Amino acid dipepetide frequency for Podoviridae sp. ctLUJ1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.956AlaAla: 8.956 ± 1.305
0.527AlaCys: 0.527 ± 0.156
4.39AlaAsp: 4.39 ± 0.393
5.883AlaGlu: 5.883 ± 0.542
3.073AlaPhe: 3.073 ± 0.436
4.259AlaGly: 4.259 ± 0.548
1.668AlaHis: 1.668 ± 0.259
5.312AlaIle: 5.312 ± 0.545
6.893AlaLys: 6.893 ± 0.778
7.771AlaLeu: 7.771 ± 0.737
2.327AlaMet: 2.327 ± 0.338
5.62AlaAsn: 5.62 ± 0.836
2.327AlaPro: 2.327 ± 0.413
3.864AlaGln: 3.864 ± 0.506
3.073AlaArg: 3.073 ± 0.386
6.234AlaSer: 6.234 ± 1.281
5.049AlaThr: 5.049 ± 0.53
6.059AlaVal: 6.059 ± 0.565
0.659AlaTrp: 0.659 ± 0.173
3.073AlaTyr: 3.073 ± 0.361
0.0AlaXaa: 0.0 ± 0.0
Cys
0.395CysAla: 0.395 ± 0.132
0.263CysCys: 0.263 ± 0.132
0.439CysAsp: 0.439 ± 0.132
0.746CysGlu: 0.746 ± 0.188
0.307CysPhe: 0.307 ± 0.112
0.878CysGly: 0.878 ± 0.236
0.176CysHis: 0.176 ± 0.096
0.615CysIle: 0.615 ± 0.18
1.098CysLys: 1.098 ± 0.268
0.79CysLeu: 0.79 ± 0.2
0.22CysMet: 0.22 ± 0.09
0.483CysAsn: 0.483 ± 0.158
0.439CysPro: 0.439 ± 0.151
0.263CysGln: 0.263 ± 0.118
0.044CysArg: 0.044 ± 0.043
0.439CysSer: 0.439 ± 0.161
0.746CysThr: 0.746 ± 0.195
0.439CysVal: 0.439 ± 0.174
0.044CysTrp: 0.044 ± 0.047
0.395CysTyr: 0.395 ± 0.134
0.0CysXaa: 0.0 ± 0.0
Asp
6.015AspAla: 6.015 ± 0.622
0.615AspCys: 0.615 ± 0.178
2.546AspAsp: 2.546 ± 0.356
4.083AspGlu: 4.083 ± 0.606
2.546AspPhe: 2.546 ± 0.351
3.381AspGly: 3.381 ± 0.51
0.615AspHis: 0.615 ± 0.184
3.688AspIle: 3.688 ± 0.354
4.522AspLys: 4.522 ± 0.317
5.356AspLeu: 5.356 ± 0.47
1.493AspMet: 1.493 ± 0.247
2.766AspAsn: 2.766 ± 0.302
1.932AspPro: 1.932 ± 0.288
0.878AspGln: 0.878 ± 0.227
2.02AspArg: 2.02 ± 0.33
3.907AspSer: 3.907 ± 0.501
3.951AspThr: 3.951 ± 0.453
2.985AspVal: 2.985 ± 0.262
0.615AspTrp: 0.615 ± 0.199
2.063AspTyr: 2.063 ± 0.223
0.0AspXaa: 0.0 ± 0.0
Glu
6.629GluAla: 6.629 ± 0.828
0.571GluCys: 0.571 ± 0.178
4.171GluAsp: 4.171 ± 0.435
5.049GluGlu: 5.049 ± 0.806
2.546GluPhe: 2.546 ± 0.352
4.259GluGly: 4.259 ± 0.349
1.01GluHis: 1.01 ± 0.22
4.171GluIle: 4.171 ± 0.377
3.907GluLys: 3.907 ± 0.48
6.717GluLeu: 6.717 ± 0.599
1.844GluMet: 1.844 ± 0.285
3.337GluAsn: 3.337 ± 0.42
1.624GluPro: 1.624 ± 0.355
2.59GluGln: 2.59 ± 0.441
2.371GluArg: 2.371 ± 0.36
3.732GluSer: 3.732 ± 0.33
4.303GluThr: 4.303 ± 0.484
5.225GluVal: 5.225 ± 0.462
0.834GluTrp: 0.834 ± 0.241
2.722GluTyr: 2.722 ± 0.325
0.0GluXaa: 0.0 ± 0.0
Phe
2.766PheAla: 2.766 ± 0.479
0.439PheCys: 0.439 ± 0.205
1.888PheAsp: 1.888 ± 0.285
1.844PheGlu: 1.844 ± 0.294
1.185PhePhe: 1.185 ± 0.203
2.678PheGly: 2.678 ± 0.336
1.054PheHis: 1.054 ± 0.172
2.81PheIle: 2.81 ± 0.446
2.327PheLys: 2.327 ± 0.308
3.688PheLeu: 3.688 ± 0.485
1.098PheMet: 1.098 ± 0.256
2.063PheAsn: 2.063 ± 0.305
1.361PhePro: 1.361 ± 0.224
1.01PheGln: 1.01 ± 0.213
1.185PheArg: 1.185 ± 0.182
2.81PheSer: 2.81 ± 0.439
2.59PheThr: 2.59 ± 0.378
2.02PheVal: 2.02 ± 0.304
0.527PheTrp: 0.527 ± 0.205
1.054PheTyr: 1.054 ± 0.201
0.0PheXaa: 0.0 ± 0.0
Gly
4.698GlyAla: 4.698 ± 0.734
0.571GlyCys: 0.571 ± 0.17
2.985GlyAsp: 2.985 ± 0.316
3.688GlyGlu: 3.688 ± 0.347
2.371GlyPhe: 2.371 ± 0.344
3.512GlyGly: 3.512 ± 0.49
1.098GlyHis: 1.098 ± 0.191
4.434GlyIle: 4.434 ± 0.393
4.786GlyLys: 4.786 ± 0.365
4.61GlyLeu: 4.61 ± 0.574
1.8GlyMet: 1.8 ± 0.262
3.205GlyAsn: 3.205 ± 0.385
0.0GlyPro: 0.0 ± 0.0
1.229GlyGln: 1.229 ± 0.175
1.932GlyArg: 1.932 ± 0.254
3.688GlySer: 3.688 ± 0.399
4.873GlyThr: 4.873 ± 0.596
4.961GlyVal: 4.961 ± 0.39
0.834GlyTrp: 0.834 ± 0.174
2.503GlyTyr: 2.503 ± 0.319
0.0GlyXaa: 0.0 ± 0.0
His
1.098HisAla: 1.098 ± 0.212
0.132HisCys: 0.132 ± 0.086
1.405HisAsp: 1.405 ± 0.241
0.834HisGlu: 0.834 ± 0.186
1.098HisPhe: 1.098 ± 0.267
0.922HisGly: 0.922 ± 0.172
0.439HisHis: 0.439 ± 0.135
1.712HisIle: 1.712 ± 0.269
1.142HisLys: 1.142 ± 0.276
1.624HisLeu: 1.624 ± 0.24
0.659HisMet: 0.659 ± 0.12
0.878HisAsn: 0.878 ± 0.166
1.317HisPro: 1.317 ± 0.286
0.527HisGln: 0.527 ± 0.189
0.746HisArg: 0.746 ± 0.146
1.317HisSer: 1.317 ± 0.199
0.966HisThr: 0.966 ± 0.173
1.317HisVal: 1.317 ± 0.298
0.132HisTrp: 0.132 ± 0.092
0.746HisTyr: 0.746 ± 0.207
0.0HisXaa: 0.0 ± 0.0
Ile
5.4IleAla: 5.4 ± 0.488
0.659IleCys: 0.659 ± 0.201
4.742IleAsp: 4.742 ± 0.357
5.005IleGlu: 5.005 ± 0.488
1.844IlePhe: 1.844 ± 0.325
3.995IleGly: 3.995 ± 0.478
1.449IleHis: 1.449 ± 0.324
4.654IleIle: 4.654 ± 0.505
4.522IleLys: 4.522 ± 0.403
4.786IleLeu: 4.786 ± 0.504
1.405IleMet: 1.405 ± 0.218
3.995IleAsn: 3.995 ± 0.44
2.634IlePro: 2.634 ± 0.33
2.371IleGln: 2.371 ± 0.305
2.898IleArg: 2.898 ± 0.354
3.864IleSer: 3.864 ± 0.34
4.654IleThr: 4.654 ± 0.381
3.6IleVal: 3.6 ± 0.548
0.483IleTrp: 0.483 ± 0.155
2.327IleTyr: 2.327 ± 0.262
0.0IleXaa: 0.0 ± 0.0
Lys
6.234LysAla: 6.234 ± 0.518
0.395LysCys: 0.395 ± 0.141
4.522LysAsp: 4.522 ± 0.491
5.532LysGlu: 5.532 ± 0.471
2.503LysPhe: 2.503 ± 0.303
4.303LysGly: 4.303 ± 0.36
1.449LysHis: 1.449 ± 0.227
3.205LysIle: 3.205 ± 0.404
4.434LysLys: 4.434 ± 0.497
6.015LysLeu: 6.015 ± 0.447
1.537LysMet: 1.537 ± 0.245
4.083LysAsn: 4.083 ± 0.485
2.503LysPro: 2.503 ± 0.312
2.854LysGln: 2.854 ± 0.409
3.425LysArg: 3.425 ± 0.473
3.951LysSer: 3.951 ± 0.451
3.82LysThr: 3.82 ± 0.408
5.62LysVal: 5.62 ± 0.468
0.659LysTrp: 0.659 ± 0.173
2.503LysTyr: 2.503 ± 0.292
0.0LysXaa: 0.0 ± 0.0
Leu
8.078LeuAla: 8.078 ± 0.755
0.79LeuCys: 0.79 ± 0.226
5.708LeuAsp: 5.708 ± 0.599
5.488LeuGlu: 5.488 ± 0.481
3.161LeuPhe: 3.161 ± 0.349
4.654LeuGly: 4.654 ± 0.61
1.537LeuHis: 1.537 ± 0.271
5.356LeuIle: 5.356 ± 0.582
5.576LeuLys: 5.576 ± 0.466
7.903LeuLeu: 7.903 ± 0.682
2.678LeuMet: 2.678 ± 0.27
5.444LeuAsn: 5.444 ± 0.466
4.654LeuPro: 4.654 ± 0.464
3.205LeuGln: 3.205 ± 0.444
3.249LeuArg: 3.249 ± 0.382
6.366LeuSer: 6.366 ± 0.416
6.19LeuThr: 6.19 ± 0.392
5.356LeuVal: 5.356 ± 0.433
0.966LeuTrp: 0.966 ± 0.217
2.942LeuTyr: 2.942 ± 0.359
0.0LeuXaa: 0.0 ± 0.0
Met
2.107MetAla: 2.107 ± 0.301
0.176MetCys: 0.176 ± 0.097
1.581MetAsp: 1.581 ± 0.317
1.756MetGlu: 1.756 ± 0.248
0.878MetPhe: 0.878 ± 0.17
1.449MetGly: 1.449 ± 0.254
0.834MetHis: 0.834 ± 0.2
0.966MetIle: 0.966 ± 0.176
1.581MetLys: 1.581 ± 0.22
2.634MetLeu: 2.634 ± 0.411
0.79MetMet: 0.79 ± 0.195
1.098MetAsn: 1.098 ± 0.248
1.361MetPro: 1.361 ± 0.198
1.668MetGln: 1.668 ± 0.283
1.185MetArg: 1.185 ± 0.238
1.888MetSer: 1.888 ± 0.325
1.449MetThr: 1.449 ± 0.224
1.537MetVal: 1.537 ± 0.223
0.176MetTrp: 0.176 ± 0.075
0.746MetTyr: 0.746 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
5.444AsnAla: 5.444 ± 0.411
0.659AsnCys: 0.659 ± 0.242
2.239AsnAsp: 2.239 ± 0.365
3.512AsnGlu: 3.512 ± 0.556
1.668AsnPhe: 1.668 ± 0.258
3.907AsnGly: 3.907 ± 0.526
0.966AsnHis: 0.966 ± 0.215
3.907AsnIle: 3.907 ± 0.488
3.512AsnLys: 3.512 ± 0.39
4.786AsnLeu: 4.786 ± 0.547
1.493AsnMet: 1.493 ± 0.21
2.59AsnAsn: 2.59 ± 0.354
2.898AsnPro: 2.898 ± 0.348
2.151AsnGln: 2.151 ± 0.318
2.107AsnArg: 2.107 ± 0.289
3.381AsnSer: 3.381 ± 0.421
3.688AsnThr: 3.688 ± 0.393
3.776AsnVal: 3.776 ± 0.368
0.659AsnTrp: 0.659 ± 0.193
2.283AsnTyr: 2.283 ± 0.389
0.0AsnXaa: 0.0 ± 0.0
Pro
2.503ProAla: 2.503 ± 0.352
0.527ProCys: 0.527 ± 0.171
2.195ProAsp: 2.195 ± 0.307
2.942ProGlu: 2.942 ± 0.33
1.668ProPhe: 1.668 ± 0.312
0.088ProGly: 0.088 ± 0.071
0.702ProHis: 0.702 ± 0.178
2.239ProIle: 2.239 ± 0.302
2.942ProLys: 2.942 ± 0.343
3.864ProLeu: 3.864 ± 0.47
1.273ProMet: 1.273 ± 0.217
2.327ProAsn: 2.327 ± 0.323
1.229ProPro: 1.229 ± 0.216
1.317ProGln: 1.317 ± 0.244
1.229ProArg: 1.229 ± 0.242
3.117ProSer: 3.117 ± 0.381
2.854ProThr: 2.854 ± 0.304
2.766ProVal: 2.766 ± 0.299
0.263ProTrp: 0.263 ± 0.112
1.449ProTyr: 1.449 ± 0.265
0.0ProXaa: 0.0 ± 0.0
Gln
2.898GlnAla: 2.898 ± 0.507
0.439GlnCys: 0.439 ± 0.196
1.361GlnAsp: 1.361 ± 0.252
2.59GlnGlu: 2.59 ± 0.386
1.142GlnPhe: 1.142 ± 0.217
2.766GlnGly: 2.766 ± 0.303
0.834GlnHis: 0.834 ± 0.194
2.415GlnIle: 2.415 ± 0.329
2.678GlnLys: 2.678 ± 0.319
3.381GlnLeu: 3.381 ± 0.422
0.702GlnMet: 0.702 ± 0.177
1.976GlnAsn: 1.976 ± 0.32
0.79GlnPro: 0.79 ± 0.142
1.756GlnGln: 1.756 ± 0.41
1.493GlnArg: 1.493 ± 0.249
2.371GlnSer: 2.371 ± 0.332
2.546GlnThr: 2.546 ± 0.334
2.195GlnVal: 2.195 ± 0.367
0.483GlnTrp: 0.483 ± 0.157
1.668GlnTyr: 1.668 ± 0.286
0.0GlnXaa: 0.0 ± 0.0
Arg
3.293ArgAla: 3.293 ± 0.427
0.527ArgCys: 0.527 ± 0.163
2.195ArgAsp: 2.195 ± 0.262
3.205ArgGlu: 3.205 ± 0.348
1.185ArgPhe: 1.185 ± 0.288
2.503ArgGly: 2.503 ± 0.286
0.746ArgHis: 0.746 ± 0.174
3.381ArgIle: 3.381 ± 0.299
2.371ArgLys: 2.371 ± 0.301
3.425ArgLeu: 3.425 ± 0.303
1.229ArgMet: 1.229 ± 0.219
1.888ArgAsn: 1.888 ± 0.289
1.185ArgPro: 1.185 ± 0.247
1.317ArgGln: 1.317 ± 0.254
1.756ArgArg: 1.756 ± 0.254
1.932ArgSer: 1.932 ± 0.288
2.327ArgThr: 2.327 ± 0.339
2.678ArgVal: 2.678 ± 0.373
0.351ArgTrp: 0.351 ± 0.135
1.493ArgTyr: 1.493 ± 0.215
0.0ArgXaa: 0.0 ± 0.0
Ser
5.488SerAla: 5.488 ± 0.733
0.351SerCys: 0.351 ± 0.119
3.512SerAsp: 3.512 ± 0.546
4.346SerGlu: 4.346 ± 0.578
2.503SerPhe: 2.503 ± 0.339
3.732SerGly: 3.732 ± 0.522
0.922SerHis: 0.922 ± 0.244
4.61SerIle: 4.61 ± 0.485
4.961SerLys: 4.961 ± 0.535
6.41SerLeu: 6.41 ± 0.498
1.624SerMet: 1.624 ± 0.252
3.864SerAsn: 3.864 ± 0.394
3.161SerPro: 3.161 ± 0.445
2.283SerGln: 2.283 ± 0.312
2.371SerArg: 2.371 ± 0.317
4.566SerSer: 4.566 ± 0.463
4.434SerThr: 4.434 ± 0.551
4.654SerVal: 4.654 ± 0.373
0.878SerTrp: 0.878 ± 0.177
1.668SerTyr: 1.668 ± 0.264
0.0SerXaa: 0.0 ± 0.0
Thr
6.498ThrAla: 6.498 ± 0.709
0.351ThrCys: 0.351 ± 0.13
3.732ThrAsp: 3.732 ± 0.493
4.434ThrGlu: 4.434 ± 0.5
2.151ThrPhe: 2.151 ± 0.263
3.82ThrGly: 3.82 ± 0.8
1.493ThrHis: 1.493 ± 0.259
4.786ThrIle: 4.786 ± 0.497
4.39ThrLys: 4.39 ± 0.45
5.576ThrLeu: 5.576 ± 0.587
0.922ThrMet: 0.922 ± 0.175
3.6ThrAsn: 3.6 ± 0.385
3.732ThrPro: 3.732 ± 0.42
2.942ThrGln: 2.942 ± 0.312
2.722ThrArg: 2.722 ± 0.347
4.61ThrSer: 4.61 ± 0.473
4.917ThrThr: 4.917 ± 0.6
4.522ThrVal: 4.522 ± 0.541
0.439ThrTrp: 0.439 ± 0.136
2.546ThrTyr: 2.546 ± 0.331
0.0ThrXaa: 0.0 ± 0.0
Val
5.268ValAla: 5.268 ± 0.719
0.79ValCys: 0.79 ± 0.191
3.82ValAsp: 3.82 ± 0.499
3.732ValGlu: 3.732 ± 0.523
2.81ValPhe: 2.81 ± 0.33
3.556ValGly: 3.556 ± 0.538
1.01ValHis: 1.01 ± 0.201
4.346ValIle: 4.346 ± 0.454
5.093ValLys: 5.093 ± 0.409
5.225ValLeu: 5.225 ± 0.442
1.493ValMet: 1.493 ± 0.232
4.303ValAsn: 4.303 ± 0.445
2.81ValPro: 2.81 ± 0.401
2.503ValGln: 2.503 ± 0.367
2.59ValArg: 2.59 ± 0.263
4.961ValSer: 4.961 ± 0.551
5.576ValThr: 5.576 ± 0.655
4.917ValVal: 4.917 ± 0.575
0.439ValTrp: 0.439 ± 0.156
2.371ValTyr: 2.371 ± 0.255
0.0ValXaa: 0.0 ± 0.0
Trp
0.834TrpAla: 0.834 ± 0.305
0.044TrpCys: 0.044 ± 0.044
0.527TrpAsp: 0.527 ± 0.138
0.527TrpGlu: 0.527 ± 0.134
0.439TrpPhe: 0.439 ± 0.143
0.439TrpGly: 0.439 ± 0.128
0.395TrpHis: 0.395 ± 0.14
0.659TrpIle: 0.659 ± 0.179
0.527TrpLys: 0.527 ± 0.146
1.317TrpLeu: 1.317 ± 0.302
0.263TrpMet: 0.263 ± 0.147
0.439TrpAsn: 0.439 ± 0.138
0.132TrpPro: 0.132 ± 0.082
0.307TrpGln: 0.307 ± 0.129
0.439TrpArg: 0.439 ± 0.116
0.702TrpSer: 0.702 ± 0.291
0.615TrpThr: 0.615 ± 0.143
0.878TrpVal: 0.878 ± 0.207
0.088TrpTrp: 0.088 ± 0.06
0.483TrpTyr: 0.483 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.415TyrAla: 2.415 ± 0.288
0.395TyrCys: 0.395 ± 0.138
2.02TyrAsp: 2.02 ± 0.287
2.459TyrGlu: 2.459 ± 0.311
1.317TyrPhe: 1.317 ± 0.234
2.678TyrGly: 2.678 ± 0.336
0.615TyrHis: 0.615 ± 0.126
2.02TyrIle: 2.02 ± 0.302
2.283TyrLys: 2.283 ± 0.282
3.425TyrLeu: 3.425 ± 0.426
0.966TyrMet: 0.966 ± 0.212
1.668TyrAsn: 1.668 ± 0.261
1.405TyrPro: 1.405 ± 0.247
1.449TyrGln: 1.449 ± 0.257
2.151TyrArg: 2.151 ± 0.364
2.503TyrSer: 2.503 ± 0.355
2.634TyrThr: 2.634 ± 0.323
2.107TyrVal: 2.107 ± 0.301
0.527TyrTrp: 0.527 ± 0.125
1.185TyrTyr: 1.185 ± 0.366
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 84 proteins (22778 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski