Amino acid dipepetide frequency for Aquimarina sp. TRL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.249AlaAla: 4.249 ± 0.089
0.528AlaCys: 0.528 ± 0.019
3.252AlaAsp: 3.252 ± 0.098
3.274AlaGlu: 3.274 ± 0.056
2.976AlaPhe: 2.976 ± 0.05
4.031AlaGly: 4.031 ± 0.104
1.16AlaHis: 1.16 ± 0.032
5.559AlaIle: 5.559 ± 0.073
4.191AlaLys: 4.191 ± 0.063
5.78AlaLeu: 5.78 ± 0.07
1.312AlaMet: 1.312 ± 0.034
3.209AlaAsn: 3.209 ± 0.065
2.103AlaPro: 2.103 ± 0.051
2.111AlaGln: 2.111 ± 0.038
1.917AlaArg: 1.917 ± 0.049
4.274AlaSer: 4.274 ± 0.055
4.205AlaThr: 4.205 ± 0.119
3.819AlaVal: 3.819 ± 0.063
0.585AlaTrp: 0.585 ± 0.036
2.69AlaTyr: 2.69 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.41CysAla: 0.41 ± 0.016
0.128CysCys: 0.128 ± 0.01
0.476CysAsp: 0.476 ± 0.039
0.433CysGlu: 0.433 ± 0.02
0.42CysPhe: 0.42 ± 0.02
0.547CysGly: 0.547 ± 0.022
0.183CysHis: 0.183 ± 0.014
0.715CysIle: 0.715 ± 0.021
0.466CysLys: 0.466 ± 0.017
0.656CysLeu: 0.656 ± 0.021
0.149CysMet: 0.149 ± 0.01
0.459CysAsn: 0.459 ± 0.021
0.311CysPro: 0.311 ± 0.019
0.246CysGln: 0.246 ± 0.014
0.232CysArg: 0.232 ± 0.013
0.697CysSer: 0.697 ± 0.041
0.536CysThr: 0.536 ± 0.023
0.418CysVal: 0.418 ± 0.015
0.091CysTrp: 0.091 ± 0.008
0.337CysTyr: 0.337 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.508AspAla: 3.508 ± 0.098
0.453AspCys: 0.453 ± 0.04
2.845AspAsp: 2.845 ± 0.131
3.257AspGlu: 3.257 ± 0.081
3.225AspPhe: 3.225 ± 0.052
4.424AspGly: 4.424 ± 0.439
1.138AspHis: 1.138 ± 0.035
4.872AspIle: 4.872 ± 0.065
3.901AspLys: 3.901 ± 0.057
4.644AspLeu: 4.644 ± 0.085
1.044AspMet: 1.044 ± 0.03
3.305AspAsn: 3.305 ± 0.139
1.979AspPro: 1.979 ± 0.064
1.979AspGln: 1.979 ± 0.044
1.926AspArg: 1.926 ± 0.043
3.35AspSer: 3.35 ± 0.161
3.675AspThr: 3.675 ± 0.181
3.378AspVal: 3.378 ± 0.091
0.675AspTrp: 0.675 ± 0.02
2.628AspTyr: 2.628 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
4.334GluAla: 4.334 ± 0.067
0.346GluCys: 0.346 ± 0.015
3.537GluAsp: 3.537 ± 0.088
5.794GluGlu: 5.794 ± 0.097
2.527GluPhe: 2.527 ± 0.051
4.026GluGly: 4.026 ± 0.066
1.173GluHis: 1.173 ± 0.032
5.717GluIle: 5.717 ± 0.073
6.268GluLys: 6.268 ± 0.104
6.023GluLeu: 6.023 ± 0.091
1.427GluMet: 1.427 ± 0.033
4.05GluAsn: 4.05 ± 0.062
1.34GluPro: 1.34 ± 0.036
2.438GluGln: 2.438 ± 0.046
2.591GluArg: 2.591 ± 0.05
3.063GluSer: 3.063 ± 0.052
3.903GluThr: 3.903 ± 0.083
4.384GluVal: 4.384 ± 0.063
0.582GluTrp: 0.582 ± 0.021
2.526GluTyr: 2.526 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
2.393PheAla: 2.393 ± 0.046
0.437PheCys: 0.437 ± 0.018
3.174PheAsp: 3.174 ± 0.05
3.079PheGlu: 3.079 ± 0.05
2.789PhePhe: 2.789 ± 0.065
3.088PheGly: 3.088 ± 0.063
0.825PheHis: 0.825 ± 0.022
3.929PheIle: 3.929 ± 0.069
3.214PheLys: 3.214 ± 0.061
4.525PheLeu: 4.525 ± 0.082
0.988PheMet: 0.988 ± 0.024
2.696PheAsn: 2.696 ± 0.045
1.653PhePro: 1.653 ± 0.034
1.379PheGln: 1.379 ± 0.031
1.683PheArg: 1.683 ± 0.039
4.192PheSer: 4.192 ± 0.057
3.002PheThr: 3.002 ± 0.06
2.669PheVal: 2.669 ± 0.051
0.549PheTrp: 0.549 ± 0.02
2.151PheTyr: 2.151 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.216GlyAla: 4.216 ± 0.075
0.657GlyCys: 0.657 ± 0.043
3.809GlyAsp: 3.809 ± 0.211
3.681GlyGlu: 3.681 ± 0.061
3.239GlyPhe: 3.239 ± 0.061
4.674GlyGly: 4.674 ± 0.101
1.128GlyHis: 1.128 ± 0.035
5.791GlyIle: 5.791 ± 0.101
4.625GlyLys: 4.625 ± 0.078
5.126GlyLeu: 5.126 ± 0.073
1.451GlyMet: 1.451 ± 0.039
3.88GlyAsn: 3.88 ± 0.121
1.187GlyPro: 1.187 ± 0.03
1.749GlyGln: 1.749 ± 0.04
2.111GlyArg: 2.111 ± 0.044
3.968GlySer: 3.968 ± 0.097
4.592GlyThr: 4.592 ± 0.126
4.911GlyVal: 4.911 ± 0.107
0.747GlyTrp: 0.747 ± 0.022
2.982GlyTyr: 2.982 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
0.99HisAla: 0.99 ± 0.029
0.202HisCys: 0.202 ± 0.014
0.849HisAsp: 0.849 ± 0.024
1.007HisGlu: 1.007 ± 0.027
1.18HisPhe: 1.18 ± 0.028
1.078HisGly: 1.078 ± 0.031
0.558HisHis: 0.558 ± 0.025
1.706HisIle: 1.706 ± 0.04
1.414HisLys: 1.414 ± 0.035
1.873HisLeu: 1.873 ± 0.039
0.36HisMet: 0.36 ± 0.015
0.917HisAsn: 0.917 ± 0.025
0.939HisPro: 0.939 ± 0.028
0.957HisGln: 0.957 ± 0.031
0.76HisArg: 0.76 ± 0.023
1.166HisSer: 1.166 ± 0.03
1.28HisThr: 1.28 ± 0.033
0.874HisVal: 0.874 ± 0.026
0.223HisTrp: 0.223 ± 0.013
0.938HisTyr: 0.938 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.723IleAla: 5.723 ± 0.079
0.7IleCys: 0.7 ± 0.024
5.135IleAsp: 5.135 ± 0.103
5.595IleGlu: 5.595 ± 0.083
3.202IlePhe: 3.202 ± 0.064
5.275IleGly: 5.275 ± 0.094
1.746IleHis: 1.746 ± 0.04
6.06IleIle: 6.06 ± 0.087
6.004IleLys: 6.004 ± 0.088
6.954IleLeu: 6.954 ± 0.104
1.261IleMet: 1.261 ± 0.034
4.779IleAsn: 4.779 ± 0.066
3.642IlePro: 3.642 ± 0.057
2.796IleGln: 2.796 ± 0.048
2.951IleArg: 2.951 ± 0.054
6.233IleSer: 6.233 ± 0.084
5.796IleThr: 5.796 ± 0.082
4.634IleVal: 4.634 ± 0.058
0.742IleTrp: 0.742 ± 0.024
2.853IleTyr: 2.853 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.54LysAla: 4.54 ± 0.07
0.358LysCys: 0.358 ± 0.016
4.116LysAsp: 4.116 ± 0.07
7.4LysGlu: 7.4 ± 0.104
2.395LysPhe: 2.395 ± 0.042
4.646LysGly: 4.646 ± 0.075
1.455LysHis: 1.455 ± 0.037
6.043LysIle: 6.043 ± 0.086
8.176LysLys: 8.176 ± 0.114
5.965LysLeu: 5.965 ± 0.093
1.772LysMet: 1.772 ± 0.042
5.223LysAsn: 5.223 ± 0.085
2.085LysPro: 2.085 ± 0.04
2.79LysGln: 2.79 ± 0.05
3.023LysArg: 3.023 ± 0.054
3.977LysSer: 3.977 ± 0.064
4.845LysThr: 4.845 ± 0.082
4.436LysVal: 4.436 ± 0.062
0.75LysTrp: 0.75 ± 0.023
2.838LysTyr: 2.838 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
5.119LeuAla: 5.119 ± 0.071
0.734LeuCys: 0.734 ± 0.022
4.905LeuAsp: 4.905 ± 0.141
5.958LeuGlu: 5.958 ± 0.103
4.742LeuPhe: 4.742 ± 0.079
5.475LeuGly: 5.475 ± 0.077
1.829LeuHis: 1.829 ± 0.041
6.915LeuIle: 6.915 ± 0.098
6.916LeuLys: 6.916 ± 0.106
8.828LeuLeu: 8.828 ± 0.123
1.774LeuMet: 1.774 ± 0.038
4.517LeuAsn: 4.517 ± 0.07
3.471LeuPro: 3.471 ± 0.063
3.535LeuGln: 3.535 ± 0.071
3.149LeuArg: 3.149 ± 0.052
7.036LeuSer: 7.036 ± 0.087
5.551LeuThr: 5.551 ± 0.15
4.876LeuVal: 4.876 ± 0.08
0.823LeuTrp: 0.823 ± 0.026
3.372LeuTyr: 3.372 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
1.271MetAla: 1.271 ± 0.038
0.144MetCys: 0.144 ± 0.009
1.025MetAsp: 1.025 ± 0.025
1.273MetGlu: 1.273 ± 0.032
0.732MetPhe: 0.732 ± 0.023
1.21MetGly: 1.21 ± 0.031
0.371MetHis: 0.371 ± 0.015
1.609MetIle: 1.609 ± 0.043
2.034MetLys: 2.034 ± 0.041
1.713MetLeu: 1.713 ± 0.044
0.522MetMet: 0.522 ± 0.019
1.256MetAsn: 1.256 ± 0.029
0.714MetPro: 0.714 ± 0.024
0.629MetGln: 0.629 ± 0.024
0.782MetArg: 0.782 ± 0.025
1.311MetSer: 1.311 ± 0.031
1.154MetThr: 1.154 ± 0.032
1.192MetVal: 1.192 ± 0.035
0.147MetTrp: 0.147 ± 0.01
0.751MetTyr: 0.751 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.559AsnAla: 3.559 ± 0.076
0.439AsnCys: 0.439 ± 0.017
3.268AsnAsp: 3.268 ± 0.1
3.393AsnGlu: 3.393 ± 0.059
2.595AsnPhe: 2.595 ± 0.048
4.121AsnGly: 4.121 ± 0.107
1.09AsnHis: 1.09 ± 0.026
4.534AsnIle: 4.534 ± 0.066
4.249AsnLys: 4.249 ± 0.07
4.651AsnLeu: 4.651 ± 0.142
1.11AsnMet: 1.11 ± 0.03
3.561AsnAsn: 3.561 ± 0.069
2.481AsnPro: 2.481 ± 0.047
2.252AsnGln: 2.252 ± 0.063
2.226AsnArg: 2.226 ± 0.044
3.493AsnSer: 3.493 ± 0.061
4.337AsnThr: 4.337 ± 0.091
3.035AsnVal: 3.035 ± 0.065
0.722AsnTrp: 0.722 ± 0.027
2.616AsnTyr: 2.616 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
1.921ProAla: 1.921 ± 0.05
0.243ProCys: 0.243 ± 0.011
2.266ProAsp: 2.266 ± 0.068
2.764ProGlu: 2.764 ± 0.052
1.838ProPhe: 1.838 ± 0.034
1.97ProGly: 1.97 ± 0.049
0.613ProHis: 0.613 ± 0.021
2.681ProIle: 2.681 ± 0.051
2.351ProLys: 2.351 ± 0.049
2.947ProLeu: 2.947 ± 0.052
0.686ProMet: 0.686 ± 0.026
1.989ProAsn: 1.989 ± 0.047
0.955ProPro: 0.955 ± 0.034
1.103ProGln: 1.103 ± 0.03
0.93ProArg: 0.93 ± 0.025
2.452ProSer: 2.452 ± 0.057
2.179ProThr: 2.179 ± 0.086
2.537ProVal: 2.537 ± 0.055
0.349ProTrp: 0.349 ± 0.017
1.477ProTyr: 1.477 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
1.924GlnAla: 1.924 ± 0.036
0.225GlnCys: 0.225 ± 0.013
1.542GlnAsp: 1.542 ± 0.044
2.715GlnGlu: 2.715 ± 0.057
1.581GlnPhe: 1.581 ± 0.033
1.979GlnGly: 1.979 ± 0.043
0.711GlnHis: 0.711 ± 0.023
2.525GlnIle: 2.525 ± 0.048
3.111GlnLys: 3.111 ± 0.053
3.815GlnLeu: 3.815 ± 0.062
0.721GlnMet: 0.721 ± 0.022
1.923GlnAsn: 1.923 ± 0.044
0.998GlnPro: 0.998 ± 0.033
1.704GlnGln: 1.704 ± 0.037
1.291GlnArg: 1.291 ± 0.029
1.949GlnSer: 1.949 ± 0.042
1.997GlnThr: 1.997 ± 0.055
2.074GlnVal: 2.074 ± 0.037
0.436GlnTrp: 0.436 ± 0.017
1.62GlnTyr: 1.62 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
1.953ArgAla: 1.953 ± 0.046
0.216ArgCys: 0.216 ± 0.013
1.728ArgAsp: 1.728 ± 0.042
2.347ArgGlu: 2.347 ± 0.043
1.965ArgPhe: 1.965 ± 0.043
1.995ArgGly: 1.995 ± 0.045
0.647ArgHis: 0.647 ± 0.019
3.223ArgIle: 3.223 ± 0.057
3.049ArgLys: 3.049 ± 0.052
3.331ArgLeu: 3.331 ± 0.06
0.827ArgMet: 0.827 ± 0.026
2.152ArgAsn: 2.152 ± 0.043
1.074ArgPro: 1.074 ± 0.029
1.153ArgGln: 1.153 ± 0.033
1.383ArgArg: 1.383 ± 0.041
2.067ArgSer: 2.067 ± 0.05
1.979ArgThr: 1.979 ± 0.039
2.097ArgVal: 2.097 ± 0.038
0.405ArgTrp: 0.405 ± 0.015
1.745ArgTyr: 1.745 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.461SerAla: 3.461 ± 0.054
0.781SerCys: 0.781 ± 0.028
3.804SerAsp: 3.804 ± 0.149
3.904SerGlu: 3.904 ± 0.064
3.973SerPhe: 3.973 ± 0.061
4.869SerGly: 4.869 ± 0.094
1.184SerHis: 1.184 ± 0.034
5.504SerIle: 5.504 ± 0.074
4.695SerLys: 4.695 ± 0.073
6.513SerLeu: 6.513 ± 0.106
1.259SerMet: 1.259 ± 0.032
3.778SerAsn: 3.778 ± 0.064
2.296SerPro: 2.296 ± 0.048
2.066SerGln: 2.066 ± 0.047
2.203SerArg: 2.203 ± 0.047
4.747SerSer: 4.747 ± 0.075
3.703SerThr: 3.703 ± 0.072
3.966SerVal: 3.966 ± 0.067
0.802SerTrp: 0.802 ± 0.026
3.276SerTyr: 3.276 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.554ThrAla: 4.554 ± 0.176
0.363ThrCys: 0.363 ± 0.017
3.816ThrAsp: 3.816 ± 0.196
3.535ThrGlu: 3.535 ± 0.062
3.01ThrPhe: 3.01 ± 0.059
4.315ThrGly: 4.315 ± 0.087
1.253ThrHis: 1.253 ± 0.026
5.911ThrIle: 5.911 ± 0.082
4.031ThrLys: 4.031 ± 0.063
5.65ThrLeu: 5.65 ± 0.083
0.98ThrMet: 0.98 ± 0.028
3.596ThrAsn: 3.596 ± 0.102
3.127ThrPro: 3.127 ± 0.063
1.907ThrGln: 1.907 ± 0.036
1.874ThrArg: 1.874 ± 0.042
4.57ThrSer: 4.57 ± 0.093
4.661ThrThr: 4.661 ± 0.161
4.471ThrVal: 4.471 ± 0.188
0.602ThrTrp: 0.602 ± 0.046
3.011ThrTyr: 3.011 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
4.114ValAla: 4.114 ± 0.07
0.488ValCys: 0.488 ± 0.02
3.591ValAsp: 3.591 ± 0.177
3.438ValGlu: 3.438 ± 0.054
3.303ValPhe: 3.303 ± 0.056
3.471ValGly: 3.471 ± 0.061
1.054ValHis: 1.054 ± 0.031
4.934ValIle: 4.934 ± 0.073
3.959ValLys: 3.959 ± 0.054
5.881ValLeu: 5.881 ± 0.068
1.186ValMet: 1.186 ± 0.036
3.141ValAsn: 3.141 ± 0.046
2.136ValPro: 2.136 ± 0.051
1.888ValGln: 1.888 ± 0.046
2.01ValArg: 2.01 ± 0.039
4.738ValSer: 4.738 ± 0.081
4.285ValThr: 4.285 ± 0.182
3.996ValVal: 3.996 ± 0.07
0.581ValTrp: 0.581 ± 0.02
2.505ValTyr: 2.505 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.546TrpAla: 0.546 ± 0.02
0.11TrpCys: 0.11 ± 0.009
0.585TrpAsp: 0.585 ± 0.02
0.701TrpGlu: 0.701 ± 0.022
0.513TrpPhe: 0.513 ± 0.021
0.68TrpGly: 0.68 ± 0.023
0.196TrpHis: 0.196 ± 0.011
0.796TrpIle: 0.796 ± 0.03
0.886TrpLys: 0.886 ± 0.026
0.886TrpLeu: 0.886 ± 0.028
0.267TrpMet: 0.267 ± 0.013
0.756TrpAsn: 0.756 ± 0.034
0.182TrpPro: 0.182 ± 0.013
0.364TrpGln: 0.364 ± 0.015
0.435TrpArg: 0.435 ± 0.02
0.727TrpSer: 0.727 ± 0.043
0.557TrpThr: 0.557 ± 0.021
0.645TrpVal: 0.645 ± 0.022
0.145TrpTrp: 0.145 ± 0.011
0.464TrpTyr: 0.464 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.442TyrAla: 2.442 ± 0.039
0.357TyrCys: 0.357 ± 0.019
2.481TyrAsp: 2.481 ± 0.064
2.501TyrGlu: 2.501 ± 0.049
2.213TyrPhe: 2.213 ± 0.045
2.65TyrGly: 2.65 ± 0.047
0.955TyrHis: 0.955 ± 0.026
3.056TyrIle: 3.056 ± 0.047
3.292TyrLys: 3.292 ± 0.062
3.764TyrLeu: 3.764 ± 0.056
0.745TyrMet: 0.745 ± 0.025
2.548TyrAsn: 2.548 ± 0.046
1.58TyrPro: 1.58 ± 0.045
1.795TyrGln: 1.795 ± 0.036
1.858TyrArg: 1.858 ± 0.043
2.774TyrSer: 2.774 ± 0.05
3.002TyrThr: 3.002 ± 0.061
2.284TyrVal: 2.284 ± 0.068
0.485TyrTrp: 0.485 ± 0.017
2.016TyrTyr: 2.016 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4415 proteins (1568201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski