Amino acid dipepetide frequency for Nilaparvata lugens reovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.692AlaAla: 2.692 ± 0.882
0.897AlaCys: 0.897 ± 0.425
2.804AlaAsp: 2.804 ± 0.788
2.58AlaGlu: 2.58 ± 0.621
2.916AlaPhe: 2.916 ± 0.59
2.58AlaGly: 2.58 ± 0.708
1.458AlaHis: 1.458 ± 0.303
3.702AlaIle: 3.702 ± 0.602
2.58AlaLys: 2.58 ± 0.561
4.936AlaLeu: 4.936 ± 0.74
1.346AlaMet: 1.346 ± 0.243
2.356AlaAsn: 2.356 ± 0.825
1.346AlaPro: 1.346 ± 0.335
2.131AlaGln: 2.131 ± 0.395
2.356AlaArg: 2.356 ± 0.627
4.599AlaSer: 4.599 ± 1.295
3.141AlaThr: 3.141 ± 0.755
2.468AlaVal: 2.468 ± 0.398
0.337AlaTrp: 0.337 ± 0.133
2.356AlaTyr: 2.356 ± 0.468
0.0AlaXaa: 0.0 ± 0.0
Cys
1.01CysAla: 1.01 ± 0.329
0.112CysCys: 0.112 ± 0.101
1.01CysAsp: 1.01 ± 0.33
0.673CysGlu: 0.673 ± 0.215
1.122CysPhe: 1.122 ± 0.404
0.673CysGly: 0.673 ± 0.234
0.224CysHis: 0.224 ± 0.137
0.785CysIle: 0.785 ± 0.166
1.01CysLys: 1.01 ± 0.294
2.131CysLeu: 2.131 ± 0.47
0.449CysMet: 0.449 ± 0.241
1.01CysAsn: 1.01 ± 0.351
0.224CysPro: 0.224 ± 0.131
0.224CysGln: 0.224 ± 0.135
0.337CysArg: 0.337 ± 0.236
1.01CysSer: 1.01 ± 0.374
0.673CysThr: 0.673 ± 0.3
0.561CysVal: 0.561 ± 0.186
0.337CysTrp: 0.337 ± 0.263
0.897CysTyr: 0.897 ± 0.215
0.0CysXaa: 0.0 ± 0.0
Asp
3.814AspAla: 3.814 ± 0.629
0.561AspCys: 0.561 ± 0.251
4.599AspAsp: 4.599 ± 0.608
4.15AspGlu: 4.15 ± 0.594
3.029AspPhe: 3.029 ± 0.501
2.468AspGly: 2.468 ± 0.515
1.346AspHis: 1.346 ± 0.229
5.384AspIle: 5.384 ± 0.671
3.589AspLys: 3.589 ± 0.295
4.936AspLeu: 4.936 ± 0.74
1.683AspMet: 1.683 ± 0.466
3.702AspAsn: 3.702 ± 0.616
2.692AspPro: 2.692 ± 0.536
2.356AspGln: 2.356 ± 0.614
2.356AspArg: 2.356 ± 0.602
5.048AspSer: 5.048 ± 1.022
3.814AspThr: 3.814 ± 0.799
3.477AspVal: 3.477 ± 0.606
0.673AspTrp: 0.673 ± 0.31
2.131AspTyr: 2.131 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
2.243GluAla: 2.243 ± 0.512
0.785GluCys: 0.785 ± 0.291
2.356GluAsp: 2.356 ± 0.422
2.019GluGlu: 2.019 ± 0.448
2.356GluPhe: 2.356 ± 0.585
2.468GluGly: 2.468 ± 0.374
1.234GluHis: 1.234 ± 0.346
3.477GluIle: 3.477 ± 0.557
2.804GluLys: 2.804 ± 0.794
5.048GluLeu: 5.048 ± 0.936
1.57GluMet: 1.57 ± 0.278
3.365GluAsn: 3.365 ± 0.514
1.458GluPro: 1.458 ± 0.374
2.019GluGln: 2.019 ± 0.59
2.58GluArg: 2.58 ± 0.486
4.038GluSer: 4.038 ± 1.01
3.477GluThr: 3.477 ± 0.765
2.916GluVal: 2.916 ± 0.4
0.449GluTrp: 0.449 ± 0.193
3.365GluTyr: 3.365 ± 0.622
0.0GluXaa: 0.0 ± 0.0
Phe
2.243PheAla: 2.243 ± 0.381
1.01PheCys: 1.01 ± 0.357
3.814PheAsp: 3.814 ± 0.794
3.253PheGlu: 3.253 ± 0.493
1.122PhePhe: 1.122 ± 0.22
4.038PheGly: 4.038 ± 0.373
0.897PheHis: 0.897 ± 0.379
3.702PheIle: 3.702 ± 0.785
3.253PheLys: 3.253 ± 0.333
3.926PheLeu: 3.926 ± 0.704
1.57PheMet: 1.57 ± 0.337
3.926PheAsn: 3.926 ± 0.754
1.907PhePro: 1.907 ± 0.484
1.346PheGln: 1.346 ± 0.281
2.468PheArg: 2.468 ± 0.597
5.833PheSer: 5.833 ± 0.843
3.589PheThr: 3.589 ± 0.493
3.253PheVal: 3.253 ± 0.444
0.337PheTrp: 0.337 ± 0.218
1.683PheTyr: 1.683 ± 0.439
0.0PheXaa: 0.0 ± 0.0
Gly
1.795GlyAla: 1.795 ± 0.553
0.785GlyCys: 0.785 ± 0.22
2.019GlyAsp: 2.019 ± 0.366
2.019GlyGlu: 2.019 ± 0.565
2.692GlyPhe: 2.692 ± 0.558
2.131GlyGly: 2.131 ± 0.576
1.01GlyHis: 1.01 ± 0.312
6.057GlyIle: 6.057 ± 0.974
3.029GlyLys: 3.029 ± 0.414
3.477GlyLeu: 3.477 ± 0.611
1.234GlyMet: 1.234 ± 0.274
2.243GlyAsn: 2.243 ± 0.495
1.234GlyPro: 1.234 ± 0.436
1.122GlyGln: 1.122 ± 0.371
2.468GlyArg: 2.468 ± 0.486
4.375GlySer: 4.375 ± 0.654
3.477GlyThr: 3.477 ± 0.638
2.019GlyVal: 2.019 ± 0.28
0.449GlyTrp: 0.449 ± 0.272
2.019GlyTyr: 2.019 ± 0.462
0.0GlyXaa: 0.0 ± 0.0
His
1.57HisAla: 1.57 ± 0.319
0.112HisCys: 0.112 ± 0.092
1.122HisAsp: 1.122 ± 0.371
1.234HisGlu: 1.234 ± 0.354
1.795HisPhe: 1.795 ± 0.452
0.561HisGly: 0.561 ± 0.208
0.337HisHis: 0.337 ± 0.188
2.019HisIle: 2.019 ± 0.353
1.122HisLys: 1.122 ± 0.29
1.907HisLeu: 1.907 ± 0.376
0.449HisMet: 0.449 ± 0.18
1.122HisAsn: 1.122 ± 0.351
0.897HisPro: 0.897 ± 0.306
0.337HisGln: 0.337 ± 0.145
0.673HisArg: 0.673 ± 0.182
1.346HisSer: 1.346 ± 0.435
1.346HisThr: 1.346 ± 0.487
2.019HisVal: 2.019 ± 0.386
0.337HisTrp: 0.337 ± 0.221
1.01HisTyr: 1.01 ± 0.436
0.0HisXaa: 0.0 ± 0.0
Ile
3.814IleAla: 3.814 ± 0.673
0.785IleCys: 0.785 ± 0.24
4.936IleAsp: 4.936 ± 0.866
3.702IleGlu: 3.702 ± 0.512
4.487IlePhe: 4.487 ± 0.671
3.253IleGly: 3.253 ± 0.775
1.01IleHis: 1.01 ± 0.281
3.477IleIle: 3.477 ± 0.411
5.721IleLys: 5.721 ± 0.833
6.057IleLeu: 6.057 ± 1.009
2.468IleMet: 2.468 ± 0.569
4.936IleAsn: 4.936 ± 0.896
2.804IlePro: 2.804 ± 0.339
2.131IleGln: 2.131 ± 0.677
2.468IleArg: 2.468 ± 0.436
6.169IleSer: 6.169 ± 0.844
5.721IleThr: 5.721 ± 0.88
4.038IleVal: 4.038 ± 0.563
0.561IleTrp: 0.561 ± 0.214
4.262IleTyr: 4.262 ± 0.665
0.0IleXaa: 0.0 ± 0.0
Lys
2.58LysAla: 2.58 ± 0.467
0.561LysCys: 0.561 ± 0.279
2.58LysAsp: 2.58 ± 0.505
3.814LysGlu: 3.814 ± 0.732
3.253LysPhe: 3.253 ± 0.471
1.683LysGly: 1.683 ± 0.542
1.683LysHis: 1.683 ± 0.435
4.599LysIle: 4.599 ± 0.787
3.365LysLys: 3.365 ± 0.535
6.057LysLeu: 6.057 ± 0.79
2.019LysMet: 2.019 ± 0.518
4.599LysAsn: 4.599 ± 0.571
2.692LysPro: 2.692 ± 0.392
3.141LysGln: 3.141 ± 0.47
3.029LysArg: 3.029 ± 1.045
4.15LysSer: 4.15 ± 0.526
5.272LysThr: 5.272 ± 0.953
3.926LysVal: 3.926 ± 0.775
0.561LysTrp: 0.561 ± 0.181
3.365LysTyr: 3.365 ± 0.659
0.0LysXaa: 0.0 ± 0.0
Leu
4.15LeuAla: 4.15 ± 0.681
1.57LeuCys: 1.57 ± 0.29
4.936LeuAsp: 4.936 ± 0.508
3.589LeuGlu: 3.589 ± 0.753
5.048LeuPhe: 5.048 ± 0.569
3.926LeuGly: 3.926 ± 0.957
1.907LeuHis: 1.907 ± 0.261
5.945LeuIle: 5.945 ± 0.693
4.823LeuLys: 4.823 ± 0.95
7.403LeuLeu: 7.403 ± 0.736
2.131LeuMet: 2.131 ± 0.454
7.179LeuAsn: 7.179 ± 0.792
4.038LeuPro: 4.038 ± 0.944
2.468LeuGln: 2.468 ± 0.576
4.038LeuArg: 4.038 ± 0.97
8.188LeuSer: 8.188 ± 0.835
5.272LeuThr: 5.272 ± 1.067
5.609LeuVal: 5.609 ± 0.609
0.224LeuTrp: 0.224 ± 0.145
3.926LeuTyr: 3.926 ± 0.525
0.0LeuXaa: 0.0 ± 0.0
Met
1.122MetAla: 1.122 ± 0.348
0.561MetCys: 0.561 ± 0.206
1.907MetAsp: 1.907 ± 0.615
1.57MetGlu: 1.57 ± 0.411
1.234MetPhe: 1.234 ± 0.414
1.57MetGly: 1.57 ± 0.449
1.122MetHis: 1.122 ± 0.318
1.907MetIle: 1.907 ± 0.322
1.346MetLys: 1.346 ± 0.344
2.916MetLeu: 2.916 ± 0.468
0.224MetMet: 0.224 ± 0.125
2.131MetAsn: 2.131 ± 0.463
1.01MetPro: 1.01 ± 0.364
0.224MetGln: 0.224 ± 0.134
0.673MetArg: 0.673 ± 0.271
3.029MetSer: 3.029 ± 0.471
2.468MetThr: 2.468 ± 0.51
1.683MetVal: 1.683 ± 0.426
0.337MetTrp: 0.337 ± 0.177
1.346MetTyr: 1.346 ± 0.328
0.0MetXaa: 0.0 ± 0.0
Asn
4.823AsnAla: 4.823 ± 0.575
0.897AsnCys: 0.897 ± 0.257
3.589AsnAsp: 3.589 ± 0.321
3.589AsnGlu: 3.589 ± 0.306
3.141AsnPhe: 3.141 ± 0.46
3.814AsnGly: 3.814 ± 0.775
1.01AsnHis: 1.01 ± 0.388
5.16AsnIle: 5.16 ± 0.882
4.711AsnLys: 4.711 ± 0.584
5.609AsnLeu: 5.609 ± 0.391
1.234AsnMet: 1.234 ± 0.312
5.272AsnAsn: 5.272 ± 0.844
2.468AsnPro: 2.468 ± 0.377
3.029AsnGln: 3.029 ± 0.276
1.907AsnArg: 1.907 ± 0.514
5.272AsnSer: 5.272 ± 0.794
4.823AsnThr: 4.823 ± 0.602
4.936AsnVal: 4.936 ± 1.669
0.449AsnTrp: 0.449 ± 0.208
2.468AsnTyr: 2.468 ± 0.358
0.0AsnXaa: 0.0 ± 0.0
Pro
1.234ProAla: 1.234 ± 0.426
0.449ProCys: 0.449 ± 0.206
3.253ProAsp: 3.253 ± 0.596
1.683ProGlu: 1.683 ± 0.399
1.458ProPhe: 1.458 ± 0.412
1.346ProGly: 1.346 ± 0.364
0.785ProHis: 0.785 ± 0.286
4.375ProIle: 4.375 ± 0.521
2.356ProLys: 2.356 ± 0.502
3.589ProLeu: 3.589 ± 0.547
1.346ProMet: 1.346 ± 0.289
2.804ProAsn: 2.804 ± 0.602
1.907ProPro: 1.907 ± 0.726
0.897ProGln: 0.897 ± 0.317
1.795ProArg: 1.795 ± 0.489
3.589ProSer: 3.589 ± 1.067
2.356ProThr: 2.356 ± 0.321
2.243ProVal: 2.243 ± 0.346
0.0ProTrp: 0.0 ± 0.0
1.458ProTyr: 1.458 ± 0.511
0.0ProXaa: 0.0 ± 0.0
Gln
2.243GlnAla: 2.243 ± 0.525
0.561GlnCys: 0.561 ± 0.383
1.683GlnAsp: 1.683 ± 0.421
0.785GlnGlu: 0.785 ± 0.254
2.356GlnPhe: 2.356 ± 0.364
0.785GlnGly: 0.785 ± 0.275
0.897GlnHis: 0.897 ± 0.336
2.243GlnIle: 2.243 ± 0.492
2.58GlnLys: 2.58 ± 0.473
2.019GlnLeu: 2.019 ± 0.53
1.01GlnMet: 1.01 ± 0.213
2.019GlnAsn: 2.019 ± 0.42
0.673GlnPro: 0.673 ± 0.246
1.234GlnGln: 1.234 ± 0.218
1.795GlnArg: 1.795 ± 0.471
2.468GlnSer: 2.468 ± 0.72
3.029GlnThr: 3.029 ± 0.621
2.468GlnVal: 2.468 ± 0.3
0.337GlnTrp: 0.337 ± 0.179
1.795GlnTyr: 1.795 ± 0.662
0.0GlnXaa: 0.0 ± 0.0
Arg
1.458ArgAla: 1.458 ± 0.393
0.561ArgCys: 0.561 ± 0.22
2.356ArgAsp: 2.356 ± 0.372
1.683ArgGlu: 1.683 ± 0.631
2.804ArgPhe: 2.804 ± 0.588
1.01ArgGly: 1.01 ± 0.397
0.561ArgHis: 0.561 ± 0.3
3.589ArgIle: 3.589 ± 0.639
3.365ArgLys: 3.365 ± 0.473
4.711ArgLeu: 4.711 ± 0.706
1.795ArgMet: 1.795 ± 0.515
2.804ArgAsn: 2.804 ± 0.698
1.795ArgPro: 1.795 ± 0.312
1.234ArgGln: 1.234 ± 0.347
1.57ArgArg: 1.57 ± 0.409
3.926ArgSer: 3.926 ± 0.881
2.131ArgThr: 2.131 ± 0.416
3.477ArgVal: 3.477 ± 0.743
0.224ArgTrp: 0.224 ± 0.163
2.019ArgTyr: 2.019 ± 0.415
0.0ArgXaa: 0.0 ± 0.0
Ser
5.048SerAla: 5.048 ± 1.131
1.57SerCys: 1.57 ± 0.368
5.496SerAsp: 5.496 ± 0.622
4.038SerGlu: 4.038 ± 0.754
3.702SerPhe: 3.702 ± 0.446
4.487SerGly: 4.487 ± 0.716
1.458SerHis: 1.458 ± 0.397
4.936SerIle: 4.936 ± 0.56
5.048SerLys: 5.048 ± 0.89
7.179SerLeu: 7.179 ± 0.757
1.795SerMet: 1.795 ± 0.503
5.609SerAsn: 5.609 ± 0.729
3.926SerPro: 3.926 ± 0.828
2.468SerGln: 2.468 ± 0.635
4.262SerArg: 4.262 ± 0.595
7.403SerSer: 7.403 ± 1.602
5.496SerThr: 5.496 ± 0.823
6.394SerVal: 6.394 ± 0.799
0.673SerTrp: 0.673 ± 0.249
3.477SerTyr: 3.477 ± 0.652
0.0SerXaa: 0.0 ± 0.0
Thr
3.029ThrAla: 3.029 ± 0.792
0.673ThrCys: 0.673 ± 0.254
3.814ThrAsp: 3.814 ± 0.55
3.926ThrGlu: 3.926 ± 0.652
4.262ThrPhe: 4.262 ± 0.577
2.692ThrGly: 2.692 ± 0.477
1.795ThrHis: 1.795 ± 0.532
4.375ThrIle: 4.375 ± 0.643
6.169ThrLys: 6.169 ± 0.739
6.057ThrLeu: 6.057 ± 0.561
2.019ThrMet: 2.019 ± 0.294
4.375ThrAsn: 4.375 ± 0.672
3.141ThrPro: 3.141 ± 0.831
2.243ThrGln: 2.243 ± 0.562
3.253ThrArg: 3.253 ± 0.759
5.16ThrSer: 5.16 ± 0.659
4.599ThrThr: 4.599 ± 0.744
4.262ThrVal: 4.262 ± 0.42
0.112ThrTrp: 0.112 ± 0.093
2.916ThrTyr: 2.916 ± 0.426
0.0ThrXaa: 0.0 ± 0.0
Val
2.468ValAla: 2.468 ± 0.457
1.01ValCys: 1.01 ± 0.333
5.272ValAsp: 5.272 ± 0.68
3.589ValGlu: 3.589 ± 0.73
4.15ValPhe: 4.15 ± 0.57
3.029ValGly: 3.029 ± 0.396
1.57ValHis: 1.57 ± 0.314
3.702ValIle: 3.702 ± 0.751
3.926ValLys: 3.926 ± 0.283
4.262ValLeu: 4.262 ± 0.696
2.692ValMet: 2.692 ± 0.602
4.599ValAsn: 4.599 ± 0.758
2.131ValPro: 2.131 ± 0.386
1.795ValGln: 1.795 ± 0.488
3.141ValArg: 3.141 ± 0.55
4.823ValSer: 4.823 ± 0.91
4.936ValThr: 4.936 ± 0.691
3.702ValVal: 3.702 ± 0.766
0.673ValTrp: 0.673 ± 0.202
2.131ValTyr: 2.131 ± 0.41
0.0ValXaa: 0.0 ± 0.0
Trp
0.673TrpAla: 0.673 ± 0.293
0.112TrpCys: 0.112 ± 0.101
0.337TrpAsp: 0.337 ± 0.193
0.112TrpGlu: 0.112 ± 0.133
0.449TrpPhe: 0.449 ± 0.165
0.112TrpGly: 0.112 ± 0.101
0.0TrpHis: 0.0 ± 0.0
0.561TrpIle: 0.561 ± 0.186
0.673TrpLys: 0.673 ± 0.35
0.785TrpLeu: 0.785 ± 0.237
0.337TrpMet: 0.337 ± 0.193
0.561TrpAsn: 0.561 ± 0.154
0.224TrpPro: 0.224 ± 0.154
0.224TrpGln: 0.224 ± 0.12
0.224TrpArg: 0.224 ± 0.131
0.449TrpSer: 0.449 ± 0.19
0.673TrpThr: 0.673 ± 0.423
0.449TrpVal: 0.449 ± 0.271
0.112TrpTrp: 0.112 ± 0.106
0.224TrpTyr: 0.224 ± 0.163
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.57TyrAla: 1.57 ± 0.459
0.897TyrCys: 0.897 ± 0.335
3.926TyrAsp: 3.926 ± 0.954
2.019TyrGlu: 2.019 ± 0.516
1.795TyrPhe: 1.795 ± 0.482
3.029TyrGly: 3.029 ± 0.631
1.01TyrHis: 1.01 ± 0.207
2.804TyrIle: 2.804 ± 0.559
1.458TyrLys: 1.458 ± 0.353
3.365TyrLeu: 3.365 ± 0.544
0.897TyrMet: 0.897 ± 0.267
3.589TyrAsn: 3.589 ± 0.616
2.356TyrPro: 2.356 ± 0.466
2.356TyrGln: 2.356 ± 0.524
1.683TyrArg: 1.683 ± 0.546
3.702TyrSer: 3.702 ± 0.424
2.58TyrThr: 2.58 ± 0.323
3.702TyrVal: 3.702 ± 0.53
0.112TyrTrp: 0.112 ± 0.093
3.253TyrTyr: 3.253 ± 0.798
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (8916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski