Amino acid dipepetide frequency for Sulfolobales archaeon SCGC AB-777_K20

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.356AlaAla: 4.356 ± 0.198
0.399AlaCys: 0.399 ± 0.065
3.279AlaAsp: 3.279 ± 0.165
4.901AlaGlu: 4.901 ± 0.194
2.9AlaPhe: 2.9 ± 0.154
4.589AlaGly: 4.589 ± 0.207
0.978AlaHis: 0.978 ± 0.096
4.988AlaIle: 4.988 ± 0.19
5.181AlaLys: 5.181 ± 0.164
8.845AlaLeu: 8.845 ± 0.269
1.709AlaMet: 1.709 ± 0.112
2.175AlaAsn: 2.175 ± 0.133
2.062AlaPro: 2.062 ± 0.126
1.762AlaGln: 1.762 ± 0.126
3.944AlaArg: 3.944 ± 0.175
4.289AlaSer: 4.289 ± 0.199
3.159AlaThr: 3.159 ± 0.189
6.251AlaVal: 6.251 ± 0.222
0.625AlaTrp: 0.625 ± 0.079
3.052AlaTyr: 3.052 ± 0.149
0.0AlaXaa: 0.0 ± 0.0
Cys
0.386CysAla: 0.386 ± 0.054
0.126CysCys: 0.126 ± 0.03
0.466CysAsp: 0.466 ± 0.055
0.559CysGlu: 0.559 ± 0.058
0.206CysPhe: 0.206 ± 0.046
0.718CysGly: 0.718 ± 0.072
0.14CysHis: 0.14 ± 0.03
0.319CysIle: 0.319 ± 0.049
0.459CysLys: 0.459 ± 0.059
0.412CysLeu: 0.412 ± 0.06
0.12CysMet: 0.12 ± 0.033
0.299CysAsn: 0.299 ± 0.052
0.559CysPro: 0.559 ± 0.076
0.126CysGln: 0.126 ± 0.026
0.313CysArg: 0.313 ± 0.051
0.432CysSer: 0.432 ± 0.058
0.339CysThr: 0.339 ± 0.053
0.492CysVal: 0.492 ± 0.054
0.06CysTrp: 0.06 ± 0.02
0.299CysTyr: 0.299 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
2.973AspAla: 2.973 ± 0.14
0.352AspCys: 0.352 ± 0.053
2.028AspAsp: 2.028 ± 0.109
4.243AspGlu: 4.243 ± 0.177
2.181AspPhe: 2.181 ± 0.129
3.086AspGly: 3.086 ± 0.158
0.579AspHis: 0.579 ± 0.064
2.939AspIle: 2.939 ± 0.144
3.066AspLys: 3.066 ± 0.139
5.693AspLeu: 5.693 ± 0.205
1.031AspMet: 1.031 ± 0.078
1.503AspAsn: 1.503 ± 0.094
2.66AspPro: 2.66 ± 0.139
0.845AspGln: 0.845 ± 0.075
2.647AspArg: 2.647 ± 0.149
2.647AspSer: 2.647 ± 0.143
1.616AspThr: 1.616 ± 0.088
5.619AspVal: 5.619 ± 0.205
0.519AspTrp: 0.519 ± 0.059
2.634AspTyr: 2.634 ± 0.161
0.0AspXaa: 0.0 ± 0.0
Glu
5.819GluAla: 5.819 ± 0.209
0.525GluCys: 0.525 ± 0.063
3.318GluAsp: 3.318 ± 0.172
6.63GluGlu: 6.63 ± 0.245
2.84GluPhe: 2.84 ± 0.139
5.254GluGly: 5.254 ± 0.193
0.918GluHis: 0.918 ± 0.083
6.258GluIle: 6.258 ± 0.218
5.48GluLys: 5.48 ± 0.272
8.572GluLeu: 8.572 ± 0.299
1.722GluMet: 1.722 ± 0.115
2.554GluAsn: 2.554 ± 0.132
2.367GluPro: 2.367 ± 0.127
1.111GluGln: 1.111 ± 0.094
5.154GluArg: 5.154 ± 0.196
3.737GluSer: 3.737 ± 0.141
3.046GluThr: 3.046 ± 0.139
7.262GluVal: 7.262 ± 0.232
0.751GluTrp: 0.751 ± 0.075
2.767GluTyr: 2.767 ± 0.134
0.0GluXaa: 0.0 ± 0.0
Phe
2.387PheAla: 2.387 ± 0.126
0.259PheCys: 0.259 ± 0.042
2.028PheAsp: 2.028 ± 0.12
2.84PheGlu: 2.84 ± 0.141
1.623PhePhe: 1.623 ± 0.13
2.826PheGly: 2.826 ± 0.16
0.505PheHis: 0.505 ± 0.054
2.554PheIle: 2.554 ± 0.141
2.434PheLys: 2.434 ± 0.149
4.655PheLeu: 4.655 ± 0.213
0.911PheMet: 0.911 ± 0.072
1.716PheAsn: 1.716 ± 0.119
1.656PhePro: 1.656 ± 0.121
0.805PheGln: 0.805 ± 0.083
2.121PheArg: 2.121 ± 0.127
2.86PheSer: 2.86 ± 0.14
1.902PheThr: 1.902 ± 0.109
3.451PheVal: 3.451 ± 0.186
0.306PheTrp: 0.306 ± 0.047
1.829PheTyr: 1.829 ± 0.113
0.0PheXaa: 0.0 ± 0.0
Gly
4.502GlyAla: 4.502 ± 0.201
0.525GlyCys: 0.525 ± 0.069
3.491GlyAsp: 3.491 ± 0.149
4.855GlyGlu: 4.855 ± 0.19
3.099GlyPhe: 3.099 ± 0.127
4.748GlyGly: 4.748 ± 0.193
0.958GlyHis: 0.958 ± 0.078
5.427GlyIle: 5.427 ± 0.19
5.393GlyLys: 5.393 ± 0.215
7.136GlyLeu: 7.136 ± 0.256
1.629GlyMet: 1.629 ± 0.105
2.614GlyAsn: 2.614 ± 0.131
2.115GlyPro: 2.115 ± 0.136
1.29GlyGln: 1.29 ± 0.105
3.644GlyArg: 3.644 ± 0.15
4.422GlySer: 4.422 ± 0.206
3.624GlyThr: 3.624 ± 0.169
5.899GlyVal: 5.899 ± 0.237
0.732GlyTrp: 0.732 ± 0.063
3.179GlyTyr: 3.179 ± 0.167
0.0GlyXaa: 0.0 ± 0.0
His
0.958HisAla: 0.958 ± 0.085
0.14HisCys: 0.14 ± 0.031
0.625HisAsp: 0.625 ± 0.066
0.931HisGlu: 0.931 ± 0.079
0.525HisPhe: 0.525 ± 0.059
1.237HisGly: 1.237 ± 0.089
0.266HisHis: 0.266 ± 0.045
0.732HisIle: 0.732 ± 0.072
0.645HisLys: 0.645 ± 0.073
1.244HisLeu: 1.244 ± 0.093
0.259HisMet: 0.259 ± 0.049
0.499HisAsn: 0.499 ± 0.064
0.745HisPro: 0.745 ± 0.077
0.266HisGln: 0.266 ± 0.046
0.618HisArg: 0.618 ± 0.064
0.658HisSer: 0.658 ± 0.068
0.618HisThr: 0.618 ± 0.059
1.423HisVal: 1.423 ± 0.103
0.12HisTrp: 0.12 ± 0.025
0.638HisTyr: 0.638 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
5.619IleAla: 5.619 ± 0.225
0.372IleCys: 0.372 ± 0.053
4.136IleAsp: 4.136 ± 0.183
5.24IleGlu: 5.24 ± 0.176
2.387IlePhe: 2.387 ± 0.158
4.356IleGly: 4.356 ± 0.192
1.031IleHis: 1.031 ± 0.093
4.868IleIle: 4.868 ± 0.217
4.961IleLys: 4.961 ± 0.184
6.511IleLeu: 6.511 ± 0.244
1.303IleMet: 1.303 ± 0.106
2.68IleAsn: 2.68 ± 0.148
3.039IlePro: 3.039 ± 0.142
1.35IleGln: 1.35 ± 0.104
4.123IleArg: 4.123 ± 0.152
4.875IleSer: 4.875 ± 0.241
3.791IleThr: 3.791 ± 0.189
5.959IleVal: 5.959 ± 0.191
0.412IleTrp: 0.412 ± 0.052
2.727IleTyr: 2.727 ± 0.134
0.0IleXaa: 0.0 ± 0.0
Lys
5.327LysAla: 5.327 ± 0.236
0.466LysCys: 0.466 ± 0.061
3.811LysAsp: 3.811 ± 0.17
6.77LysGlu: 6.77 ± 0.265
2.381LysPhe: 2.381 ± 0.133
5.506LysGly: 5.506 ± 0.206
0.751LysHis: 0.751 ± 0.064
4.708LysIle: 4.708 ± 0.21
4.535LysLys: 4.535 ± 0.222
7.349LysLeu: 7.349 ± 0.256
1.357LysMet: 1.357 ± 0.096
2.341LysAsn: 2.341 ± 0.156
2.547LysPro: 2.547 ± 0.136
1.164LysGln: 1.164 ± 0.08
4.509LysArg: 4.509 ± 0.196
3.398LysSer: 3.398 ± 0.175
2.913LysThr: 2.913 ± 0.135
7.269LysVal: 7.269 ± 0.249
0.672LysTrp: 0.672 ± 0.061
3.146LysTyr: 3.146 ± 0.145
0.0LysXaa: 0.0 ± 0.0
Leu
8.127LeuAla: 8.127 ± 0.273
0.618LeuCys: 0.618 ± 0.07
5.147LeuAsp: 5.147 ± 0.197
8.027LeuGlu: 8.027 ± 0.247
3.777LeuPhe: 3.777 ± 0.177
7.415LeuGly: 7.415 ± 0.245
1.337LeuHis: 1.337 ± 0.087
7.861LeuIle: 7.861 ± 0.289
8.173LeuLys: 8.173 ± 0.257
9.862LeuLeu: 9.862 ± 0.329
2.494LeuMet: 2.494 ± 0.122
4.296LeuAsn: 4.296 ± 0.2
4.283LeuPro: 4.283 ± 0.167
2.101LeuGln: 2.101 ± 0.125
6.218LeuArg: 6.218 ± 0.211
7.927LeuSer: 7.927 ± 0.256
5.094LeuThr: 5.094 ± 0.205
7.581LeuVal: 7.581 ± 0.224
0.678LeuTrp: 0.678 ± 0.075
3.93LeuTyr: 3.93 ± 0.171
0.0LeuXaa: 0.0 ± 0.0
Met
1.742MetAla: 1.742 ± 0.118
0.1MetCys: 0.1 ± 0.024
1.104MetAsp: 1.104 ± 0.086
1.297MetGlu: 1.297 ± 0.1
0.665MetPhe: 0.665 ± 0.068
1.476MetGly: 1.476 ± 0.102
0.226MetHis: 0.226 ± 0.041
1.423MetIle: 1.423 ± 0.095
1.955MetLys: 1.955 ± 0.095
1.942MetLeu: 1.942 ± 0.122
0.532MetMet: 0.532 ± 0.067
0.898MetAsn: 0.898 ± 0.077
0.845MetPro: 0.845 ± 0.076
0.419MetGln: 0.419 ± 0.056
1.656MetArg: 1.656 ± 0.109
1.643MetSer: 1.643 ± 0.101
1.117MetThr: 1.117 ± 0.082
1.45MetVal: 1.45 ± 0.094
0.186MetTrp: 0.186 ± 0.032
0.751MetTyr: 0.751 ± 0.064
0.0MetXaa: 0.0 ± 0.0
Asn
2.594AsnAla: 2.594 ± 0.13
0.313AsnCys: 0.313 ± 0.046
1.702AsnAsp: 1.702 ± 0.111
2.753AsnGlu: 2.753 ± 0.143
1.503AsnPhe: 1.503 ± 0.103
2.441AsnGly: 2.441 ± 0.199
0.392AsnHis: 0.392 ± 0.053
2.088AsnIle: 2.088 ± 0.151
2.062AsnLys: 2.062 ± 0.14
4.01AsnLeu: 4.01 ± 0.163
0.605AsnMet: 0.605 ± 0.065
1.224AsnAsn: 1.224 ± 0.109
2.354AsnPro: 2.354 ± 0.14
0.758AsnGln: 0.758 ± 0.087
1.862AsnArg: 1.862 ± 0.098
2.241AsnSer: 2.241 ± 0.155
1.623AsnThr: 1.623 ± 0.129
4.183AsnVal: 4.183 ± 0.177
0.412AsnTrp: 0.412 ± 0.051
1.955AsnTyr: 1.955 ± 0.136
0.0AsnXaa: 0.0 ± 0.0
Pro
2.241ProAla: 2.241 ± 0.132
0.246ProCys: 0.246 ± 0.039
2.161ProAsp: 2.161 ± 0.127
3.318ProGlu: 3.318 ± 0.162
2.042ProPhe: 2.042 ± 0.116
2.866ProGly: 2.866 ± 0.163
0.725ProHis: 0.725 ± 0.067
2.634ProIle: 2.634 ± 0.146
3.019ProLys: 3.019 ± 0.149
4.236ProLeu: 4.236 ± 0.206
0.738ProMet: 0.738 ± 0.078
1.822ProAsn: 1.822 ± 0.118
2.068ProPro: 2.068 ± 0.124
1.164ProGln: 1.164 ± 0.1
1.929ProArg: 1.929 ± 0.122
3.086ProSer: 3.086 ± 0.178
1.955ProThr: 1.955 ± 0.116
3.292ProVal: 3.292 ± 0.179
0.446ProTrp: 0.446 ± 0.062
1.889ProTyr: 1.889 ± 0.108
0.0ProXaa: 0.0 ± 0.0
Gln
1.776GlnAla: 1.776 ± 0.106
0.126GlnCys: 0.126 ± 0.031
0.845GlnAsp: 0.845 ± 0.085
1.583GlnGlu: 1.583 ± 0.123
0.612GlnPhe: 0.612 ± 0.072
1.576GlnGly: 1.576 ± 0.11
0.233GlnHis: 0.233 ± 0.041
1.41GlnIle: 1.41 ± 0.096
1.383GlnLys: 1.383 ± 0.101
2.394GlnLeu: 2.394 ± 0.146
0.532GlnMet: 0.532 ± 0.058
0.585GlnAsn: 0.585 ± 0.071
0.765GlnPro: 0.765 ± 0.082
0.565GlnGln: 0.565 ± 0.063
1.037GlnArg: 1.037 ± 0.083
1.097GlnSer: 1.097 ± 0.09
1.017GlnThr: 1.017 ± 0.101
1.842GlnVal: 1.842 ± 0.115
0.186GlnTrp: 0.186 ± 0.033
0.898GlnTyr: 0.898 ± 0.08
0.0GlnXaa: 0.0 ± 0.0
Arg
3.957ArgAla: 3.957 ± 0.179
0.386ArgCys: 0.386 ± 0.051
2.806ArgAsp: 2.806 ± 0.135
4.642ArgGlu: 4.642 ± 0.208
2.281ArgPhe: 2.281 ± 0.106
4.163ArgGly: 4.163 ± 0.171
0.572ArgHis: 0.572 ± 0.051
4.369ArgIle: 4.369 ± 0.199
4.688ArgLys: 4.688 ± 0.193
5.919ArgLeu: 5.919 ± 0.221
1.024ArgMet: 1.024 ± 0.076
1.902ArgAsn: 1.902 ± 0.109
2.254ArgPro: 2.254 ± 0.135
1.124ArgGln: 1.124 ± 0.094
3.924ArgArg: 3.924 ± 0.172
3.013ArgSer: 3.013 ± 0.148
2.66ArgThr: 2.66 ± 0.151
5.167ArgVal: 5.167 ± 0.181
0.512ArgTrp: 0.512 ± 0.064
1.988ArgTyr: 1.988 ± 0.121
0.0ArgXaa: 0.0 ± 0.0
Ser
3.831SerAla: 3.831 ± 0.17
0.479SerCys: 0.479 ± 0.055
2.793SerAsp: 2.793 ± 0.141
4.442SerGlu: 4.442 ± 0.188
2.727SerPhe: 2.727 ± 0.181
4.509SerGly: 4.509 ± 0.198
0.931SerHis: 0.931 ± 0.073
3.804SerIle: 3.804 ± 0.167
4.655SerLys: 4.655 ± 0.224
7.189SerLeu: 7.189 ± 0.295
1.463SerMet: 1.463 ± 0.107
2.294SerAsn: 2.294 ± 0.146
2.866SerPro: 2.866 ± 0.138
1.523SerGln: 1.523 ± 0.097
3.531SerArg: 3.531 ± 0.134
5.048SerSer: 5.048 ± 0.241
3.006SerThr: 3.006 ± 0.171
5.58SerVal: 5.58 ± 0.225
0.632SerTrp: 0.632 ± 0.066
2.607SerTyr: 2.607 ± 0.125
0.0SerXaa: 0.0 ± 0.0
Thr
3.445ThrAla: 3.445 ± 0.179
0.412ThrCys: 0.412 ± 0.049
1.915ThrAsp: 1.915 ± 0.116
3.066ThrGlu: 3.066 ± 0.131
1.915ThrPhe: 1.915 ± 0.133
3.491ThrGly: 3.491 ± 0.187
0.672ThrHis: 0.672 ± 0.059
3.285ThrIle: 3.285 ± 0.203
2.554ThrLys: 2.554 ± 0.127
5.274ThrLeu: 5.274 ± 0.169
0.964ThrMet: 0.964 ± 0.089
1.968ThrAsn: 1.968 ± 0.145
2.427ThrPro: 2.427 ± 0.137
1.097ThrGln: 1.097 ± 0.096
2.155ThrArg: 2.155 ± 0.117
3.126ThrSer: 3.126 ± 0.149
2.454ThrThr: 2.454 ± 0.204
4.456ThrVal: 4.456 ± 0.219
0.419ThrTrp: 0.419 ± 0.049
2.002ThrTyr: 2.002 ± 0.144
0.0ThrXaa: 0.0 ± 0.0
Val
5.912ValAla: 5.912 ± 0.224
0.599ValCys: 0.599 ± 0.067
4.263ValAsp: 4.263 ± 0.197
6.344ValGlu: 6.344 ± 0.211
3.717ValPhe: 3.717 ± 0.162
5.44ValGly: 5.44 ± 0.221
1.144ValHis: 1.144 ± 0.083
6.83ValIle: 6.83 ± 0.229
7.142ValLys: 7.142 ± 0.263
8.592ValLeu: 8.592 ± 0.22
2.028ValMet: 2.028 ± 0.124
3.664ValAsn: 3.664 ± 0.194
4.143ValPro: 4.143 ± 0.169
1.729ValGln: 1.729 ± 0.122
5.44ValArg: 5.44 ± 0.233
6.085ValSer: 6.085 ± 0.197
4.682ValThr: 4.682 ± 0.218
8.12ValVal: 8.12 ± 0.285
0.672ValTrp: 0.672 ± 0.069
3.837ValTyr: 3.837 ± 0.165
0.0ValXaa: 0.0 ± 0.0
Trp
0.612TrpAla: 0.612 ± 0.055
0.033TrpCys: 0.033 ± 0.013
0.565TrpAsp: 0.565 ± 0.066
0.658TrpGlu: 0.658 ± 0.06
0.386TrpPhe: 0.386 ± 0.042
0.599TrpGly: 0.599 ± 0.074
0.153TrpHis: 0.153 ± 0.033
0.645TrpIle: 0.645 ± 0.055
0.745TrpLys: 0.745 ± 0.071
0.918TrpLeu: 0.918 ± 0.078
0.206TrpMet: 0.206 ± 0.038
0.326TrpAsn: 0.326 ± 0.041
0.279TrpPro: 0.279 ± 0.041
0.16TrpGln: 0.16 ± 0.035
0.472TrpArg: 0.472 ± 0.055
0.432TrpSer: 0.432 ± 0.056
0.466TrpThr: 0.466 ± 0.062
0.785TrpVal: 0.785 ± 0.066
0.126TrpTrp: 0.126 ± 0.03
0.406TrpTyr: 0.406 ± 0.047
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.88TyrAla: 2.88 ± 0.138
0.352TyrCys: 0.352 ± 0.051
2.374TyrAsp: 2.374 ± 0.14
2.986TyrGlu: 2.986 ± 0.152
1.895TyrPhe: 1.895 ± 0.124
2.986TyrGly: 2.986 ± 0.136
0.638TyrHis: 0.638 ± 0.078
2.6TyrIle: 2.6 ± 0.147
2.387TyrLys: 2.387 ± 0.126
4.196TyrLeu: 4.196 ± 0.189
0.798TyrMet: 0.798 ± 0.067
1.716TyrAsn: 1.716 ± 0.123
1.842TyrPro: 1.842 ± 0.104
1.104TyrGln: 1.104 ± 0.105
2.055TyrArg: 2.055 ± 0.119
2.893TyrSer: 2.893 ± 0.151
2.015TyrThr: 2.015 ± 0.124
4.303TyrVal: 4.303 ± 0.171
0.512TyrTrp: 0.512 ± 0.061
1.988TyrTyr: 1.988 ± 0.129
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 579 proteins (150371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski