Amino acid dipepetide frequency for Acinetobacter sp. ANC 4999

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.204AlaAla: 7.204 ± 0.122
0.947AlaCys: 0.947 ± 0.037
4.334AlaAsp: 4.334 ± 0.083
5.577AlaGlu: 5.577 ± 0.087
3.293AlaPhe: 3.293 ± 0.067
5.704AlaGly: 5.704 ± 0.109
1.784AlaHis: 1.784 ± 0.054
6.228AlaIle: 6.228 ± 0.085
5.13AlaLys: 5.13 ± 0.103
9.527AlaLeu: 9.527 ± 0.134
2.528AlaMet: 2.528 ± 0.054
3.545AlaAsn: 3.545 ± 0.08
2.854AlaPro: 2.854 ± 0.063
4.735AlaGln: 4.735 ± 0.098
3.305AlaArg: 3.305 ± 0.073
4.761AlaSer: 4.761 ± 0.089
4.671AlaThr: 4.671 ± 0.079
5.628AlaVal: 5.628 ± 0.101
1.086AlaTrp: 1.086 ± 0.033
2.558AlaTyr: 2.558 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.719CysAla: 0.719 ± 0.031
0.125CysCys: 0.125 ± 0.012
0.516CysAsp: 0.516 ± 0.025
0.493CysGlu: 0.493 ± 0.023
0.466CysPhe: 0.466 ± 0.02
0.782CysGly: 0.782 ± 0.037
0.283CysHis: 0.283 ± 0.019
0.658CysIle: 0.658 ± 0.03
0.382CysLys: 0.382 ± 0.021
0.991CysLeu: 0.991 ± 0.035
0.244CysMet: 0.244 ± 0.019
0.32CysAsn: 0.32 ± 0.019
0.404CysPro: 0.404 ± 0.022
0.394CysGln: 0.394 ± 0.023
0.382CysArg: 0.382 ± 0.02
0.651CysSer: 0.651 ± 0.031
0.468CysThr: 0.468 ± 0.027
0.659CysVal: 0.659 ± 0.027
0.109CysTrp: 0.109 ± 0.012
0.312CysTyr: 0.312 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.582AspAla: 4.582 ± 0.083
0.427AspCys: 0.427 ± 0.02
2.779AspAsp: 2.779 ± 0.075
3.318AspGlu: 3.318 ± 0.072
2.391AspPhe: 2.391 ± 0.056
3.262AspGly: 3.262 ± 0.075
1.256AspHis: 1.256 ± 0.039
3.711AspIle: 3.711 ± 0.065
2.652AspLys: 2.652 ± 0.064
5.707AspLeu: 5.707 ± 0.084
1.249AspMet: 1.249 ± 0.038
1.899AspAsn: 1.899 ± 0.047
2.075AspPro: 2.075 ± 0.05
2.968AspGln: 2.968 ± 0.053
2.279AspArg: 2.279 ± 0.062
2.684AspSer: 2.684 ± 0.059
2.463AspThr: 2.463 ± 0.058
3.662AspVal: 3.662 ± 0.068
0.793AspTrp: 0.793 ± 0.032
1.955AspTyr: 1.955 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.683GluAla: 4.683 ± 0.091
0.396GluCys: 0.396 ± 0.023
2.64GluAsp: 2.64 ± 0.058
2.927GluGlu: 2.927 ± 0.07
2.251GluPhe: 2.251 ± 0.044
2.912GluGly: 2.912 ± 0.07
1.663GluHis: 1.663 ± 0.046
4.446GluIle: 4.446 ± 0.076
4.106GluLys: 4.106 ± 0.082
6.017GluLeu: 6.017 ± 0.106
1.56GluMet: 1.56 ± 0.042
3.012GluAsn: 3.012 ± 0.061
1.621GluPro: 1.621 ± 0.048
4.053GluGln: 4.053 ± 0.078
2.709GluArg: 2.709 ± 0.074
3.115GluSer: 3.115 ± 0.073
2.923GluThr: 2.923 ± 0.056
3.728GluVal: 3.728 ± 0.067
0.769GluTrp: 0.769 ± 0.028
1.868GluTyr: 1.868 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.544PheAla: 3.544 ± 0.063
0.476PheCys: 0.476 ± 0.024
2.72PheAsp: 2.72 ± 0.065
2.619PheGlu: 2.619 ± 0.06
1.884PhePhe: 1.884 ± 0.059
3.252PheGly: 3.252 ± 0.063
0.848PheHis: 0.848 ± 0.031
3.21PheIle: 3.21 ± 0.071
2.694PheLys: 2.694 ± 0.059
3.833PheLeu: 3.833 ± 0.088
1.061PheMet: 1.061 ± 0.038
2.227PheAsn: 2.227 ± 0.057
1.462PhePro: 1.462 ± 0.041
1.643PheGln: 1.643 ± 0.048
1.371PheArg: 1.371 ± 0.038
3.166PheSer: 3.166 ± 0.059
2.174PheThr: 2.174 ± 0.057
2.559PheVal: 2.559 ± 0.055
0.585PheTrp: 0.585 ± 0.026
1.506PheTyr: 1.506 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
5.058GlyAla: 5.058 ± 0.103
0.802GlyCys: 0.802 ± 0.034
3.012GlyAsp: 3.012 ± 0.068
3.523GlyGlu: 3.523 ± 0.071
3.269GlyPhe: 3.269 ± 0.066
4.844GlyGly: 4.844 ± 0.143
1.565GlyHis: 1.565 ± 0.047
4.793GlyIle: 4.793 ± 0.077
3.772GlyLys: 3.772 ± 0.078
7.048GlyLeu: 7.048 ± 0.113
1.879GlyMet: 1.879 ± 0.046
2.597GlyAsn: 2.597 ± 0.101
1.374GlyPro: 1.374 ± 0.039
3.254GlyGln: 3.254 ± 0.081
2.753GlyArg: 2.753 ± 0.068
4.009GlySer: 4.009 ± 0.102
3.714GlyThr: 3.714 ± 0.128
4.765GlyVal: 4.765 ± 0.086
0.877GlyTrp: 0.877 ± 0.036
2.392GlyTyr: 2.392 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
2.02HisAla: 2.02 ± 0.052
0.245HisCys: 0.245 ± 0.016
1.171HisAsp: 1.171 ± 0.042
1.186HisGlu: 1.186 ± 0.036
1.22HisPhe: 1.22 ± 0.041
1.561HisGly: 1.561 ± 0.044
0.802HisHis: 0.802 ± 0.034
1.652HisIle: 1.652 ± 0.043
1.018HisLys: 1.018 ± 0.035
2.574HisLeu: 2.574 ± 0.053
0.536HisMet: 0.536 ± 0.026
0.848HisAsn: 0.848 ± 0.032
1.316HisPro: 1.316 ± 0.044
1.345HisGln: 1.345 ± 0.043
1.04HisArg: 1.04 ± 0.035
1.403HisSer: 1.403 ± 0.041
1.169HisThr: 1.169 ± 0.038
1.529HisVal: 1.529 ± 0.041
0.375HisTrp: 0.375 ± 0.02
0.971HisTyr: 0.971 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.907IleAla: 6.907 ± 0.097
0.77IleCys: 0.77 ± 0.03
4.326IleAsp: 4.326 ± 0.079
4.685IleGlu: 4.685 ± 0.084
2.941IlePhe: 2.941 ± 0.074
4.955IleGly: 4.955 ± 0.081
1.614IleHis: 1.614 ± 0.045
4.471IleIle: 4.471 ± 0.085
3.642IleLys: 3.642 ± 0.068
6.814IleLeu: 6.814 ± 0.108
1.495IleMet: 1.495 ± 0.038
3.145IleAsn: 3.145 ± 0.084
3.038IlePro: 3.038 ± 0.063
3.936IleGln: 3.936 ± 0.076
2.999IleArg: 2.999 ± 0.061
4.607IleSer: 4.607 ± 0.084
3.74IleThr: 3.74 ± 0.065
4.381IleVal: 4.381 ± 0.078
0.742IleTrp: 0.742 ± 0.028
2.262IleTyr: 2.262 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
5.066LysAla: 5.066 ± 0.105
0.329LysCys: 0.329 ± 0.02
3.147LysAsp: 3.147 ± 0.064
3.083LysGlu: 3.083 ± 0.067
2.128LysPhe: 2.128 ± 0.053
3.119LysGly: 3.119 ± 0.061
1.243LysHis: 1.243 ± 0.037
4.275LysIle: 4.275 ± 0.08
3.665LysLys: 3.665 ± 0.086
5.534LysLeu: 5.534 ± 0.084
1.604LysMet: 1.604 ± 0.045
3.324LysAsn: 3.324 ± 0.072
2.317LysPro: 2.317 ± 0.049
3.318LysGln: 3.318 ± 0.074
2.411LysArg: 2.411 ± 0.048
3.274LysSer: 3.274 ± 0.068
3.353LysThr: 3.353 ± 0.067
3.925LysVal: 3.925 ± 0.074
0.592LysTrp: 0.592 ± 0.027
1.715LysTyr: 1.715 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
9.353LeuAla: 9.353 ± 0.13
1.051LeuCys: 1.051 ± 0.036
5.762LeuAsp: 5.762 ± 0.071
5.928LeuGlu: 5.928 ± 0.093
4.09LeuPhe: 4.09 ± 0.091
7.067LeuGly: 7.067 ± 0.116
2.166LeuHis: 2.166 ± 0.051
7.304LeuIle: 7.304 ± 0.108
6.72LeuLys: 6.72 ± 0.086
9.717LeuLeu: 9.717 ± 0.149
2.661LeuMet: 2.661 ± 0.065
5.723LeuAsn: 5.723 ± 0.106
4.387LeuPro: 4.387 ± 0.074
4.492LeuGln: 4.492 ± 0.09
3.952LeuArg: 3.952 ± 0.076
7.344LeuSer: 7.344 ± 0.091
5.779LeuThr: 5.779 ± 0.092
6.322LeuVal: 6.322 ± 0.092
1.133LeuTrp: 1.133 ± 0.043
2.769LeuTyr: 2.769 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.179MetAla: 2.179 ± 0.056
0.206MetCys: 0.206 ± 0.016
1.091MetAsp: 1.091 ± 0.034
0.973MetGlu: 0.973 ± 0.035
0.9MetPhe: 0.9 ± 0.038
1.743MetGly: 1.743 ± 0.044
0.615MetHis: 0.615 ± 0.032
1.726MetIle: 1.726 ± 0.044
1.451MetLys: 1.451 ± 0.042
2.733MetLeu: 2.733 ± 0.065
0.814MetMet: 0.814 ± 0.03
1.429MetAsn: 1.429 ± 0.042
1.18MetPro: 1.18 ± 0.042
1.57MetGln: 1.57 ± 0.048
1.102MetArg: 1.102 ± 0.037
1.954MetSer: 1.954 ± 0.044
1.564MetThr: 1.564 ± 0.035
1.624MetVal: 1.624 ± 0.04
0.229MetTrp: 0.229 ± 0.018
0.553MetTyr: 0.553 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.833AsnAla: 3.833 ± 0.086
0.37AsnCys: 0.37 ± 0.021
2.285AsnAsp: 2.285 ± 0.056
2.371AsnGlu: 2.371 ± 0.06
2.105AsnPhe: 2.105 ± 0.057
2.978AsnGly: 2.978 ± 0.107
1.145AsnHis: 1.145 ± 0.035
3.646AsnIle: 3.646 ± 0.089
2.495AsnLys: 2.495 ± 0.062
4.728AsnLeu: 4.728 ± 0.082
1.148AsnMet: 1.148 ± 0.045
2.227AsnAsn: 2.227 ± 0.099
2.341AsnPro: 2.341 ± 0.061
2.707AsnGln: 2.707 ± 0.082
1.82AsnArg: 1.82 ± 0.049
2.87AsnSer: 2.87 ± 0.075
2.685AsnThr: 2.685 ± 0.077
2.757AsnVal: 2.757 ± 0.071
0.604AsnTrp: 0.604 ± 0.029
1.615AsnTyr: 1.615 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.925ProAla: 2.925 ± 0.063
0.251ProCys: 0.251 ± 0.02
2.021ProAsp: 2.021 ± 0.05
3.136ProGlu: 3.136 ± 0.072
1.694ProPhe: 1.694 ± 0.045
1.567ProGly: 1.567 ± 0.051
0.931ProHis: 0.931 ± 0.028
2.792ProIle: 2.792 ± 0.068
2.412ProLys: 2.412 ± 0.06
3.788ProLeu: 3.788 ± 0.074
0.966ProMet: 0.966 ± 0.033
2.052ProAsn: 2.052 ± 0.053
1.045ProPro: 1.045 ± 0.042
1.915ProGln: 1.915 ± 0.054
1.409ProArg: 1.409 ± 0.05
2.364ProSer: 2.364 ± 0.06
2.165ProThr: 2.165 ± 0.058
2.832ProVal: 2.832 ± 0.054
0.445ProTrp: 0.445 ± 0.023
1.322ProTyr: 1.322 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.908GlnAla: 4.908 ± 0.085
0.405GlnCys: 0.405 ± 0.019
2.436GlnAsp: 2.436 ± 0.057
2.469GlnGlu: 2.469 ± 0.06
2.3GlnPhe: 2.3 ± 0.06
3.22GlnGly: 3.22 ± 0.081
1.719GlnHis: 1.719 ± 0.051
3.603GlnIle: 3.603 ± 0.074
3.087GlnLys: 3.087 ± 0.061
5.738GlnLeu: 5.738 ± 0.108
1.257GlnMet: 1.257 ± 0.047
2.69GlnAsn: 2.69 ± 0.065
1.97GlnPro: 1.97 ± 0.044
4.115GlnGln: 4.115 ± 0.111
2.411GlnArg: 2.411 ± 0.058
3.143GlnSer: 3.143 ± 0.082
2.716GlnThr: 2.716 ± 0.067
3.426GlnVal: 3.426 ± 0.076
0.647GlnTrp: 0.647 ± 0.026
1.802GlnTyr: 1.802 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.104ArgAla: 3.104 ± 0.056
0.348ArgCys: 0.348 ± 0.02
2.146ArgAsp: 2.146 ± 0.054
2.575ArgGlu: 2.575 ± 0.063
1.997ArgPhe: 1.997 ± 0.049
2.311ArgGly: 2.311 ± 0.055
1.067ArgHis: 1.067 ± 0.034
3.077ArgIle: 3.077 ± 0.065
2.298ArgLys: 2.298 ± 0.05
4.581ArgLeu: 4.581 ± 0.076
1.109ArgMet: 1.109 ± 0.037
1.76ArgAsn: 1.76 ± 0.049
1.624ArgPro: 1.624 ± 0.046
2.16ArgGln: 2.16 ± 0.061
1.93ArgArg: 1.93 ± 0.052
2.224ArgSer: 2.224 ± 0.045
1.984ArgThr: 1.984 ± 0.047
2.694ArgVal: 2.694 ± 0.062
0.497ArgTrp: 0.497 ± 0.024
1.635ArgTyr: 1.635 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.918SerAla: 4.918 ± 0.089
0.565SerCys: 0.565 ± 0.029
3.061SerAsp: 3.061 ± 0.066
3.347SerGlu: 3.347 ± 0.062
2.886SerPhe: 2.886 ± 0.056
4.416SerGly: 4.416 ± 0.12
1.524SerHis: 1.524 ± 0.04
4.591SerIle: 4.591 ± 0.081
3.443SerLys: 3.443 ± 0.066
6.449SerLeu: 6.449 ± 0.101
1.607SerMet: 1.607 ± 0.041
3.013SerAsn: 3.013 ± 0.084
2.206SerPro: 2.206 ± 0.055
2.868SerGln: 2.868 ± 0.067
2.45SerArg: 2.45 ± 0.057
4.129SerSer: 4.129 ± 0.079
3.569SerThr: 3.569 ± 0.078
3.823SerVal: 3.823 ± 0.064
0.634SerTrp: 0.634 ± 0.03
1.986SerTyr: 1.986 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.141ThrAla: 5.141 ± 0.097
0.457ThrCys: 0.457 ± 0.026
2.769ThrAsp: 2.769 ± 0.061
3.037ThrGlu: 3.037 ± 0.061
2.098ThrPhe: 2.098 ± 0.05
4.271ThrGly: 4.271 ± 0.119
1.306ThrHis: 1.306 ± 0.041
3.582ThrIle: 3.582 ± 0.067
2.508ThrLys: 2.508 ± 0.06
6.021ThrLeu: 6.021 ± 0.112
1.081ThrMet: 1.081 ± 0.038
2.043ThrAsn: 2.043 ± 0.062
2.578ThrPro: 2.578 ± 0.052
2.897ThrGln: 2.897 ± 0.063
2.064ThrArg: 2.064 ± 0.049
3.04ThrSer: 3.04 ± 0.074
3.224ThrThr: 3.224 ± 0.099
3.792ThrVal: 3.792 ± 0.077
0.701ThrTrp: 0.701 ± 0.031
1.59ThrTyr: 1.59 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
5.671ValAla: 5.671 ± 0.088
0.672ValCys: 0.672 ± 0.028
3.686ValAsp: 3.686 ± 0.072
4.075ValGlu: 4.075 ± 0.086
2.714ValPhe: 2.714 ± 0.059
4.476ValGly: 4.476 ± 0.097
1.336ValHis: 1.336 ± 0.037
4.788ValIle: 4.788 ± 0.075
3.586ValLys: 3.586 ± 0.067
6.787ValLeu: 6.787 ± 0.094
1.798ValMet: 1.798 ± 0.053
2.968ValAsn: 2.968 ± 0.082
2.54ValPro: 2.54 ± 0.052
2.943ValGln: 2.943 ± 0.059
2.64ValArg: 2.64 ± 0.057
4.0ValSer: 4.0 ± 0.064
3.601ValThr: 3.601 ± 0.078
4.627ValVal: 4.627 ± 0.078
0.784ValTrp: 0.784 ± 0.032
1.805ValTyr: 1.805 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.848TrpAla: 0.848 ± 0.034
0.152TrpCys: 0.152 ± 0.013
0.551TrpAsp: 0.551 ± 0.025
0.448TrpGlu: 0.448 ± 0.025
0.609TrpPhe: 0.609 ± 0.027
0.736TrpGly: 0.736 ± 0.03
0.318TrpHis: 0.318 ± 0.018
0.927TrpIle: 0.927 ± 0.036
0.682TrpLys: 0.682 ± 0.026
1.56TrpLeu: 1.56 ± 0.049
0.44TrpMet: 0.44 ± 0.023
0.618TrpAsn: 0.618 ± 0.022
0.341TrpPro: 0.341 ± 0.019
0.76TrpGln: 0.76 ± 0.034
0.546TrpArg: 0.546 ± 0.027
0.75TrpSer: 0.75 ± 0.031
0.595TrpThr: 0.595 ± 0.03
0.807TrpVal: 0.807 ± 0.035
0.15TrpTrp: 0.15 ± 0.016
0.396TrpTyr: 0.396 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.736TyrAla: 2.736 ± 0.057
0.366TyrCys: 0.366 ± 0.021
1.663TyrAsp: 1.663 ± 0.047
1.63TyrGlu: 1.63 ± 0.043
1.599TyrPhe: 1.599 ± 0.049
2.123TyrGly: 2.123 ± 0.055
0.799TyrHis: 0.799 ± 0.036
1.991TyrIle: 1.991 ± 0.043
1.676TyrLys: 1.676 ± 0.049
3.572TyrLeu: 3.572 ± 0.078
0.599TyrMet: 0.599 ± 0.027
1.289TyrAsn: 1.289 ± 0.048
1.359TyrPro: 1.359 ± 0.04
1.987TyrGln: 1.987 ± 0.05
1.55TyrArg: 1.55 ± 0.04
1.997TyrSer: 1.997 ± 0.055
1.64TyrThr: 1.64 ± 0.042
1.954TyrVal: 1.954 ± 0.05
0.482TyrTrp: 0.482 ± 0.02
1.003TyrTyr: 1.003 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2794 proteins (873642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski