Amino acid dipepetide frequency for Circoviridae 11 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.785AlaAla: 4.785 ± 1.691
0.0AlaCys: 0.0 ± 0.0
4.785AlaAsp: 4.785 ± 1.477
3.589AlaGlu: 3.589 ± 1.68
3.589AlaPhe: 3.589 ± 1.178
2.392AlaGly: 2.392 ± 1.496
1.196AlaHis: 1.196 ± 0.907
3.589AlaIle: 3.589 ± 1.94
5.981AlaLys: 5.981 ± 2.951
4.785AlaLeu: 4.785 ± 2.647
2.392AlaMet: 2.392 ± 2.291
2.392AlaAsn: 2.392 ± 1.496
5.981AlaPro: 5.981 ± 3.141
3.589AlaGln: 3.589 ± 0.997
5.981AlaArg: 5.981 ± 1.814
4.785AlaSer: 4.785 ± 1.987
8.373AlaThr: 8.373 ± 3.312
2.392AlaVal: 2.392 ± 1.3
0.0AlaTrp: 0.0 ± 0.0
5.981AlaTyr: 5.981 ± 3.209
0.0AlaXaa: 0.0 ± 0.0
Cys
3.589CysAla: 3.589 ± 2.772
0.0CysCys: 0.0 ± 0.0
2.392CysAsp: 2.392 ± 1.3
0.0CysGlu: 0.0 ± 0.0
1.196CysPhe: 1.196 ± 0.907
1.196CysGly: 1.196 ± 1.375
0.0CysHis: 0.0 ± 0.0
1.196CysIle: 1.196 ± 1.375
0.0CysLys: 0.0 ± 0.0
1.196CysLeu: 1.196 ± 1.375
0.0CysMet: 0.0 ± 0.0
1.196CysAsn: 1.196 ± 0.907
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
2.392CysArg: 2.392 ± 1.813
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
1.196CysTrp: 1.196 ± 0.907
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.589AspAla: 3.589 ± 2.281
0.0AspCys: 0.0 ± 0.0
2.392AspAsp: 2.392 ± 1.813
2.392AspGlu: 2.392 ± 2.131
1.196AspPhe: 1.196 ± 0.907
4.785AspGly: 4.785 ± 3.626
1.196AspHis: 1.196 ± 1.205
4.785AspIle: 4.785 ± 1.909
1.196AspLys: 1.196 ± 1.375
5.981AspLeu: 5.981 ± 1.307
0.0AspMet: 0.0 ± 0.0
1.196AspAsn: 1.196 ± 1.375
1.196AspPro: 1.196 ± 0.907
2.392AspGln: 2.392 ± 1.076
2.392AspArg: 2.392 ± 1.813
3.589AspSer: 3.589 ± 1.422
4.785AspThr: 4.785 ± 3.729
4.785AspVal: 4.785 ± 2.647
0.0AspTrp: 0.0 ± 0.0
2.392AspTyr: 2.392 ± 1.3
0.0AspXaa: 0.0 ± 0.0
Glu
4.785GluAla: 4.785 ± 3.626
1.196GluCys: 1.196 ± 1.145
2.392GluAsp: 2.392 ± 0.991
3.589GluGlu: 3.589 ± 1.516
1.196GluPhe: 1.196 ± 1.066
2.392GluGly: 2.392 ± 1.496
2.392GluHis: 2.392 ± 1.076
2.392GluIle: 2.392 ± 0.991
5.981GluLys: 5.981 ± 4.335
5.981GluLeu: 5.981 ± 3.33
2.392GluMet: 2.392 ± 1.488
1.196GluAsn: 1.196 ± 1.145
0.0GluPro: 0.0 ± 0.0
1.196GluGln: 1.196 ± 1.066
3.589GluArg: 3.589 ± 0.997
4.785GluSer: 4.785 ± 1.983
2.392GluThr: 2.392 ± 1.076
2.392GluVal: 2.392 ± 1.813
1.196GluTrp: 1.196 ± 0.907
3.589GluTyr: 3.589 ± 1.94
0.0GluXaa: 0.0 ± 0.0
Phe
2.392PheAla: 2.392 ± 1.496
0.0PheCys: 0.0 ± 0.0
1.196PheAsp: 1.196 ± 0.907
3.589PheGlu: 3.589 ± 1.922
1.196PhePhe: 1.196 ± 1.205
3.589PheGly: 3.589 ± 1.771
1.196PheHis: 1.196 ± 1.205
0.0PheIle: 0.0 ± 0.0
1.196PheLys: 1.196 ± 1.145
5.981PheLeu: 5.981 ± 3.432
1.196PheMet: 1.196 ± 0.907
1.196PheAsn: 1.196 ± 0.907
1.196PhePro: 1.196 ± 1.066
0.0PheGln: 0.0 ± 0.0
2.392PheArg: 2.392 ± 0.991
1.196PheSer: 1.196 ± 0.907
2.392PheThr: 2.392 ± 1.323
1.196PheVal: 1.196 ± 0.907
0.0PheTrp: 0.0 ± 0.0
1.196PheTyr: 1.196 ± 1.066
0.0PheXaa: 0.0 ± 0.0
Gly
3.589GlyAla: 3.589 ± 1.516
0.0GlyCys: 0.0 ± 0.0
1.196GlyAsp: 1.196 ± 0.907
4.785GlyGlu: 4.785 ± 1.23
1.196GlyPhe: 1.196 ± 0.907
3.589GlyGly: 3.589 ± 2.72
2.392GlyHis: 2.392 ± 1.864
3.589GlyIle: 3.589 ± 0.997
8.373GlyLys: 8.373 ± 2.435
2.392GlyLeu: 2.392 ± 1.813
2.392GlyMet: 2.392 ± 0.991
3.589GlyAsn: 3.589 ± 0.997
2.392GlyPro: 2.392 ± 2.409
2.392GlyGln: 2.392 ± 1.488
5.981GlyArg: 5.981 ± 2.081
0.0GlySer: 0.0 ± 0.0
7.177GlyThr: 7.177 ± 2.95
3.589GlyVal: 3.589 ± 1.516
0.0GlyTrp: 0.0 ± 0.0
7.177GlyTyr: 7.177 ± 1.461
0.0GlyXaa: 0.0 ± 0.0
His
1.196HisAla: 1.196 ± 0.907
1.196HisCys: 1.196 ± 0.907
2.392HisAsp: 2.392 ± 1.864
1.196HisGlu: 1.196 ± 1.145
4.785HisPhe: 4.785 ± 2.167
1.196HisGly: 1.196 ± 0.907
1.196HisHis: 1.196 ± 1.375
1.196HisIle: 1.196 ± 1.145
0.0HisLys: 0.0 ± 0.0
4.785HisLeu: 4.785 ± 1.691
1.196HisMet: 1.196 ± 1.04
0.0HisAsn: 0.0 ± 0.0
2.392HisPro: 2.392 ± 1.457
1.196HisGln: 1.196 ± 1.375
1.196HisArg: 1.196 ± 1.375
1.196HisSer: 1.196 ± 1.205
0.0HisThr: 0.0 ± 0.0
2.392HisVal: 2.392 ± 1.3
0.0HisTrp: 0.0 ± 0.0
1.196HisTyr: 1.196 ± 1.066
0.0HisXaa: 0.0 ± 0.0
Ile
2.392IleAla: 2.392 ± 1.076
1.196IleCys: 1.196 ± 0.907
5.981IleAsp: 5.981 ± 1.011
1.196IleGlu: 1.196 ± 1.145
3.589IlePhe: 3.589 ± 1.771
3.589IleGly: 3.589 ± 2.393
1.196IleHis: 1.196 ± 1.145
2.392IleIle: 2.392 ± 1.656
1.196IleLys: 1.196 ± 0.907
3.589IleLeu: 3.589 ± 2.549
1.196IleMet: 1.196 ± 1.145
2.392IleAsn: 2.392 ± 1.656
4.785IlePro: 4.785 ± 2.652
2.392IleGln: 2.392 ± 1.457
3.589IleArg: 3.589 ± 2.795
7.177IleSer: 7.177 ± 4.751
4.785IleThr: 4.785 ± 2.601
4.785IleVal: 4.785 ± 2.152
2.392IleTrp: 2.392 ± 1.488
3.589IleTyr: 3.589 ± 1.459
0.0IleXaa: 0.0 ± 0.0
Lys
5.981LysAla: 5.981 ± 3.974
