Amino acid dipepetide frequency for Bordetella phage BPP-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.608AlaAla: 18.608 ± 1.724
0.513AlaCys: 0.513 ± 0.222
9.963AlaAsp: 9.963 ± 0.784
9.67AlaGlu: 9.67 ± 0.923
3.663AlaPhe: 3.663 ± 0.698
12.747AlaGly: 12.747 ± 1.305
2.198AlaHis: 2.198 ± 0.491
5.128AlaIle: 5.128 ± 0.5
5.861AlaLys: 5.861 ± 0.701
11.502AlaLeu: 11.502 ± 1.14
3.077AlaMet: 3.077 ± 0.489
5.421AlaAsn: 5.421 ± 1.249
4.689AlaPro: 4.689 ± 0.683
6.374AlaGln: 6.374 ± 0.971
8.791AlaArg: 8.791 ± 1.036
5.421AlaSer: 5.421 ± 0.554
7.912AlaThr: 7.912 ± 1.166
9.304AlaVal: 9.304 ± 1.252
2.344AlaTrp: 2.344 ± 0.395
3.81AlaTyr: 3.81 ± 0.742
0.0AlaXaa: 0.0 ± 0.0
Cys
1.026CysAla: 1.026 ± 0.29
0.147CysCys: 0.147 ± 0.104
0.586CysAsp: 0.586 ± 0.251
0.659CysGlu: 0.659 ± 0.238
0.147CysPhe: 0.147 ± 0.099
0.513CysGly: 0.513 ± 0.21
0.22CysHis: 0.22 ± 0.146
0.22CysIle: 0.22 ± 0.131
0.513CysLys: 0.513 ± 0.238
0.733CysLeu: 0.733 ± 0.303
0.073CysMet: 0.073 ± 0.072
0.293CysAsn: 0.293 ± 0.145
0.586CysPro: 0.586 ± 0.29
0.22CysGln: 0.22 ± 0.113
0.879CysArg: 0.879 ± 0.275
0.22CysSer: 0.22 ± 0.13
0.073CysThr: 0.073 ± 0.064
0.293CysVal: 0.293 ± 0.148
0.073CysTrp: 0.073 ± 0.074
0.22CysTyr: 0.22 ± 0.14
0.0CysXaa: 0.0 ± 0.0
Asp
8.645AspAla: 8.645 ± 0.878
0.147AspCys: 0.147 ± 0.139
4.029AspAsp: 4.029 ± 0.521
2.93AspGlu: 2.93 ± 0.511
2.198AspPhe: 2.198 ± 0.472
5.128AspGly: 5.128 ± 0.626
1.245AspHis: 1.245 ± 0.292
3.37AspIle: 3.37 ± 0.443
2.711AspLys: 2.711 ± 0.563
7.106AspLeu: 7.106 ± 0.751
1.612AspMet: 1.612 ± 0.286
2.344AspAsn: 2.344 ± 0.484
3.004AspPro: 3.004 ± 0.443
1.832AspGln: 1.832 ± 0.563
3.37AspArg: 3.37 ± 0.573
3.004AspSer: 3.004 ± 0.41
4.322AspThr: 4.322 ± 0.413
4.249AspVal: 4.249 ± 0.562
0.659AspTrp: 0.659 ± 0.18
1.905AspTyr: 1.905 ± 0.3
0.0AspXaa: 0.0 ± 0.0
Glu
8.498GluAla: 8.498 ± 0.803
0.44GluCys: 0.44 ± 0.206
2.344GluAsp: 2.344 ± 0.556
2.125GluGlu: 2.125 ± 0.459
2.344GluPhe: 2.344 ± 0.427
4.176GluGly: 4.176 ± 0.53
1.392GluHis: 1.392 ± 0.325
2.271GluIle: 2.271 ± 0.327
2.491GluLys: 2.491 ± 0.423
5.714GluLeu: 5.714 ± 0.589
1.319GluMet: 1.319 ± 0.257
1.905GluAsn: 1.905 ± 0.487
1.758GluPro: 1.758 ± 0.349
3.37GluGln: 3.37 ± 0.458
4.396GluArg: 4.396 ± 0.626
3.077GluSer: 3.077 ± 0.444
2.271GluThr: 2.271 ± 0.387
3.956GluVal: 3.956 ± 0.501
1.172GluTrp: 1.172 ± 0.292
1.758GluTyr: 1.758 ± 0.301
0.0GluXaa: 0.0 ± 0.0
Phe
3.37PheAla: 3.37 ± 0.52
0.366PheCys: 0.366 ± 0.155
2.418PheAsp: 2.418 ± 0.425
1.832PheGlu: 1.832 ± 0.42
1.099PhePhe: 1.099 ± 0.331
3.15PheGly: 3.15 ± 0.387
0.366PheHis: 0.366 ± 0.152
1.538PheIle: 1.538 ± 0.361
1.172PheLys: 1.172 ± 0.269
2.344PheLeu: 2.344 ± 0.435
0.44PheMet: 0.44 ± 0.157
1.319PheAsn: 1.319 ± 0.282
0.806PhePro: 0.806 ± 0.249
1.465PheGln: 1.465 ± 0.299
1.758PheArg: 1.758 ± 0.343
2.051PheSer: 2.051 ± 0.49
1.685PheThr: 1.685 ± 0.371
2.491PheVal: 2.491 ± 0.418
0.659PheTrp: 0.659 ± 0.177
1.099PheTyr: 1.099 ± 0.272
0.0PheXaa: 0.0 ± 0.0
Gly
10.037GlyAla: 10.037 ± 0.842
0.586GlyCys: 0.586 ± 0.213
4.908GlyAsp: 4.908 ± 0.505
4.835GlyGlu: 4.835 ± 0.69
2.491GlyPhe: 2.491 ± 0.43
7.033GlyGly: 7.033 ± 0.891
1.685GlyHis: 1.685 ± 0.431
3.956GlyIle: 3.956 ± 0.534
4.908GlyLys: 4.908 ± 0.564
6.227GlyLeu: 6.227 ± 0.74
1.832GlyMet: 1.832 ± 0.387
3.37GlyAsn: 3.37 ± 0.701
2.857GlyPro: 2.857 ± 0.325
3.443GlyGln: 3.443 ± 0.519
4.835GlyArg: 4.835 ± 0.656
3.81GlySer: 3.81 ± 0.608
5.861GlyThr: 5.861 ± 1.312
5.421GlyVal: 5.421 ± 0.649
0.806GlyTrp: 0.806 ± 0.197
3.516GlyTyr: 3.516 ± 1.088
0.0GlyXaa: 0.0 ± 0.0
His
2.344HisAla: 2.344 ± 0.456
0.366HisCys: 0.366 ± 0.181
1.319HisAsp: 1.319 ± 0.321
1.245HisGlu: 1.245 ± 0.307
0.806HisPhe: 0.806 ± 0.249
1.392HisGly: 1.392 ± 0.37
0.586HisHis: 0.586 ± 0.169
0.586HisIle: 0.586 ± 0.211
0.733HisLys: 0.733 ± 0.23
1.978HisLeu: 1.978 ± 0.351
0.366HisMet: 0.366 ± 0.157
0.44HisAsn: 0.44 ± 0.176
1.172HisPro: 1.172 ± 0.233
0.806HisGln: 0.806 ± 0.217
0.733HisArg: 0.733 ± 0.204
0.586HisSer: 0.586 ± 0.218
0.513HisThr: 0.513 ± 0.173
0.733HisVal: 0.733 ± 0.211
0.513HisTrp: 0.513 ± 0.187
0.733HisTyr: 0.733 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
5.714IleAla: 5.714 ± 0.728
0.513IleCys: 0.513 ± 0.227
4.249IleAsp: 4.249 ± 0.617
3.37IleGlu: 3.37 ± 0.482
0.659IlePhe: 0.659 ± 0.209
3.443IleGly: 3.443 ± 0.538
0.733IleHis: 0.733 ± 0.164
1.099IleIle: 1.099 ± 0.304
1.685IleLys: 1.685 ± 0.377
2.564IleLeu: 2.564 ± 0.392
0.366IleMet: 0.366 ± 0.154
1.832IleAsn: 1.832 ± 0.586
1.832IlePro: 1.832 ± 0.366
1.465IleGln: 1.465 ± 0.34
2.491IleArg: 2.491 ± 0.557
1.612IleSer: 1.612 ± 0.446
2.198IleThr: 2.198 ± 0.288
2.564IleVal: 2.564 ± 0.394
0.366IleTrp: 0.366 ± 0.152
1.026IleTyr: 1.026 ± 0.325
0.0IleXaa: 0.0 ± 0.0
Lys
5.861LysAla: 5.861 ± 0.675
0.659LysCys: 0.659 ± 0.338
2.271LysAsp: 2.271 ± 0.439
1.685LysGlu: 1.685 ± 0.338
1.392LysPhe: 1.392 ± 0.329
2.784LysGly: 2.784 ± 0.369
0.879LysHis: 0.879 ± 0.291
1.392LysIle: 1.392 ± 0.301
1.538LysLys: 1.538 ± 0.335
4.249LysLeu: 4.249 ± 0.52
0.586LysMet: 0.586 ± 0.181
1.319LysAsn: 1.319 ± 0.314
2.344LysPro: 2.344 ± 0.62
2.344LysGln: 2.344 ± 0.37
2.784LysArg: 2.784 ± 0.475
2.271LysSer: 2.271 ± 0.529
2.564LysThr: 2.564 ± 0.416
2.418LysVal: 2.418 ± 0.349
1.099LysTrp: 1.099 ± 0.262
1.245LysTyr: 1.245 ± 0.294
0.0LysXaa: 0.0 ± 0.0
Leu
12.161LeuAla: 12.161 ± 1.175
1.026LeuCys: 1.026 ± 0.356
5.495LeuAsp: 5.495 ± 0.818
3.443LeuGlu: 3.443 ± 0.472
2.711LeuPhe: 2.711 ± 0.483
6.96LeuGly: 6.96 ± 0.618
1.319LeuHis: 1.319 ± 0.268
3.223LeuIle: 3.223 ± 0.502
4.542LeuLys: 4.542 ± 0.62
7.033LeuLeu: 7.033 ± 0.827
2.271LeuMet: 2.271 ± 0.381
2.491LeuAsn: 2.491 ± 0.514
5.714LeuPro: 5.714 ± 0.578
3.004LeuGln: 3.004 ± 0.471
6.52LeuArg: 6.52 ± 0.676
4.103LeuSer: 4.103 ± 0.565
6.447LeuThr: 6.447 ± 0.688
4.396LeuVal: 4.396 ± 0.684
1.026LeuTrp: 1.026 ± 0.269
1.685LeuTyr: 1.685 ± 0.338
0.0LeuXaa: 0.0 ± 0.0
Met
1.978MetAla: 1.978 ± 0.466
0.073MetCys: 0.073 ± 0.072
0.879MetAsp: 0.879 ± 0.242
1.465MetGlu: 1.465 ± 0.345
0.366MetPhe: 0.366 ± 0.176
1.538MetGly: 1.538 ± 0.337
0.22MetHis: 0.22 ± 0.119
0.586MetIle: 0.586 ± 0.186
0.952MetLys: 0.952 ± 0.271
2.491MetLeu: 2.491 ± 0.473
0.586MetMet: 0.586 ± 0.173
0.366MetAsn: 0.366 ± 0.165
1.612MetPro: 1.612 ± 0.417
0.879MetGln: 0.879 ± 0.246
1.465MetArg: 1.465 ± 0.295
2.198MetSer: 2.198 ± 0.331
2.418MetThr: 2.418 ± 0.429
1.392MetVal: 1.392 ± 0.281
0.22MetTrp: 0.22 ± 0.107
0.44MetTyr: 0.44 ± 0.146
0.0MetXaa: 0.0 ± 0.0
Asn
4.835AsnAla: 4.835 ± 0.885
0.147AsnCys: 0.147 ± 0.129
1.758AsnAsp: 1.758 ± 0.439
1.612AsnGlu: 1.612 ± 0.389
0.586AsnPhe: 0.586 ± 0.229
2.93AsnGly: 2.93 ± 0.461
0.44AsnHis: 0.44 ± 0.181
2.711AsnIle: 2.711 ± 1.204
0.952AsnLys: 0.952 ± 0.262
2.564AsnLeu: 2.564 ± 0.39
1.026AsnMet: 1.026 ± 0.291
1.319AsnAsn: 1.319 ± 0.395
2.198AsnPro: 2.198 ± 0.496
1.978AsnGln: 1.978 ± 0.428
1.465AsnArg: 1.465 ± 0.393
1.465AsnSer: 1.465 ± 0.44
2.418AsnThr: 2.418 ± 0.537
2.637AsnVal: 2.637 ± 0.472
0.513AsnTrp: 0.513 ± 0.207
0.879AsnTyr: 0.879 ± 0.246
0.0AsnXaa: 0.0 ± 0.0
Pro
6.667ProAla: 6.667 ± 0.679
0.366ProCys: 0.366 ± 0.178
4.029ProAsp: 4.029 ± 0.533
3.59ProGlu: 3.59 ± 0.475
1.172ProPhe: 1.172 ± 0.292
3.077ProGly: 3.077 ± 0.571
0.952ProHis: 0.952 ± 0.323
1.905ProIle: 1.905 ± 0.361
1.538ProLys: 1.538 ± 0.328
3.37ProLeu: 3.37 ± 0.446
0.659ProMet: 0.659 ± 0.215
1.172ProAsn: 1.172 ± 0.263
2.125ProPro: 2.125 ± 0.405
2.051ProGln: 2.051 ± 0.357
2.711ProArg: 2.711 ± 0.528
1.832ProSer: 1.832 ± 0.375
4.176ProThr: 4.176 ± 0.723
3.37ProVal: 3.37 ± 0.424
0.879ProTrp: 0.879 ± 0.286
1.245ProTyr: 1.245 ± 0.413
0.0ProXaa: 0.0 ± 0.0
Gln
6.74GlnAla: 6.74 ± 0.764
0.22GlnCys: 0.22 ± 0.14
2.198GlnAsp: 2.198 ± 0.383
1.538GlnGlu: 1.538 ± 0.335
1.832GlnPhe: 1.832 ± 0.359
3.516GlnGly: 3.516 ± 0.611
0.806GlnHis: 0.806 ± 0.239
2.198GlnIle: 2.198 ± 0.398
1.172GlnLys: 1.172 ± 0.322
3.15GlnLeu: 3.15 ± 0.458
0.806GlnMet: 0.806 ± 0.207
1.099GlnAsn: 1.099 ± 0.273
2.637GlnPro: 2.637 ± 0.555
4.029GlnGln: 4.029 ± 0.961
3.81GlnArg: 3.81 ± 0.447
2.711GlnSer: 2.711 ± 0.553
2.271GlnThr: 2.271 ± 0.398
2.93GlnVal: 2.93 ± 0.552
0.513GlnTrp: 0.513 ± 0.16
0.806GlnTyr: 0.806 ± 0.195
0.0GlnXaa: 0.0 ± 0.0
Arg
8.864ArgAla: 8.864 ± 1.096
0.44ArgCys: 0.44 ± 0.177
4.176ArgAsp: 4.176 ± 0.534
3.81ArgGlu: 3.81 ± 0.537
2.711ArgPhe: 2.711 ± 0.415
5.348ArgGly: 5.348 ± 1.026
1.392ArgHis: 1.392 ± 0.369
1.978ArgIle: 1.978 ± 0.369
2.93ArgLys: 2.93 ± 0.504
6.886ArgLeu: 6.886 ± 0.722
1.758ArgMet: 1.758 ± 0.346
1.538ArgAsn: 1.538 ± 0.388
3.223ArgPro: 3.223 ± 0.406
2.125ArgGln: 2.125 ± 0.421
4.908ArgArg: 4.908 ± 0.744
2.344ArgSer: 2.344 ± 0.558
3.59ArgThr: 3.59 ± 0.474
5.055ArgVal: 5.055 ± 0.567
1.465ArgTrp: 1.465 ± 0.5
1.832ArgTyr: 1.832 ± 0.308
0.0ArgXaa: 0.0 ± 0.0
Ser
6.593SerAla: 6.593 ± 0.78
0.147SerCys: 0.147 ± 0.094
3.59SerAsp: 3.59 ± 0.461
2.711SerGlu: 2.711 ± 0.452
1.538SerPhe: 1.538 ± 0.278
5.128SerGly: 5.128 ± 0.681
0.733SerHis: 0.733 ± 0.233
1.978SerIle: 1.978 ± 0.272
2.125SerLys: 2.125 ± 0.481
3.59SerLeu: 3.59 ± 0.367
1.465SerMet: 1.465 ± 0.252
1.905SerAsn: 1.905 ± 0.371
2.418SerPro: 2.418 ± 0.391
1.978SerGln: 1.978 ± 0.41
3.004SerArg: 3.004 ± 0.462
3.077SerSer: 3.077 ± 0.476
3.15SerThr: 3.15 ± 0.635
2.857SerVal: 2.857 ± 0.477
0.513SerTrp: 0.513 ± 0.201
1.099SerTyr: 1.099 ± 0.258
0.0SerXaa: 0.0 ± 0.0
Thr
8.864ThrAla: 8.864 ± 2.512
0.44ThrCys: 0.44 ± 0.174
3.223ThrAsp: 3.223 ± 0.437
3.663ThrGlu: 3.663 ± 0.645
1.612ThrPhe: 1.612 ± 0.364
4.762ThrGly: 4.762 ± 0.641
1.172ThrHis: 1.172 ± 0.336
2.344ThrIle: 2.344 ± 0.45
1.905ThrLys: 1.905 ± 0.395
4.835ThrLeu: 4.835 ± 0.789
1.245ThrMet: 1.245 ± 0.279
2.418ThrAsn: 2.418 ± 0.405
3.15ThrPro: 3.15 ± 0.489
1.905ThrGln: 1.905 ± 0.416
2.711ThrArg: 2.711 ± 0.407
3.736ThrSer: 3.736 ± 0.634
4.103ThrThr: 4.103 ± 0.54
5.201ThrVal: 5.201 ± 0.935
1.685ThrTrp: 1.685 ± 0.337
2.051ThrTyr: 2.051 ± 0.509
0.0ThrXaa: 0.0 ± 0.0
Val
10.549ValAla: 10.549 ± 1.555
0.513ValCys: 0.513 ± 0.191
3.956ValAsp: 3.956 ± 0.476
4.908ValGlu: 4.908 ± 0.687
1.758ValPhe: 1.758 ± 0.316
5.055ValGly: 5.055 ± 0.683
0.586ValHis: 0.586 ± 0.268
2.564ValIle: 2.564 ± 0.633
2.271ValLys: 2.271 ± 0.426
5.348ValLeu: 5.348 ± 0.614
1.832ValMet: 1.832 ± 0.305
2.125ValAsn: 2.125 ± 0.396
2.637ValPro: 2.637 ± 0.355
3.663ValGln: 3.663 ± 0.468
5.055ValArg: 5.055 ± 0.768
4.176ValSer: 4.176 ± 0.481
3.004ValThr: 3.004 ± 0.569
4.029ValVal: 4.029 ± 0.689
1.099ValTrp: 1.099 ± 0.227
1.465ValTyr: 1.465 ± 0.252
0.0ValXaa: 0.0 ± 0.0
Trp
1.832TrpAla: 1.832 ± 0.39
0.366TrpCys: 0.366 ± 0.183
0.952TrpAsp: 0.952 ± 0.212
0.366TrpGlu: 0.366 ± 0.136
1.026TrpPhe: 1.026 ± 0.25
1.319TrpGly: 1.319 ± 0.23
0.586TrpHis: 0.586 ± 0.151
0.293TrpIle: 0.293 ± 0.165
0.659TrpLys: 0.659 ± 0.229
2.051TrpLeu: 2.051 ± 0.307
0.293TrpMet: 0.293 ± 0.129
0.733TrpAsn: 0.733 ± 0.231
0.659TrpPro: 0.659 ± 0.251
0.952TrpGln: 0.952 ± 0.262
1.392TrpArg: 1.392 ± 0.401
0.513TrpSer: 0.513 ± 0.169
0.586TrpThr: 0.586 ± 0.196
1.172TrpVal: 1.172 ± 0.305
0.366TrpTrp: 0.366 ± 0.142
0.293TrpTyr: 0.293 ± 0.166
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.81TyrAla: 3.81 ± 0.448
0.22TyrCys: 0.22 ± 0.131
1.465TyrAsp: 1.465 ± 0.285
1.392TyrGlu: 1.392 ± 0.286
1.319TyrPhe: 1.319 ± 0.28
2.418TyrGly: 2.418 ± 0.337
0.44TyrHis: 0.44 ± 0.206
0.44TyrIle: 0.44 ± 0.219
1.026TyrLys: 1.026 ± 0.235
1.832TyrLeu: 1.832 ± 0.408
0.44TyrMet: 0.44 ± 0.153
1.026TyrAsn: 1.026 ± 0.4
1.465TyrPro: 1.465 ± 0.285
1.099TyrGln: 1.099 ± 0.253
3.297TyrArg: 3.297 ± 1.185
1.392TyrSer: 1.392 ± 0.295
1.465TyrThr: 1.465 ± 0.326
2.125TyrVal: 2.125 ± 0.466
0.44TyrTrp: 0.44 ± 0.163
0.366TyrTyr: 0.366 ± 0.152
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (13651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski