Amino acid dipepetide frequency for Mycoplasma wenyonii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.167AlaAla: 1.167 ± 0.085
0.544AlaCys: 0.544 ± 0.055
1.682AlaAsp: 1.682 ± 0.105
3.468AlaGlu: 3.468 ± 0.138
2.22AlaPhe: 2.22 ± 0.124
2.97AlaGly: 2.97 ± 0.134
0.755AlaHis: 0.755 ± 0.072
3.788AlaIle: 3.788 ± 0.181
4.023AlaLys: 4.023 ± 0.164
5.207AlaLeu: 5.207 ± 0.186
0.715AlaMet: 0.715 ± 0.072
2.089AlaAsn: 2.089 ± 0.114
1.408AlaPro: 1.408 ± 0.09
1.825AlaGln: 1.825 ± 0.097
1.808AlaArg: 1.808 ± 0.117
3.164AlaSer: 3.164 ± 0.135
2.558AlaThr: 2.558 ± 0.131
2.478AlaVal: 2.478 ± 0.123
0.509AlaTrp: 0.509 ± 0.052
1.488AlaTyr: 1.488 ± 0.091
0.0AlaXaa: 0.0 ± 0.0
Cys
0.446CysAla: 0.446 ± 0.052
0.309CysCys: 0.309 ± 0.074
0.492CysAsp: 0.492 ± 0.055
0.938CysGlu: 0.938 ± 0.077
0.818CysPhe: 0.818 ± 0.073
0.727CysGly: 0.727 ± 0.066
0.155CysHis: 0.155 ± 0.03
0.595CysIle: 0.595 ± 0.067
1.345CysLys: 1.345 ± 0.083
1.047CysLeu: 1.047 ± 0.086
0.074CysMet: 0.074 ± 0.021
0.664CysAsn: 0.664 ± 0.051
0.361CysPro: 0.361 ± 0.057
0.464CysGln: 0.464 ± 0.057
0.458CysArg: 0.458 ± 0.052
1.35CysSer: 1.35 ± 0.083
0.67CysThr: 0.67 ± 0.073
0.526CysVal: 0.526 ± 0.058
0.24CysTrp: 0.24 ± 0.039
0.412CysTyr: 0.412 ± 0.05
0.0CysXaa: 0.0 ± 0.0
Asp
1.339AspAla: 1.339 ± 0.094
0.658AspCys: 0.658 ± 0.06
1.774AspAsp: 1.774 ± 0.105
3.096AspGlu: 3.096 ± 0.154
2.552AspPhe: 2.552 ± 0.126
2.323AspGly: 2.323 ± 0.12
0.675AspHis: 0.675 ± 0.069
2.93AspIle: 2.93 ± 0.135
4.652AspLys: 4.652 ± 0.168
5.19AspLeu: 5.19 ± 0.192
0.555AspMet: 0.555 ± 0.054
2.346AspAsn: 2.346 ± 0.114
1.265AspPro: 1.265 ± 0.081
1.825AspGln: 1.825 ± 0.1
1.808AspArg: 1.808 ± 0.099
4.544AspSer: 4.544 ± 0.175
2.157AspThr: 2.157 ± 0.124
1.911AspVal: 1.911 ± 0.116
1.064AspTrp: 1.064 ± 0.077
2.346AspTyr: 2.346 ± 0.115
0.0AspXaa: 0.0 ± 0.0
Glu
3.033GluAla: 3.033 ± 0.144
0.807GluCys: 0.807 ± 0.068
3.611GluAsp: 3.611 ± 0.167
7.491GluGlu: 7.491 ± 0.297
3.142GluPhe: 3.142 ± 0.145
3.994GluGly: 3.994 ± 0.192
1.19GluHis: 1.19 ± 0.084
6.741GluIle: 6.741 ± 0.229
8.795GluLys: 8.795 ± 0.239
9.236GluLeu: 9.236 ± 0.29
1.144GluMet: 1.144 ± 0.085
4.194GluAsn: 4.194 ± 0.17
1.74GluPro: 1.74 ± 0.099
3.353GluGln: 3.353 ± 0.153
3.353GluArg: 3.353 ± 0.136
5.093GluSer: 5.093 ± 0.195
3.885GluThr: 3.885 ± 0.152
3.868GluVal: 3.868 ± 0.162
1.144GluTrp: 1.144 ± 0.089
2.381GluTyr: 2.381 ± 0.118
0.0GluXaa: 0.0 ± 0.0
Phe
2.272PheAla: 2.272 ± 0.111
0.767PheCys: 0.767 ± 0.07
2.386PheAsp: 2.386 ± 0.13
3.531PheGlu: 3.531 ± 0.168
3.479PhePhe: 3.479 ± 0.19
2.752PheGly: 2.752 ± 0.127
0.658PheHis: 0.658 ± 0.065
3.359PheIle: 3.359 ± 0.16
4.687PheLys: 4.687 ± 0.151
6.426PheLeu: 6.426 ± 0.266
0.595PheMet: 0.595 ± 0.071
2.775PheAsn: 2.775 ± 0.13
2.146PhePro: 2.146 ± 0.122
2.071PheGln: 2.071 ± 0.113
1.928PheArg: 1.928 ± 0.089
5.768PheSer: 5.768 ± 0.172
2.363PheThr: 2.363 ± 0.118
2.529PheVal: 2.529 ± 0.146
0.847PheTrp: 0.847 ± 0.08
2.272PheTyr: 2.272 ± 0.107
0.0PheXaa: 0.0 ± 0.0
Gly
3.119GlyAla: 3.119 ± 0.128
0.71GlyCys: 0.71 ± 0.062
2.752GlyAsp: 2.752 ± 0.145
4.2GlyGlu: 4.2 ± 0.156
2.833GlyPhe: 2.833 ± 0.136
4.938GlyGly: 4.938 ± 0.243
0.784GlyHis: 0.784 ± 0.075
4.578GlyIle: 4.578 ± 0.188
5.047GlyLys: 5.047 ± 0.19
4.778GlyLeu: 4.778 ± 0.179
0.904GlyMet: 0.904 ± 0.08
2.684GlyAsn: 2.684 ± 0.13
1.236GlyPro: 1.236 ± 0.091
1.991GlyGln: 1.991 ± 0.116
2.506GlyArg: 2.506 ± 0.128
4.252GlySer: 4.252 ± 0.194
2.953GlyThr: 2.953 ± 0.143
3.245GlyVal: 3.245 ± 0.192
0.944GlyTrp: 0.944 ± 0.078
1.854GlyTyr: 1.854 ± 0.107
0.0GlyXaa: 0.0 ± 0.0
His
0.475HisAla: 0.475 ± 0.051
0.195HisCys: 0.195 ± 0.033
0.441HisAsp: 0.441 ± 0.046
0.595HisGlu: 0.595 ± 0.066
1.007HisPhe: 1.007 ± 0.078
0.687HisGly: 0.687 ± 0.069
0.269HisHis: 0.269 ± 0.045
1.162HisIle: 1.162 ± 0.079
1.419HisLys: 1.419 ± 0.082
2.009HisLeu: 2.009 ± 0.109
0.217HisMet: 0.217 ± 0.037
0.984HisAsn: 0.984 ± 0.084
0.418HisPro: 0.418 ± 0.05
0.607HisGln: 0.607 ± 0.056
0.561HisArg: 0.561 ± 0.054
1.476HisSer: 1.476 ± 0.076
0.675HisThr: 0.675 ± 0.075
0.618HisVal: 0.618 ± 0.069
0.32HisTrp: 0.32 ± 0.042
0.755HisTyr: 0.755 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
4.08IleAla: 4.08 ± 0.165
0.944IleCys: 0.944 ± 0.092
3.388IleAsp: 3.388 ± 0.153
5.259IleGlu: 5.259 ± 0.14
4.332IlePhe: 4.332 ± 0.18
4.017IleGly: 4.017 ± 0.164
1.036IleHis: 1.036 ± 0.093
4.618IleIle: 4.618 ± 0.197
6.495IleLys: 6.495 ± 0.185
6.123IleLeu: 6.123 ± 0.2
0.938IleMet: 0.938 ± 0.084
3.863IleAsn: 3.863 ± 0.173
3.01IlePro: 3.01 ± 0.135
2.718IleGln: 2.718 ± 0.135
2.661IleArg: 2.661 ± 0.112
6.775IleSer: 6.775 ± 0.224
3.868IleThr: 3.868 ± 0.155
4.303IleVal: 4.303 ± 0.162
0.847IleTrp: 0.847 ± 0.077
2.73IleTyr: 2.73 ± 0.12
0.0IleXaa: 0.0 ± 0.0
Lys
4.137LysAla: 4.137 ± 0.167
0.979LysCys: 0.979 ± 0.07
4.916LysAsp: 4.916 ± 0.171
9.556LysGlu: 9.556 ± 0.255
4.206LysPhe: 4.206 ± 0.169
4.978LysGly: 4.978 ± 0.19
1.448LysHis: 1.448 ± 0.096
7.101LysIle: 7.101 ± 0.199
9.677LysLys: 9.677 ± 0.311
10.146LysLeu: 10.146 ± 0.26
1.551LysMet: 1.551 ± 0.104
6.071LysAsn: 6.071 ± 0.226
2.363LysPro: 2.363 ± 0.14
3.514LysGln: 3.514 ± 0.182
3.645LysArg: 3.645 ± 0.17
6.363LysSer: 6.363 ± 0.201
5.15LysThr: 5.15 ± 0.188
5.156LysVal: 5.156 ± 0.175
1.883LysTrp: 1.883 ± 0.101
3.851LysTyr: 3.851 ± 0.147
0.0LysXaa: 0.0 ± 0.0
Leu
5.373LeuAla: 5.373 ± 0.199
0.824LeuCys: 0.824 ± 0.067
4.978LeuAsp: 4.978 ± 0.181
8.177LeuGlu: 8.177 ± 0.254
6.26LeuPhe: 6.26 ± 0.227
5.785LeuGly: 5.785 ± 0.227
1.368LeuHis: 1.368 ± 0.087
8.0LeuIle: 8.0 ± 0.257
10.815LeuLys: 10.815 ± 0.293
11.187LeuLeu: 11.187 ± 0.319
1.448LeuMet: 1.448 ± 0.103
6.031LeuAsn: 6.031 ± 0.188
3.731LeuPro: 3.731 ± 0.16
3.468LeuGln: 3.468 ± 0.144
3.874LeuArg: 3.874 ± 0.141
10.306LeuSer: 10.306 ± 0.292
5.974LeuThr: 5.974 ± 0.18
5.883LeuVal: 5.883 ± 0.163
1.156LeuTrp: 1.156 ± 0.07
2.93LeuTyr: 2.93 ± 0.152
0.0LeuXaa: 0.0 ± 0.0
Met
0.773MetAla: 0.773 ± 0.067
0.149MetCys: 0.149 ± 0.03
0.589MetAsp: 0.589 ± 0.062
1.001MetGlu: 1.001 ± 0.071
0.698MetPhe: 0.698 ± 0.071
1.047MetGly: 1.047 ± 0.084
0.189MetHis: 0.189 ± 0.029
0.956MetIle: 0.956 ± 0.085
1.35MetLys: 1.35 ± 0.087
1.213MetLeu: 1.213 ± 0.072
0.143MetMet: 0.143 ± 0.031
0.767MetAsn: 0.767 ± 0.062
0.629MetPro: 0.629 ± 0.066
0.481MetGln: 0.481 ± 0.053
0.584MetArg: 0.584 ± 0.059
1.511MetSer: 1.511 ± 0.082
0.698MetThr: 0.698 ± 0.06
0.83MetVal: 0.83 ± 0.074
0.2MetTrp: 0.2 ± 0.035
0.406MetTyr: 0.406 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
1.803AsnAla: 1.803 ± 0.093
1.019AsnCys: 1.019 ± 0.074
1.705AsnAsp: 1.705 ± 0.11
2.861AsnGlu: 2.861 ± 0.133
3.199AsnPhe: 3.199 ± 0.147
2.678AsnGly: 2.678 ± 0.191
0.801AsnHis: 0.801 ± 0.079
3.628AsnIle: 3.628 ± 0.155
5.099AsnLys: 5.099 ± 0.205
6.42AsnLeu: 6.42 ± 0.22
0.813AsnMet: 0.813 ± 0.067
3.17AsnAsn: 3.17 ± 0.162
1.957AsnPro: 1.957 ± 0.102
2.129AsnGln: 2.129 ± 0.124
1.94AsnArg: 1.94 ± 0.093
5.213AsnSer: 5.213 ± 0.179
2.535AsnThr: 2.535 ± 0.112
2.243AsnVal: 2.243 ± 0.103
1.328AsnTrp: 1.328 ± 0.096
2.907AsnTyr: 2.907 ± 0.138
0.0AsnXaa: 0.0 ± 0.0
Pro
1.528ProAla: 1.528 ± 0.097
0.303ProCys: 0.303 ± 0.041
1.305ProAsp: 1.305 ± 0.099
3.142ProGlu: 3.142 ± 0.149
1.659ProPhe: 1.659 ± 0.089
0.784ProGly: 0.784 ± 0.074
0.578ProHis: 0.578 ± 0.056
2.438ProIle: 2.438 ± 0.132
3.256ProLys: 3.256 ± 0.132
3.182ProLeu: 3.182 ± 0.134
0.303ProMet: 0.303 ± 0.045
1.705ProAsn: 1.705 ± 0.11
1.293ProPro: 1.293 ± 0.107
1.27ProGln: 1.27 ± 0.091
0.956ProArg: 0.956 ± 0.086
2.712ProSer: 2.712 ± 0.152
1.883ProThr: 1.883 ± 0.094
2.06ProVal: 2.06 ± 0.115
0.498ProTrp: 0.498 ± 0.051
1.116ProTyr: 1.116 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
1.688GlnAla: 1.688 ± 0.113
0.24GlnCys: 0.24 ± 0.037
1.78GlnAsp: 1.78 ± 0.118
4.029GlnGlu: 4.029 ± 0.172
1.562GlnPhe: 1.562 ± 0.084
1.928GlnGly: 1.928 ± 0.105
0.521GlnHis: 0.521 ± 0.049
2.678GlnIle: 2.678 ± 0.14
4.017GlnLys: 4.017 ± 0.157
5.179GlnLeu: 5.179 ± 0.197
0.589GlnMet: 0.589 ± 0.05
1.757GlnAsn: 1.757 ± 0.096
0.996GlnPro: 0.996 ± 0.076
1.9GlnGln: 1.9 ± 0.143
1.528GlnArg: 1.528 ± 0.103
2.649GlnSer: 2.649 ± 0.121
1.837GlnThr: 1.837 ± 0.119
2.02GlnVal: 2.02 ± 0.107
0.589GlnTrp: 0.589 ± 0.062
1.127GlnTyr: 1.127 ± 0.094
0.0GlnXaa: 0.0 ± 0.0
Arg
2.037ArgAla: 2.037 ± 0.1
0.303ArgCys: 0.303 ± 0.044
2.009ArgAsp: 2.009 ± 0.086
4.017ArgGlu: 4.017 ± 0.18
1.797ArgPhe: 1.797 ± 0.106
2.335ArgGly: 2.335 ± 0.122
0.641ArgHis: 0.641 ± 0.066
2.672ArgIle: 2.672 ± 0.145
3.628ArgLys: 3.628 ± 0.159
3.977ArgLeu: 3.977 ± 0.147
0.715ArgMet: 0.715 ± 0.058
2.009ArgAsn: 2.009 ± 0.112
0.778ArgPro: 0.778 ± 0.067
1.339ArgGln: 1.339 ± 0.075
1.608ArgArg: 1.608 ± 0.107
2.232ArgSer: 2.232 ± 0.13
1.757ArgThr: 1.757 ± 0.109
2.083ArgVal: 2.083 ± 0.114
0.629ArgTrp: 0.629 ± 0.056
1.551ArgTyr: 1.551 ± 0.118
0.0ArgXaa: 0.0 ± 0.0
Ser
3.588SerAla: 3.588 ± 0.156
1.299SerCys: 1.299 ± 0.09
3.8SerAsp: 3.8 ± 0.189
5.905SerGlu: 5.905 ± 0.236
5.047SerPhe: 5.047 ± 0.186
4.898SerGly: 4.898 ± 0.187
1.265SerHis: 1.265 ± 0.083
5.699SerIle: 5.699 ± 0.203
7.731SerLys: 7.731 ± 0.2
9.654SerLeu: 9.654 ± 0.29
1.27SerMet: 1.27 ± 0.081
4.635SerAsn: 4.635 ± 0.186
2.993SerPro: 2.993 ± 0.141
3.634SerGln: 3.634 ± 0.146
3.13SerArg: 3.13 ± 0.131
9.39SerSer: 9.39 ± 0.322
3.954SerThr: 3.954 ± 0.164
4.091SerVal: 4.091 ± 0.175
1.442SerTrp: 1.442 ± 0.102
2.878SerTyr: 2.878 ± 0.119
0.0SerXaa: 0.0 ± 0.0
Thr
1.923ThrAla: 1.923 ± 0.101
0.67ThrCys: 0.67 ± 0.061
2.197ThrAsp: 2.197 ± 0.108
3.748ThrGlu: 3.748 ± 0.147
2.546ThrPhe: 2.546 ± 0.122
3.439ThrGly: 3.439 ± 0.159
0.956ThrHis: 0.956 ± 0.071
3.914ThrIle: 3.914 ± 0.146
4.984ThrLys: 4.984 ± 0.197
5.219ThrLeu: 5.219 ± 0.186
0.767ThrMet: 0.767 ± 0.069
2.873ThrAsn: 2.873 ± 0.144
2.049ThrPro: 2.049 ± 0.118
2.34ThrGln: 2.34 ± 0.125
1.951ThrArg: 1.951 ± 0.102
4.2ThrSer: 4.2 ± 0.183
3.359ThrThr: 3.359 ± 0.175
2.958ThrVal: 2.958 ± 0.141
0.664ThrTrp: 0.664 ± 0.075
1.591ThrTyr: 1.591 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
2.918ValAla: 2.918 ± 0.147
0.755ValCys: 0.755 ± 0.075
2.695ValAsp: 2.695 ± 0.119
3.542ValGlu: 3.542 ± 0.171
2.941ValPhe: 2.941 ± 0.152
3.348ValGly: 3.348 ± 0.147
0.795ValHis: 0.795 ± 0.067
3.891ValIle: 3.891 ± 0.165
4.498ValLys: 4.498 ± 0.182
4.967ValLeu: 4.967 ± 0.188
0.67ValMet: 0.67 ± 0.06
2.541ValAsn: 2.541 ± 0.121
2.037ValPro: 2.037 ± 0.123
1.665ValGln: 1.665 ± 0.094
1.631ValArg: 1.631 ± 0.093
4.669ValSer: 4.669 ± 0.175
3.502ValThr: 3.502 ± 0.188
3.182ValVal: 3.182 ± 0.163
0.658ValTrp: 0.658 ± 0.065
1.511ValTyr: 1.511 ± 0.098
0.0ValXaa: 0.0 ± 0.0
Trp
0.801TrpAla: 0.801 ± 0.074
0.109TrpCys: 0.109 ± 0.023
0.933TrpAsp: 0.933 ± 0.071
1.288TrpGlu: 1.288 ± 0.081
0.91TrpPhe: 0.91 ± 0.076
1.019TrpGly: 1.019 ± 0.084
0.195TrpHis: 0.195 ± 0.032
1.099TrpIle: 1.099 ± 0.076
1.757TrpLys: 1.757 ± 0.11
1.328TrpLeu: 1.328 ± 0.085
0.383TrpMet: 0.383 ± 0.048
0.893TrpAsn: 0.893 ± 0.074
0.406TrpPro: 0.406 ± 0.053
0.549TrpGln: 0.549 ± 0.05
0.618TrpArg: 0.618 ± 0.065
0.887TrpSer: 0.887 ± 0.075
0.904TrpThr: 0.904 ± 0.079
0.979TrpVal: 0.979 ± 0.08
0.326TrpTrp: 0.326 ± 0.051
0.572TrpTyr: 0.572 ± 0.06
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.368TyrAla: 1.368 ± 0.094
0.509TyrCys: 0.509 ± 0.056
1.579TyrAsp: 1.579 ± 0.1
2.352TyrGlu: 2.352 ± 0.12
2.403TyrPhe: 2.403 ± 0.121
1.659TyrGly: 1.659 ± 0.086
0.612TyrHis: 0.612 ± 0.056
2.157TyrIle: 2.157 ± 0.102
3.416TyrLys: 3.416 ± 0.141
5.081TyrLeu: 5.081 ± 0.166
0.412TyrMet: 0.412 ± 0.058
1.396TyrAsn: 1.396 ± 0.089
1.156TyrPro: 1.156 ± 0.084
1.471TyrGln: 1.471 ± 0.082
1.568TyrArg: 1.568 ± 0.103
3.754TyrSer: 3.754 ± 0.162
1.665TyrThr: 1.665 ± 0.107
1.453TyrVal: 1.453 ± 0.093
0.664TyrTrp: 0.664 ± 0.06
1.694TyrTyr: 1.694 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 629 proteins (174754 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski