LeuIle: 8.387 ± 0.198
8.475LeuLys: 8.475 ± 0.156
10.74LeuLeu: 10.74 ± 0.26
2.161LeuMet: 2.161 ± 0.073
5.9LeuAsn: 5.9 ± 0.142
3.561LeuPro: 3.561 ± 0.113
3.597LeuGln: 3.597 ± 0.101
3.561LeuArg: 3.561 ± 0.094
8.364LeuSer: 8.364 ± 0.135
4.381LeuThr: 4.381 ± 0.1
5.441LeuVal: 5.441 ± 0.125
0.796LeuTrp: 0.796 ± 0.048
3.341LeuTyr: 3.341 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.295MetAla: 1.295 ± 0.06
0.246MetCys: 0.246 ± 0.025
1.11MetAsp: 1.11 ± 0.054
1.119MetGlu: 1.119 ± 0.052
0.87MetPhe: 0.87 ± 0.043
1.209MetGly: 1.209 ± 0.06
0.622MetHis: 0.622 ± 0.039
1.757MetIle: 1.757 ± 0.07
1.571MetLys: 1.571 ± 0.063
2.369MetLeu: 2.369 ± 0.081
0.552MetMet: 0.552 ± 0.033
0.999MetAsn: 0.999 ± 0.045
0.999MetPro: 0.999 ± 0.042
1.164MetGln: 1.164 ± 0.053
1.001MetArg: 1.001 ± 0.048
1.707MetSer: 1.707 ± 0.057
1.033MetThr: 1.033 ± 0.044
1.214MetVal: 1.214 ± 0.068
0.142MetTrp: 0.142 ± 0.02
0.665MetTyr: 0.665 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.332AsnAla: 3.332 ± 0.097
0.581AsnCys: 0.581 ± 0.04
2.588AsnAsp: 2.588 ± 0.084
2.767AsnGlu: 2.767 ± 0.078
3.158AsnPhe: 3.158 ± 0.092
2.649AsnGly: 2.649 ± 0.121
1.255AsnHis: 1.255 ± 0.057
5.724AsnIle: 5.724 ± 0.155
4.887AsnLys: 4.887 ± 0.129
6.942AsnLeu: 6.942 ± 0.148
1.185AsnMet: 1.185 ± 0.056
3.434AsnAsn: 3.434 ± 0.096
2.625AsnPro: 2.625 ± 0.082
2.423AsnGln: 2.423 ± 0.084
1.7AsnArg: 1.7 ± 0.077
3.687AsnSer: 3.687 ± 0.087
2.923AsnThr: 2.923 ± 0.092
2.989AsnVal: 2.989 ± 0.091
0.484AsnTrp: 0.484 ± 0.036
2.191AsnTyr: 2.191 ± 0.081
0.0AsnXaa: 0.0 ± 0.0
Pro
1.894ProAla: 1.894 ± 0.115
0.355ProCys: 0.355 ± 0.025
1.969ProAsp: 1.969 ± 0.07
2.552ProGlu: 2.552 ± 0.084
1.508ProPhe: 1.508 ± 0.06
1.784ProGly: 1.784 ± 0.074
0.617ProHis: 0.617 ± 0.039
2.72ProIle: 2.72 ± 0.077
2.713ProLys: 2.713 ± 0.086
4.119ProLeu: 4.119 ± 0.138
0.599ProMet: 0.599 ± 0.034
2.136ProAsn: 2.136 ± 0.07
1.166ProPro: 1.166 ± 0.102
1.447ProGln: 1.447 ± 0.073
1.013ProArg: 1.013 ± 0.049
2.482ProSer: 2.482 ± 0.082
1.707ProThr: 1.707 ± 0.069
1.766ProVal: 1.766 ± 0.07
0.278ProTrp: 0.278 ± 0.024
1.234ProTyr: 1.234 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
2.484GlnAla: 2.484 ± 0.102
0.251GlnCys: 0.251 ± 0.024
2.683GlnAsp: 2.683 ± 0.084
3.084GlnGlu: 3.084 ± 0.091
1.266GlnPhe: 1.266 ± 0.055
2.412GlnGly: 2.412 ± 0.11
0.658GlnHis: 0.658 ± 0.039
3.511GlnIle: 3.511 ± 0.097
3.732GlnLys: 3.732 ± 0.123
2.842GlnLeu: 2.842 ± 0.08
0.9GlnMet: 0.9 ± 0.046
2.946GlnAsn: 2.946 ± 0.095
0.959GlnPro: 0.959 ± 0.07
1.302GlnGln: 1.302 ± 0.068
1.261GlnArg: 1.261 ± 0.062
2.206GlnSer: 2.206 ± 0.091
2.145GlnThr: 2.145 ± 0.094
2.197GlnVal: 2.197 ± 0.08
0.21GlnTrp: 0.21 ± 0.024
1.16GlnTyr: 1.16 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
2.249ArgAla: 2.249 ± 0.106
0.38ArgCys: 0.38 ± 0.029
2.026ArgAsp: 2.026 ± 0.086
2.209ArgGlu: 2.209 ± 0.08
1.662ArgPhe: 1.662 ± 0.063
2.093ArgGly: 2.093 ± 0.079
0.782ArgHis: 0.782 ± 0.044
2.941ArgIle: 2.941 ± 0.087
2.622ArgLys: 2.622 ± 0.096
3.303ArgLeu: 3.303 ± 0.103
0.843ArgMet: 0.843 ± 0.042
1.854ArgAsn: 1.854 ± 0.063
1.187ArgPro: 1.187 ± 0.058
1.379ArgGln: 1.379 ± 0.067
1.313ArgArg: 1.313 ± 0.068
2.455ArgSer: 2.455 ± 0.074
1.445ArgThr: 1.445 ± 0.066
1.885ArgVal: 1.885 ± 0.076
0.285ArgTrp: 0.285 ± 0.021
1.44ArgTyr: 1.44 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
4.112SerAla: 4.112 ± 0.124
0.827SerCys: 0.827 ± 0.04
3.723SerAsp: 3.723 ± 0.078
3.653SerGlu: 3.653 ± 0.099
3.579SerPhe: 3.579 ± 0.101
4.327SerGly: 4.327 ± 0.119
1.413SerHis: 1.413 ± 0.059
6.192SerIle: 6.192 ± 0.136
6.081SerLys: 6.081 ± 0.132
7.759SerLeu: 7.759 ± 0.151
1.637SerMet: 1.637 ± 0.064
4.2SerAsn: 4.2 ± 0.114
2.439SerPro: 2.439 ± 0.09
2.654SerGln: 2.654 ± 0.084
2.265SerArg: 2.265 ± 0.081
5.789SerSer: 5.789 ± 0.175
3.606SerThr: 3.606 ± 0.13
3.701SerVal: 3.701 ± 0.103
0.68SerTrp: 0.68 ± 0.04
2.715SerTyr: 2.715 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
3.201ThrAla: 3.201 ± 0.101
0.565ThrCys: 0.565 ± 0.05
2.441ThrAsp: 2.441 ± 0.082
2.41ThrGlu: 2.41 ± 0.09
2.238ThrPhe: 2.238 ± 0.072
2.677ThrGly: 2.677 ± 0.118
0.929ThrHis: 0.929 ± 0.046
3.662ThrIle: 3.662 ± 0.105
3.886ThrLys: 3.886 ± 0.102
5.001ThrLeu: 5.001 ± 0.105
0.789ThrMet: 0.789 ± 0.039
2.661ThrAsn: 2.661 ± 0.079
2.993ThrPro: 2.993 ± 0.132
1.958ThrGln: 1.958 ± 0.079
1.634ThrArg: 1.634 ± 0.062
3.82ThrSer: 3.82 ± 0.122
2.753ThrThr: 2.753 ± 0.133
2.387ThrVal: 2.387 ± 0.1
0.389ThrTrp: 0.389 ± 0.041
1.68ThrTyr: 1.68 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
3.798ValAla: 3.798 ± 0.098
0.712ValCys: 0.712 ± 0.041
3.294ValAsp: 3.294 ± 0.091
3.714ValGlu: 3.714 ± 0.116
2.247ValPhe: 2.247 ± 0.072
3.172ValGly: 3.172 ± 0.108
0.999ValHis: 0.999 ± 0.048
4.759ValIle: 4.759 ± 0.121
4.869ValLys: 4.869 ± 0.129
5.482ValLeu: 5.482 ± 0.136
1.338ValMet: 1.338 ± 0.067
3.158ValAsn: 3.158 ± 0.089
1.813ValPro: 1.813 ± 0.08
1.906ValGln: 1.906 ± 0.076
2.118ValArg: 2.118 ± 0.068
3.997ValSer: 3.997 ± 0.121
2.866ValThr: 2.866 ± 0.084
3.664ValVal: 3.664 ± 0.131
0.43ValTrp: 0.43 ± 0.032
1.641ValTyr: 1.641 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.576TrpAla: 0.576 ± 0.044
0.072TrpCys: 0.072 ± 0.013
0.445TrpAsp: 0.445 ± 0.031
0.441TrpGlu: 0.441 ± 0.031
0.396TrpPhe: 0.396 ± 0.031
0.461TrpGly: 0.461 ± 0.035
0.24TrpHis: 0.24 ± 0.024
0.604TrpIle: 0.604 ± 0.04
0.511TrpLys: 0.511 ± 0.034
0.895TrpLeu: 0.895 ± 0.043
0.142TrpMet: 0.142 ± 0.018
0.445TrpAsn: 0.445 ± 0.033
0.271TrpPro: 0.271 ± 0.028
0.484TrpGln: 0.484 ± 0.032
0.328TrpArg: 0.328 ± 0.027
0.581TrpSer: 0.581 ± 0.044
0.425TrpThr: 0.425 ± 0.042
0.405TrpVal: 0.405 ± 0.034
0.102TrpTrp: 0.102 ± 0.018
0.274TrpTyr: 0.274 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.304TyrAla: 2.304 ± 0.067
0.486TyrCys: 0.486 ± 0.033
2.109TyrAsp: 2.109 ± 0.071
2.03TyrGlu: 2.03 ± 0.076
1.933TyrPhe: 1.933 ± 0.068
2.279TyrGly: 2.279 ± 0.082
0.83TyrHis: 0.83 ± 0.047
2.833TyrIle: 2.833 ± 0.082
2.796TyrLys: 2.796 ± 0.092
4.128TyrLeu: 4.128 ± 0.125
0.717TyrMet: 0.717 ± 0.042
2.1TyrAsn: 2.1 ± 0.08
1.146TyrPro: 1.146 ± 0.057
1.406TyrGln: 1.406 ± 0.064
1.277TyrArg: 1.277 ± 0.056
2.514TyrSer: 2.514 ± 0.096
1.689TyrThr: 1.689 ± 0.062
1.888TyrVal: 1.888 ± 0.064
0.307TyrTrp: 0.307 ± 0.03
1.397TyrTyr: 1.397 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1244 proteins (442354 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski