Amino acid dipepetide frequency for Fusibacter sp. A1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.589AlaAla: 4.589 ± 0.083	0.765AlaCys: 0.765 ± 0.028	3.437AlaAsp: 3.437 ± 0.054	3.63AlaGlu: 3.63 ± 0.068	3.448AlaPhe: 3.448 ± 0.054	4.513AlaGly: 4.513 ± 0.081	1.215AlaHis: 1.215 ± 0.031	6.086AlaIle: 6.086 ± 0.086	4.478AlaLys: 4.478 ± 0.066	7.382AlaLeu: 7.382 ± 0.087	2.19AlaMet: 2.19 ± 0.047	2.529AlaAsn: 2.529 ± 0.047	1.734AlaPro: 1.734 ± 0.045	2.021AlaGln: 2.021 ± 0.043	2.437AlaArg: 2.437 ± 0.044	4.378AlaSer: 4.378 ± 0.066	3.603AlaThr: 3.603 ± 0.066	5.572AlaVal: 5.572 ± 0.081	0.47AlaTrp: 0.47 ± 0.019	2.825AlaTyr: 2.825 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.53CysAla: 0.53 ± 0.02	0.102CysCys: 0.102 ± 0.011	0.616CysAsp: 0.616 ± 0.028	0.666CysGlu: 0.666 ± 0.024	0.391CysPhe: 0.391 ± 0.017	0.847CysGly: 0.847 ± 0.032	0.248CysHis: 0.248 ± 0.014	0.623CysIle: 0.623 ± 0.021	0.505CysLys: 0.505 ± 0.022	0.751CysLeu: 0.751 ± 0.026	0.238CysMet: 0.238 ± 0.015	0.323CysAsn: 0.323 ± 0.018	0.428CysPro: 0.428 ± 0.025	0.261CysGln: 0.261 ± 0.014	0.302CysArg: 0.302 ± 0.016	0.579CysSer: 0.579 ± 0.025	0.482CysThr: 0.482 ± 0.02	0.588CysVal: 0.588 ± 0.024	0.053CysTrp: 0.053 ± 0.007	0.358CysTyr: 0.358 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.949AspAla: 3.949 ± 0.059	0.482AspCys: 0.482 ± 0.024	3.303AspAsp: 3.303 ± 0.063	5.013AspGlu: 5.013 ± 0.068	2.901AspPhe: 2.901 ± 0.055	3.851AspGly: 3.851 ± 0.064	1.426AspHis: 1.426 ± 0.036	4.637AspIle: 4.637 ± 0.059	3.94AspLys: 3.94 ± 0.06	5.881AspLeu: 5.881 ± 0.073	1.816AspMet: 1.816 ± 0.042	2.155AspAsn: 2.155 ± 0.043	1.749AspPro: 1.749 ± 0.04	1.976AspGln: 1.976 ± 0.036	2.552AspArg: 2.552 ± 0.043	3.266AspSer: 3.266 ± 0.053	2.888AspThr: 2.888 ± 0.048	4.276AspVal: 4.276 ± 0.069	0.602AspTrp: 0.602 ± 0.022	2.914AspTyr: 2.914 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.285GluAla: 5.285 ± 0.073	0.482GluCys: 0.482 ± 0.021	4.012GluAsp: 4.012 ± 0.067	5.42GluGlu: 5.42 ± 0.08	2.768GluPhe: 2.768 ± 0.052	4.103GluGly: 4.103 ± 0.066	1.666GluHis: 1.666 ± 0.039	5.518GluIle: 5.518 ± 0.086	5.389GluLys: 5.389 ± 0.08	7.557GluLeu: 7.557 ± 0.093	2.31GluMet: 2.31 ± 0.041	3.582GluAsn: 3.582 ± 0.048	1.821GluPro: 1.821 ± 0.043	2.375GluGln: 2.375 ± 0.045	3.202GluArg: 3.202 ± 0.06	4.3GluSer: 4.3 ± 0.07	3.632GluThr: 3.632 ± 0.057	5.318GluVal: 5.318 ± 0.072	0.578GluTrp: 0.578 ± 0.022	2.429GluTyr: 2.429 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.672PheAla: 2.672 ± 0.047	0.377PheCys: 0.377 ± 0.017	3.379PheAsp: 3.379 ± 0.059	3.658PheGlu: 3.658 ± 0.052	1.873PhePhe: 1.873 ± 0.046	3.143PheGly: 3.143 ± 0.055	0.736PheHis: 0.736 ± 0.028	3.673PheIle: 3.673 ± 0.066	3.163PheLys: 3.163 ± 0.047	3.511PheLeu: 3.511 ± 0.057	1.275PheMet: 1.275 ± 0.032	2.139PheAsn: 2.139 ± 0.049	1.058PhePro: 1.058 ± 0.027	0.871PheGln: 0.871 ± 0.031	1.454PheArg: 1.454 ± 0.033	3.18PheSer: 3.18 ± 0.052	2.506PheThr: 2.506 ± 0.05	3.104PheVal: 3.104 ± 0.057	0.359PheTrp: 0.359 ± 0.02	1.691PheTyr: 1.691 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.497GlyAla: 4.497 ± 0.08	0.732GlyCys: 0.732 ± 0.027	3.609GlyAsp: 3.609 ± 0.061	4.141GlyGlu: 4.141 ± 0.062	3.372GlyPhe: 3.372 ± 0.061	4.332GlyGly: 4.332 ± 0.084	1.449GlyHis: 1.449 ± 0.036	6.071GlyIle: 6.071 ± 0.076	4.295GlyLys: 4.295 ± 0.066	6.701GlyLeu: 6.701 ± 0.08	2.196GlyMet: 2.196 ± 0.047	2.537GlyAsn: 2.537 ± 0.047	1.403GlyPro: 1.403 ± 0.034	1.918GlyGln: 1.918 ± 0.042	2.579GlyArg: 2.579 ± 0.048	3.835GlySer: 3.835 ± 0.067	3.61GlyThr: 3.61 ± 0.054	5.211GlyVal: 5.211 ± 0.076	0.567GlyTrp: 0.567 ± 0.026	3.11GlyTyr: 3.11 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.384HisAla: 1.384 ± 0.037	0.206HisCys: 0.206 ± 0.014	1.199HisAsp: 1.199 ± 0.031	1.526HisGlu: 1.526 ± 0.036	0.95HisPhe: 0.95 ± 0.029	1.405HisGly: 1.405 ± 0.033	0.709HisHis: 0.709 ± 0.029	1.616HisIle: 1.616 ± 0.034	1.163HisLys: 1.163 ± 0.033	2.198HisLeu: 2.198 ± 0.044	0.601HisMet: 0.601 ± 0.023	0.731HisAsn: 0.731 ± 0.027	0.928HisPro: 0.928 ± 0.029	0.789HisGln: 0.789 ± 0.025	0.914HisArg: 0.914 ± 0.027	1.167HisSer: 1.167 ± 0.033	1.107HisThr: 1.107 ± 0.032	1.496HisVal: 1.496 ± 0.038	0.16HisTrp: 0.16 ± 0.012	0.978HisTyr: 0.978 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.178IleAla: 6.178 ± 0.076	0.736IleCys: 0.736 ± 0.028	5.726IleAsp: 5.726 ± 0.072	6.477IleGlu: 6.477 ± 0.08	2.926IlePhe: 2.926 ± 0.059	6.125IleGly: 6.125 ± 0.081	1.619IleHis: 1.619 ± 0.036	5.907IleIle: 5.907 ± 0.084	5.473IleLys: 5.473 ± 0.074	7.093IleLeu: 7.093 ± 0.085	2.047IleMet: 2.047 ± 0.038	3.641IleAsn: 3.641 ± 0.056	2.64IlePro: 2.64 ± 0.053	2.178IleGln: 2.178 ± 0.044	3.384IleArg: 3.384 ± 0.062	5.236IleSer: 5.236 ± 0.071	4.538IleThr: 4.538 ± 0.063	5.618IleVal: 5.618 ± 0.079	0.592IleTrp: 0.592 ± 0.022	2.568IleTyr: 2.568 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.781LysAla: 4.781 ± 0.071	0.495LysCys: 0.495 ± 0.023	4.023LysAsp: 4.023 ± 0.06	5.729LysGlu: 5.729 ± 0.087	2.149LysPhe: 2.149 ± 0.044	4.308LysGly: 4.308 ± 0.067	1.564LysHis: 1.564 ± 0.039	4.672LysIle: 4.672 ± 0.065	5.136LysLys: 5.136 ± 0.083	6.356LysLeu: 6.356 ± 0.085	2.19LysMet: 2.19 ± 0.044	3.278LysAsn: 3.278 ± 0.049	2.052LysPro: 2.052 ± 0.043	2.243LysGln: 2.243 ± 0.048	3.476LysArg: 3.476 ± 0.057	4.364LysSer: 4.364 ± 0.059	3.853LysThr: 3.853 ± 0.056	4.711LysVal: 4.711 ± 0.066	0.63LysTrp: 0.63 ± 0.021	2.392LysTyr: 2.392 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.473LeuAla: 6.473 ± 0.08	0.809LeuCys: 0.809 ± 0.025	5.857LeuAsp: 5.857 ± 0.064	6.839LeuGlu: 6.839 ± 0.092	4.235LeuPhe: 4.235 ± 0.073	6.462LeuGly: 6.462 ± 0.072	1.72LeuHis: 1.72 ± 0.041	8.184LeuIle: 8.184 ± 0.096	7.57LeuLys: 7.57 ± 0.089	9.757LeuLeu: 9.757 ± 0.122	3.204LeuMet: 3.204 ± 0.05	4.811LeuAsn: 4.811 ± 0.086	3.225LeuPro: 3.225 ± 0.052	2.397LeuGln: 2.397 ± 0.049	3.497LeuArg: 3.497 ± 0.057	7.695LeuSer: 7.695 ± 0.096	5.724LeuThr: 5.724 ± 0.081	6.961LeuVal: 6.961 ± 0.077	0.678LeuTrp: 0.678 ± 0.024	3.244LeuTyr: 3.244 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.11MetAla: 2.11 ± 0.05	0.224MetCys: 0.224 ± 0.014	1.741MetAsp: 1.741 ± 0.037	1.623MetGlu: 1.623 ± 0.038	1.113MetPhe: 1.113 ± 0.026	1.931MetGly: 1.931 ± 0.041	0.585MetHis: 0.585 ± 0.026	2.726MetIle: 2.726 ± 0.046	2.545MetLys: 2.545 ± 0.038	3.055MetLeu: 3.055 ± 0.049	1.106MetMet: 1.106 ± 0.032	1.714MetAsn: 1.714 ± 0.038	1.122MetPro: 1.122 ± 0.034	0.909MetGln: 0.909 ± 0.029	1.175MetArg: 1.175 ± 0.03	2.066MetSer: 2.066 ± 0.04	1.897MetThr: 1.897 ± 0.036	2.067MetVal: 2.067 ± 0.039	0.18MetTrp: 0.18 ± 0.012	0.87MetTyr: 0.87 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.793AsnAla: 2.793 ± 0.051	0.4AsnCys: 0.4 ± 0.017	2.471AsnAsp: 2.471 ± 0.045	3.296AsnGlu: 3.296 ± 0.057	1.719AsnPhe: 1.719 ± 0.04	2.838AsnGly: 2.838 ± 0.049	1.111AsnHis: 1.111 ± 0.034	3.265AsnIle: 3.265 ± 0.055	2.836AsnLys: 2.836 ± 0.047	4.272AsnLeu: 4.272 ± 0.064	1.363AsnMet: 1.363 ± 0.038	1.728AsnAsn: 1.728 ± 0.041	1.754AsnPro: 1.754 ± 0.044	1.74AsnGln: 1.74 ± 0.039	2.181AsnArg: 2.181 ± 0.047	2.289AsnSer: 2.289 ± 0.052	2.237AsnThr: 2.237 ± 0.044	2.764AsnVal: 2.764 ± 0.049	0.42AsnTrp: 0.42 ± 0.018	1.829AsnTyr: 1.829 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	1.762ProAla: 1.762 ± 0.045	0.271ProCys: 0.271 ± 0.018	1.904ProAsp: 1.904 ± 0.047	2.425ProGlu: 2.425 ± 0.05	1.587ProPhe: 1.587 ± 0.036	1.845ProGly: 1.845 ± 0.04	0.62ProHis: 0.62 ± 0.021	2.633ProIle: 2.633 ± 0.052	1.863ProLys: 1.863 ± 0.044	2.922ProLeu: 2.922 ± 0.051	0.852ProMet: 0.852 ± 0.026	1.231ProAsn: 1.231 ± 0.028	0.695ProPro: 0.695 ± 0.027	0.916ProGln: 0.916 ± 0.025	0.847ProArg: 0.847 ± 0.023	1.884ProSer: 1.884 ± 0.039	1.732ProThr: 1.732 ± 0.046	2.67ProVal: 2.67 ± 0.055	0.289ProTrp: 0.289 ± 0.016	1.305ProTyr: 1.305 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.261GlnAla: 2.261 ± 0.046	0.201GlnCys: 0.201 ± 0.013	1.325GlnAsp: 1.325 ± 0.035	1.932GlnGlu: 1.932 ± 0.041	1.262GlnPhe: 1.262 ± 0.03	1.761GlnGly: 1.761 ± 0.038	0.548GlnHis: 0.548 ± 0.021	2.522GlnIle: 2.522 ± 0.047	1.989GlnLys: 1.989 ± 0.044	3.368GlnLeu: 3.368 ± 0.056	1.088GlnMet: 1.088 ± 0.029	1.345GlnAsn: 1.345 ± 0.032	0.846GlnPro: 0.846 ± 0.028	0.933GlnGln: 0.933 ± 0.036	1.146GlnArg: 1.146 ± 0.034	1.987GlnSer: 1.987 ± 0.044	1.813GlnThr: 1.813 ± 0.042	2.341GlnVal: 2.341 ± 0.049	0.273GlnTrp: 0.273 ± 0.016	1.016GlnTyr: 1.016 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.465ArgAla: 2.465 ± 0.05	0.361ArgCys: 0.361 ± 0.02	1.944ArgAsp: 1.944 ± 0.048	2.808ArgGlu: 2.808 ± 0.052	1.905ArgPhe: 1.905 ± 0.039	2.185ArgGly: 2.185 ± 0.043	0.893ArgHis: 0.893 ± 0.025	3.577ArgIle: 3.577 ± 0.062	2.63ArgLys: 2.63 ± 0.049	4.335ArgLeu: 4.335 ± 0.069	1.428ArgMet: 1.428 ± 0.035	1.761ArgAsn: 1.761 ± 0.04	1.157ArgPro: 1.157 ± 0.032	1.293ArgGln: 1.293 ± 0.036	1.78ArgArg: 1.78 ± 0.041	2.366ArgSer: 2.366 ± 0.047	2.12ArgThr: 2.12 ± 0.042	2.935ArgVal: 2.935 ± 0.051	0.323ArgTrp: 0.323 ± 0.018	1.644ArgTyr: 1.644 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.068SerAla: 4.068 ± 0.064	0.6SerCys: 0.6 ± 0.024	3.915SerAsp: 3.915 ± 0.062	4.6SerGlu: 4.6 ± 0.066	3.077SerPhe: 3.077 ± 0.057	4.763SerGly: 4.763 ± 0.058	1.338SerHis: 1.338 ± 0.03	5.366SerIle: 5.366 ± 0.071	4.294SerLys: 4.294 ± 0.058	6.356SerLeu: 6.356 ± 0.086	1.88SerMet: 1.88 ± 0.039	2.594SerAsn: 2.594 ± 0.052	1.716SerPro: 1.716 ± 0.041	1.931SerGln: 1.931 ± 0.035	2.469SerArg: 2.469 ± 0.046	4.114SerSer: 4.114 ± 0.071	3.319SerThr: 3.319 ± 0.068	4.627SerVal: 4.627 ± 0.064	0.479SerTrp: 0.479 ± 0.02	2.501SerTyr: 2.501 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.709ThrAla: 3.709 ± 0.058	0.49ThrCys: 0.49 ± 0.021	3.177ThrAsp: 3.177 ± 0.053	3.5ThrGlu: 3.5 ± 0.066	2.489ThrPhe: 2.489 ± 0.043	4.166ThrGly: 4.166 ± 0.071	1.175ThrHis: 1.175 ± 0.032	4.388ThrIle: 4.388 ± 0.063	3.283ThrLys: 3.283 ± 0.052	5.79ThrLeu: 5.79 ± 0.077	1.424ThrMet: 1.424 ± 0.032	2.061ThrAsn: 2.061 ± 0.042	2.035ThrPro: 2.035 ± 0.049	1.626ThrGln: 1.626 ± 0.044	1.971ThrArg: 1.971 ± 0.042	3.451ThrSer: 3.451 ± 0.059	3.249ThrThr: 3.249 ± 0.09	4.105ThrVal: 4.105 ± 0.066	0.427ThrTrp: 0.427 ± 0.02	2.228ThrTyr: 2.228 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.895ValAla: 4.895 ± 0.076	0.661ValCys: 0.661 ± 0.027	4.725ValAsp: 4.725 ± 0.069	5.094ValGlu: 5.094 ± 0.065	3.354ValPhe: 3.354 ± 0.052	4.429ValGly: 4.429 ± 0.067	1.377ValHis: 1.377 ± 0.033	6.122ValIle: 6.122 ± 0.079	5.031ValLys: 5.031 ± 0.069	7.303ValLeu: 7.303 ± 0.084	2.207ValMet: 2.207 ± 0.044	3.229ValAsn: 3.229 ± 0.059	2.331ValPro: 2.331 ± 0.043	1.816ValGln: 1.816 ± 0.039	2.545ValArg: 2.545 ± 0.05	4.889ValSer: 4.889 ± 0.071	4.045ValThr: 4.045 ± 0.074	5.927ValVal: 5.927 ± 0.089	0.528ValTrp: 0.528 ± 0.021	2.657ValTyr: 2.657 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.485TrpAla: 0.485 ± 0.021	0.09TrpCys: 0.09 ± 0.009	0.456TrpAsp: 0.456 ± 0.023	0.416TrpGlu: 0.416 ± 0.02	0.395TrpPhe: 0.395 ± 0.02	0.549TrpGly: 0.549 ± 0.026	0.212TrpHis: 0.212 ± 0.014	0.705TrpIle: 0.705 ± 0.026	0.457TrpLys: 0.457 ± 0.018	0.847TrpLeu: 0.847 ± 0.026	0.283TrpMet: 0.283 ± 0.019	0.393TrpAsn: 0.393 ± 0.018	0.21TrpPro: 0.21 ± 0.013	0.311TrpGln: 0.311 ± 0.018	0.285TrpArg: 0.285 ± 0.015	0.565TrpSer: 0.565 ± 0.024	0.422TrpThr: 0.422 ± 0.022	0.525TrpVal: 0.525 ± 0.022	0.108TrpTrp: 0.108 ± 0.009	0.347TrpTyr: 0.347 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.42TyrAla: 2.42 ± 0.048	0.406TyrCys: 0.406 ± 0.021	2.755TyrAsp: 2.755 ± 0.048	2.955TyrGlu: 2.955 ± 0.048	1.909TyrPhe: 1.909 ± 0.046	2.608TyrGly: 2.608 ± 0.047	1.015TyrHis: 1.015 ± 0.028	2.411TyrIle: 2.411 ± 0.048	2.364TyrLys: 2.364 ± 0.045	3.905TyrLeu: 3.905 ± 0.063	1.058TyrMet: 1.058 ± 0.029	1.526TyrAsn: 1.526 ± 0.041	1.351TyrPro: 1.351 ± 0.031	1.451TyrGln: 1.451 ± 0.039	1.714TyrArg: 1.714 ± 0.038	2.398TyrSer: 2.398 ± 0.05	1.965TyrThr: 1.965 ± 0.047	2.352TyrVal: 2.352 ± 0.049	0.344TyrTrp: 0.344 ± 0.016	1.754TyrTyr: 1.754 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3729 proteins (1207282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---