0.0LysCys: 0.0 ± 0.0
3.589LysAsp: 3.589 ± 1.94
3.589LysGlu: 3.589 ± 2.281
0.0LysPhe: 0.0 ± 0.0
2.392LysGly: 2.392 ± 1.813
1.196LysHis: 1.196 ± 1.066
2.392LysIle: 2.392 ± 1.656
14.354LysLys: 14.354 ± 7.984
4.785LysLeu: 4.785 ± 2.152
2.392LysMet: 2.392 ± 2.289
4.785LysAsn: 4.785 ± 4.262
1.196LysPro: 1.196 ± 1.375
3.589LysGln: 3.589 ± 0.997
5.981LysArg: 5.981 ± 1.731
4.785LysSer: 4.785 ± 3.292
2.392LysThr: 2.392 ± 1.813
3.589LysVal: 3.589 ± 2.393
2.392LysTrp: 2.392 ± 2.131
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
8.373LeuAla: 8.373 ± 2.18
2.392LeuCys: 2.392 ± 1.3
5.981LeuAsp: 5.981 ± 2.972
7.177LeuGlu: 7.177 ± 2.311
2.392LeuPhe: 2.392 ± 1.656
3.589LeuGly: 3.589 ± 1.68
1.196LeuHis: 1.196 ± 1.205
7.177LeuIle: 7.177 ± 2.769
3.589LeuLys: 3.589 ± 3.197
5.981LeuLeu: 5.981 ± 2.072
0.0LeuMet: 0.0 ± 0.0
4.785LeuAsn: 4.785 ± 2.647
1.196LeuPro: 1.196 ± 0.907
3.589LeuGln: 3.589 ± 2.72
7.177LeuArg: 7.177 ± 4.163
4.785LeuSer: 4.785 ± 1.716
1.196LeuThr: 1.196 ± 1.145
3.589LeuVal: 3.589 ± 1.422
3.589LeuTrp: 3.589 ± 1.68
2.392LeuTyr: 2.392 ± 2.409
0.0LeuXaa: 0.0 ± 0.0
Met
2.392MetAla: 2.392 ± 2.289
0.0MetCys: 0.0 ± 0.0
2.392MetAsp: 2.392 ± 1.3
4.785MetGlu: 4.785 ± 1.858
0.0MetPhe: 0.0 ± 0.0
1.196MetGly: 1.196 ± 1.205
0.0MetHis: 0.0 ± 0.0
1.196MetIle: 1.196 ± 1.145
2.392MetLys: 2.392 ± 1.457
1.196MetLeu: 1.196 ± 0.907
0.0MetMet: 0.0 ± 0.0
1.196MetAsn: 1.196 ± 1.066
2.392MetPro: 2.392 ± 1.323
0.0MetGln: 0.0 ± 0.0
1.196MetArg: 1.196 ± 1.205
0.0MetSer: 0.0 ± 0.0
1.196MetThr: 1.196 ± 1.066
2.392MetVal: 2.392 ± 1.457
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.589AsnAla: 3.589 ± 1.636
0.0AsnCys: 0.0 ± 0.0
1.196AsnAsp: 1.196 ± 0.907
2.392AsnGlu: 2.392 ± 1.813
1.196AsnPhe: 1.196 ± 1.145
1.196AsnGly: 1.196 ± 1.205
0.0AsnHis: 0.0 ± 0.0
5.981AsnIle: 5.981 ± 2.699
2.392AsnLys: 2.392 ± 2.131
1.196AsnLeu: 1.196 ± 1.205
3.589AsnMet: 3.589 ± 1.243
1.196AsnAsn: 1.196 ± 0.907
2.392AsnPro: 2.392 ± 1.646
0.0AsnGln: 0.0 ± 0.0
2.392AsnArg: 2.392 ± 2.131
2.392AsnSer: 2.392 ± 2.409
3.589AsnThr: 3.589 ± 2.375
2.392AsnVal: 2.392 ± 1.3
0.0AsnTrp: 0.0 ± 0.0
2.392AsnTyr: 2.392 ± 0.991
0.0AsnXaa: 0.0 ± 0.0
Pro
4.785ProAla: 4.785 ± 2.275
0.0ProCys: 0.0 ± 0.0
2.392ProAsp: 2.392 ± 1.656
2.392ProGlu: 2.392 ± 1.323
2.392ProPhe: 2.392 ± 1.323
1.196ProGly: 1.196 ± 0.907
2.392ProHis: 2.392 ± 1.3
3.589ProIle: 3.589 ± 1.308
1.196ProLys: 1.196 ± 0.907
4.785ProLeu: 4.785 ± 2.698
0.0ProMet: 0.0 ± 0.0
1.196ProAsn: 1.196 ± 1.375
1.196ProPro: 1.196 ± 0.907
0.0ProGln: 0.0 ± 0.0
1.196ProArg: 1.196 ± 0.907
1.196ProSer: 1.196 ± 1.205
4.785ProThr: 4.785 ± 1.23
1.196ProVal: 1.196 ± 1.145
0.0ProTrp: 0.0 ± 0.0
1.196ProTyr: 1.196 ± 1.145
0.0ProXaa: 0.0 ± 0.0
Gln
1.196GlnAla: 1.196 ± 0.907
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
2.392GlnGlu: 2.392 ± 1.813
1.196GlnPhe: 1.196 ± 1.375
4.785GlnGly: 4.785 ± 2.477
1.196GlnHis: 1.196 ± 0.907
0.0GlnIle: 0.0 ± 0.0
1.196GlnLys: 1.196 ± 1.066
2.392GlnLeu: 2.392 ± 1.076
1.196GlnMet: 1.196 ± 1.145
2.392GlnAsn: 2.392 ± 1.457
0.0GlnPro: 0.0 ± 0.0
0.0GlnGln: 0.0 ± 0.0
2.392GlnArg: 2.392 ± 2.131
1.196GlnSer: 1.196 ± 1.145
2.392GlnThr: 2.392 ± 1.488
1.196GlnVal: 1.196 ± 0.907
4.785GlnTrp: 4.785 ± 1.351
2.392GlnTyr: 2.392 ± 0.991
0.0GlnXaa: 0.0 ± 0.0
Arg
4.785ArgAla: 4.785 ± 3.626
2.392ArgCys: 2.392 ± 2.75
2.392ArgAsp: 2.392 ± 1.323
4.785ArgGlu: 4.785 ± 2.152
0.0ArgPhe: 0.0 ± 0.0
9.569ArgGly: 9.569 ± 3.515
3.589ArgHis: 3.589 ± 2.518
4.785ArgIle: 4.785 ± 2.564
8.373ArgLys: 8.373 ± 2.713
5.981ArgLeu: 5.981 ± 2.972
3.589ArgMet: 3.589 ± 1.94
4.785ArgAsn: 4.785 ± 2.991
0.0ArgPro: 0.0 ± 0.0
2.392ArgGln: 2.392 ± 1.646
10.766ArgArg: 10.766 ± 5.032
4.785ArgSer: 4.785 ± 2.802
2.392ArgThr: 2.392 ± 1.323
2.392ArgVal: 2.392 ± 1.656
1.196ArgTrp: 1.196 ± 0.907
3.589ArgTyr: 3.589 ± 1.771
1.196ArgXaa: 1.196 ± 1.145
Ser
4.785SerAla: 4.785 ± 4.578
0.0SerCys: 0.0 ± 0.0
1.196SerAsp: 1.196 ± 1.066
0.0SerGlu: 0.0 ± 0.0
1.196SerPhe: 1.196 ± 1.066
5.981SerGly: 5.981 ± 4.146
3.589SerHis: 3.589 ± 1.178
5.981SerIle: 5.981 ± 1.307
3.589SerLys: 3.589 ± 1.786
3.589SerLeu: 3.589 ± 1.993
0.0SerMet: 0.0 ± 0.0
1.196SerAsn: 1.196 ± 0.907
2.392SerPro: 2.392 ± 1.323
3.589SerGln: 3.589 ± 0.997
8.373SerArg: 8.373 ± 3.658
7.177SerSer: 7.177 ± 3.85
4.785SerThr: 4.785 ± 3.578
5.981SerVal: 5.981 ± 1.307
0.0SerTrp: 0.0 ± 0.0
1.196SerTyr: 1.196 ± 1.145
0.0SerXaa: 0.0 ± 0.0
Thr
7.177ThrAla: 7.177 ± 3.131
1.196ThrCys: 1.196 ± 1.145
2.392ThrAsp: 2.392 ± 1.864
4.785ThrGlu: 4.785 ± 1.23
3.589ThrPhe: 3.589 ± 1.922
1.196ThrGly: 1.196 ± 1.066
1.196ThrHis: 1.196 ± 1.145
5.981ThrIle: 5.981 ± 2.535
2.392ThrLys: 2.392 ± 2.131
5.981ThrLeu: 5.981 ± 2.347
1.196ThrMet: 1.196 ± 1.229
2.392ThrAsn: 2.392 ± 1.496
5.981ThrPro: 5.981 ± 2.347
1.196ThrGln: 1.196 ± 0.907
4.785ThrArg: 4.785 ± 1.716
4.785ThrSer: 4.785 ± 1.477
4.785ThrThr: 4.785 ± 1.391
0.0ThrVal: 0.0 ± 0.0
0.0ThrTrp: 0.0 ± 0.0
2.392ThrTyr: 2.392 ± 1.076
0.0ThrXaa: 0.0 ± 0.0
Val
5.981ValAla: 5.981 ± 2.376
3.589ValCys: 3.589 ± 2.518
3.589ValAsp: 3.589 ± 2.463
1.196ValGlu: 1.196 ± 1.145
1.196ValPhe: 1.196 ± 1.145
5.981ValGly: 5.981 ± 2.951
1.196ValHis: 1.196 ± 0.907
1.196ValIle: 1.196 ± 1.375
1.196ValLys: 1.196 ± 0.907
4.785ValLeu: 4.785 ± 1.716
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
1.196ValPro: 1.196 ± 0.907
2.392ValGln: 2.392 ± 0.991
4.785ValArg: 4.785 ± 2.459
3.589ValSer: 3.589 ± 1.178
3.589ValThr: 3.589 ± 1.771
2.392ValVal: 2.392 ± 0.991
0.0ValTrp: 0.0 ± 0.0
2.392ValTyr: 2.392 ± 0.991
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
1.196TrpCys: 1.196 ± 0.907
0.0TrpAsp: 0.0 ± 0.0
1.196TrpGlu: 1.196 ± 1.066
1.196TrpPhe: 1.196 ± 0.907
2.392TrpGly: 2.392 ± 1.076
0.0TrpHis: 0.0 ± 0.0
4.785TrpIle: 4.785 ± 2.152
0.0TrpLys: 0.0 ± 0.0
1.196TrpLeu: 1.196 ± 1.066
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
3.589TrpArg: 3.589 ± 1.422
1.196TrpSer: 1.196 ± 1.145
1.196TrpThr: 1.196 ± 0.907
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.196TrpTyr: 1.196 ± 1.066
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.392TyrAla: 2.392 ± 1.488
1.196TyrCys: 1.196 ± 0.907
2.392TyrAsp: 2.392 ± 1.076
0.0TyrGlu: 0.0 ± 0.0
0.0TyrPhe: 0.0 ± 0.0
3.589TyrGly: 3.589 ± 1.308
2.392TyrHis: 2.392 ± 1.488
1.196TyrIle: 1.196 ± 0.907
4.785TyrLys: 4.785 ± 3.457
3.589TyrLeu: 3.589 ± 1.308
0.0TyrMet: 0.0 ± 0.0
2.392TyrAsn: 2.392 ± 1.488
1.196TyrPro: 1.196 ± 0.907
2.392TyrGln: 2.392 ± 1.813
3.589TyrArg: 3.589 ± 2.393
5.981TyrSer: 5.981 ± 4.894
1.196TyrThr: 1.196 ± 0.907
3.589TyrVal: 3.589 ± 1.308
2.392TyrTrp: 2.392 ± 1.076
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
1.196XaaHis: 1.196 ± 1.145
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
2.392XaaXaa: 2.392 ± 2.289
Statistics based on 5 proteins (837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski