Amino acid dipepetide frequency for Plasticicumulans lactativorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.741AlaAla: 23.741 ± 0.301	1.62AlaCys: 1.62 ± 0.042	7.56AlaAsp: 7.56 ± 0.101	8.418AlaGlu: 8.418 ± 0.105	4.386AlaPhe: 4.386 ± 0.059	12.86AlaGly: 12.86 ± 0.131	3.09AlaHis: 3.09 ± 0.054	5.337AlaIle: 5.337 ± 0.075	2.619AlaLys: 2.619 ± 0.063	17.92AlaLeu: 17.92 ± 0.161	2.799AlaMet: 2.799 ± 0.049	2.404AlaAsn: 2.404 ± 0.048	7.407AlaPro: 7.407 ± 0.13	4.797AlaGln: 4.797 ± 0.074	12.118AlaArg: 12.118 ± 0.144	5.515AlaSer: 5.515 ± 0.069	6.405AlaThr: 6.405 ± 0.083	10.098AlaVal: 10.098 ± 0.096	2.196AlaTrp: 2.196 ± 0.052	2.73AlaTyr: 2.73 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.411CysAla: 1.411 ± 0.037	0.159CysCys: 0.159 ± 0.012	0.557CysAsp: 0.557 ± 0.023	0.595CysGlu: 0.595 ± 0.026	0.334CysPhe: 0.334 ± 0.015	1.09CysGly: 1.09 ± 0.034	0.267CysHis: 0.267 ± 0.014	0.387CysIle: 0.387 ± 0.017	0.166CysLys: 0.166 ± 0.012	0.965CysLeu: 0.965 ± 0.028	0.155CysMet: 0.155 ± 0.011	0.211CysAsn: 0.211 ± 0.012	0.562CysPro: 0.562 ± 0.023	0.22CysGln: 0.22 ± 0.012	0.8CysArg: 0.8 ± 0.028	0.481CysSer: 0.481 ± 0.02	0.509CysThr: 0.509 ± 0.018	0.797CysVal: 0.797 ± 0.024	0.112CysTrp: 0.112 ± 0.009	0.228CysTyr: 0.228 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.64AspAla: 8.64 ± 0.111	0.504AspCys: 0.504 ± 0.022	3.093AspAsp: 3.093 ± 0.047	3.315AspGlu: 3.315 ± 0.054	2.104AspPhe: 2.104 ± 0.043	5.367AspGly: 5.367 ± 0.075	1.107AspHis: 1.107 ± 0.029	2.255AspIle: 2.255 ± 0.046	1.21AspLys: 1.21 ± 0.034	5.659AspLeu: 5.659 ± 0.073	0.946AspMet: 0.946 ± 0.029	1.06AspAsn: 1.06 ± 0.029	3.438AspPro: 3.438 ± 0.057	1.223AspGln: 1.223 ± 0.035	3.7AspArg: 3.7 ± 0.059	1.923AspSer: 1.923 ± 0.036	2.701AspThr: 2.701 ± 0.04	4.021AspVal: 4.021 ± 0.053	1.075AspTrp: 1.075 ± 0.029	1.509AspTyr: 1.509 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.907GluAla: 7.907 ± 0.103	0.402GluCys: 0.402 ± 0.018	2.241GluAsp: 2.241 ± 0.039	2.462GluGlu: 2.462 ± 0.054	1.696GluPhe: 1.696 ± 0.037	3.656GluGly: 3.656 ± 0.062	1.689GluHis: 1.689 ± 0.036	2.469GluIle: 2.469 ± 0.049	1.251GluLys: 1.251 ± 0.038	7.103GluLeu: 7.103 ± 0.089	1.0GluMet: 1.0 ± 0.031	1.042GluAsn: 1.042 ± 0.033	2.881GluPro: 2.881 ± 0.058	2.238GluGln: 2.238 ± 0.05	6.38GluArg: 6.38 ± 0.084	2.009GluSer: 2.009 ± 0.045	2.565GluThr: 2.565 ± 0.05	4.378GluVal: 4.378 ± 0.064	0.693GluTrp: 0.693 ± 0.023	1.072GluTyr: 1.072 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.632PheAla: 4.632 ± 0.072	0.376PheCys: 0.376 ± 0.018	2.48PheAsp: 2.48 ± 0.047	2.151PheGlu: 2.151 ± 0.035	1.213PhePhe: 1.213 ± 0.035	3.566PheGly: 3.566 ± 0.063	0.754PheHis: 0.754 ± 0.028	1.413PheIle: 1.413 ± 0.037	0.759PheLys: 0.759 ± 0.025	3.074PheLeu: 3.074 ± 0.049	0.646PheMet: 0.646 ± 0.027	0.959PheAsn: 0.959 ± 0.025	1.5PhePro: 1.5 ± 0.031	0.899PheGln: 0.899 ± 0.026	2.147PheArg: 2.147 ± 0.041	1.644PheSer: 1.644 ± 0.037	1.815PheThr: 1.815 ± 0.044	2.773PheVal: 2.773 ± 0.052	0.485PheTrp: 0.485 ± 0.022	0.854PheTyr: 0.854 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.567GlyAla: 10.567 ± 0.114	1.081GlyCys: 1.081 ± 0.029	4.363GlyAsp: 4.363 ± 0.066	4.966GlyGlu: 4.966 ± 0.062	3.342GlyPhe: 3.342 ± 0.051	7.585GlyGly: 7.585 ± 0.113	2.129GlyHis: 2.129 ± 0.047	3.826GlyIle: 3.826 ± 0.058	2.384GlyLys: 2.384 ± 0.055	9.658GlyLeu: 9.658 ± 0.095	2.029GlyMet: 2.029 ± 0.043	1.884GlyAsn: 1.884 ± 0.045	3.441GlyPro: 3.441 ± 0.049	2.666GlyGln: 2.666 ± 0.049	7.332GlyArg: 7.332 ± 0.088	4.3GlySer: 4.3 ± 0.077	4.31GlyThr: 4.31 ± 0.071	7.097GlyVal: 7.097 ± 0.078	1.527GlyTrp: 1.527 ± 0.038	2.384GlyTyr: 2.384 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	3.368HisAla: 3.368 ± 0.058	0.301HisCys: 0.301 ± 0.015	1.24HisAsp: 1.24 ± 0.03	1.142HisGlu: 1.142 ± 0.033	0.861HisPhe: 0.861 ± 0.026	2.328HisGly: 2.328 ± 0.044	0.654HisHis: 0.654 ± 0.027	0.814HisIle: 0.814 ± 0.025	0.424HisLys: 0.424 ± 0.018	2.565HisLeu: 2.565 ± 0.054	0.411HisMet: 0.411 ± 0.021	0.451HisAsn: 0.451 ± 0.023	1.707HisPro: 1.707 ± 0.04	0.596HisGln: 0.596 ± 0.019	1.656HisArg: 1.656 ± 0.035	0.82HisSer: 0.82 ± 0.027	1.001HisThr: 1.001 ± 0.029	1.776HisVal: 1.776 ± 0.041	0.419HisTrp: 0.419 ± 0.017	0.713HisTyr: 0.713 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.093IleAla: 6.093 ± 0.065	0.361IleCys: 0.361 ± 0.017	2.916IleAsp: 2.916 ± 0.048	2.968IleGlu: 2.968 ± 0.054	1.087IlePhe: 1.087 ± 0.033	4.237IleGly: 4.237 ± 0.063	0.789IleHis: 0.789 ± 0.024	1.284IleIle: 1.284 ± 0.038	1.031IleLys: 1.031 ± 0.032	3.091IleLeu: 3.091 ± 0.046	0.584IleMet: 0.584 ± 0.023	1.108IleAsn: 1.108 ± 0.033	1.941IlePro: 1.941 ± 0.035	0.922IleGln: 0.922 ± 0.027	2.817IleArg: 2.817 ± 0.053	1.71IleSer: 1.71 ± 0.046	2.11IleThr: 2.11 ± 0.042	3.454IleVal: 3.454 ± 0.066	0.38IleTrp: 0.38 ± 0.019	0.793IleTyr: 0.793 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.957LysAla: 2.957 ± 0.064	0.139LysCys: 0.139 ± 0.01	1.079LysAsp: 1.079 ± 0.035	1.063LysGlu: 1.063 ± 0.04	0.602LysPhe: 0.602 ± 0.025	1.761LysGly: 1.761 ± 0.043	0.479LysHis: 0.479 ± 0.019	1.032LysIle: 1.032 ± 0.032	0.804LysLys: 0.804 ± 0.032	2.569LysLeu: 2.569 ± 0.049	0.449LysMet: 0.449 ± 0.022	0.552LysAsn: 0.552 ± 0.026	1.433LysPro: 1.433 ± 0.038	0.721LysGln: 0.721 ± 0.027	1.774LysArg: 1.774 ± 0.033	1.131LysSer: 1.131 ± 0.034	1.199LysThr: 1.199 ± 0.032	1.806LysVal: 1.806 ± 0.043	0.237LysTrp: 0.237 ± 0.013	0.488LysTyr: 0.488 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	19.057LeuAla: 19.057 ± 0.169	1.127LeuCys: 1.127 ± 0.029	7.427LeuAsp: 7.427 ± 0.072	5.925LeuGlu: 5.925 ± 0.076	3.706LeuPhe: 3.706 ± 0.066	10.229LeuGly: 10.229 ± 0.113	2.553LeuHis: 2.553 ± 0.051	4.254LeuIle: 4.254 ± 0.069	2.638LeuLys: 2.638 ± 0.047	13.36LeuLeu: 13.36 ± 0.146	1.957LeuMet: 1.957 ± 0.04	2.328LeuAsn: 2.328 ± 0.048	6.789LeuPro: 6.789 ± 0.08	3.262LeuGln: 3.262 ± 0.059	9.605LeuArg: 9.605 ± 0.131	4.984LeuSer: 4.984 ± 0.066	5.173LeuThr: 5.173 ± 0.079	8.464LeuVal: 8.464 ± 0.097	1.398LeuTrp: 1.398 ± 0.038	2.38LeuTyr: 2.38 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.23MetAla: 2.23 ± 0.044	0.148MetCys: 0.148 ± 0.01	0.898MetAsp: 0.898 ± 0.026	0.802MetGlu: 0.802 ± 0.027	0.55MetPhe: 0.55 ± 0.023	1.321MetGly: 1.321 ± 0.036	0.46MetHis: 0.46 ± 0.021	0.814MetIle: 0.814 ± 0.028	0.679MetLys: 0.679 ± 0.024	2.198MetLeu: 2.198 ± 0.05	0.397MetMet: 0.397 ± 0.021	0.725MetAsn: 0.725 ± 0.024	1.198MetPro: 1.198 ± 0.028	0.669MetGln: 0.669 ± 0.021	1.464MetArg: 1.464 ± 0.037	1.425MetSer: 1.425 ± 0.033	1.134MetThr: 1.134 ± 0.033	1.301MetVal: 1.301 ± 0.035	0.156MetTrp: 0.156 ± 0.01	0.311MetTyr: 0.311 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.804AsnAla: 2.804 ± 0.047	0.233AsnCys: 0.233 ± 0.014	1.121AsnAsp: 1.121 ± 0.037	0.933AsnGlu: 0.933 ± 0.029	0.751AsnPhe: 0.751 ± 0.024	1.821AsnGly: 1.821 ± 0.046	0.416AsnHis: 0.416 ± 0.018	0.917AsnIle: 0.917 ± 0.034	0.488AsnLys: 0.488 ± 0.021	2.431AsnLeu: 2.431 ± 0.046	0.383AsnMet: 0.383 ± 0.017	0.531AsnAsn: 0.531 ± 0.023	1.718AsnPro: 1.718 ± 0.039	0.586AsnGln: 0.586 ± 0.021	1.7AsnArg: 1.7 ± 0.043	0.826AsnSer: 0.826 ± 0.026	1.001AsnThr: 1.001 ± 0.03	1.664AsnVal: 1.664 ± 0.038	0.33AsnTrp: 0.33 ± 0.016	0.514AsnTyr: 0.514 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.97ProAla: 8.97 ± 0.137	0.482ProCys: 0.482 ± 0.019	3.421ProAsp: 3.421 ± 0.057	3.528ProGlu: 3.528 ± 0.058	1.761ProPhe: 1.761 ± 0.038	5.096ProGly: 5.096 ± 0.065	1.21ProHis: 1.21 ± 0.032	1.694ProIle: 1.694 ± 0.037	1.086ProLys: 1.086 ± 0.033	6.26ProLeu: 6.26 ± 0.071	1.027ProMet: 1.027 ± 0.028	1.081ProAsn: 1.081 ± 0.028	3.578ProPro: 3.578 ± 0.087	1.756ProGln: 1.756 ± 0.039	3.756ProArg: 3.756 ± 0.062	2.253ProSer: 2.253 ± 0.042	2.353ProThr: 2.353 ± 0.043	4.397ProVal: 4.397 ± 0.061	0.847ProTrp: 0.847 ± 0.03	1.21ProTyr: 1.21 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.787GlnAla: 4.787 ± 0.085	0.234GlnCys: 0.234 ± 0.014	1.205GlnAsp: 1.205 ± 0.033	1.334GlnGlu: 1.334 ± 0.038	0.995GlnPhe: 0.995 ± 0.029	2.442GlnGly: 2.442 ± 0.05	0.768GlnHis: 0.768 ± 0.025	1.275GlnIle: 1.275 ± 0.029	0.71GlnLys: 0.71 ± 0.026	3.404GlnLeu: 3.404 ± 0.056	0.666GlnMet: 0.666 ± 0.024	0.592GlnAsn: 0.592 ± 0.022	1.911GlnPro: 1.911 ± 0.042	1.28GlnGln: 1.28 ± 0.034	2.914GlnArg: 2.914 ± 0.05	1.264GlnSer: 1.264 ± 0.029	1.371GlnThr: 1.371 ± 0.033	2.639GlnVal: 2.639 ± 0.053	0.445GlnTrp: 0.445 ± 0.018	0.611GlnTyr: 0.611 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.525ArgAla: 10.525 ± 0.131	0.803ArgCys: 0.803 ± 0.026	4.343ArgAsp: 4.343 ± 0.069	5.119ArgGlu: 5.119 ± 0.08	3.195ArgPhe: 3.195 ± 0.047	5.724ArgGly: 5.724 ± 0.071	2.203ArgHis: 2.203 ± 0.042	3.667ArgIle: 3.667 ± 0.055	1.661ArgLys: 1.661 ± 0.035	10.461ArgLeu: 10.461 ± 0.132	1.678ArgMet: 1.678 ± 0.036	1.642ArgAsn: 1.642 ± 0.036	4.226ArgPro: 4.226 ± 0.068	2.784ArgGln: 2.784 ± 0.051	7.308ArgArg: 7.308 ± 0.113	3.322ArgSer: 3.322 ± 0.049	3.383ArgThr: 3.383 ± 0.054	6.168ArgVal: 6.168 ± 0.076	1.299ArgTrp: 1.299 ± 0.033	2.21ArgTyr: 2.21 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.679SerAla: 5.679 ± 0.062	0.353SerCys: 0.353 ± 0.017	2.047SerAsp: 2.047 ± 0.048	1.992SerGlu: 1.992 ± 0.041	1.694SerPhe: 1.694 ± 0.037	4.788SerGly: 4.788 ± 0.08	0.963SerHis: 0.963 ± 0.03	1.77SerIle: 1.77 ± 0.034	0.987SerLys: 0.987 ± 0.034	4.712SerLeu: 4.712 ± 0.077	0.841SerMet: 0.841 ± 0.026	0.98SerAsn: 0.98 ± 0.027	2.425SerPro: 2.425 ± 0.045	1.223SerGln: 1.223 ± 0.033	3.162SerArg: 3.162 ± 0.056	2.054SerSer: 2.054 ± 0.048	2.261SerThr: 2.261 ± 0.041	3.47SerVal: 3.47 ± 0.068	0.521SerTrp: 0.521 ± 0.024	1.024SerTyr: 1.024 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.991ThrAla: 5.991 ± 0.086	0.41ThrCys: 0.41 ± 0.018	2.346ThrAsp: 2.346 ± 0.04	2.25ThrGlu: 2.25 ± 0.043	1.653ThrPhe: 1.653 ± 0.041	4.226ThrGly: 4.226 ± 0.065	1.114ThrHis: 1.114 ± 0.03	1.736ThrIle: 1.736 ± 0.041	0.771ThrLys: 0.771 ± 0.026	6.734ThrLeu: 6.734 ± 0.083	0.735ThrMet: 0.735 ± 0.025	0.864ThrAsn: 0.864 ± 0.032	3.462ThrPro: 3.462 ± 0.059	1.31ThrGln: 1.31 ± 0.031	3.617ThrArg: 3.617 ± 0.056	1.986ThrSer: 1.986 ± 0.042	2.402ThrThr: 2.402 ± 0.048	4.075ThrVal: 4.075 ± 0.065	0.579ThrTrp: 0.579 ± 0.022	0.995ThrTyr: 0.995 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.284ValAla: 10.284 ± 0.105	0.835ValCys: 0.835 ± 0.029	4.606ValAsp: 4.606 ± 0.063	4.503ValGlu: 4.503 ± 0.061	2.833ValPhe: 2.833 ± 0.055	5.727ValGly: 5.727 ± 0.082	1.713ValHis: 1.713 ± 0.044	3.431ValIle: 3.431 ± 0.065	1.782ValLys: 1.782 ± 0.043	9.46ValLeu: 9.46 ± 0.102	1.569ValMet: 1.569 ± 0.042	1.844ValAsn: 1.844 ± 0.038	4.21ValPro: 4.21 ± 0.056	2.307ValGln: 2.307 ± 0.048	5.921ValArg: 5.921 ± 0.061	3.623ValSer: 3.623 ± 0.054	3.79ValThr: 3.79 ± 0.058	6.525ValVal: 6.525 ± 0.089	0.944ValTrp: 0.944 ± 0.026	1.74ValTyr: 1.74 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.357TrpAla: 1.357 ± 0.035	0.185TrpCys: 0.185 ± 0.011	0.643TrpAsp: 0.643 ± 0.02	0.647TrpGlu: 0.647 ± 0.024	0.527TrpPhe: 0.527 ± 0.023	0.962TrpGly: 0.962 ± 0.027	0.364TrpHis: 0.364 ± 0.017	0.589TrpIle: 0.589 ± 0.023	0.354TrpLys: 0.354 ± 0.017	2.278TrpLeu: 2.278 ± 0.053	0.286TrpMet: 0.286 ± 0.012	0.394TrpAsn: 0.394 ± 0.015	0.767TrpPro: 0.767 ± 0.028	0.66TrpGln: 0.66 ± 0.024	1.381TrpArg: 1.381 ± 0.036	0.688TrpSer: 0.688 ± 0.025	0.636TrpThr: 0.636 ± 0.023	0.995TrpVal: 0.995 ± 0.025	0.26TrpTrp: 0.26 ± 0.014	0.288TrpTyr: 0.288 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.021TyrAla: 3.021 ± 0.056	0.252TyrCys: 0.252 ± 0.013	1.265TyrAsp: 1.265 ± 0.036	1.023TyrGlu: 1.023 ± 0.032	0.851TyrPhe: 0.851 ± 0.026	2.082TyrGly: 2.082 ± 0.044	0.524TyrHis: 0.524 ± 0.019	0.713TyrIle: 0.713 ± 0.026	0.472TyrLys: 0.472 ± 0.021	2.713TyrLeu: 2.713 ± 0.047	0.321TyrMet: 0.321 ± 0.016	0.513TyrAsn: 0.513 ± 0.024	1.172TyrPro: 1.172 ± 0.036	0.73TyrGln: 0.73 ± 0.027	2.169TyrArg: 2.169 ± 0.043	0.988TyrSer: 0.988 ± 0.029	1.136TyrThr: 1.136 ± 0.03	1.75TyrVal: 1.75 ± 0.034	0.357TyrTrp: 0.357 ± 0.017	0.628TyrTyr: 0.628 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3868 proteins (1298026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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