Amino acid dipepetide frequency for Streptococcus satellite phage Javan529

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.272AlaAla: 0.272 ± 0.314
0.0AlaCys: 0.0 ± 0.0
1.634AlaAsp: 1.634 ± 0.571
4.358AlaGlu: 4.358 ± 1.251
2.452AlaPhe: 2.452 ± 0.635
2.724AlaGly: 2.724 ± 0.805
0.272AlaHis: 0.272 ± 0.232
5.448AlaIle: 5.448 ± 1.134
5.448AlaLys: 5.448 ± 1.312
4.631AlaLeu: 4.631 ± 1.29
0.817AlaMet: 0.817 ± 0.503
1.907AlaAsn: 1.907 ± 0.622
1.634AlaPro: 1.634 ± 0.54
1.09AlaGln: 1.09 ± 0.418
2.452AlaArg: 2.452 ± 0.649
4.358AlaSer: 4.358 ± 1.244
4.086AlaThr: 4.086 ± 1.157
1.907AlaVal: 1.907 ± 0.785
0.545AlaTrp: 0.545 ± 0.523
1.362AlaTyr: 1.362 ± 0.445
0.0AlaXaa: 0.0 ± 0.0
Cys
0.272CysAla: 0.272 ± 0.281
0.0CysCys: 0.0 ± 0.0
0.545CysAsp: 0.545 ± 0.373
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.09CysGly: 1.09 ± 0.613
0.0CysHis: 0.0 ± 0.0
0.272CysIle: 0.272 ± 0.248
0.817CysLys: 0.817 ± 0.551
1.634CysLeu: 1.634 ± 0.582
0.0CysMet: 0.0 ± 0.0
0.817CysAsn: 0.817 ± 0.551
0.0CysPro: 0.0 ± 0.0
0.272CysGln: 0.272 ± 0.232
0.817CysArg: 0.817 ± 0.568
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.272CysTyr: 0.272 ± 0.281
0.0CysXaa: 0.0 ± 0.0
Asp
1.634AspAla: 1.634 ± 0.545
0.545AspCys: 0.545 ± 0.398
2.724AspAsp: 2.724 ± 1.14
5.176AspGlu: 5.176 ± 1.549
2.724AspPhe: 2.724 ± 1.245
2.996AspGly: 2.996 ± 0.879
0.817AspHis: 0.817 ± 0.436
6.538AspIle: 6.538 ± 1.176
5.993AspLys: 5.993 ± 0.803
6.538AspLeu: 6.538 ± 1.007
1.09AspMet: 1.09 ± 0.645
2.452AspAsn: 2.452 ± 0.78
0.817AspPro: 0.817 ± 0.531
0.817AspGln: 0.817 ± 0.381
2.996AspArg: 2.996 ± 0.693
2.724AspSer: 2.724 ± 0.788
2.996AspThr: 2.996 ± 0.811
1.907AspVal: 1.907 ± 0.759
0.545AspTrp: 0.545 ± 0.461
5.448AspTyr: 5.448 ± 1.325
0.0AspXaa: 0.0 ± 0.0
Glu
5.176GluAla: 5.176 ± 1.531
1.09GluCys: 1.09 ± 0.568
5.448GluAsp: 5.448 ± 1.166
6.81GluGlu: 6.81 ± 1.516
2.996GluPhe: 2.996 ± 0.841
3.269GluGly: 3.269 ± 0.764
0.817GluHis: 0.817 ± 0.422
5.176GluIle: 5.176 ± 0.988
7.9GluLys: 7.9 ± 1.666
7.9GluLeu: 7.9 ± 1.328
2.452GluMet: 2.452 ± 0.621
3.541GluAsn: 3.541 ± 0.797
1.09GluPro: 1.09 ± 0.581
5.176GluGln: 5.176 ± 1.437
5.448GluArg: 5.448 ± 1.441
3.541GluSer: 3.541 ± 1.182
3.814GluThr: 3.814 ± 1.098
4.086GluVal: 4.086 ± 1.065
0.817GluTrp: 0.817 ± 0.46
4.903GluTyr: 4.903 ± 0.896
0.0GluXaa: 0.0 ± 0.0
Phe
1.907PheAla: 1.907 ± 0.697
0.0PheCys: 0.0 ± 0.0
2.996PheAsp: 2.996 ± 0.729
2.724PheGlu: 2.724 ± 0.968
2.179PhePhe: 2.179 ± 0.702
1.634PheGly: 1.634 ± 0.555
1.09PheHis: 1.09 ± 0.402
3.541PheIle: 3.541 ± 1.201
3.269PheLys: 3.269 ± 0.93
3.541PheLeu: 3.541 ± 0.943
0.817PheMet: 0.817 ± 0.486
3.269PheAsn: 3.269 ± 0.876
0.817PhePro: 0.817 ± 0.389
2.724PheGln: 2.724 ± 1.083
1.907PheArg: 1.907 ± 0.613
5.176PheSer: 5.176 ± 1.08
3.269PheThr: 3.269 ± 0.727
2.452PheVal: 2.452 ± 0.678
0.272PheTrp: 0.272 ± 0.232
1.634PheTyr: 1.634 ± 0.7
0.0PheXaa: 0.0 ± 0.0
Gly
1.362GlyAla: 1.362 ± 0.519
0.817GlyCys: 0.817 ± 0.483
2.996GlyAsp: 2.996 ± 0.883
2.724GlyGlu: 2.724 ± 0.715
2.724GlyPhe: 2.724 ± 0.786
1.09GlyGly: 1.09 ± 0.547
1.09GlyHis: 1.09 ± 0.626
2.724GlyIle: 2.724 ± 1.008
3.814GlyLys: 3.814 ± 0.944
4.631GlyLeu: 4.631 ± 1.252
1.09GlyMet: 1.09 ± 0.659
1.362GlyAsn: 1.362 ± 0.587
0.272GlyPro: 0.272 ± 0.252
3.269GlyGln: 3.269 ± 1.05
2.996GlyArg: 2.996 ± 1.208
1.907GlySer: 1.907 ± 0.764
3.269GlyThr: 3.269 ± 0.974
3.814GlyVal: 3.814 ± 1.03
1.362GlyTrp: 1.362 ± 0.528
3.269GlyTyr: 3.269 ± 1.102
0.0GlyXaa: 0.0 ± 0.0
His
1.362HisAla: 1.362 ± 0.983
0.0HisCys: 0.0 ± 0.0
0.545HisAsp: 0.545 ± 0.396
0.545HisGlu: 0.545 ± 0.326
0.0HisPhe: 0.0 ± 0.0
0.545HisGly: 0.545 ± 0.35
0.817HisHis: 0.817 ± 0.48
0.817HisIle: 0.817 ± 0.453
1.362HisLys: 1.362 ± 0.837
2.996HisLeu: 2.996 ± 1.288
0.0HisMet: 0.0 ± 0.0
0.545HisAsn: 0.545 ± 0.497
1.362HisPro: 1.362 ± 0.629
1.362HisGln: 1.362 ± 0.675
0.817HisArg: 0.817 ± 0.568
0.545HisSer: 0.545 ± 0.347
1.362HisThr: 1.362 ± 0.383
0.545HisVal: 0.545 ± 0.386
0.272HisTrp: 0.272 ± 0.232
2.179HisTyr: 2.179 ± 0.685
0.0HisXaa: 0.0 ± 0.0
Ile
4.358IleAla: 4.358 ± 1.187
1.362IleCys: 1.362 ± 1.02
5.448IleAsp: 5.448 ± 1.094
7.083IleGlu: 7.083 ± 1.701
3.269IlePhe: 3.269 ± 0.947
3.541IleGly: 3.541 ± 0.753
0.545IleHis: 0.545 ± 0.439
2.452IleIle: 2.452 ± 0.881
9.534IleLys: 9.534 ± 1.625
3.541IleLeu: 3.541 ± 0.768
1.362IleMet: 1.362 ± 0.659
3.814IleAsn: 3.814 ± 0.922
2.179IlePro: 2.179 ± 0.578
3.541IleGln: 3.541 ± 0.851
2.179IleArg: 2.179 ± 0.789
4.086IleSer: 4.086 ± 1.17
5.721IleThr: 5.721 ± 1.038
2.179IleVal: 2.179 ± 0.681
0.545IleTrp: 0.545 ± 0.504
2.724IleTyr: 2.724 ± 1.054
0.0IleXaa: 0.0 ± 0.0
Lys
7.083LysAla: 7.083 ± 1.396
