Amino acid dipepetide frequency for Anopheles sinensis (Mosquito)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.401AlaAla: 7.401 ± 0.07	1.226AlaCys: 1.226 ± 0.019	3.44AlaAsp: 3.44 ± 0.023	4.15AlaGlu: 4.15 ± 0.029	2.369AlaPhe: 2.369 ± 0.02	5.572AlaGly: 5.572 ± 0.044	1.656AlaHis: 1.656 ± 0.017	3.573AlaIle: 3.573 ± 0.025	3.787AlaLys: 3.787 ± 0.031	6.185AlaLeu: 6.185 ± 0.04	1.708AlaMet: 1.708 ± 0.018	3.214AlaAsn: 3.214 ± 0.022	3.975AlaPro: 3.975 ± 0.035	2.688AlaGln: 2.688 ± 0.022	3.895AlaArg: 3.895 ± 0.028	6.402AlaSer: 6.402 ± 0.041	4.949AlaThr: 4.949 ± 0.034	4.704AlaVal: 4.704 ± 0.026	0.606AlaTrp: 0.606 ± 0.008	1.761AlaTyr: 1.761 ± 0.017	0.004AlaXaa: 0.004 ± 0.001
Cys	1.305CysAla: 1.305 ± 0.019	0.516CysCys: 0.516 ± 0.009	1.091CysAsp: 1.091 ± 0.021	1.1CysGlu: 1.1 ± 0.02	0.761CysPhe: 0.761 ± 0.014	1.396CysGly: 1.396 ± 0.019	0.495CysHis: 0.495 ± 0.01	0.947CysIle: 0.947 ± 0.015	0.856CysLys: 0.856 ± 0.014	1.688CysLeu: 1.688 ± 0.019	0.393CysMet: 0.393 ± 0.007	0.819CysAsn: 0.819 ± 0.013	1.09CysPro: 1.09 ± 0.02	0.707CysGln: 0.707 ± 0.014	1.226CysArg: 1.226 ± 0.018	1.563CysSer: 1.563 ± 0.021	1.096CysThr: 1.096 ± 0.015	1.307CysVal: 1.307 ± 0.021	0.25CysTrp: 0.25 ± 0.006	0.581CysTyr: 0.581 ± 0.011	0.002CysXaa: 0.002 ± 0.0
Asp	3.495AspAla: 3.495 ± 0.025	0.998AspCys: 0.998 ± 0.016	4.084AspAsp: 4.084 ± 0.04	4.234AspGlu: 4.234 ± 0.034	1.985AspPhe: 1.985 ± 0.016	4.096AspGly: 4.096 ± 0.033	1.199AspHis: 1.199 ± 0.015	2.606AspIle: 2.606 ± 0.024	2.272AspLys: 2.272 ± 0.022	4.306AspLeu: 4.306 ± 0.03	1.112AspMet: 1.112 ± 0.013	1.993AspAsn: 1.993 ± 0.017	2.61AspPro: 2.61 ± 0.022	1.797AspGln: 1.797 ± 0.016	3.277AspArg: 3.277 ± 0.028	3.876AspSer: 3.876 ± 0.029	2.66AspThr: 2.66 ± 0.021	3.325AspVal: 3.325 ± 0.022	0.598AspTrp: 0.598 ± 0.01	1.616AspTyr: 1.616 ± 0.016	0.003AspXaa: 0.003 ± 0.001
Glu	4.222GluAla: 4.222 ± 0.034	1.173GluCys: 1.173 ± 0.024	3.601GluAsp: 3.601 ± 0.03	5.433GluGlu: 5.433 ± 0.059	1.999GluPhe: 1.999 ± 0.018	3.288GluGly: 3.288 ± 0.021	1.521GluHis: 1.521 ± 0.015	3.011GluIle: 3.011 ± 0.027	4.056GluLys: 4.056 ± 0.043	5.77GluLeu: 5.77 ± 0.044	1.583GluMet: 1.583 ± 0.017	2.848GluAsn: 2.848 ± 0.02	2.985GluPro: 2.985 ± 0.03	3.086GluGln: 3.086 ± 0.026	4.275GluArg: 4.275 ± 0.037	4.2GluSer: 4.2 ± 0.029	3.469GluThr: 3.469 ± 0.027	3.499GluVal: 3.499 ± 0.028	0.637GluTrp: 0.637 ± 0.011	1.756GluTyr: 1.756 ± 0.016	0.003GluXaa: 0.003 ± 0.001
Phe	2.388PheAla: 2.388 ± 0.022	0.784PheCys: 0.784 ± 0.012	2.052PheAsp: 2.052 ± 0.02	2.078PheGlu: 2.078 ± 0.022	1.483PhePhe: 1.483 ± 0.017	2.644PheGly: 2.644 ± 0.027	0.97PheHis: 0.97 ± 0.011	1.765PheIle: 1.765 ± 0.021	1.582PheLys: 1.582 ± 0.016	3.364PheLeu: 3.364 ± 0.027	0.758PheMet: 0.758 ± 0.011	1.573PheAsn: 1.573 ± 0.017	1.849PhePro: 1.849 ± 0.018	1.327PheGln: 1.327 ± 0.014	2.268PheArg: 2.268 ± 0.02	2.717PheSer: 2.717 ± 0.021	1.929PheThr: 1.929 ± 0.022	2.516PheVal: 2.516 ± 0.021	0.44PheTrp: 0.44 ± 0.008	1.221PheTyr: 1.221 ± 0.015	0.002PheXaa: 0.002 ± 0.001
Gly	5.115GlyAla: 5.115 ± 0.04	1.192GlyCys: 1.192 ± 0.017	3.224GlyAsp: 3.224 ± 0.029	3.625GlyGlu: 3.625 ± 0.03	2.308GlyPhe: 2.308 ± 0.019	8.708GlyGly: 8.708 ± 0.107	1.702GlyHis: 1.702 ± 0.02	2.833GlyIle: 2.833 ± 0.024	3.607GlyLys: 3.607 ± 0.026	4.825GlyLeu: 4.825 ± 0.038	1.533GlyMet: 1.533 ± 0.019	2.929GlyAsn: 2.929 ± 0.026	3.195GlyPro: 3.195 ± 0.041	2.469GlyGln: 2.469 ± 0.022	3.929GlyArg: 3.929 ± 0.036	6.596GlySer: 6.596 ± 0.052	4.319GlyThr: 4.319 ± 0.031	4.077GlyVal: 4.077 ± 0.03	0.803GlyTrp: 0.803 ± 0.012	1.94GlyTyr: 1.94 ± 0.021	0.004GlyXaa: 0.004 ± 0.001
His	1.543HisAla: 1.543 ± 0.017	0.565HisCys: 0.565 ± 0.01	1.143HisAsp: 1.143 ± 0.014	1.352HisGlu: 1.352 ± 0.015	1.0HisPhe: 1.0 ± 0.014	1.735HisGly: 1.735 ± 0.02	1.922HisHis: 1.922 ± 0.042	1.158HisIle: 1.158 ± 0.013	1.091HisLys: 1.091 ± 0.014	2.391HisLeu: 2.391 ± 0.023	0.585HisMet: 0.585 ± 0.01	1.079HisAsn: 1.079 ± 0.014	1.741HisPro: 1.741 ± 0.022	1.589HisGln: 1.589 ± 0.019	1.885HisArg: 1.885 ± 0.02	2.05HisSer: 2.05 ± 0.02	1.404HisThr: 1.404 ± 0.016	1.424HisVal: 1.424 ± 0.017	0.3HisTrp: 0.3 ± 0.006	0.858HisTyr: 0.858 ± 0.012	0.002HisXaa: 0.002 ± 0.001
Ile	3.52IleAla: 3.52 ± 0.024	1.04IleCys: 1.04 ± 0.014	2.864IleAsp: 2.864 ± 0.022	3.1IleGlu: 3.1 ± 0.026	1.797IlePhe: 1.797 ± 0.019	3.013IleGly: 3.013 ± 0.022	1.129IleHis: 1.129 ± 0.013	2.438IleIle: 2.438 ± 0.027	2.392IleLys: 2.392 ± 0.02	4.104IleLeu: 4.104 ± 0.032	1.017IleMet: 1.017 ± 0.013	2.15IleAsn: 2.15 ± 0.02	2.604IlePro: 2.604 ± 0.023	1.751IleGln: 1.751 ± 0.019	2.79IleArg: 2.79 ± 0.027	3.57IleSer: 3.57 ± 0.026	2.721IleThr: 2.721 ± 0.022	3.575IleVal: 3.575 ± 0.028	0.457IleTrp: 0.457 ± 0.009	1.405IleTyr: 1.405 ± 0.016	0.003IleXaa: 0.003 ± 0.001
Lys	3.368LysAla: 3.368 ± 0.028	1.014LysCys: 1.014 ± 0.014	2.654LysAsp: 2.654 ± 0.021	3.606LysGlu: 3.606 ± 0.033	1.714LysPhe: 1.714 ± 0.018	2.592LysGly: 2.592 ± 0.027	1.418LysHis: 1.418 ± 0.017	2.612LysIle: 2.612 ± 0.024	3.777LysLys: 3.777 ± 0.048	5.022LysLeu: 5.022 ± 0.037	1.344LysMet: 1.344 ± 0.016	2.219LysAsn: 2.219 ± 0.021	2.982LysPro: 2.982 ± 0.033	2.543LysGln: 2.543 ± 0.025	3.623LysArg: 3.623 ± 0.028	3.748LysSer: 3.748 ± 0.033	2.961LysThr: 2.961 ± 0.025	3.12LysVal: 3.12 ± 0.026	0.53LysTrp: 0.53 ± 0.009	1.633LysTyr: 1.633 ± 0.018	0.002LysXaa: 0.002 ± 0.0
Leu	6.549LeuAla: 6.549 ± 0.042	1.685LeuCys: 1.685 ± 0.02	4.533LeuAsp: 4.533 ± 0.033	5.678LeuGlu: 5.678 ± 0.048	3.177LeuPhe: 3.177 ± 0.028	4.867LeuGly: 4.867 ± 0.032	2.44LeuHis: 2.44 ± 0.019	3.921LeuIle: 3.921 ± 0.03	4.887LeuLys: 4.887 ± 0.04	8.831LeuLeu: 8.831 ± 0.056	2.008LeuMet: 2.008 ± 0.02	3.747LeuAsn: 3.747 ± 0.026	5.075LeuPro: 5.075 ± 0.028	4.341LeuGln: 4.341 ± 0.03	5.439LeuArg: 5.439 ± 0.035	6.52LeuSer: 6.52 ± 0.034	4.827LeuThr: 4.827 ± 0.03	5.445LeuVal: 5.445 ± 0.035	0.913LeuTrp: 0.913 ± 0.013	2.488LeuTyr: 2.488 ± 0.025	0.007LeuXaa: 0.007 ± 0.001
Met	1.963MetAla: 1.963 ± 0.018	0.408MetCys: 0.408 ± 0.008	1.292MetAsp: 1.292 ± 0.014	1.523MetGlu: 1.523 ± 0.015	0.882MetPhe: 0.882 ± 0.012	1.259MetGly: 1.259 ± 0.017	0.602MetHis: 0.602 ± 0.009	1.067MetIle: 1.067 ± 0.013	1.324MetLys: 1.324 ± 0.015	2.18MetLeu: 2.18 ± 0.019	0.743MetMet: 0.743 ± 0.013	0.993MetAsn: 0.993 ± 0.011	1.137MetPro: 1.137 ± 0.014	1.009MetGln: 1.009 ± 0.012	1.297MetArg: 1.297 ± 0.013	1.647MetSer: 1.647 ± 0.017	1.182MetThr: 1.182 ± 0.012	1.524MetVal: 1.524 ± 0.016	0.21MetTrp: 0.21 ± 0.005	0.645MetTyr: 0.645 ± 0.01	0.002MetXaa: 0.002 ± 0.0
Asn	3.039AsnAla: 3.039 ± 0.023	0.845AsnCys: 0.845 ± 0.013	2.307AsnAsp: 2.307 ± 0.019	2.672AsnGlu: 2.672 ± 0.026	1.585AsnPhe: 1.585 ± 0.017	3.816AsnGly: 3.816 ± 0.036	1.145AsnHis: 1.145 ± 0.016	2.253AsnIle: 2.253 ± 0.018	1.932AsnLys: 1.932 ± 0.021	3.763AsnLeu: 3.763 ± 0.033	0.959AsnMet: 0.959 ± 0.014	2.556AsnAsn: 2.556 ± 0.036	2.253AsnPro: 2.253 ± 0.02	1.721AsnGln: 1.721 ± 0.023	2.737AsnArg: 2.737 ± 0.02	3.33AsnSer: 3.33 ± 0.03	2.304AsnThr: 2.304 ± 0.019	3.025AsnVal: 3.025 ± 0.027	0.443AsnTrp: 0.443 ± 0.009	1.343AsnTyr: 1.343 ± 0.015	0.002AsnXaa: 0.002 ± 0.001
Pro	4.584ProAla: 4.584 ± 0.034	0.8ProCys: 0.8 ± 0.017	2.604ProAsp: 2.604 ± 0.022	3.468ProGlu: 3.468 ± 0.031	1.9ProPhe: 1.9 ± 0.018	3.656ProGly: 3.656 ± 0.057	1.35ProHis: 1.35 ± 0.017	2.513ProIle: 2.513 ± 0.02	2.825ProLys: 2.825 ± 0.029	4.288ProLeu: 4.288 ± 0.028	1.195ProMet: 1.195 ± 0.016	2.344ProAsn: 2.344 ± 0.021	5.16ProPro: 5.16 ± 0.074	2.231ProGln: 2.231 ± 0.023	2.726ProArg: 2.726 ± 0.026	5.195ProSer: 5.195 ± 0.045	3.917ProThr: 3.917 ± 0.034	3.822ProVal: 3.822 ± 0.029	0.499ProTrp: 0.499 ± 0.008	1.481ProTyr: 1.481 ± 0.016	0.004ProXaa: 0.004 ± 0.001
Gln	2.664GlnAla: 2.664 ± 0.021	0.819GlnCys: 0.819 ± 0.018	1.688GlnAsp: 1.688 ± 0.017	2.565GlnGlu: 2.565 ± 0.024	1.426GlnPhe: 1.426 ± 0.015	1.908GlnGly: 1.908 ± 0.021	1.691GlnHis: 1.691 ± 0.02	1.939GlnIle: 1.939 ± 0.018	2.244GlnLys: 2.244 ± 0.023	4.289GlnLeu: 4.289 ± 0.03	1.063GlnMet: 1.063 ± 0.014	1.8GlnAsn: 1.8 ± 0.021	2.672GlnPro: 2.672 ± 0.029	4.746GlnGln: 4.746 ± 0.076	2.872GlnArg: 2.872 ± 0.023	3.057GlnSer: 3.057 ± 0.025	2.428GlnThr: 2.428 ± 0.02	2.097GlnVal: 2.097 ± 0.017	0.444GlnTrp: 0.444 ± 0.009	1.313GlnTyr: 1.313 ± 0.014	0.003GlnXaa: 0.003 ± 0.001
Arg	3.861ArgAla: 3.861 ± 0.024	1.331ArgCys: 1.331 ± 0.02	2.93ArgAsp: 2.93 ± 0.025	3.667ArgGlu: 3.667 ± 0.033	2.372ArgPhe: 2.372 ± 0.022	3.281ArgGly: 3.281 ± 0.034	1.695ArgHis: 1.695 ± 0.016	2.845ArgIle: 2.845 ± 0.021	4.015ArgLys: 4.015 ± 0.03	5.275ArgLeu: 5.275 ± 0.036	1.508ArgMet: 1.508 ± 0.014	2.866ArgAsn: 2.866 ± 0.023	3.141ArgPro: 3.141 ± 0.031	2.627ArgGln: 2.627 ± 0.02	4.757ArgArg: 4.757 ± 0.04	4.988ArgSer: 4.988 ± 0.041	3.641ArgThr: 3.641 ± 0.028	3.243ArgVal: 3.243 ± 0.023	0.787ArgTrp: 0.787 ± 0.011	1.928ArgTyr: 1.928 ± 0.019	0.005ArgXaa: 0.005 ± 0.001
Ser	6.022SerAla: 6.022 ± 0.038	1.436SerCys: 1.436 ± 0.018	4.007SerAsp: 4.007 ± 0.03	4.361SerGlu: 4.361 ± 0.03	2.92SerPhe: 2.92 ± 0.022	6.182SerGly: 6.182 ± 0.043	1.813SerHis: 1.813 ± 0.018	3.82SerIle: 3.82 ± 0.026	3.854SerLys: 3.854 ± 0.029	6.614SerLeu: 6.614 ± 0.037	1.713SerMet: 1.713 ± 0.016	3.791SerAsn: 3.791 ± 0.03	4.678SerPro: 4.678 ± 0.043	2.803SerGln: 2.803 ± 0.025	4.365SerArg: 4.365 ± 0.036	10.186SerSer: 10.186 ± 0.119	5.609SerThr: 5.609 ± 0.049	5.201SerVal: 5.201 ± 0.029	0.77SerTrp: 0.77 ± 0.012	2.148SerTyr: 2.148 ± 0.02	0.004SerXaa: 0.004 ± 0.001
Thr	4.729ThrAla: 4.729 ± 0.033	1.017ThrCys: 1.017 ± 0.018	2.921ThrAsp: 2.921 ± 0.024	3.472ThrGlu: 3.472 ± 0.029	2.11ThrPhe: 2.11 ± 0.023	4.17ThrGly: 4.17 ± 0.032	1.317ThrHis: 1.317 ± 0.015	3.283ThrIle: 3.283 ± 0.023	2.846ThrLys: 2.846 ± 0.022	5.139ThrLeu: 5.139 ± 0.034	1.363ThrMet: 1.363 ± 0.016	2.676ThrAsn: 2.676 ± 0.021	3.807ThrPro: 3.807 ± 0.036	1.99ThrGln: 1.99 ± 0.018	2.892ThrArg: 2.892 ± 0.024	5.101ThrSer: 5.101 ± 0.037	5.413ThrThr: 5.413 ± 0.081	4.611ThrVal: 4.611 ± 0.028	0.481ThrTrp: 0.481 ± 0.009	1.452ThrTyr: 1.452 ± 0.013	0.005ThrXaa: 0.005 ± 0.001
Val	5.067ValAla: 5.067 ± 0.03	1.462ValCys: 1.462 ± 0.02	3.384ValAsp: 3.384 ± 0.024	3.981ValGlu: 3.981 ± 0.034	2.306ValPhe: 2.306 ± 0.023	4.098ValGly: 4.098 ± 0.028	1.595ValHis: 1.595 ± 0.015	2.872ValIle: 2.872 ± 0.022	3.174ValLys: 3.174 ± 0.026	5.762ValLeu: 5.762 ± 0.04	1.364ValMet: 1.364 ± 0.013	2.539ValAsn: 2.539 ± 0.02	3.807ValPro: 3.807 ± 0.029	2.641ValGln: 2.641 ± 0.021	3.822ValArg: 3.822 ± 0.027	4.755ValSer: 4.755 ± 0.029	3.763ValThr: 3.763 ± 0.027	4.545ValVal: 4.545 ± 0.035	0.667ValTrp: 0.667 ± 0.011	1.802ValTyr: 1.802 ± 0.017	0.004ValXaa: 0.004 ± 0.001
Trp	0.57TrpAla: 0.57 ± 0.009	0.231TrpCys: 0.231 ± 0.006	0.523TrpAsp: 0.523 ± 0.009	0.573TrpGlu: 0.573 ± 0.009	0.418TrpPhe: 0.418 ± 0.008	0.56TrpGly: 0.56 ± 0.01	0.276TrpHis: 0.276 ± 0.006	0.61TrpIle: 0.61 ± 0.01	0.646TrpLys: 0.646 ± 0.011	1.027TrpLeu: 1.027 ± 0.014	0.313TrpMet: 0.313 ± 0.007	0.562TrpAsn: 0.562 ± 0.011	0.453TrpPro: 0.453 ± 0.009	0.427TrpGln: 0.427 ± 0.008	0.698TrpArg: 0.698 ± 0.01	0.767TrpSer: 0.767 ± 0.012	0.632TrpThr: 0.632 ± 0.011	0.55TrpVal: 0.55 ± 0.01	0.198TrpTrp: 0.198 ± 0.006	0.351TrpTyr: 0.351 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.857TyrAla: 1.857 ± 0.018	0.65TyrCys: 0.65 ± 0.012	1.799TyrAsp: 1.799 ± 0.017	1.776TyrGlu: 1.776 ± 0.019	1.198TyrPhe: 1.198 ± 0.014	2.084TyrGly: 2.084 ± 0.022	0.879TyrHis: 0.879 ± 0.014	1.37TyrIle: 1.37 ± 0.016	1.313TyrLys: 1.313 ± 0.016	2.547TyrLeu: 2.547 ± 0.024	0.622TyrMet: 0.622 ± 0.011	1.329TyrAsn: 1.329 ± 0.015	1.344TyrPro: 1.344 ± 0.019	1.236TyrGln: 1.236 ± 0.017	1.984TyrArg: 1.984 ± 0.02	2.022TyrSer: 2.022 ± 0.018	1.566TyrThr: 1.566 ± 0.016	1.797TyrVal: 1.797 ± 0.018	0.349TyrTrp: 0.349 ± 0.009	1.138TyrTyr: 1.138 ± 0.016	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.002XaaGlu: 0.002 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.004XaaGly: 0.004 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.003XaaIle: 0.003 ± 0.001	0.004XaaLys: 0.004 ± 0.001	0.006XaaLeu: 0.006 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.004XaaPro: 0.004 ± 0.001	0.003XaaGln: 0.003 ± 0.001	0.005XaaArg: 0.005 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.005XaaVal: 0.005 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.442XaaXaa: 0.442 ± 0.033

Statistics based on 19343 proteins (7280472 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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