Amino acid dipepetide frequency for Mycolicibacterium neoaurum VKM Ac-1815D

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.705AlaAla: 20.705 ± 0.173	0.952AlaCys: 0.952 ± 0.025	9.042AlaAsp: 9.042 ± 0.083	8.036AlaGlu: 8.036 ± 0.084	3.468AlaPhe: 3.468 ± 0.057	12.326AlaGly: 12.326 ± 0.089	2.578AlaHis: 2.578 ± 0.041	5.487AlaIle: 5.487 ± 0.06	2.872AlaLys: 2.872 ± 0.052	13.405AlaLeu: 13.405 ± 0.107	2.904AlaMet: 2.904 ± 0.044	2.441AlaAsn: 2.441 ± 0.043	6.471AlaPro: 6.471 ± 0.09	4.061AlaGln: 4.061 ± 0.061	8.483AlaArg: 8.483 ± 0.091	5.545AlaSer: 5.545 ± 0.056	7.387AlaThr: 7.387 ± 0.074	12.196AlaVal: 12.196 ± 0.093	1.555AlaTrp: 1.555 ± 0.034	2.309AlaTyr: 2.309 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.107CysAla: 1.107 ± 0.026	0.086CysCys: 0.086 ± 0.008	0.482CysAsp: 0.482 ± 0.018	0.358CysGlu: 0.358 ± 0.013	0.208CysPhe: 0.208 ± 0.012	0.914CysGly: 0.914 ± 0.025	0.168CysHis: 0.168 ± 0.01	0.259CysIle: 0.259 ± 0.013	0.106CysLys: 0.106 ± 0.01	0.619CysLeu: 0.619 ± 0.017	0.123CysMet: 0.123 ± 0.009	0.16CysAsn: 0.16 ± 0.01	0.46CysPro: 0.46 ± 0.016	0.194CysGln: 0.194 ± 0.012	0.565CysArg: 0.565 ± 0.018	0.466CysSer: 0.466 ± 0.017	0.498CysThr: 0.498 ± 0.02	0.627CysVal: 0.627 ± 0.02	0.112CysTrp: 0.112 ± 0.008	0.18CysTyr: 0.18 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.899AspAla: 7.899 ± 0.074	0.45AspCys: 0.45 ± 0.016	4.291AspAsp: 4.291 ± 0.061	4.002AspGlu: 4.002 ± 0.054	1.8AspPhe: 1.8 ± 0.035	6.119AspGly: 6.119 ± 0.075	1.415AspHis: 1.415 ± 0.03	3.025AspIle: 3.025 ± 0.044	1.284AspLys: 1.284 ± 0.034	6.229AspLeu: 6.229 ± 0.057	1.028AspMet: 1.028 ± 0.028	1.301AspAsn: 1.301 ± 0.032	4.58AspPro: 4.58 ± 0.057	1.746AspGln: 1.746 ± 0.035	4.742AspArg: 4.742 ± 0.058	2.968AspSer: 2.968 ± 0.047	3.522AspThr: 3.522 ± 0.045	5.151AspVal: 5.151 ± 0.06	0.969AspTrp: 0.969 ± 0.024	1.402AspTyr: 1.402 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.855GluAla: 5.855 ± 0.072	0.333GluCys: 0.333 ± 0.015	2.56GluAsp: 2.56 ± 0.051	2.319GluGlu: 2.319 ± 0.044	1.796GluPhe: 1.796 ± 0.035	3.194GluGly: 3.194 ± 0.051	1.511GluHis: 1.511 ± 0.032	2.642GluIle: 2.642 ± 0.045	1.318GluLys: 1.318 ± 0.033	6.673GluLeu: 6.673 ± 0.067	1.044GluMet: 1.044 ± 0.027	1.194GluAsn: 1.194 ± 0.031	3.06GluPro: 3.06 ± 0.054	2.294GluGln: 2.294 ± 0.038	4.273GluArg: 4.273 ± 0.064	2.728GluSer: 2.728 ± 0.046	2.61GluThr: 2.61 ± 0.039	4.266GluVal: 4.266 ± 0.048	0.687GluTrp: 0.687 ± 0.021	1.117GluTyr: 1.117 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.115PheAla: 4.115 ± 0.048	0.302PheCys: 0.302 ± 0.013	2.482PheAsp: 2.482 ± 0.045	1.532PheGlu: 1.532 ± 0.032	1.006PhePhe: 1.006 ± 0.031	3.618PheGly: 3.618 ± 0.052	0.582PheHis: 0.582 ± 0.018	1.11PheIle: 1.11 ± 0.03	0.517PheLys: 0.517 ± 0.02	2.571PheLeu: 2.571 ± 0.042	0.493PheMet: 0.493 ± 0.02	0.745PheAsn: 0.745 ± 0.022	1.372PhePro: 1.372 ± 0.03	0.66PheGln: 0.66 ± 0.022	1.607PheArg: 1.607 ± 0.031	1.681PheSer: 1.681 ± 0.036	2.157PheThr: 2.157 ± 0.037	2.666PheVal: 2.666 ± 0.043	0.475PheTrp: 0.475 ± 0.017	0.712PheTyr: 0.712 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.648GlyAla: 10.648 ± 0.087	0.795GlyCys: 0.795 ± 0.021	5.037GlyAsp: 5.037 ± 0.059	4.349GlyGlu: 4.349 ± 0.053	3.139GlyPhe: 3.139 ± 0.048	7.908GlyGly: 7.908 ± 0.099	2.054GlyHis: 2.054 ± 0.042	4.363GlyIle: 4.363 ± 0.05	2.211GlyLys: 2.211 ± 0.042	8.878GlyLeu: 8.878 ± 0.08	2.132GlyMet: 2.132 ± 0.04	1.94GlyAsn: 1.94 ± 0.048	4.574GlyPro: 4.574 ± 0.054	2.865GlyGln: 2.865 ± 0.048	6.175GlyArg: 6.175 ± 0.067	5.282GlySer: 5.282 ± 0.061	5.601GlyThr: 5.601 ± 0.072	7.703GlyVal: 7.703 ± 0.077	1.644GlyTrp: 1.644 ± 0.03	2.4GlyTyr: 2.4 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.401HisAla: 2.401 ± 0.045	0.204HisCys: 0.204 ± 0.013	1.411HisAsp: 1.411 ± 0.03	1.048HisGlu: 1.048 ± 0.031	0.678HisPhe: 0.678 ± 0.025	2.125HisGly: 2.125 ± 0.035	0.678HisHis: 0.678 ± 0.023	0.887HisIle: 0.887 ± 0.026	0.343HisLys: 0.343 ± 0.015	2.117HisLeu: 2.117 ± 0.04	0.355HisMet: 0.355 ± 0.015	0.461HisAsn: 0.461 ± 0.017	1.628HisPro: 1.628 ± 0.034	0.619HisGln: 0.619 ± 0.022	1.86HisArg: 1.86 ± 0.035	1.063HisSer: 1.063 ± 0.026	1.216HisThr: 1.216 ± 0.03	1.625HisVal: 1.625 ± 0.031	0.361HisTrp: 0.361 ± 0.015	0.547HisTyr: 0.547 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.907IleAla: 6.907 ± 0.065	0.405IleCys: 0.405 ± 0.016	3.606IleAsp: 3.606 ± 0.043	2.64IleGlu: 2.64 ± 0.046	1.162IlePhe: 1.162 ± 0.033	4.925IleGly: 4.925 ± 0.062	0.754IleHis: 0.754 ± 0.021	1.68IleIle: 1.68 ± 0.038	0.871IleLys: 0.871 ± 0.025	3.175IleLeu: 3.175 ± 0.048	0.659IleMet: 0.659 ± 0.022	1.128IleAsn: 1.128 ± 0.029	2.403IlePro: 2.403 ± 0.039	0.947IleGln: 0.947 ± 0.023	2.668IleArg: 2.668 ± 0.038	2.366IleSer: 2.366 ± 0.037	3.038IleThr: 3.038 ± 0.046	3.882IleVal: 3.882 ± 0.054	0.495IleTrp: 0.495 ± 0.017	0.822IleTyr: 0.822 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.609LysAla: 2.609 ± 0.049	0.111LysCys: 0.111 ± 0.008	1.106LysAsp: 1.106 ± 0.028	0.907LysGlu: 0.907 ± 0.027	0.6LysPhe: 0.6 ± 0.02	1.518LysGly: 1.518 ± 0.037	0.428LysHis: 0.428 ± 0.017	1.046LysIle: 1.046 ± 0.025	0.639LysLys: 0.639 ± 0.029	2.154LysLeu: 2.154 ± 0.04	0.463LysMet: 0.463 ± 0.016	0.526LysAsn: 0.526 ± 0.019	1.319LysPro: 1.319 ± 0.03	0.689LysGln: 0.689 ± 0.021	1.453LysArg: 1.453 ± 0.033	1.206LysSer: 1.206 ± 0.03	1.3LysThr: 1.3 ± 0.031	1.907LysVal: 1.907 ± 0.033	0.303LysTrp: 0.303 ± 0.014	0.448LysTyr: 0.448 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.15LeuAla: 14.15 ± 0.117	0.814LeuCys: 0.814 ± 0.021	6.57LeuAsp: 6.57 ± 0.072	4.205LeuGlu: 4.205 ± 0.064	2.751LeuPhe: 2.751 ± 0.041	8.916LeuGly: 8.916 ± 0.082	2.054LeuHis: 2.054 ± 0.035	4.411LeuIle: 4.411 ± 0.053	1.775LeuLys: 1.775 ± 0.037	9.811LeuLeu: 9.811 ± 0.101	1.735LeuMet: 1.735 ± 0.032	2.141LeuAsn: 2.141 ± 0.039	5.81LeuPro: 5.81 ± 0.074	2.633LeuGln: 2.633 ± 0.041	7.464LeuArg: 7.464 ± 0.075	5.862LeuSer: 5.862 ± 0.06	6.672LeuThr: 6.672 ± 0.067	8.597LeuVal: 8.597 ± 0.08	1.193LeuTrp: 1.193 ± 0.029	1.707LeuTyr: 1.707 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.614MetAla: 2.614 ± 0.042	0.174MetCys: 0.174 ± 0.011	0.862MetAsp: 0.862 ± 0.024	0.663MetGlu: 0.663 ± 0.02	0.633MetPhe: 0.633 ± 0.019	1.478MetGly: 1.478 ± 0.029	0.377MetHis: 0.377 ± 0.016	0.915MetIle: 0.915 ± 0.027	0.457MetLys: 0.457 ± 0.019	2.116MetLeu: 2.116 ± 0.041	0.416MetMet: 0.416 ± 0.015	0.538MetAsn: 0.538 ± 0.019	1.18MetPro: 1.18 ± 0.03	0.563MetGln: 0.563 ± 0.023	1.536MetArg: 1.536 ± 0.027	1.603MetSer: 1.603 ± 0.031	1.807MetThr: 1.807 ± 0.035	1.71MetVal: 1.71 ± 0.032	0.246MetTrp: 0.246 ± 0.011	0.341MetTyr: 0.341 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.641AsnAla: 2.641 ± 0.045	0.184AsnCys: 0.184 ± 0.011	1.216AsnAsp: 1.216 ± 0.025	0.979AsnGlu: 0.979 ± 0.025	0.68AsnPhe: 0.68 ± 0.025	2.107AsnGly: 2.107 ± 0.051	0.455AsnHis: 0.455 ± 0.019	1.017AsnIle: 1.017 ± 0.025	0.459AsnLys: 0.459 ± 0.019	2.07AsnLeu: 2.07 ± 0.038	0.428AsnMet: 0.428 ± 0.017	0.584AsnAsn: 0.584 ± 0.019	1.738AsnPro: 1.738 ± 0.034	0.646AsnGln: 0.646 ± 0.02	1.517AsnArg: 1.517 ± 0.031	1.167AsnSer: 1.167 ± 0.025	1.334AsnThr: 1.334 ± 0.032	1.709AsnVal: 1.709 ± 0.034	0.397AsnTrp: 0.397 ± 0.014	0.54AsnTyr: 0.54 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.731ProAla: 7.731 ± 0.095	0.287ProCys: 0.287 ± 0.014	4.471ProAsp: 4.471 ± 0.06	3.638ProGlu: 3.638 ± 0.051	1.622ProPhe: 1.622 ± 0.033	5.593ProGly: 5.593 ± 0.066	1.218ProHis: 1.218 ± 0.027	2.175ProIle: 2.175 ± 0.042	1.19ProLys: 1.19 ± 0.024	4.866ProLeu: 4.866 ± 0.061	1.197ProMet: 1.197 ± 0.027	1.221ProAsn: 1.221 ± 0.028	3.415ProPro: 3.415 ± 0.083	1.791ProGln: 1.791 ± 0.033	3.267ProArg: 3.267 ± 0.051	2.904ProSer: 2.904 ± 0.042	3.54ProThr: 3.54 ± 0.051	5.164ProVal: 5.164 ± 0.059	0.859ProTrp: 0.859 ± 0.022	1.111ProTyr: 1.111 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.562GlnAla: 3.562 ± 0.056	0.203GlnCys: 0.203 ± 0.01	1.283GlnAsp: 1.283 ± 0.029	1.077GlnGlu: 1.077 ± 0.029	0.98GlnPhe: 0.98 ± 0.027	2.007GlnGly: 2.007 ± 0.034	0.747GlnHis: 0.747 ± 0.021	1.618GlnIle: 1.618 ± 0.032	0.638GlnLys: 0.638 ± 0.022	3.433GlnLeu: 3.433 ± 0.053	0.694GlnMet: 0.694 ± 0.023	0.687GlnAsn: 0.687 ± 0.021	1.761GlnPro: 1.761 ± 0.036	1.312GlnGln: 1.312 ± 0.035	2.71GlnArg: 2.71 ± 0.038	1.477GlnSer: 1.477 ± 0.029	1.66GlnThr: 1.66 ± 0.034	2.527GlnVal: 2.527 ± 0.042	0.614GlnTrp: 0.614 ± 0.019	0.66GlnTyr: 0.66 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.279ArgAla: 8.279 ± 0.085	0.553ArgCys: 0.553 ± 0.018	4.218ArgAsp: 4.218 ± 0.052	3.656ArgGlu: 3.656 ± 0.049	2.331ArgPhe: 2.331 ± 0.038	5.059ArgGly: 5.059 ± 0.062	1.712ArgHis: 1.712 ± 0.037	3.544ArgIle: 3.544 ± 0.054	1.454ArgLys: 1.454 ± 0.029	7.161ArgLeu: 7.161 ± 0.076	1.713ArgMet: 1.713 ± 0.029	1.622ArgAsn: 1.622 ± 0.033	3.826ArgPro: 3.826 ± 0.057	2.16ArgGln: 2.16 ± 0.037	6.365ArgArg: 6.365 ± 0.085	3.95ArgSer: 3.95 ± 0.051	4.408ArgThr: 4.408 ± 0.049	5.515ArgVal: 5.515 ± 0.055	1.28ArgTrp: 1.28 ± 0.027	1.909ArgTyr: 1.909 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.204SerAla: 7.204 ± 0.071	0.386SerCys: 0.386 ± 0.018	3.231SerAsp: 3.231 ± 0.045	2.602SerGlu: 2.602 ± 0.045	1.7SerPhe: 1.7 ± 0.029	5.617SerGly: 5.617 ± 0.055	0.985SerHis: 0.985 ± 0.025	2.2SerIle: 2.2 ± 0.045	1.089SerLys: 1.089 ± 0.03	4.645SerLeu: 4.645 ± 0.055	1.355SerMet: 1.355 ± 0.025	1.112SerAsn: 1.112 ± 0.028	2.957SerPro: 2.957 ± 0.044	1.375SerGln: 1.375 ± 0.03	3.524SerArg: 3.524 ± 0.051	3.071SerSer: 3.071 ± 0.057	3.535SerThr: 3.535 ± 0.051	4.686SerVal: 4.686 ± 0.053	0.94SerTrp: 0.94 ± 0.023	1.218SerTyr: 1.218 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.469ThrAla: 8.469 ± 0.08	0.377ThrCys: 0.377 ± 0.014	4.104ThrAsp: 4.104 ± 0.054	3.409ThrGlu: 3.409 ± 0.045	1.906ThrPhe: 1.906 ± 0.04	6.128ThrGly: 6.128 ± 0.061	1.205ThrHis: 1.205 ± 0.026	2.584ThrIle: 2.584 ± 0.041	1.194ThrLys: 1.194 ± 0.03	5.839ThrLeu: 5.839 ± 0.06	1.227ThrMet: 1.227 ± 0.026	1.198ThrAsn: 1.198 ± 0.028	3.923ThrPro: 3.923 ± 0.047	1.496ThrGln: 1.496 ± 0.031	3.62ThrArg: 3.62 ± 0.047	3.164ThrSer: 3.164 ± 0.047	4.014ThrThr: 4.014 ± 0.079	6.295ThrVal: 6.295 ± 0.076	0.819ThrTrp: 0.819 ± 0.023	1.331ThrTyr: 1.331 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	11.364ValAla: 11.364 ± 0.104	0.711ValCys: 0.711 ± 0.021	5.836ValAsp: 5.836 ± 0.06	4.414ValGlu: 4.414 ± 0.052	2.629ValPhe: 2.629 ± 0.043	7.122ValGly: 7.122 ± 0.07	1.892ValHis: 1.892 ± 0.032	4.215ValIle: 4.215 ± 0.053	1.622ValLys: 1.622 ± 0.034	9.412ValLeu: 9.412 ± 0.085	1.623ValMet: 1.623 ± 0.033	2.0ValAsn: 2.0 ± 0.039	4.743ValPro: 4.743 ± 0.058	2.27ValGln: 2.27 ± 0.036	5.816ValArg: 5.816 ± 0.06	4.9ValSer: 4.9 ± 0.059	5.816ValThr: 5.816 ± 0.072	8.23ValVal: 8.23 ± 0.088	1.01ValTrp: 1.01 ± 0.023	1.575ValTyr: 1.575 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.527TrpAla: 1.527 ± 0.032	0.146TrpCys: 0.146 ± 0.009	0.764TrpAsp: 0.764 ± 0.021	0.613TrpGlu: 0.613 ± 0.02	0.547TrpPhe: 0.547 ± 0.017	1.017TrpGly: 1.017 ± 0.024	0.379TrpHis: 0.379 ± 0.016	0.631TrpIle: 0.631 ± 0.021	0.303TrpLys: 0.303 ± 0.014	1.696TrpLeu: 1.696 ± 0.035	0.338TrpMet: 0.338 ± 0.015	0.402TrpAsn: 0.402 ± 0.017	0.818TrpPro: 0.818 ± 0.025	0.628TrpGln: 0.628 ± 0.02	1.213TrpArg: 1.213 ± 0.028	0.917TrpSer: 0.917 ± 0.028	0.922TrpThr: 0.922 ± 0.02	1.129TrpVal: 1.129 ± 0.027	0.334TrpTrp: 0.334 ± 0.016	0.318TrpTyr: 0.318 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.433TyrAla: 2.433 ± 0.043	0.22TyrCys: 0.22 ± 0.013	1.35TyrAsp: 1.35 ± 0.031	1.026TyrGlu: 1.026 ± 0.029	0.77TyrPhe: 0.77 ± 0.023	2.009TyrGly: 2.009 ± 0.036	0.436TyrHis: 0.436 ± 0.018	0.726TyrIle: 0.726 ± 0.017	0.388TyrLys: 0.388 ± 0.02	2.401TyrLeu: 2.401 ± 0.042	0.305TyrMet: 0.305 ± 0.014	0.468TyrAsn: 0.468 ± 0.018	1.222TyrPro: 1.222 ± 0.03	0.702TyrGln: 0.702 ± 0.018	1.855TyrArg: 1.855 ± 0.03	1.111TyrSer: 1.111 ± 0.029	1.266TyrThr: 1.266 ± 0.029	1.614TyrVal: 1.614 ± 0.033	0.346TyrTrp: 0.346 ± 0.014	0.465TyrTyr: 0.465 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4995 proteins (1627888 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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