0.545LysCys: 0.545 ± 0.581
4.631LysAsp: 4.631 ± 1.108
9.262LysGlu: 9.262 ± 1.809
3.269LysPhe: 3.269 ± 1.193
5.721LysGly: 5.721 ± 1.633
2.996LysHis: 2.996 ± 0.875
7.083LysIle: 7.083 ± 1.092
11.713LysLys: 11.713 ± 2.76
8.172LysLeu: 8.172 ± 1.665
2.452LysMet: 2.452 ± 1.07
5.993LysAsn: 5.993 ± 0.911
3.269LysPro: 3.269 ± 1.243
4.631LysGln: 4.631 ± 1.215
5.176LysArg: 5.176 ± 1.458
4.631LysSer: 4.631 ± 1.172
4.631LysThr: 4.631 ± 1.093
4.086LysVal: 4.086 ± 1.075
0.272LysTrp: 0.272 ± 0.255
2.179LysTyr: 2.179 ± 0.781
0.0LysXaa: 0.0 ± 0.0
Leu
6.265LeuAla: 6.265 ± 1.224
0.545LeuCys: 0.545 ± 0.338
6.538LeuAsp: 6.538 ± 1.671
8.989LeuGlu: 8.989 ± 1.539
4.903LeuPhe: 4.903 ± 1.18
4.358LeuGly: 4.358 ± 0.995
1.362LeuHis: 1.362 ± 0.529
5.993LeuIle: 5.993 ± 1.187
8.445LeuLys: 8.445 ± 1.285
11.441LeuLeu: 11.441 ± 2.196
2.724LeuMet: 2.724 ± 0.769
4.903LeuAsn: 4.903 ± 1.056
5.176LeuPro: 5.176 ± 1.358
3.814LeuGln: 3.814 ± 0.991
3.541LeuArg: 3.541 ± 0.89
5.176LeuSer: 5.176 ± 1.384
4.903LeuThr: 4.903 ± 0.959
5.721LeuVal: 5.721 ± 1.61
0.545LeuTrp: 0.545 ± 0.316
4.903LeuTyr: 4.903 ± 0.872
0.0LeuXaa: 0.0 ± 0.0
Met
2.452MetAla: 2.452 ± 0.869
0.0MetCys: 0.0 ± 0.0
1.907MetAsp: 1.907 ± 0.638
1.09MetGlu: 1.09 ± 0.513
0.545MetPhe: 0.545 ± 0.415
0.272MetGly: 0.272 ± 0.235
0.0MetHis: 0.0 ± 0.0
1.09MetIle: 1.09 ± 0.635
2.996MetLys: 2.996 ± 0.797
3.541MetLeu: 3.541 ± 0.63
0.817MetMet: 0.817 ± 0.523
1.907MetAsn: 1.907 ± 0.834
0.545MetPro: 0.545 ± 0.341
0.272MetGln: 0.272 ± 0.272
1.362MetArg: 1.362 ± 0.545
1.907MetSer: 1.907 ± 1.051
2.724MetThr: 2.724 ± 0.684
0.545MetVal: 0.545 ± 0.378
0.0MetTrp: 0.0 ± 0.0
0.817MetTyr: 0.817 ± 0.485
0.0MetXaa: 0.0 ± 0.0
Asn
2.724AsnAla: 2.724 ± 1.108
0.0AsnCys: 0.0 ± 0.0
1.907AsnAsp: 1.907 ± 0.645
4.631AsnGlu: 4.631 ± 1.098
1.09AsnPhe: 1.09 ± 0.599
4.086AsnGly: 4.086 ± 0.895
2.452AsnHis: 2.452 ± 0.916
1.907AsnIle: 1.907 ± 0.837
4.358AsnLys: 4.358 ± 0.762
5.721AsnLeu: 5.721 ± 0.806
1.362AsnMet: 1.362 ± 0.504
2.996AsnAsn: 2.996 ± 1.123
1.362AsnPro: 1.362 ± 0.538
4.086AsnGln: 4.086 ± 1.336
3.269AsnArg: 3.269 ± 0.729
3.814AsnSer: 3.814 ± 1.023
2.179AsnThr: 2.179 ± 0.604
2.179AsnVal: 2.179 ± 0.832
0.545AsnTrp: 0.545 ± 0.427
1.907AsnTyr: 1.907 ± 0.598
0.0AsnXaa: 0.0 ± 0.0
Pro
0.817ProAla: 0.817 ± 0.422
0.0ProCys: 0.0 ± 0.0
1.362ProAsp: 1.362 ± 0.545
3.541ProGlu: 3.541 ± 0.856
2.179ProPhe: 2.179 ± 0.739
0.272ProGly: 0.272 ± 0.261
0.272ProHis: 0.272 ± 0.248
2.179ProIle: 2.179 ± 0.783
4.358ProLys: 4.358 ± 0.95
2.724ProLeu: 2.724 ± 0.718
0.272ProMet: 0.272 ± 0.326
2.452ProAsn: 2.452 ± 0.899
1.362ProPro: 1.362 ± 0.647
0.817ProGln: 0.817 ± 0.39
1.907ProArg: 1.907 ± 0.8
1.362ProSer: 1.362 ± 0.635
1.09ProThr: 1.09 ± 0.559
1.907ProVal: 1.907 ± 0.681
0.0ProTrp: 0.0 ± 0.0
1.907ProTyr: 1.907 ± 0.751
0.0ProXaa: 0.0 ± 0.0
Gln
1.362GlnAla: 1.362 ± 0.637
0.272GlnCys: 0.272 ± 0.248
4.086GlnAsp: 4.086 ± 1.146
5.176GlnGlu: 5.176 ± 1.329
1.907GlnPhe: 1.907 ± 0.803
1.634GlnGly: 1.634 ± 0.656
1.362GlnHis: 1.362 ± 0.719
3.814GlnIle: 3.814 ± 0.905
5.448GlnLys: 5.448 ± 1.405
5.721GlnLeu: 5.721 ± 1.241
1.09GlnMet: 1.09 ± 0.589
2.452GlnAsn: 2.452 ± 0.71
1.09GlnPro: 1.09 ± 0.587
1.907GlnGln: 1.907 ± 0.862
2.996GlnArg: 2.996 ± 0.853
1.907GlnSer: 1.907 ± 0.763
0.817GlnThr: 0.817 ± 0.404
1.907GlnVal: 1.907 ± 0.656
0.0GlnTrp: 0.0 ± 0.0
2.724GlnTyr: 2.724 ± 0.954
0.0GlnXaa: 0.0 ± 0.0
Arg
2.179ArgAla: 2.179 ± 0.726
0.0ArgCys: 0.0 ± 0.0
2.452ArgAsp: 2.452 ± 0.777
2.996ArgGlu: 2.996 ± 0.895
2.996ArgPhe: 2.996 ± 1.099
2.724ArgGly: 2.724 ± 0.923
0.545ArgHis: 0.545 ± 0.392
2.452ArgIle: 2.452 ± 0.681
4.358ArgLys: 4.358 ± 0.814
4.903ArgLeu: 4.903 ± 0.885
1.907ArgMet: 1.907 ± 0.669
2.452ArgAsn: 2.452 ± 0.736
1.634ArgPro: 1.634 ± 0.646
3.269ArgGln: 3.269 ± 0.859
2.724ArgArg: 2.724 ± 0.895
1.362ArgSer: 1.362 ± 0.682
4.086ArgThr: 4.086 ± 0.838
3.269ArgVal: 3.269 ± 0.941
0.545ArgTrp: 0.545 ± 0.36
2.179ArgTyr: 2.179 ± 0.948
0.0ArgXaa: 0.0 ± 0.0
Ser
2.452SerAla: 2.452 ± 0.647
0.272SerCys: 0.272 ± 0.326
3.814SerAsp: 3.814 ± 0.967
5.448SerGlu: 5.448 ± 1.369
2.724SerPhe: 2.724 ± 0.951
1.634SerGly: 1.634 ± 0.663
0.0SerHis: 0.0 ± 0.0
5.993SerIle: 5.993 ± 1.111
3.541SerLys: 3.541 ± 1.109
5.993SerLeu: 5.993 ± 1.162
1.362SerMet: 1.362 ± 0.573
3.269SerAsn: 3.269 ± 0.78
1.09SerPro: 1.09 ± 0.464
2.996SerGln: 2.996 ± 0.991
1.634SerArg: 1.634 ± 0.548
2.724SerSer: 2.724 ± 0.77
2.179SerThr: 2.179 ± 0.68
4.631SerVal: 4.631 ± 1.083
0.817SerTrp: 0.817 ± 0.505
4.358SerTyr: 4.358 ± 1.171
0.0SerXaa: 0.0 ± 0.0
Thr
2.452ThrAla: 2.452 ± 1.042
0.272ThrCys: 0.272 ± 0.3
2.179ThrAsp: 2.179 ± 0.753
4.631ThrGlu: 4.631 ± 1.154
2.996ThrPhe: 2.996 ± 0.768
4.631ThrGly: 4.631 ± 1.094
0.817ThrHis: 0.817 ± 0.419
4.086ThrIle: 4.086 ± 0.85
4.358ThrLys: 4.358 ± 0.907
5.721ThrLeu: 5.721 ± 1.397
1.907ThrMet: 1.907 ± 0.483
2.452ThrAsn: 2.452 ± 0.958
3.541ThrPro: 3.541 ± 0.928
1.362ThrGln: 1.362 ± 0.743
1.362ThrArg: 1.362 ± 0.584
3.814ThrSer: 3.814 ± 1.148
4.631ThrThr: 4.631 ± 1.435
4.358ThrVal: 4.358 ± 0.997
0.817ThrTrp: 0.817 ± 0.381
2.179ThrTyr: 2.179 ± 1.035
0.0ThrXaa: 0.0 ± 0.0
Val
1.907ValAla: 1.907 ± 0.778
0.272ValCys: 0.272 ± 0.258
2.724ValAsp: 2.724 ± 0.911
1.907ValGlu: 1.907 ± 0.758
3.269ValPhe: 3.269 ± 0.873
1.362ValGly: 1.362 ± 0.549
1.634ValHis: 1.634 ± 0.639
4.358ValIle: 4.358 ± 1.187
3.541ValLys: 3.541 ± 0.702
5.176ValLeu: 5.176 ± 1.225
2.179ValMet: 2.179 ± 0.664
2.452ValAsn: 2.452 ± 0.907
1.362ValPro: 1.362 ± 0.556
1.634ValGln: 1.634 ± 0.709
1.907ValArg: 1.907 ± 0.627
3.541ValSer: 3.541 ± 0.879
5.176ValThr: 5.176 ± 1.503
2.724ValVal: 2.724 ± 0.971
1.362ValTrp: 1.362 ± 0.688
1.634ValTyr: 1.634 ± 0.399
0.0ValXaa: 0.0 ± 0.0
Trp
0.272TrpAla: 0.272 ± 0.314
0.0TrpCys: 0.0 ± 0.0
0.817TrpAsp: 0.817 ± 0.564
1.634TrpGlu: 1.634 ± 0.673
0.0TrpPhe: 0.0 ± 0.0
0.272TrpGly: 0.272 ± 0.336
0.272TrpHis: 0.272 ± 0.252
0.817TrpIle: 0.817 ± 0.463
0.817TrpLys: 0.817 ± 0.569
1.09TrpLeu: 1.09 ± 0.715
0.0TrpMet: 0.0 ± 0.0
0.545TrpAsn: 0.545 ± 0.38
0.272TrpPro: 0.272 ± 0.232
0.545TrpGln: 0.545 ± 0.406
0.0TrpArg: 0.0 ± 0.0
1.09TrpSer: 1.09 ± 0.447
0.0TrpThr: 0.0 ± 0.0
0.272TrpVal: 0.272 ± 0.255
0.272TrpTrp: 0.272 ± 0.261
0.545TrpTyr: 0.545 ± 0.383
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.09TyrAla: 1.09 ± 0.427
0.817TyrCys: 0.817 ± 0.443
2.724TyrAsp: 2.724 ± 0.935
2.724TyrGlu: 2.724 ± 0.802
2.996TyrPhe: 2.996 ± 0.626
2.996TyrGly: 2.996 ± 0.946
0.817TyrHis: 0.817 ± 0.453
2.724TyrIle: 2.724 ± 0.704
5.721TyrLys: 5.721 ± 1.014
4.631TyrLeu: 4.631 ± 1.054
0.817TyrMet: 0.817 ± 0.363
2.996TyrAsn: 2.996 ± 0.864
1.907TyrPro: 1.907 ± 0.781
4.086TyrGln: 4.086 ± 1.196
3.541TyrArg: 3.541 ± 1.028
3.269TyrSer: 3.269 ± 0.85
1.634TyrThr: 1.634 ± 0.52
1.634TyrVal: 1.634 ± 0.576
0.0TyrTrp: 0.0 ± 0.0
2.452TyrTyr: 2.452 ± 0.832
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 30 proteins (3672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski