Amino acid dipepetide frequency for Wenzhou picorna-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.157AlaAla: 5.157 ± 0.14
0.793AlaCys: 0.793 ± 0.429
3.173AlaAsp: 3.173 ± 1.714
3.57AlaGlu: 3.57 ± 0.266
3.967AlaPhe: 3.967 ± 0.68
3.967AlaGly: 3.967 ± 2.978
0.793AlaHis: 0.793 ± 0.429
3.173AlaIle: 3.173 ± 0.251
3.967AlaLys: 3.967 ± 0.783
7.537AlaLeu: 7.537 ± 0.414
0.397AlaMet: 0.397 ± 0.214
3.57AlaAsn: 3.57 ± 0.466
3.57AlaPro: 3.57 ± 0.997
2.777AlaGln: 2.777 ± 0.694
1.983AlaArg: 1.983 ± 0.34
4.363AlaSer: 4.363 ± 0.569
4.363AlaThr: 4.363 ± 2.763
4.363AlaVal: 4.363 ± 0.163
1.19AlaTrp: 1.19 ± 0.089
4.363AlaTyr: 4.363 ± 1.626
0.0AlaXaa: 0.0 ± 0.0
Cys
0.397CysAla: 0.397 ± 0.214
0.397CysCys: 0.397 ± 0.214
0.397CysAsp: 0.397 ± 0.214
2.38CysGlu: 2.38 ± 1.286
0.397CysPhe: 0.397 ± 0.214
2.38CysGly: 2.38 ± 0.554
0.793CysHis: 0.793 ± 0.303
1.19CysIle: 1.19 ± 0.643
1.983CysLys: 1.983 ± 1.071
1.19CysLeu: 1.19 ± 0.089
0.0CysMet: 0.0 ± 0.0
0.793CysAsn: 0.793 ± 0.429
1.19CysPro: 1.19 ± 0.82
0.793CysGln: 0.793 ± 0.429
1.19CysArg: 1.19 ± 0.643
0.0CysSer: 0.0 ± 0.0
1.983CysThr: 1.983 ± 2.586
1.587CysVal: 1.587 ± 0.857
0.0CysTrp: 0.0 ± 0.0
1.587CysTyr: 1.587 ± 0.606
0.0CysXaa: 0.0 ± 0.0
Asp
5.553AspAla: 5.553 ± 0.805
0.397AspCys: 0.397 ± 0.214
3.57AspAsp: 3.57 ± 0.266
4.363AspGlu: 4.363 ± 1.3
4.363AspPhe: 4.363 ± 0.894
2.777AspGly: 2.777 ± 0.768
0.793AspHis: 0.793 ± 0.303
3.57AspIle: 3.57 ± 0.466
4.363AspLys: 4.363 ± 0.894
4.363AspLeu: 4.363 ± 0.894
1.19AspMet: 1.19 ± 0.142
1.983AspAsn: 1.983 ± 1.123
1.587AspPro: 1.587 ± 1.337
0.793AspGln: 0.793 ± 0.429
1.19AspArg: 1.19 ± 0.643
1.587AspSer: 1.587 ± 0.857
3.57AspThr: 3.57 ± 0.266
3.967AspVal: 3.967 ± 1.411
0.397AspTrp: 0.397 ± 0.214
3.173AspTyr: 3.173 ± 0.983
0.0AspXaa: 0.0 ± 0.0
Glu
3.173GluAla: 3.173 ± 0.251
1.587GluCys: 1.587 ± 0.126
3.57GluAsp: 3.57 ± 0.266
0.793GluGlu: 0.793 ± 0.303
2.38GluPhe: 2.38 ± 0.177
2.777GluGly: 2.777 ± 1.5
1.587GluHis: 1.587 ± 0.126
3.173GluIle: 3.173 ± 0.251
2.777GluLys: 2.777 ± 0.694
4.76GluLeu: 4.76 ± 1.108
1.587GluMet: 1.587 ± 0.126
2.777GluAsn: 2.777 ± 0.768
2.38GluPro: 2.38 ± 0.909
2.38GluGln: 2.38 ± 0.554
1.587GluArg: 1.587 ± 0.126
2.777GluSer: 2.777 ± 0.694
1.983GluThr: 1.983 ± 0.34
5.553GluVal: 5.553 ± 1.389
1.587GluTrp: 1.587 ± 0.126
3.57GluTyr: 3.57 ± 0.997
0.0GluXaa: 0.0 ± 0.0
Phe
4.363PheAla: 4.363 ± 1.3
0.397PheCys: 0.397 ± 0.214
2.38PheAsp: 2.38 ± 1.286
3.57PheGlu: 3.57 ± 0.466
3.57PhePhe: 3.57 ± 1.197
2.38PheGly: 2.38 ± 0.554
1.587PheHis: 1.587 ± 0.126
3.967PheIle: 3.967 ± 0.68
2.38PheLys: 2.38 ± 0.554
6.347PheLeu: 6.347 ± 1.965
1.19PheMet: 1.19 ± 0.643
3.173PheAsn: 3.173 ± 1.714
1.983PhePro: 1.983 ± 0.34
1.983PheGln: 1.983 ± 1.123
1.983PheArg: 1.983 ± 1.123
3.57PheSer: 3.57 ± 0.466
2.38PheThr: 2.38 ± 0.177
3.57PheVal: 3.57 ± 0.266
0.397PheTrp: 0.397 ± 0.214
3.173PheTyr: 3.173 ± 0.983
0.0PheXaa: 0.0 ± 0.0
Gly
4.76GlyAla: 4.76 ± 1.108
1.19GlyCys: 1.19 ± 0.643
3.967GlyAsp: 3.967 ± 1.411
3.57GlyGlu: 3.57 ± 0.266
3.173GlyPhe: 3.173 ± 0.251
1.983GlyGly: 1.983 ± 1.123
1.19GlyHis: 1.19 ± 0.643
3.57GlyIle: 3.57 ± 1.197
3.967GlyLys: 3.967 ± 0.68
4.363GlyLeu: 4.363 ± 0.569
1.19GlyMet: 1.19 ± 1.552
4.76GlyAsn: 4.76 ± 1.818
3.967GlyPro: 3.967 ± 1.515
1.19GlyGln: 1.19 ± 0.089
1.983GlyArg: 1.983 ± 1.854
3.967GlySer: 3.967 ± 0.68
3.173GlyThr: 3.173 ± 0.48
5.95GlyVal: 5.95 ± 1.175
1.19GlyTrp: 1.19 ± 1.552
3.173GlyTyr: 3.173 ± 0.983
0.0GlyXaa: 0.0 ± 0.0
His
1.983HisAla: 1.983 ± 1.123
1.587HisCys: 1.587 ± 0.606
0.0HisAsp: 0.0 ± 0.0
1.19HisGlu: 1.19 ± 0.643
1.587HisPhe: 1.587 ± 0.857
3.173HisGly: 3.173 ± 0.251
0.397HisHis: 0.397 ± 0.517
3.173HisIle: 3.173 ± 0.983
1.983HisLys: 1.983 ± 0.34
1.587HisLeu: 1.587 ± 0.857
0.793HisMet: 0.793 ± 0.303
0.397HisAsn: 0.397 ± 0.517
0.793HisPro: 0.793 ± 0.429
0.0HisGln: 0.0 ± 0.0
0.793HisArg: 0.793 ± 0.429
1.19HisSer: 1.19 ± 0.089
0.397HisThr: 0.397 ± 0.517
1.587HisVal: 1.587 ± 0.857
0.0HisTrp: 0.0 ± 0.0
1.19HisTyr: 1.19 ± 0.089
0.0HisXaa: 0.0 ± 0.0
Ile
5.553IleAla: 5.553 ± 0.074
0.793IleCys: 0.793 ± 0.429
5.157IleAsp: 5.157 ± 2.054
3.173IleGlu: 3.173 ± 0.48
3.173IlePhe: 3.173 ± 0.983
1.983IleGly: 1.983 ± 0.34
0.793IleHis: 0.793 ± 0.429
4.363IleIle: 4.363 ± 0.894
3.57IleLys: 3.57 ± 0.266
2.777IleLeu: 2.777 ± 1.5
3.173IleMet: 3.173 ± 0.983
2.777IleAsn: 2.777 ± 0.768
3.173IlePro: 3.173 ± 1.212
1.983IleGln: 1.983 ± 0.34
3.967IleArg: 3.967 ± 2.143
7.537IleSer: 7.537 ± 1.049
3.967IleThr: 3.967 ± 2.978
3.57IleVal: 3.57 ± 0.266
1.587IleTrp: 1.587 ± 0.857
2.38IleTyr: 2.38 ± 1.286
0.0IleXaa: 0.0 ± 0.0
Lys
2.777LysAla: 2.777 ± 0.768
1.19LysCys: 1.19 ± 0.089
3.173LysAsp: 3.173 ± 0.251
5.157LysGlu: 5.157 ± 0.14
2.38LysPhe: 2.38 ± 0.554
3.57LysGly: 3.57 ± 0.466
2.777LysHis: 2.777 ± 1.5
2.777LysIle: 2.777 ± 1.5
3.173LysLys: 3.173 ± 0.983
4.76LysLeu: 4.76 ± 1.108
1.983LysMet: 1.983 ± 0.34
1.587LysAsn: 1.587 ± 0.857
2.38LysPro: 2.38 ± 0.909
1.983LysGln: 1.983 ± 0.392
4.363LysArg: 4.363 ± 1.626
6.347LysSer: 6.347 ± 1.234
2.777LysThr: 2.777 ± 1.5
3.967LysVal: 3.967 ± 1.411
0.0LysTrp: 0.0 ± 0.0
3.967LysTyr: 3.967 ± 0.68
0.0LysXaa: 0.0 ± 0.0
Leu
5.95LeuAla: 5.95 ± 0.288
3.57LeuCys: 3.57 ± 0.466
4.363LeuAsp: 4.363 ± 0.569
3.57LeuGlu: 3.57 ± 1.197
5.157LeuPhe: 5.157 ± 1.323
3.173LeuGly: 3.173 ± 0.983
2.777LeuHis: 2.777 ± 0.768
5.157LeuIle: 5.157 ± 1.323
5.553LeuLys: 5.553 ± 1.537
6.743LeuLeu: 6.743 ± 0.717
2.38LeuMet: 2.38 ± 0.177
6.347LeuAsn: 6.347 ± 0.503
2.38LeuPro: 2.38 ± 0.554
1.983LeuGln: 1.983 ± 0.392
4.363LeuArg: 4.363 ± 0.894
5.553LeuSer: 5.553 ± 0.657
5.157LeuThr: 5.157 ± 2.335
3.967LeuVal: 3.967 ± 1.411
0.397LeuTrp: 0.397 ± 0.214
2.38LeuTyr: 2.38 ± 0.177
0.0LeuXaa: 0.0 ± 0.0
Met
1.983MetAla: 1.983 ± 0.392
0.397MetCys: 0.397 ± 0.214
1.587MetAsp: 1.587 ± 0.126
0.793MetGlu: 0.793 ± 0.429
1.587MetPhe: 1.587 ± 0.857
1.587MetGly: 1.587 ± 0.606
0.0MetHis: 0.0 ± 0.0
1.587MetIle: 1.587 ± 0.126
1.19MetLys: 1.19 ± 0.643
1.983MetLeu: 1.983 ± 0.34
0.0MetMet: 0.0 ± 0.0
3.967MetAsn: 3.967 ± 0.052
1.587MetPro: 1.587 ± 0.857
0.793MetGln: 0.793 ± 0.303
1.19MetArg: 1.19 ± 0.643
2.38MetSer: 2.38 ± 0.554
1.587MetThr: 1.587 ± 1.337
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
1.587MetTyr: 1.587 ± 0.606
0.0MetXaa: 0.0 ± 0.0
Asn
3.57AsnAla: 3.57 ± 0.266
0.397AsnCys: 0.397 ± 0.214
2.777AsnAsp: 2.777 ± 1.5
1.19AsnGlu: 1.19 ± 0.089
1.983AsnPhe: 1.983 ± 1.071
5.553AsnGly: 5.553 ± 0.657
0.397AsnHis: 0.397 ± 0.214
5.95AsnIle: 5.95 ± 0.288
1.587AsnLys: 1.587 ± 0.606
6.347AsnLeu: 6.347 ± 1.234
0.793AsnMet: 0.793 ± 0.429
1.587AsnAsn: 1.587 ± 0.126
3.967AsnPro: 3.967 ± 0.052
3.173AsnGln: 3.173 ± 1.212
1.983AsnArg: 1.983 ± 0.392
5.157AsnSer: 5.157 ± 0.14
2.38AsnThr: 2.38 ± 0.554
3.57AsnVal: 3.57 ± 0.997
0.0AsnTrp: 0.0 ± 0.0
1.983AsnTyr: 1.983 ± 0.392
0.0AsnXaa: 0.0 ± 0.0
Pro
1.983ProAla: 1.983 ± 1.854
1.19ProCys: 1.19 ± 0.82
3.173ProAsp: 3.173 ± 0.983
2.38ProGlu: 2.38 ± 0.177
2.777ProPhe: 2.777 ± 0.037
1.19ProGly: 1.19 ± 0.089
0.793ProHis: 0.793 ± 0.303
3.173ProIle: 3.173 ± 1.212
2.38ProLys: 2.38 ± 0.554
3.173ProLeu: 3.173 ± 0.48
1.19ProMet: 1.19 ± 0.643
1.19ProAsn: 1.19 ± 0.82
2.38ProPro: 2.38 ± 1.64
3.173ProGln: 3.173 ± 0.48
1.587ProArg: 1.587 ± 1.337
2.777ProSer: 2.777 ± 0.694
4.363ProThr: 4.363 ± 1.3
3.173ProVal: 3.173 ± 3.406
0.793ProTrp: 0.793 ± 0.429
1.983ProTyr: 1.983 ± 0.392
0.0ProXaa: 0.0 ± 0.0
Gln
1.19GlnAla: 1.19 ± 0.089
1.19GlnCys: 1.19 ± 0.089
1.19GlnAsp: 1.19 ± 0.089
1.587GlnGlu: 1.587 ± 0.126
3.173GlnPhe: 3.173 ± 0.251
1.19GlnGly: 1.19 ± 0.82
1.587GlnHis: 1.587 ± 0.606
3.173GlnIle: 3.173 ± 0.48
2.38GlnLys: 2.38 ± 0.554
1.983GlnLeu: 1.983 ± 1.071
0.793GlnMet: 0.793 ± 0.303
1.19GlnAsn: 1.19 ± 0.089
0.793GlnPro: 0.793 ± 0.303
0.397GlnGln: 0.397 ± 0.517
1.587GlnArg: 1.587 ± 0.606
5.95GlnSer: 5.95 ± 1.906
1.19GlnThr: 1.19 ± 1.552
1.587GlnVal: 1.587 ± 0.126
0.793GlnTrp: 0.793 ± 0.303
1.587GlnTyr: 1.587 ± 0.126
0.0GlnXaa: 0.0 ± 0.0
Arg
1.587ArgAla: 1.587 ± 0.126
0.793ArgCys: 0.793 ± 0.429
1.587ArgAsp: 1.587 ± 0.126
1.983ArgGlu: 1.983 ± 0.392
2.777ArgPhe: 2.777 ± 0.037
3.967ArgGly: 3.967 ± 0.68
1.983ArgHis: 1.983 ± 0.392
4.363ArgIle: 4.363 ± 0.894
3.173ArgLys: 3.173 ± 1.714
3.57ArgLeu: 3.57 ± 0.266
1.19ArgMet: 1.19 ± 0.089
1.587ArgAsn: 1.587 ± 0.126
1.587ArgPro: 1.587 ± 1.337
1.983ArgGln: 1.983 ± 0.392
3.173ArgArg: 3.173 ± 0.48
2.777ArgSer: 2.777 ± 1.5
3.173ArgThr: 3.173 ± 1.212
1.983ArgVal: 1.983 ± 0.34
0.397ArgTrp: 0.397 ± 0.517
1.587ArgTyr: 1.587 ± 0.606
0.0ArgXaa: 0.0 ± 0.0
Ser
5.157SerAla: 5.157 ± 0.872
1.587SerCys: 1.587 ± 0.126
3.173SerAsp: 3.173 ± 0.251
4.76SerGlu: 4.76 ± 0.355
4.363SerPhe: 4.363 ± 2.032
7.933SerGly: 7.933 ± 0.835
1.19SerHis: 1.19 ± 0.82
4.363SerIle: 4.363 ± 0.569
5.553SerLys: 5.553 ± 1.537
3.57SerLeu: 3.57 ± 1.729
2.777SerMet: 2.777 ± 0.768
5.553SerAsn: 5.553 ± 1.537
1.983SerPro: 1.983 ± 0.392
2.777SerGln: 2.777 ± 0.037
1.983SerArg: 1.983 ± 0.392
4.363SerSer: 4.363 ± 0.569
4.363SerThr: 4.363 ± 1.3
6.347SerVal: 6.347 ± 0.503
0.397SerTrp: 0.397 ± 0.517
3.173SerTyr: 3.173 ± 0.983
0.0SerXaa: 0.0 ± 0.0
Thr
3.57ThrAla: 3.57 ± 2.46
1.587ThrCys: 1.587 ± 0.606
4.363ThrAsp: 4.363 ± 1.3
1.587ThrGlu: 1.587 ± 0.606
2.777ThrPhe: 2.777 ± 0.037
1.587ThrGly: 1.587 ± 1.337
0.793ThrHis: 0.793 ± 0.303
2.777ThrIle: 2.777 ± 1.426
3.967ThrLys: 3.967 ± 1.411
3.57ThrLeu: 3.57 ± 0.997
1.19ThrMet: 1.19 ± 0.219
5.95ThrAsn: 5.95 ± 3.369
2.38ThrPro: 2.38 ± 1.64
0.793ThrGln: 0.793 ± 0.303
3.173ThrArg: 3.173 ± 0.48
4.363ThrSer: 4.363 ± 2.032
3.967ThrThr: 3.967 ± 2.246
3.173ThrVal: 3.173 ± 1.212
1.19ThrTrp: 1.19 ± 0.82
2.38ThrTyr: 2.38 ± 0.554
0.0ThrXaa: 0.0 ± 0.0
Val
4.363ValAla: 4.363 ± 1.626
1.19ValCys: 1.19 ± 0.643
2.777ValAsp: 2.777 ± 2.889
3.967ValGlu: 3.967 ± 0.783
1.983ValPhe: 1.983 ± 0.34
5.157ValGly: 5.157 ± 0.872
1.983ValHis: 1.983 ± 1.071
2.38ValIle: 2.38 ± 0.554
2.38ValLys: 2.38 ± 0.554
7.537ValLeu: 7.537 ± 0.414
0.793ValMet: 0.793 ± 0.303
3.173ValAsn: 3.173 ± 0.983
3.57ValPro: 3.57 ± 0.997
2.777ValGln: 2.777 ± 0.694
3.173ValArg: 3.173 ± 0.251
5.553ValSer: 5.553 ± 0.657
2.777ValThr: 2.777 ± 0.694
2.777ValVal: 2.777 ± 0.694
0.793ValTrp: 0.793 ± 0.429
2.777ValTyr: 2.777 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.793TrpAla: 0.793 ± 0.429
0.397TrpCys: 0.397 ± 0.214
1.587TrpAsp: 1.587 ± 0.606
1.19TrpGlu: 1.19 ± 0.089
0.0TrpPhe: 0.0 ± 0.0
1.587TrpGly: 1.587 ± 0.126
0.0TrpHis: 0.0 ± 0.0
0.793TrpIle: 0.793 ± 0.429
1.19TrpLys: 1.19 ± 0.643
0.793TrpLeu: 0.793 ± 0.303
0.397TrpMet: 0.397 ± 0.517
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.793TrpGln: 0.793 ± 0.303
1.19TrpArg: 1.19 ± 1.552
0.397TrpSer: 0.397 ± 0.517
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.397TrpTyr: 0.397 ± 0.214
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.173TyrAla: 3.173 ± 0.251
0.0TyrCys: 0.0 ± 0.0
1.983TyrAsp: 1.983 ± 1.071
1.983TyrGlu: 1.983 ± 1.071
2.777TyrPhe: 2.777 ± 0.037
4.363TyrGly: 4.363 ± 1.3
1.587TyrHis: 1.587 ± 0.126
2.777TyrIle: 2.777 ± 0.037
3.57TyrLys: 3.57 ± 1.928
3.967TyrLeu: 3.967 ± 0.68
2.38TyrMet: 2.38 ± 0.554
1.983TyrAsn: 1.983 ± 0.34
3.173TyrPro: 3.173 ± 0.48
1.983TyrGln: 1.983 ± 0.392
2.777TyrArg: 2.777 ± 0.768
4.76TyrSer: 4.76 ± 0.355
1.587TyrThr: 1.587 ± 0.126
1.19TyrVal: 1.19 ± 0.643
0.397TyrTrp: 0.397 ± 0.517
3.173TyrTyr: 3.173 ± 0.251
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2522 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski